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Conserved domains on  [gi|221316632|ref|NP_001137534|]
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coatomer subunit beta [Homo sapiens]

Protein Classification

coatomer subunit beta( domain architecture ID 12024688)

coatomer subunit beta is part of the coatomer cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
18-550 2.24e-142

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 434.36  E-value: 2.24e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   18 SEPPSEISLKNDLEKG--DVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLpLQDHTIKKLLLVFWEIVPKTTPDgrll 95
Cdd:pfam01602   1 EEKRIQQELARILNSFrdDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVA-SKDFTLKRLGYLYLMLLAEESPD---- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   96 hEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPD-AP 174
Cdd:pfam01602  76 -LAILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDfVP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  175 ELIHdfLVNEKDASCKRNAFMMLIHADQD-----RALDYLSTCIDQ-VQTFGDILQLVIVELIYKVCHANPSERARFIRC 248
Cdd:pfam01602 155 ELKE--LLSDKDPGVQSAAVALLYEICKNdrlylKLLPLLFRRLCNlLGVLNPWLQVKILRLLTRLAPLDPLLPKELLED 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  249 IYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIkESDNNVKLIVLDRLIELKEHpaHERVLQDLVMDILRV 328
Cdd:pfam01602 233 LLNLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLS-SPDENLRYVALRNLNKIVMK--EPKAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  329 LSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEViktNNVSEHEdtdkYRQLLVRTLHSCSVRFPDMAANVIPVLMEF 408
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYV---HEIADPD----FKIELVRAIGRLAEKFPTDAEWYLDVLLDL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  409 LSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIqSVMTEIRRSLGEIPI 488
Cdd:pfam01602 383 LSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNG-SSPPDLLRSILEVFV 461
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  489 VESEIKKEA--------GELKPEEEITvgpvQKLVTEMGTYATQSALSSSRPTKKEEdrppLRGFLLDGD 550
Cdd:pfam01602 462 LESAKVRAAaltalaklGLTSPEETTQ----NLIIQLLLTLATQDSLDLEVRDRAVE----YLRLLSLAD 523
Coatamer_beta_C pfam07718
Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta ...
667-807 2.06e-82

Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal pfam01602 domain.


:

Pssm-ID: 462245 [Multi-domain]  Cd Length: 138  Bit Score: 262.08  E-value: 2.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  667 PDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNtqrKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVV 746
Cdd:pfam07718   1 PDDPISFRQLKGKKGESGEELQFEDDLSQATGG---DIAEDDFSSKLNKIVQLTGFSDPVYAEAYVTVHQFDIVLDVLLV 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221316632  747 NQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDV 807
Cdd:pfam07718  78 NQTSETLQNLTVELATLGDLKLVERPQPVTLAPHGFHNIKATVKVSSTETGVIFGNIVYDG 138
Coatomer_b_Cpla pfam14806
Coatomer beta subunit appendage platform; This family is found at the C-terminus of the ...
813-944 7.57e-81

Coatomer beta subunit appendage platform; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.


:

Pssm-ID: 434227  Cd Length: 128  Bit Score: 257.50  E-value: 7.57e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  813 DRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMA 892
Cdd:pfam14806   1 DRNCVILNDIHIDIMDYIKPATCDDEEFREMWAEFEWENKITVNTNITDLREYLDHLMKKTNMNCLTPEEALSGECGFLS 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 221316632  893 ANLYARSIFGEDALANVSIEKPihqgPDAAVTGHIRIRAKSQGMALSLGDKI 944
Cdd:pfam14806  81 ANLYARSIFGEDALANLSIEKD----GDGKISGHVRIRSKTQGIALSLGDKI 128
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
18-550 2.24e-142

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 434.36  E-value: 2.24e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   18 SEPPSEISLKNDLEKG--DVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLpLQDHTIKKLLLVFWEIVPKTTPDgrll 95
Cdd:pfam01602   1 EEKRIQQELARILNSFrdDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVA-SKDFTLKRLGYLYLMLLAEESPD---- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   96 hEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPD-AP 174
Cdd:pfam01602  76 -LAILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDfVP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  175 ELIHdfLVNEKDASCKRNAFMMLIHADQD-----RALDYLSTCIDQ-VQTFGDILQLVIVELIYKVCHANPSERARFIRC 248
Cdd:pfam01602 155 ELKE--LLSDKDPGVQSAAVALLYEICKNdrlylKLLPLLFRRLCNlLGVLNPWLQVKILRLLTRLAPLDPLLPKELLED 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  249 IYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIkESDNNVKLIVLDRLIELKEHpaHERVLQDLVMDILRV 328
Cdd:pfam01602 233 LLNLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLS-SPDENLRYVALRNLNKIVMK--EPKAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  329 LSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEViktNNVSEHEdtdkYRQLLVRTLHSCSVRFPDMAANVIPVLMEF 408
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYV---HEIADPD----FKIELVRAIGRLAEKFPTDAEWYLDVLLDL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  409 LSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIqSVMTEIRRSLGEIPI 488
Cdd:pfam01602 383 LSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNG-SSPPDLLRSILEVFV 461
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  489 VESEIKKEA--------GELKPEEEITvgpvQKLVTEMGTYATQSALSSSRPTKKEEdrppLRGFLLDGD 550
Cdd:pfam01602 462 LESAKVRAAaltalaklGLTSPEETTQ----NLIIQLLLTLATQDSLDLEVRDRAVE----YLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
29-916 9.48e-108

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 350.95  E-value: 9.48e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  29 DLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPlQDHTIKKLLLVFWEIVPKTTPdgrllHEMILVCDAYRKD 108
Cdd:COG5096   27 RLESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVAT-RDVELKRLLYLYLERYAKLKP-----ELALLAVNTIQKD 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 109 LQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDA-PELIHDFLVNEKDA 187
Cdd:COG5096  101 LQDPNEEIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELgLIDILKELVADSDP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 188 SCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVchanpserarfircIYNLLQSSSPAVKYEA--- 264
Cdd:COG5096  181 IVIANALASLAEIDPELAHGYSLEVILRIPQLDLLSLSVSTEWLLLI--------------ILEVLTERVPTTPDSAedf 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 265 -AGTLVTLSSA-PTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPahervlQDLVMDILRVLSTPDLEVRKKTLQ 342
Cdd:COG5096  247 eERLSPPLQHNnAEVLLIAVKVILRLLVFLPSNNLFLISSPPLVTLLAKP------ESLIQYVLRRNIQIDLEVCSKLLD 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 343 LALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTdkyrQLLVRTLHSCSVRFPDmaANVIPVLMEFLSDNNEAAAADVLE 422
Cdd:COG5096  321 KVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLS----QILLELIYYIAENHID--AEMVSEAIKALGDLASKAESSVND 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 423 FVREAIQrfdnlrmlivekmlevfhaiksvkIYRGAlWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEIKKeagelkp 502
Cdd:COG5096  395 CISELLE------------------------LLEGV-WIRGSYIVQEVRIVDCISVIRISVLVLRILPNEYPK------- 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 503 eeeitvgpvqKLVTemGTYATQSALSssrptkkEEDRPPLRgfLLDGDFFVAASLATTLTKIALRYValvqekkkqnsfv 582
Cdd:COG5096  443 ----------ILLR--GLYALEETLE-------LQSREPRA--KSVTDKYLGAWLLGEFSDIIPRLE------------- 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 583 aEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSlshmlsakleeeklsqkkesekrn 662
Cdd:COG5096  489 -PELLRIAISNFVDETLEVQYTILMSSVKLIANSIRKAKQCNSELDQDVLRRCFDY------------------------ 543
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 663 vTVQPDDpisfmQLTAKnemnckedqFQLSLLAamgntqrkeaadplasklnkvTQLTGFSDPVYAEAYVHVNQYDIVLD 742
Cdd:COG5096  544 -VLVPDL-----RDRAR---------MYSRLLS---------------------TPLPEFSDPILCEAKKSNSQFEIILS 587
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 743 VLVVNQTSDTLQNCTLELaTLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNcVVLSDI 822
Cdd:COG5096  588 ALLTNQTPELLENLRLDF-TLGTLSTIPLKPIFNLRKGAVVLQQVTVKKPNAELGFITGNINPSGAANEDLRD-INLNDS 665
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 823 HIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTN-MVDLNDYLQHILKSTNMKCLTPEKALSgycgFMAANLYARsif 901
Cdd:COG5096  666 INSISGFVNPRTVDEDYFRELWKMDEFENKIDESSNnPKKLDDYSEEKSREDNMEILTPSDDLE----FSSSSLGSK--- 738
                        890
                 ....*....|....*
gi 221316632 902 gEDALANVSIEKPIH 916
Cdd:COG5096  739 -SDALMSLCLEKPEP 752
Coatamer_beta_C pfam07718
Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta ...
667-807 2.06e-82

Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal pfam01602 domain.


Pssm-ID: 462245 [Multi-domain]  Cd Length: 138  Bit Score: 262.08  E-value: 2.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  667 PDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNtqrKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVV 746
Cdd:pfam07718   1 PDDPISFRQLKGKKGESGEELQFEDDLSQATGG---DIAEDDFSSKLNKIVQLTGFSDPVYAEAYVTVHQFDIVLDVLLV 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221316632  747 NQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDV 807
Cdd:pfam07718  78 NQTSETLQNLTVELATLGDLKLVERPQPVTLAPHGFHNIKATVKVSSTETGVIFGNIVYDG 138
Coatomer_b_Cpla pfam14806
Coatomer beta subunit appendage platform; This family is found at the C-terminus of the ...
813-944 7.57e-81

Coatomer beta subunit appendage platform; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.


Pssm-ID: 434227  Cd Length: 128  Bit Score: 257.50  E-value: 7.57e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  813 DRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMA 892
Cdd:pfam14806   1 DRNCVILNDIHIDIMDYIKPATCDDEEFREMWAEFEWENKITVNTNITDLREYLDHLMKKTNMNCLTPEEALSGECGFLS 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 221316632  893 ANLYARSIFGEDALANVSIEKPihqgPDAAVTGHIRIRAKSQGMALSLGDKI 944
Cdd:pfam14806  81 ANLYARSIFGEDALANLSIEKD----GDGKISGHVRIRSKTQGIALSLGDKI 128
PTZ00429 PTZ00429
beta-adaptin; Provisional
26-486 8.19e-06

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 49.93  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVlPLQDHTIKKLLLVFWEIVPKTTPDGRLLhemilVCDAY 105
Cdd:PTZ00429  37 LQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLA-PSTDLELKKLVYLYVLSTARLQPEKALL-----AVNTF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 106 RKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPD---APELIHdfLV 182
Cdd:PTZ00429 111 LQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQqdfKKDLVE--LL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 183 NEKDASCKRNAFMMLIHADQ-------------DRALDYLSTCIDQVQTFgdILQL--------------VIVELIYKVC 235
Cdd:PTZ00429 189 NDNNPVVASNAAAIVCEVNDygsekiessnewvNRLVYHLPECNEWGQLY--ILELlaaqrpsdkesaetLLTRVLPRMS 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 236 HANPSERARFIRCIYNLLQSSSP------AVKYEAAgtLVTLSSAptaiKAAAQcYIdlIIKesDNNVKLIVLDRLIELK 309
Cdd:PTZ00429 267 HQNPAVVMGAIKVVANLASRCSQeliercTVRVNTA--LLTLSRR----DAETQ-YI--VCK--NIHALLVIFPNLLRTN 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 310 ehpahervlqdlvMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEdtdkyrqlLVRTLHS 389
Cdd:PTZ00429 336 -------------LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVE--------VVRAIAS 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 390 CSVRFPDMAANVIPVLMEfLSDNNEAAAADVLEFVREAIQRFDNLRML-----------IVEKMLEVfhaiksvkiyrGA 458
Cdd:PTZ00429 395 LAIKVDSVAPDCANLLLQ-IVDRRPELLPQVVTAAKDIVRKYPELLMLdtlvtdygadeVVEEEAKV-----------SL 462
                        490       500
                 ....*....|....*....|....*...
gi 221316632 459 LWILGEYCSTKEDIQSVmteIRRSLGEI 486
Cdd:PTZ00429 463 LWMLGEYCDFIENGKDI---IQRFIDTI 487
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
18-550 2.24e-142

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 434.36  E-value: 2.24e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   18 SEPPSEISLKNDLEKG--DVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLpLQDHTIKKLLLVFWEIVPKTTPDgrll 95
Cdd:pfam01602   1 EEKRIQQELARILNSFrdDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVA-SKDFTLKRLGYLYLMLLAEESPD---- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632   96 hEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPD-AP 174
Cdd:pfam01602  76 -LAILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDfVP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  175 ELIHdfLVNEKDASCKRNAFMMLIHADQD-----RALDYLSTCIDQ-VQTFGDILQLVIVELIYKVCHANPSERARFIRC 248
Cdd:pfam01602 155 ELKE--LLSDKDPGVQSAAVALLYEICKNdrlylKLLPLLFRRLCNlLGVLNPWLQVKILRLLTRLAPLDPLLPKELLED 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  249 IYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIkESDNNVKLIVLDRLIELKEHpaHERVLQDLVMDILRV 328
Cdd:pfam01602 233 LLNLLQNSNNAVLYETANTIVHLAPAPELIVLAVNALGRLLS-SPDENLRYVALRNLNKIVMK--EPKAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  329 LSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEViktNNVSEHEdtdkYRQLLVRTLHSCSVRFPDMAANVIPVLMEF 408
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYV---HEIADPD----FKIELVRAIGRLAEKFPTDAEWYLDVLLDL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  409 LSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIqSVMTEIRRSLGEIPI 488
Cdd:pfam01602 383 LSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNG-SSPPDLLRSILEVFV 461
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  489 VESEIKKEA--------GELKPEEEITvgpvQKLVTEMGTYATQSALSSSRPTKKEEdrppLRGFLLDGD 550
Cdd:pfam01602 462 LESAKVRAAaltalaklGLTSPEETTQ----NLIIQLLLTLATQDSLDLEVRDRAVE----YLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
29-916 9.48e-108

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 350.95  E-value: 9.48e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  29 DLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPlQDHTIKKLLLVFWEIVPKTTPdgrllHEMILVCDAYRKD 108
Cdd:COG5096   27 RLESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVAT-RDVELKRLLYLYLERYAKLKP-----ELALLAVNTIQKD 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 109 LQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDA-PELIHDFLVNEKDA 187
Cdd:COG5096  101 LQDPNEEIRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELgLIDILKELVADSDP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 188 SCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVchanpserarfircIYNLLQSSSPAVKYEA--- 264
Cdd:COG5096  181 IVIANALASLAEIDPELAHGYSLEVILRIPQLDLLSLSVSTEWLLLI--------------ILEVLTERVPTTPDSAedf 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 265 -AGTLVTLSSA-PTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPahervlQDLVMDILRVLSTPDLEVRKKTLQ 342
Cdd:COG5096  247 eERLSPPLQHNnAEVLLIAVKVILRLLVFLPSNNLFLISSPPLVTLLAKP------ESLIQYVLRRNIQIDLEVCSKLLD 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 343 LALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTdkyrQLLVRTLHSCSVRFPDmaANVIPVLMEFLSDNNEAAAADVLE 422
Cdd:COG5096  321 KVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLS----QILLELIYYIAENHID--AEMVSEAIKALGDLASKAESSVND 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 423 FVREAIQrfdnlrmlivekmlevfhaiksvkIYRGAlWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEIKKeagelkp 502
Cdd:COG5096  395 CISELLE------------------------LLEGV-WIRGSYIVQEVRIVDCISVIRISVLVLRILPNEYPK------- 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 503 eeeitvgpvqKLVTemGTYATQSALSssrptkkEEDRPPLRgfLLDGDFFVAASLATTLTKIALRYValvqekkkqnsfv 582
Cdd:COG5096  443 ----------ILLR--GLYALEETLE-------LQSREPRA--KSVTDKYLGAWLLGEFSDIIPRLE------------- 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 583 aEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSlshmlsakleeeklsqkkesekrn 662
Cdd:COG5096  489 -PELLRIAISNFVDETLEVQYTILMSSVKLIANSIRKAKQCNSELDQDVLRRCFDY------------------------ 543
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 663 vTVQPDDpisfmQLTAKnemnckedqFQLSLLAamgntqrkeaadplasklnkvTQLTGFSDPVYAEAYVHVNQYDIVLD 742
Cdd:COG5096  544 -VLVPDL-----RDRAR---------MYSRLLS---------------------TPLPEFSDPILCEAKKSNSQFEIILS 587
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 743 VLVVNQTSDTLQNCTLELaTLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNcVVLSDI 822
Cdd:COG5096  588 ALLTNQTPELLENLRLDF-TLGTLSTIPLKPIFNLRKGAVVLQQVTVKKPNAELGFITGNINPSGAANEDLRD-INLNDS 665
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 823 HIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTN-MVDLNDYLQHILKSTNMKCLTPEKALSgycgFMAANLYARsif 901
Cdd:COG5096  666 INSISGFVNPRTVDEDYFRELWKMDEFENKIDESSNnPKKLDDYSEEKSREDNMEILTPSDDLE----FSSSSLGSK--- 738
                        890
                 ....*....|....*
gi 221316632 902 gEDALANVSIEKPIH 916
Cdd:COG5096  739 -SDALMSLCLEKPEP 752
Coatamer_beta_C pfam07718
Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta ...
667-807 2.06e-82

Coatomer beta C-terminal region; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal pfam01602 domain.


Pssm-ID: 462245 [Multi-domain]  Cd Length: 138  Bit Score: 262.08  E-value: 2.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  667 PDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNtqrKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVV 746
Cdd:pfam07718   1 PDDPISFRQLKGKKGESGEELQFEDDLSQATGG---DIAEDDFSSKLNKIVQLTGFSDPVYAEAYVTVHQFDIVLDVLLV 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221316632  747 NQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDV 807
Cdd:pfam07718  78 NQTSETLQNLTVELATLGDLKLVERPQPVTLAPHGFHNIKATVKVSSTETGVIFGNIVYDG 138
Coatomer_b_Cpla pfam14806
Coatomer beta subunit appendage platform; This family is found at the C-terminus of the ...
813-944 7.57e-81

Coatomer beta subunit appendage platform; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.


Pssm-ID: 434227  Cd Length: 128  Bit Score: 257.50  E-value: 7.57e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  813 DRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMA 892
Cdd:pfam14806   1 DRNCVILNDIHIDIMDYIKPATCDDEEFREMWAEFEWENKITVNTNITDLREYLDHLMKKTNMNCLTPEEALSGECGFLS 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 221316632  893 ANLYARSIFGEDALANVSIEKPihqgPDAAVTGHIRIRAKSQGMALSLGDKI 944
Cdd:pfam14806  81 ANLYARSIFGEDALANLSIEKD----GDGKISGHVRIRSKTQGIALSLGDKI 128
PTZ00429 PTZ00429
beta-adaptin; Provisional
26-486 8.19e-06

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 49.93  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632  26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVlPLQDHTIKKLLLVFWEIVPKTTPDGRLLhemilVCDAY 105
Cdd:PTZ00429  37 LQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLA-PSTDLELKKLVYLYVLSTARLQPEKALL-----AVNTF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 106 RKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPD---APELIHdfLV 182
Cdd:PTZ00429 111 LQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQqdfKKDLVE--LL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 183 NEKDASCKRNAFMMLIHADQ-------------DRALDYLSTCIDQVQTFgdILQL--------------VIVELIYKVC 235
Cdd:PTZ00429 189 NDNNPVVASNAAAIVCEVNDygsekiessnewvNRLVYHLPECNEWGQLY--ILELlaaqrpsdkesaetLLTRVLPRMS 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 236 HANPSERARFIRCIYNLLQSSSP------AVKYEAAgtLVTLSSAptaiKAAAQcYIdlIIKesDNNVKLIVLDRLIELK 309
Cdd:PTZ00429 267 HQNPAVVMGAIKVVANLASRCSQeliercTVRVNTA--LLTLSRR----DAETQ-YI--VCK--NIHALLVIFPNLLRTN 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 310 ehpahervlqdlvMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEdtdkyrqlLVRTLHS 389
Cdd:PTZ00429 336 -------------LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVE--------VVRAIAS 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 390 CSVRFPDMAANVIPVLMEfLSDNNEAAAADVLEFVREAIQRFDNLRML-----------IVEKMLEVfhaiksvkiyrGA 458
Cdd:PTZ00429 395 LAIKVDSVAPDCANLLLQ-IVDRRPELLPQVVTAAKDIVRKYPELLMLdtlvtdygadeVVEEEAKV-----------SL 462
                        490       500
                 ....*....|....*....|....*...
gi 221316632 459 LWILGEYCSTKEDIQSVmteIRRSLGEI 486
Cdd:PTZ00429 463 LWMLGEYCDFIENGKDI---IQRFIDTI 487
HEAT COG1413
HEAT repeat [General function prediction only];
109-209 2.25e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 109 LQHPNEFIRGSTLRFLCKLKEAELLEPLMPAiracLEHRHSYVRRNAVLAIYTIYRnfehliPDAPELIHDFLvNEKDAS 188
Cdd:COG1413   25 LADEDPDVRAAAARALGRLGDPRAVPALLEA----LKDPDPEVRAAAAEALGRIGD------PEAVPALIAAL-KDEDPE 93
                         90       100
                 ....*....|....*....|.
gi 221316632 189 CKRNAFMMLIHADQDRALDYL 209
Cdd:COG1413   94 VRRAAAEALGRLGDPAAVPAL 114
HEAT COG1413
HEAT repeat [General function prediction only];
109-197 1.39e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221316632 109 LQHPNEFIRGSTLRFLCKLKEAELLEPLMPAiracLEHRHSYVRRNAVLAIYTIYRnfehliPDAPELIHDFLvNEKDAS 188
Cdd:COG1413   56 LKDPDPEVRAAAAEALGRIGDPEAVPALIAA----LKDEDPEVRRAAAEALGRLGD------PAAVPALLEAL-KDPDWE 124

                 ....*....
gi 221316632 189 CKRNAFMML 197
Cdd:COG1413  125 VRRAAARAL 133
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
116-159 7.63e-03

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 38.21  E-value: 7.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221316632  116 IRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAI 159
Cdd:pfam12717   2 IRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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