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Conserved domains on  [gi|223890246|ref|NP_001138826|]
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muskelin isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 11-184 2.73e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


:

Pssm-ID: 284099  Cd Length: 197  Bit Score: 329.47  E-value: 2.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   11 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 90
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   91 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 169
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 223890246  170 FESLQKKTKIALEHP 184
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
261-585 2.24e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 261 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 340
Cdd:COG3055   24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 341 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 420
Cdd:COG3055   95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 421 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 500
Cdd:COG3055  153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 501 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 579
Cdd:COG3055  206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                 ....*...
gi 223890246 580 G--NPGKS 585
Cdd:COG3055  259 GetKPGVR 266
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 11-184 2.73e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 329.47  E-value: 2.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   11 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 90
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   91 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 169
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 223890246  170 FESLQKKTKIALEHP 184
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
261-585 2.24e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 261 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 340
Cdd:COG3055   24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 341 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 420
Cdd:COG3055   95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 421 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 500
Cdd:COG3055  153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 501 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 579
Cdd:COG3055  206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                 ....*...
gi 223890246 580 G--NPGKS 585
Cdd:COG3055  259 GetKPGVR 266
Kelch_3 pfam13415
Galactose oxidase, central domain;
259-311 3.81e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 223890246  259 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 311
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 284-452 1.35e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 284 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 363
Cdd:PLN02153   6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 364 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 443
Cdd:PLN02153  74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                 ....*....
gi 223890246 444 NRCLYVFGG 452
Cdd:PLN02153 137 ENHVYVFGG 145
Kelch smart00612
Kelch domain;
262-288 1.33e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*..
gi 223890246   262 VYLFGGWDGTQDLADFWAYSVKENQWT 288
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 149-179 7.93e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 7.93e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 223890246   149 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 179
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 11-184 2.73e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 329.47  E-value: 2.73e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   11 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 90
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   91 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 169
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 223890246  170 FESLQKKTKIALEHP 184
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
261-585 2.24e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 261 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 340
Cdd:COG3055   24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 341 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 420
Cdd:COG3055   95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 421 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 500
Cdd:COG3055  153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 501 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 579
Cdd:COG3055  206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                 ....*...
gi 223890246 580 G--NPGKS 585
Cdd:COG3055  259 GetKPGVR 266
Kelch_3 pfam13415
Galactose oxidase, central domain;
259-311 3.81e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 223890246  259 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 311
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 18-129 6.58e-07

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.98  E-value: 6.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246   18 NDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETftlkhk 97
Cdd:pfam00754  20 GDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSLDGENWTTVKDEKIPGNNDNNT------ 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 223890246   98 IDEQMFPC----RFIKIVPlLSWGPSFNFSIWyVEL 129
Cdd:pfam00754  94 PVTNTFDPpikaRYVRIVP-TSWNGGNGIALR-AEL 127
PLN02153 PLN02153
epithiospecifier protein
 284-452 1.35e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 284 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 363
Cdd:PLN02153   6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 364 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 443
Cdd:PLN02153  74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                 ....*....
gi 223890246 444 NRCLYVFGG 452
Cdd:PLN02153 137 ENHVYVFGG 145
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 247-291 4.52e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 4.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 223890246  247 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 291
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02153 PLN02153
epithiospecifier protein
 262-353 4.72e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 4.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 341
Cdd:PLN02153  88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                         90
                 ....*....|..
gi 223890246 342 DIDTNTWMLLSE 353
Cdd:PLN02153 165 NIADGKWVQLPD 176
PLN02193 PLN02193
nitrile-specifier protein
 261-363 1.07e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 261 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 340
Cdd:PLN02193 230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                         90       100
                 ....*....|....*....|....*.
gi 223890246 341 YDIDTNTWMLLS---EDTAADGGPKL 363
Cdd:PLN02193 299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 348-535 2.36e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 348 WMLLSEDTAADGGPKLvfDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLLredSCNAGP 427
Cdd:PLN02153   9 WIKVEQKGGKGPGPRC--SHGIAVVGDK--LYSFGGE-LKPNEHIDKD---------LYVFDFNTHTWSIA---PANGDV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 428 EDIqSRIGHCMLfhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRATIDPelNEIHVL 507
Cdd:PLN02153  72 PRI-SCLGVRMV--AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFL---TKLDEEGGPEARTFHSMASDE--NHVYVF 143

                        170       180
                 ....*....|....*....|....*...
gi 223890246 508 SGLSKDKEKREENVRNSFWIYDIVRNSW 535
Cdd:PLN02153 144 GGVSKGGLMKTPERFRTIEAYNIADGKW 171
Kelch_4 pfam13418
Galactose oxidase, central domain;
248-291 4.65e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 223890246  248 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 291
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
PLN02193 PLN02193
nitrile-specifier protein
 360-535 5.82e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 360 GPKLVFDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLlredSCNAGPEDIQSRIGHCML 439
Cdd:PLN02193 162 GPGLRCSHGIAQVGNK--IYSFGGE-FTPNQPIDKH---------LYVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223890246 440 fhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRAtidpELNEIHVLSGLSKdkekree 519
Cdd:PLN02193 226 --SIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAA----DEENVYVFGGVSA------- 289

                        170
                 ....*....|....*..
gi 223890246 520 NVR-NSFWIYDIVRNSW 535
Cdd:PLN02193 290 TARlKTLDSYNIVDKKW 306
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 433-470 1.03e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 223890246  433 RIGHCMLFHskNRCLYVFGGQRSKTYLNDFFSYDVDSD 470
Cdd:pfam01344   2 RSGAGVVVV--GGKIYVIGGFDGNQSLNSVEVYDPETN 37
Kelch smart00612
Kelch domain;
262-288 1.33e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*..
gi 223890246   262 VYLFGGWDGTQDLADFWAYSVKENQWT 288
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 149-179 7.93e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 7.93e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 223890246   149 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 179
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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