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Conserved domains on  [gi|221136777|ref|NP_001137445|]
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tectonic-3 isoform b precursor [Homo sapiens]

Protein Classification

tectonic family protein( domain architecture ID 10405)

tectonic family protein, formerly called DUF1619 domain, similar to Homo sapiens tectonic proteins which are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, and is required for hedgehog signaling transduction

Gene Ontology:  GO:0008589|GO:1904491
PubMed:  16357211|22179047

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCTN_DUF1619 super family cl06690
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 90-301 1.18e-33

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


The actual alignment was detected with superfamily member pfam07773:

Pssm-ID: 462260  Cd Length: 315  Bit Score: 128.82  E-value: 1.18e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777   90 CVCDLTPGACDINCCCDRDCYLLHPRTvFSFCLPGSVRSSSWVCVDNSVIFRSNSPFP--SRVFMDSNGIRQFCVHVNN- 166
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLST-FSSCLVGVVSGDSQLCSQKSAIFRSNLPPQrlFGLVTDQINPDLFCVQSSNn 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  167 ---------------------------------------------------------------------------C---- 167
Cdd:pfam07773  80 nsplgsffqpptsvptpsnfedslykkftgfsfasesdvssstssgykvgdpiqtynpsssvgyltlpqsslsgqCvdnn 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  168 ---FLESKSTTCTRFFKNLASSCTLDSALNAASYYNFtvLKVPRSMTDPqnmeafQQSTAASLTSPRSGNPGyivgkpLL 244
Cdd:pfam07773 160 pvaFLQNQSTSCTRRVTDLLDSCTTLPALSAASYTSN--FILPAVPNSQ------VVPVTVQSTYLQSLNSG------LL 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136777  245 ALTDDISYSMTLLQSQGNGSCS--VKRHEVQFGVNA---ISGCKLRLKKADCSHLQQEIYQT 301
Cdd:pfam07773 226 TTLTSTSLRGSPSPLLNNGTCRnvVLEVKYVITYNGtggITEATVSLVLANVSASQLPLQQR 287
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 90-301 1.18e-33

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 128.82  E-value: 1.18e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777   90 CVCDLTPGACDINCCCDRDCYLLHPRTvFSFCLPGSVRSSSWVCVDNSVIFRSNSPFP--SRVFMDSNGIRQFCVHVNN- 166
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLST-FSSCLVGVVSGDSQLCSQKSAIFRSNLPPQrlFGLVTDQINPDLFCVQSSNn 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  167 ---------------------------------------------------------------------------C---- 167
Cdd:pfam07773  80 nsplgsffqpptsvptpsnfedslykkftgfsfasesdvssstssgykvgdpiqtynpsssvgyltlpqsslsgqCvdnn 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  168 ---FLESKSTTCTRFFKNLASSCTLDSALNAASYYNFtvLKVPRSMTDPqnmeafQQSTAASLTSPRSGNPGyivgkpLL 244
Cdd:pfam07773 160 pvaFLQNQSTSCTRRVTDLLDSCTTLPALSAASYTSN--FILPAVPNSQ------VVPVTVQSTYLQSLNSG------LL 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136777  245 ALTDDISYSMTLLQSQGNGSCS--VKRHEVQFGVNA---ISGCKLRLKKADCSHLQQEIYQT 301
Cdd:pfam07773 226 TTLTSTSLRGSPSPLLNNGTCRnvVLEVKYVITYNGtggITEATVSLVLANVSASQLPLQQR 287
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 90-301 1.18e-33

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 128.82  E-value: 1.18e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777   90 CVCDLTPGACDINCCCDRDCYLLHPRTvFSFCLPGSVRSSSWVCVDNSVIFRSNSPFP--SRVFMDSNGIRQFCVHVNN- 166
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLST-FSSCLVGVVSGDSQLCSQKSAIFRSNLPPQrlFGLVTDQINPDLFCVQSSNn 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  167 ---------------------------------------------------------------------------C---- 167
Cdd:pfam07773  80 nsplgsffqpptsvptpsnfedslykkftgfsfasesdvssstssgykvgdpiqtynpsssvgyltlpqsslsgqCvdnn 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136777  168 ---FLESKSTTCTRFFKNLASSCTLDSALNAASYYNFtvLKVPRSMTDPqnmeafQQSTAASLTSPRSGNPGyivgkpLL 244
Cdd:pfam07773 160 pvaFLQNQSTSCTRRVTDLLDSCTTLPALSAASYTSN--FILPAVPNSQ------VVPVTVQSTYLQSLNSG------LL 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136777  245 ALTDDISYSMTLLQSQGNGSCS--VKRHEVQFGVNA---ISGCKLRLKKADCSHLQQEIYQT 301
Cdd:pfam07773 226 TTLTSTSLRGSPSPLLNNGTCRnvVLEVKYVITYNGtggITEATVSLVLANVSASQLPLQQR 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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