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Conserved domains on  [gi|219555700|ref|NP_001137229|]
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leucine-rich repeat-containing protein 27 isoform a [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.36e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555700 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
PTZ00121 super family cl31754
MAEBL; Provisional
 225-496 1.71e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  225 MKEKASflppvEKPDLSELRKSAD----SSENWPSEEEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEeakkAEEAKKKAEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRrfhgqap 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE------- 1642

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 219555700  460 lEEMRKAAEDLEIATElQDEVLKLKLGLTLNKDRRRA 496
Cdd:PTZ00121 1643 -AEEKKKAEELKKAEE-ENKIKAAEEAKKAEEDKKKA 1677
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.36e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555700 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
67-126 2.34e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219555700   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 1.20e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 219555700 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PTZ00121 PTZ00121
MAEBL; Provisional
 225-496 1.71e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  225 MKEKASflppvEKPDLSELRKSAD----SSENWPSEEEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEeakkAEEAKKKAEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRrfhgqap 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE------- 1642

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 219555700  460 lEEMRKAAEDLEIATElQDEVLKLKLGLTLNKDRRRA 496
Cdd:PTZ00121 1643 -AEEKKKAEELKKAEE-ENKIKAAEEAKKAEEDKKKA 1677
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 330-469 4.70e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  330 IRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKipsatDLIDNRKVPL 409
Cdd:pfam17380 435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEK-----ELEERKQAMI 509

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  410 NPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHgqaplEEMRKAAED 469
Cdd:pfam17380 510 EEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQ-----EQMRKATEE 564
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 1.66e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
LRR smart00370
Leucine-rich repeats, outliers;
90-113 3.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.83e-03
                           10        20
                   ....*....|....*....|....
gi 219555700    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.36e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555700 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 2.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 2.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  52 LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV 131
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176

                         90       100
                 ....*....|....*....|....*
gi 219555700 132 ELGSVTTLKALNLRHCPL-EFPPQL 155
Cdd:COG4886  177 ELGNLTNLKELDLSNNQItDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 1.58e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  187 LDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                         90       100
                 ....*....|....*....|..
gi 219555700 129 LPvELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  265 LP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 7.44e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 7.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNalcvipqDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKML 129
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100
                 ....*....|....*....|.
gi 219555700 130 PVELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLT 172
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-132 2.13e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 2.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  210 LDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286


                 ....
gi 219555700 129 LPVE 132
Cdd:COG4886  287 LKLK 290
LRR_8 pfam13855
Leucine rich repeat;
67-126 2.34e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219555700   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 1.20e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 219555700 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PTZ00121 PTZ00121
MAEBL; Provisional
 225-496 1.71e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  225 MKEKASflppvEKPDLSELRKSAD----SSENWPSEEEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEeakkAEEAKKKAEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRrfhgqap 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE------- 1642

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 219555700  460 lEEMRKAAEDLEIATElQDEVLKLKLGLTLNKDRRRA 496
Cdd:PTZ00121 1643 -AEEKKKAEELKKAEE-ENKIKAAEEAKKAEEDKKKA 1677
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 330-469 4.70e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  330 IRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKipsatDLIDNRKVPL 409
Cdd:pfam17380 435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEK-----ELEERKQAMI 509

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  410 NPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHgqaplEEMRKAAED 469
Cdd:pfam17380 510 EEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQ-----EQMRKATEE 564
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-106 4.80e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 219555700  49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFqlLPNLTWLDLRYNRIKAL 106
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL 287
PTZ00121 PTZ00121
MAEBL; Provisional
 332-477 8.82e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  332 AKRLEESRAAALRELQEKQALMEQQRR--EKRALQEWRE-----RAQRMRKrKEELSKLLPPRRSMVASKIPSATDLIDN 404
Cdd:PTZ00121 1145 ARKAEDAKRVEIARKAEDARKAEEARKaeDAKKAEAARKaeevrKAEELRK-AEDARKAEAARKAEEERKAEEARKAEDA 1223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 219555700  405 RKVPlnppgKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKA-----AEDLEIATELQ 477
Cdd:PTZ00121 1224 KKAE-----AVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKAdelkkAEEKKKADEAK 1296
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 1.66e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-123 1.92e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219555700  57 LCRLEEVFRIPSLQQLHLQRNALCVIpqDFFQLLPNLTWLDLRYNRIKALpSGIGAHQHLKTLLLER 123
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-144 3.12e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  63 VFRIPSLQQLHLQRNALC-VIPQDFFQLLPNLTWLDLRYNRIK-ALPSgiGAHQHLKTLLLERNPIK-MLPVELGSVTTL 139
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGSFSSL 166


                 ....*
gi 219555700 140 KALNL 144
Cdd:PLN00113 167 KVLDL 171
LRR smart00370
Leucine-rich repeats, outliers;
90-113 3.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.83e-03
                           10        20
                   ....*....|....*....|....
gi 219555700    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
90-113 3.83e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.83e-03
                           10        20
                   ....*....|....*....|....
gi 219555700    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PTZ00121 PTZ00121
MAEBL; Provisional
 209-484 9.69e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  209 ASNQGAVNAQDPEGAVMKEKASflppvEKPDLSELRKSadssenwpseEEIRRFWKLRQEIVEHVKADVLGDQllTRELP 288
Cdd:PTZ00121 1266 ARRQAAIKAEEARKADELKKAE-----EKKKADEAKKA----------EEKKKADEAKKKAEEAKKADEAKKK--AEEAK 1328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  289 PNLKAALNIEKELPKPRHVFRRKTASSRSILpdllspyqmairAKRLEESRAAALRELQEKQALMEQQRR--EKRALQEW 366
Cdd:PTZ00121 1329 KKADAAKKKAEEAKKAAEAAKAEAEAAADEA------------EAAEEKAEAAEKKKEEAKKKADAAKKKaeEKKKADEA 1396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555700  367 RERAQRMRKRKEELSKLLPPRRSM-VASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSAL---QERNLEEKIK 442
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKAdEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKkkaEEAKKADEAK 1476

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 219555700  443 QHVLQMREQRRFHGQAplEEMRKAAEDLEIATELQDEVLKLK 484
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKA--EEAKKKADEAKKAAEAKKKADEAK 1516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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