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vacuolar protein sorting-associated protein 37A isoform 2 [Homo sapiens]
vacuolar protein sorting family 37 protein( domain architecture ID 12073684)
vacuolar protein sorting family 37 protein similar to vacuolar protein sorting-associated protein 37 (Vps37), which is a component of the ESCRT-I complex, a regulator of vesicular trafficking process
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Mod_r | pfam07200 | Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ... |
210-355 | 1.19e-46 | |||
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors. : Pssm-ID: 462117 [Multi-domain] Cd Length: 146 Bit Score: 155.85 E-value: 1.19e-46
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UEV_TSG101-like | cd11685 | ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ... |
44-106 | 3.21e-04 | |||
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity. : Pssm-ID: 467408 Cd Length: 126 Bit Score: 39.98 E-value: 3.21e-04
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Name | Accession | Description | Interval | E-value | |||
Mod_r | pfam07200 | Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ... |
210-355 | 1.19e-46 | |||
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors. Pssm-ID: 462117 [Multi-domain] Cd Length: 146 Bit Score: 155.85 E-value: 1.19e-46
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UEV_TSG101-like | cd11685 | ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ... |
44-106 | 3.21e-04 | |||
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity. Pssm-ID: 467408 Cd Length: 126 Bit Score: 39.98 E-value: 3.21e-04
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Name | Accession | Description | Interval | E-value | |||
Mod_r | pfam07200 | Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ... |
210-355 | 1.19e-46 | |||
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors. Pssm-ID: 462117 [Multi-domain] Cd Length: 146 Bit Score: 155.85 E-value: 1.19e-46
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UEV_TSG101-like | cd11685 | ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ... |
44-106 | 3.21e-04 | |||
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity. Pssm-ID: 467408 Cd Length: 126 Bit Score: 39.98 E-value: 3.21e-04
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Blast search parameters | ||||
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