NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|223005922|ref|NP_001138549|]
View 

leucine-rich repeat-containing protein 10B [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-218 1.40e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.36  E-value: 1.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGtglrelpeeieelrelrilaldfNKLERLPDGLCRLPRLTRLYLGGNRLL 103
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSN-----------------------NQLTDLPEPLGNLTNLKSLDLSNNQLT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 104 ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPpALLRMGR 183
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 223005922 184 LHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTG 218
Cdd:COG4886  252 LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-218 1.40e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.36  E-value: 1.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGtglrelpeeieelrelrilaldfNKLERLPDGLCRLPRLTRLYLGGNRLL 103
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSN-----------------------NQLTDLPEPLGNLTNLKSLDLSNNQLT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 104 ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPpALLRMGR 183
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 223005922 184 LHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTG 218
Cdd:COG4886  252 LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
77-222 4.53e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 4.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLERLPDglcRLP-RLTRLYLGGNRLLALPADFAQlqSLRCLWIEGNFLRRFPRPLLRlvALQSLQMGDNRLRALPAEL 155
Cdd:PRK15370 230 NQLTSIPA---TLPdTIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHL 302

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223005922 156 PrmTGLRGLWLYGNRFeEFPPALLRMGrLHILDLDRNRLGGFPDLHPlRALRVFSYDHN-----PVTGPPRV 222
Cdd:PRK15370 303 P--SGITHLNVQSNSL-TALPETLPPG-LKTLEAGENALTSLPASLP-PELQVLDVSKNqitvlPETLPPTI 369
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 77-226 9.11e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 9.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLERLpDGLCRLPRLTRLYLGGNRLLALpADFAQLQSLRCLWIEGNFLRR-----F-PRPLLRL-VALQSLQMGDNRLR 149
Cdd:cd21340   56 NQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltFdPRSLAALsNSLRVLNISGNNID 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 150 ALpaelprmTGLRGLWlygnrfeefppallrmgRLHILDLDRNRLGGFPD----LHPLRALRVFSYDHNPVTGPPRVADT 225
Cdd:cd21340  134 SL-------EPLAPLR-----------------NLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPVCKKPKYRDK 189


                 .
gi 223005922 226 V 226
Cdd:cd21340  190 I 190
LRR_8 pfam13855
Leucine rich repeat;
90-148 6.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 6.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223005922   90 PRLTRLYLGGNRLLALPAD-FAQLQSLRCLWIEGNFLRRF-PRPLLRLVALQSLQMGDNRL 148
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-218 1.40e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.36  E-value: 1.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGtglrelpeeieelrelrilaldfNKLERLPDGLCRLPRLTRLYLGGNRLL 103
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSN-----------------------NQLTDLPEPLGNLTNLKSLDLSNNQLT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 104 ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPpALLRMGR 183
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 223005922 184 LHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTG 218
Cdd:COG4886  252 LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-220 5.46e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 5.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  74 LDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPA 153
Cdd:COG4886  120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223005922 154 ELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTGPP 220
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-151 1.39e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGtglrelpeeieelrelrilaldfNKLERLPDGLCRLPRLTRLYLGGNRLL 103
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSG-----------------------NQLTDLPEPLANLTNLETLDLSNNQLT 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 223005922 104 ALPaDFAQLQSLRCLWIEGNFLRRFPrPLLRLVALQSLQMGDNRLRAL 151
Cdd:COG4886  242 DLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-217 1.50e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  92 LTRLYLGGNRLLALPADFAQLQSLRCLWIEGNflrrfpRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRF 171
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 223005922 172 EEFPPALLRMGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVT 217
Cdd:COG4886  149 TDLPEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQIT 195
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
77-222 4.53e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 4.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLERLPDglcRLP-RLTRLYLGGNRLLALPADFAQlqSLRCLWIEGNFLRRFPRPLLRlvALQSLQMGDNRLRALPAEL 155
Cdd:PRK15370 230 NQLTSIPA---TLPdTIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHL 302

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223005922 156 PrmTGLRGLWLYGNRFeEFPPALLRMGrLHILDLDRNRLGGFPDLHPlRALRVFSYDHN-----PVTGPPRV 222
Cdd:PRK15370 303 P--SGITHLNVQSNSL-TALPETLPPG-LKTLEAGENALTSLPASLP-PELQVLDVSKNqitvlPETLPPTI 369
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-204 1.19e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  35 RLPSAVCALSRLQKLYV-SGTGLRELPEEIEELRELRILALDFNKLE-RLPDGLCRLPRLTRLYLGGNRLLA-LPADFAQ 111
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGA 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 112 LQSLRCLWIEGN-FLRRFPRPLLRLVALQSLQMGDNRLRA-LPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDL 189
Cdd:PLN00113 403 CRSLRRVRLQDNsFSGELPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDL 482

                        170       180
                 ....*....|....*....|...
gi 223005922 190 DRNR--------LGGFPDLHPLR 204
Cdd:PLN00113 483 SRNQfsgavprkLGSLSELMQLK 505
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 77-226 9.11e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 9.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLERLpDGLCRLPRLTRLYLGGNRLLALpADFAQLQSLRCLWIEGNFLRR-----F-PRPLLRL-VALQSLQMGDNRLR 149
Cdd:cd21340   56 NQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltFdPRSLAALsNSLRVLNISGNNID 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 150 ALpaelprmTGLRGLWlygnrfeefppallrmgRLHILDLDRNRLGGFPD----LHPLRALRVFSYDHNPVTGPPRVADT 225
Cdd:cd21340  134 SL-------EPLAPLR-----------------NLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPVCKKPKYRDK 189


                 .
gi 223005922 226 V 226
Cdd:cd21340  190 I 190
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-200 1.81e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  79 LERLPDGLCRL--------------PRLTRLYLGGNRLLALPAdfaqLQSLRC-LWIEGNFLRRFPR-PllrlVALQSLQ 142
Cdd:PRK15387 277 LPALPSGLCKLwifgnqltslpvlpPGLQELSVSDNQLASLPA----LPSELCkLWAYNNQLTSLPTlP----SGLQELS 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 143 MGDNRLRALPAeLPrmTGLRGLWLYGNRFEEFP--PALLRMgrlhiLDLDRNRLGGFPDL 200
Cdd:PRK15387 349 VSDNQLASLPT-LP--SELYKLWAYNNRLTSLPalPSGLKE-----LIVSGNRLTSLPVL 400
LRR_8 pfam13855
Leucine rich repeat;
90-148 6.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 6.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223005922   90 PRLTRLYLGGNRLLALPAD-FAQLQSLRCLWIEGNFLRRF-PRPLLRLVALQSLQMGDNRL 148
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
76-219 8.13e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  76 FNKLERLPDGLCRLPRLTrlylggNRLLALPAdfaqLQSLRC-LWIEGNFLRRFPrplLRLVALQSLQMGDNRLRALPAe 154
Cdd:PRK15387 254 LTSLPVLPPGLLELSIFS------NPLTHLPA----LPSGLCkLWIFGNQLTSLP---VLPPGLQELSVSDNQLASLPA- 319

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223005922 155 LPrmTGLRGLWLYGNRFEEFPPALLRMGRLHILDldrNRLGGFPDLhPLRALRVFSYDHNPVTGP 219
Cdd:PRK15387 320 LP--SELCKLWAYNNQLTSLPTLPSGLQELSVSD---NQLASLPTL-PSELYKLWAYNNRLTSLP 378
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-218 1.24e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLE-RLPDGLCRLPRLTRLYLGGNRLLA-LPADFAQLQSLRCLWI-EGNFLRRFPRPLLRLVALQSLQMGDNRLRA-LP 152
Cdd:PLN00113 270 NKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIP 349

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223005922 153 AELPRMTGLRGLWLYGNRFE-EFPPALLRMGRLHILDLDRNRLGGF--PDLHPLRALRVFSYDHNPVTG 218
Cdd:PLN00113 350 KNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDNSFSG 418
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
6-217 1.60e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.15  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922   6 STPDELPSDAEEQLRSGDQQLELSgrrlRRLPSAvcalsrLQKLYVSgtglrelpeeieelrelrilaldFNKL----ER 81
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRITELP----ERLPSA------LQSLDLF-----------------------HNKIsclpEN 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  82 LPDGL--------------CRLPR-LTRLYLGGNRLLALPADFAQlqSLRCLWIEGNFLRRFPRPLLRlvALQSLQMGDN 146
Cdd:PRK15370 281 LPEELrylsvydnsirtlpAHLPSgITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLPP--ELQVLDVSKN 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 147 RLRALPAELPrmTGLRGLWLYGNRFEEFP---PALLRmgrlhILDLDRNRLGGFPDL---------HPLRALrvfsYDHN 214
Cdd:PRK15370 357 QITVLPETLP--PTITTLDVSRNALTNLPenlPAALQ-----IMQASRNNLVRLPESlphfrgegpQPTRII----VEYN 425


                 ...
gi 223005922 215 PVT 217
Cdd:PRK15370 426 PFS 428
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 26-218 4.41e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  26 LELSGRRLR-RLPSAVCALSRLQKLYV-SGTGLRELPEEIEELRELRILALDFNKLE-RLPDGLCRLPRLTRLYLGGNRL 102
Cdd:PLN00113 169 LDLGGNVLVgKIPNSLTNLTSLEFLTLaSNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 103 LA-LPADFAQLQSLRCLWIEGNFLR-RFPRPLLRLVALQSLQMGDNRLRA-LPAELPRMTGLRGLWLYGNRFE-EFPPAL 178
Cdd:PLN00113 249 TGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVAL 328

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 223005922 179 LRMGRLHILDLDRNRL-GGFP-DLHPLRALRVFSYDHNPVTG 218
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFsGEIPkNLGKHNNLTVLDLSTNNLTG 370
PLN03150 PLN03150
hypothetical protein; Provisional
 105-202 4.90e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 4.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922 105 LPADFAQLQSLRCLWIEGNFLR-RFPRPLLRLVALQSLQMGDNRLR-ALPAELPRMTGLRGLWLYGNRFEEFPPALLRMG 182
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513

                         90       100
                 ....*....|....*....|...
gi 223005922 183 RLH--ILDLDRNR-LGGFPDLHP 202
Cdd:PLN03150 514 LLHraSFNFTDNAgLCGIPGLRA 536
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
77-207 9.11e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.53  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  77 NKLERLPDglcrLP-RLTRLYLGGNRLLALPADFAQLQSLrclWIEGNFLRRFPrplLRLVALQSLQMGDNRLRALPAeL 155
Cdd:PRK15387 352 NQLASLPT----LPsELYKLWAYNNRLTSLPALPSGLKEL---IVSGNRLTSLP---VLPSELKELMVSGNRLTSLPM-L 420

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223005922 156 PrmTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGfpdlHPLRALR 207
Cdd:PRK15387 421 P--SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE----RTLQALR 466
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 89-195 2.03e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223005922  89 LPRLTRLYLGGNRLLALpADFAQLQSLRCLWIEGNFLRRFprplLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYG 168
Cdd:COG5238  143 LIQVLKDPLGGNAVHLL-GLAARLGLLAAISMAKALQNNS----VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKR 217

                         90       100       110
                 ....*....|....*....|....*....|..
gi 223005922 169 NRF-----EEFPPALLRMGRLHILDLDRNRLG 195
Cdd:COG5238  218 NPIgdegaEILAEALKGNKSLTTLDLSNNQIG 249
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 90-123 7.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 7.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 223005922   90 PRLTRLYLGGNRLLALPAdFAQLQSLRCLWIEGN 123
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH