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Conserved domains on  [gi|223890281|ref|NP_001138733|]
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nuclear receptor coactivator 4 isoform 2 [Homo sapiens]

Protein Classification

ARA70 domain-containing protein( domain architecture ID 10575819)

ARA70 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 215-344 4.49e-56

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 186.10  E-value: 4.49e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  215 VPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKS------EKSSYQKC 288
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQqqlvvpLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  289 NSHSTTSSFSIEMEKVGDQELPDQDEM----DLSDWLVTPQESHKLRKPengsrETSEKF 344
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 54-160 6.29e-24

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 97.50  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281   54 EQQIKDNLrEVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEEtlQQQAQQLYsllGQFNCLTHQLECTQNK--DLA 131
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100
                  ....*....|....*....|....*....
gi 223890281  132 NQVSvcLERLGSLTLKPEDSTVLLFEADT 160
Cdd:pfam12489 106 EQLT--LEDLSDWLLTPEESPKLEFPADS 132
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 215-344 4.49e-56

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 186.10  E-value: 4.49e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  215 VPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKS------EKSSYQKC 288
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQqqlvvpLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  289 NSHSTTSSFSIEMEKVGDQELPDQDEM----DLSDWLVTPQESHKLRKPengsrETSEKF 344
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 54-160 6.29e-24

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 97.50  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281   54 EQQIKDNLrEVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEEtlQQQAQQLYsllGQFNCLTHQLECTQNK--DLA 131
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100
                  ....*....|....*....|....*....
gi 223890281  132 NQVSvcLERLGSLTLKPEDSTVLLFEADT 160
Cdd:pfam12489 106 EQLT--LEDLSDWLLTPEESPKLEFPADS 132
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 55-164 9.46e-04

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 39.56  E-value: 9.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281    55 QQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQfncLTHQLECTQNkdlanqv 134
Cdd:smart00502  31 QEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLTQKQEK---LSHAINFTEE------- 100

                           90       100       110
                   ....*....|....*....|....*....|
gi 223890281   135 svclerlgslTLKPEDSTVLLFEADTITLR 164
Cdd:smart00502 101 ----------ALNSGDPTELLLSKKLIIER 120
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 215-344 4.49e-56

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 186.10  E-value: 4.49e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  215 VPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKS------EKSSYQKC 288
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQqqlvvpLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281  289 NSHSTTSSFSIEMEKVGDQELPDQDEM----DLSDWLVTPQESHKLRKPengsrETSEKF 344
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 54-160 6.29e-24

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 97.50  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281   54 EQQIKDNLrEVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEEtlQQQAQQLYsllGQFNCLTHQLECTQNK--DLA 131
Cdd:pfam12489  32 QKQTKENS-QVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPE--QQQLNSLS---GTSSFSIEQLKVSDLEllDQE 105

                          90       100
                  ....*....|....*....|....*....
gi 223890281  132 NQVSvcLERLGSLTLKPEDSTVLLFEADT 160
Cdd:pfam12489 106 EQLT--LEDLSDWLLTPEESPKLEFPADS 132
BBC smart00502
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains
 55-164 9.46e-04

B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains


Pssm-ID: 128778  Cd Length: 127  Bit Score: 39.56  E-value: 9.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890281    55 QQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQfncLTHQLECTQNkdlanqv 134
Cdd:smart00502  31 QEVEENAADVEAQIKAAFDELRNALNKRKKQLLEDLEEQKENKLKVLEQQLESLTQKQEK---LSHAINFTEE------- 100

                           90       100       110
                   ....*....|....*....|....*....|
gi 223890281   135 svclerlgslTLKPEDSTVLLFEADTITLR 164
Cdd:smart00502 101 ----------ALNSGDPTELLLSKKLIIER 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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