|
Name |
Accession |
Description |
Interval |
E-value |
| fabF |
TIGR03150 |
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ... |
42-372 |
1.14e-140 |
|
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 274452 [Multi-domain] Cd Length: 407 Bit Score: 405.71 E-value: 1.14e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:TIGR03150 1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITRFDASDLPVKIAGEVK------DFDPEDYIDKKEARRMDRFIQY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWhPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:TIGR03150 75 ALAAAKEAVEDSGL-DIEEEDAERVGVIIGSGIGGLETIEEQHIVLLEKGPRRVSPFFIPMSIINMAAGQISIRYGAKGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:TIGR03150 154 NHAVVTACATGTHAIGDAFRLIQRGdadvmiaggaeaaitplgiagfaamkalstrnddpekasrpfdkdrdgfvmgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:TIGR03150 234 gvlvleelehakargakiyaeivgygmsgDAYHITAPAPEGEGAARAMRAALKDAGINPEDVDYINAHGTSTPLGDKAET 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:TIGR03150 314 KAIKKVFGDHAYKLAVSSTKSMTGHLLGAAGAIEAIFTVLAIRDGIVPPTINLDNPDPECDLDYVPNEAREAKID---YA 390
|
410
....*....|....*
gi 223972627 358 LTNSFGFGGTNATLC 372
Cdd:TIGR03150 391 LSNSFGFGGTNASLV 405
|
|
| KAS_I_II |
cd00834 |
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ... |
42-373 |
1.35e-140 |
|
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.
Pssm-ID: 238430 [Multi-domain] Cd Length: 406 Bit Score: 405.38 E-value: 1.35e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRgsdegqFNEQNFVSKSDIKSMSSPTIM 121
Cdd:cd00834 1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPITRFDASGFPSRIAGEVPD------FDPEDYLDRKELRRMDRFAQF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPQSEaDQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:cd00834 75 ALAAAEEALADAGLDPEEL-DPERIGVVIGSGIGGLATIEEAYRALLEKGPRRVSPFFVPMALPNMAAGQVAIRLGLRGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:cd00834 154 NYTVSTACASGAHAIGDAARLIRLGradvviaggaealitpltlagfaalralstrnddpekasrpfdkdrdgfvlgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:cd00834 234 gvlvleslehakargakiyaeilgygassDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAES 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:cd00834 314 KAIKRVFGEHAKKVPVSSTKSMTGHLLGAAGAVEAIATLLALRDGVLPPTINLEEPDPECDLDYVPNEAREAPIR---YA 390
|
410
....*....|....*.
gi 223972627 358 LTNSFGFGGTNATLCI 373
Cdd:cd00834 391 LSNSFGFGGHNASLVF 406
|
|
| PRK07314 |
PRK07314 |
beta-ketoacyl-ACP synthase II; |
42-371 |
3.41e-138 |
|
beta-ketoacyl-ACP synthase II;
Pssm-ID: 235987 [Multi-domain] Cd Length: 411 Bit Score: 399.55 E-value: 3.41e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIvSLVGEEYKS-IPCSVAAYVPRgsdegqFNEQNFVSKSDIKSMSSPTI 120
Cdd:PRK07314 2 RRVVVTGLGAVSPLGNDVESTWKNLLAGKSGI-GPITHFDTSdLAVKIAGEVKD------FNPDDYMSRKEARRMDRFIQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKG 200
Cdd:PRK07314 75 YGIAAAKQAVEDAGLEI-TEENADRIGVIIGSGIGGLETIEEQHITLLEKGPRRVSPFFVPMAIINMAAGHVSIRYGAKG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 201 PNHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------ 226
Cdd:PRK07314 154 PNHSIVTACATGAHAIGDAARLIAYGdadvmvaggaeaaitplgiagfaaaralstrnddperasrpfdkdrdgfvmgeg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 ------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAE 276
Cdd:PRK07314 234 agilvleelehakargakiyaevvgygmtgDAYHMTAPAPDGEGAARAMKLALKDAGINPEDIDYINAHGTSTPAGDKAE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 277 NKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfI 356
Cdd:PRK07314 314 TQAIKRVFGEHAYKVAVSSTKSMTGHLLGAAGAVEAIFSVLAIRDQVIPPTINLDNPDEECDLDYVPNEARERKID---Y 390
|
410
....*....|....*
gi 223972627 357 GLTNSFGFGGTNATL 371
Cdd:PRK07314 391 ALSNSFGFGGTNASL 405
|
|
| FabB |
COG0304 |
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ... |
42-373 |
2.23e-135 |
|
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis
Pssm-ID: 440073 [Multi-domain] Cd Length: 409 Bit Score: 392.54 E-value: 2.23e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:COG0304 1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASGLPVRIAGEVK------DFDPEEYLDRKELRRMDRFTQY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:COG0304 75 ALAAAREALADAGLDL-DEVDPDRTGVIIGSGIGGLDTLEEAYRALLEKGPRRVSPFFVPMMMPNMAAGHVSIRFGLKGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:COG0304 154 NYTVSTACASGAHAIGEAYRLIRRGradvmiaggaeaaitplglagfdalgalstrnddpekasrpfdkdrdgfvlgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:COG0304 234 gvlvleelehakargakiyaevvgygassDAYHITAPAPDGEGAARAMRAALKDAGLSPEDIDYINAHGTSTPLGDAAET 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:COG0304 314 KAIKRVFGDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAKID---YA 390
|
410
....*....|....*.
gi 223972627 358 LTNSFGFGGTNATLCI 373
Cdd:COG0304 391 LSNSFGFGGHNASLVF 406
|
|
| Ketoacyl-synt_C |
pfam02801 |
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ... |
226-331 |
1.21e-41 |
|
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 426989 Cd Length: 118 Bit Score: 141.94 E-value: 1.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 226 GDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAY--ALAVSSTKGATGHL 303
Cdd:pfam02801 11 HDGRHNGLTAPNGEGQARAIRRALADAGVDPEDVDYVEAHGTGTPLGDPIEAEALKRVFGSGARkqPLAIGSVKSNIGHL 90
|
90 100
....*....|....*....|....*...
gi 223972627 304 LGAAGAVEAAFTTLACYYQKLPPTLNLD 331
Cdd:pfam02801 91 EGAAGAAGLIKVVLALRHGVIPPTLNLE 118
|
|
| PKS_KS |
smart00825 |
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ... |
291-369 |
2.20e-11 |
|
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 214836 [Multi-domain] Cd Length: 298 Bit Score: 63.89 E-value: 2.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 291 LAVSSTKGATGHLLGAAGAveAAF--TTLACYYQKLPPTLNLDCSEPEFDLN----YVPLKAQEWKTE--KRFIGLtNSF 362
Cdd:smart00825 209 LLIGSVKSNIGHLEAAAGV--AGLikVVLALKHGVIPPTLHFETPNPHIDLEesplRVPTELTPWPPPgrPRRAGV-SSF 285
|
....*..
gi 223972627 363 GFGGTNA 369
Cdd:smart00825 286 GFGGTNA 292
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| fabF |
TIGR03150 |
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ... |
42-372 |
1.14e-140 |
|
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 274452 [Multi-domain] Cd Length: 407 Bit Score: 405.71 E-value: 1.14e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:TIGR03150 1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITRFDASDLPVKIAGEVK------DFDPEDYIDKKEARRMDRFIQY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWhPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:TIGR03150 75 ALAAAKEAVEDSGL-DIEEEDAERVGVIIGSGIGGLETIEEQHIVLLEKGPRRVSPFFIPMSIINMAAGQISIRYGAKGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:TIGR03150 154 NHAVVTACATGTHAIGDAFRLIQRGdadvmiaggaeaaitplgiagfaamkalstrnddpekasrpfdkdrdgfvmgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:TIGR03150 234 gvlvleelehakargakiyaeivgygmsgDAYHITAPAPEGEGAARAMRAALKDAGINPEDVDYINAHGTSTPLGDKAET 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:TIGR03150 314 KAIKKVFGDHAYKLAVSSTKSMTGHLLGAAGAIEAIFTVLAIRDGIVPPTINLDNPDPECDLDYVPNEAREAKID---YA 390
|
410
....*....|....*
gi 223972627 358 LTNSFGFGGTNATLC 372
Cdd:TIGR03150 391 LSNSFGFGGTNASLV 405
|
|
| KAS_I_II |
cd00834 |
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ... |
42-373 |
1.35e-140 |
|
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.
Pssm-ID: 238430 [Multi-domain] Cd Length: 406 Bit Score: 405.38 E-value: 1.35e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRgsdegqFNEQNFVSKSDIKSMSSPTIM 121
Cdd:cd00834 1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPITRFDASGFPSRIAGEVPD------FDPEDYLDRKELRRMDRFAQF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPQSEaDQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:cd00834 75 ALAAAEEALADAGLDPEEL-DPERIGVVIGSGIGGLATIEEAYRALLEKGPRRVSPFFVPMALPNMAAGQVAIRLGLRGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:cd00834 154 NYTVSTACASGAHAIGDAARLIRLGradvviaggaealitpltlagfaalralstrnddpekasrpfdkdrdgfvlgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:cd00834 234 gvlvleslehakargakiyaeilgygassDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAES 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:cd00834 314 KAIKRVFGEHAKKVPVSSTKSMTGHLLGAAGAVEAIATLLALRDGVLPPTINLEEPDPECDLDYVPNEAREAPIR---YA 390
|
410
....*....|....*.
gi 223972627 358 LTNSFGFGGTNATLCI 373
Cdd:cd00834 391 LSNSFGFGGHNASLVF 406
|
|
| PRK07314 |
PRK07314 |
beta-ketoacyl-ACP synthase II; |
42-371 |
3.41e-138 |
|
beta-ketoacyl-ACP synthase II;
Pssm-ID: 235987 [Multi-domain] Cd Length: 411 Bit Score: 399.55 E-value: 3.41e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIvSLVGEEYKS-IPCSVAAYVPRgsdegqFNEQNFVSKSDIKSMSSPTI 120
Cdd:PRK07314 2 RRVVVTGLGAVSPLGNDVESTWKNLLAGKSGI-GPITHFDTSdLAVKIAGEVKD------FNPDDYMSRKEARRMDRFIQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKG 200
Cdd:PRK07314 75 YGIAAAKQAVEDAGLEI-TEENADRIGVIIGSGIGGLETIEEQHITLLEKGPRRVSPFFVPMAIINMAAGHVSIRYGAKG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 201 PNHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------ 226
Cdd:PRK07314 154 PNHSIVTACATGAHAIGDAARLIAYGdadvmvaggaeaaitplgiagfaaaralstrnddperasrpfdkdrdgfvmgeg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 ------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAE 276
Cdd:PRK07314 234 agilvleelehakargakiyaevvgygmtgDAYHMTAPAPDGEGAARAMKLALKDAGINPEDIDYINAHGTSTPAGDKAE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 277 NKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfI 356
Cdd:PRK07314 314 TQAIKRVFGEHAYKVAVSSTKSMTGHLLGAAGAVEAIFSVLAIRDQVIPPTINLDNPDEECDLDYVPNEARERKID---Y 390
|
410
....*....|....*
gi 223972627 357 GLTNSFGFGGTNATL 371
Cdd:PRK07314 391 ALSNSFGFGGTNASL 405
|
|
| FabB |
COG0304 |
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ... |
42-373 |
2.23e-135 |
|
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis
Pssm-ID: 440073 [Multi-domain] Cd Length: 409 Bit Score: 392.54 E-value: 2.23e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:COG0304 1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASGLPVRIAGEVK------DFDPEEYLDRKELRRMDRFTQY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:COG0304 75 ALAAAREALADAGLDL-DEVDPDRTGVIIGSGIGGLDTLEEAYRALLEKGPRRVSPFFVPMMMPNMAAGHVSIRFGLKGP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------- 226
Cdd:COG0304 154 NYTVSTACASGAHAIGEAYRLIRRGradvmiaggaeaaitplglagfdalgalstrnddpekasrpfdkdrdgfvlgega 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:COG0304 234 gvlvleelehakargakiyaevvgygassDAYHITAPAPDGEGAARAMRAALKDAGLSPEDIDYINAHGTSTPLGDAAET 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:COG0304 314 KAIKRVFGDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAKID---YA 390
|
410
....*....|....*.
gi 223972627 358 LTNSFGFGGTNATLCI 373
Cdd:COG0304 391 LSNSFGFGGHNASLVF 406
|
|
| PLN02836 |
PLN02836 |
3-oxoacyl-[acyl-carrier-protein] synthase |
41-371 |
4.92e-122 |
|
3-oxoacyl-[acyl-carrier-protein] synthase
Pssm-ID: 215449 [Multi-domain] Cd Length: 437 Bit Score: 359.49 E-value: 4.92e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 41 HRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYK--------------SIPCSVAAYVPRGSDEGQFNEQNF 106
Cdd:PLN02836 5 TRRVVVTGLGLVTPLGCGVETTWRRLIAGECGVRALTQDDLKmksedeetqlytldQLPSRVAALVPRGTGPGDFDEELW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 107 VSKsdiKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVN 186
Cdd:PLN02836 85 LNS---RSSSRFIGYALCAADEALSDARWLPSEDEAKERTGVSIGGGIGSITDILEAAQLICEKRLRRLSPFFVPRILIN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 187 MAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDAG------------------------------------- 229
Cdd:PLN02836 162 MAAGHVSIRYGFQGPNHAAVTACATGAHSIGDAFRMIQFGDADvmvaggtessidalsiagfsrsralstkfnscpteas 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 230 ------------------------------------------------HITAPDPEGEGALRCMAAALKDAGVQPEEISY 261
Cdd:PLN02836 242 rpfdcdrdgfvigegagvlvleelehakrrgakiyaevrgygmsgdahHITQPHEDGRGAVLAMTRALQQSGLHPNQVDY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 262 INAHATSTPLGDAAENKAIKHLFKDHAY--ALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDL 339
Cdd:PLN02836 322 VNAHATSTPLGDAVEARAIKTVFSEHATsgGLAFSSTKGATGHLLGAAGAVEAIFSVLAIHHGIAPPTLNLERPDPIFDD 401
|
410 420 430
....*....|....*....|....*....|..
gi 223972627 340 NYVPLKAQewKTEKRFIGLTNSFGFGGTNATL 371
Cdd:PLN02836 402 GFVPLTAS--KAMLIRAALSNSFGFGGTNASL 431
|
|
| PRK06333 |
PRK06333 |
beta-ketoacyl-ACP synthase; |
41-371 |
4.82e-116 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235781 [Multi-domain] Cd Length: 424 Bit Score: 343.90 E-value: 4.82e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 41 HRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSD--EGQFNEQNFVSKSDIKSMSSP 118
Cdd:PRK06333 3 KKRIVVTGMGAVSPLGCGVETFWQRLLAGQSGIRTLTDFPVGDLATKIGGQVPDLAEdaEAGFDPDRYLDPKDQRKMDRF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 119 TIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKL 198
Cdd:PRK06333 83 ILFAMAAAKEALAQAGWDPDTLEDRERTATIIGSGVGGFPAIAEAVRTLDSRGPRRLSPFTIPSFLTNMAAGHVSIRYGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 199 KGPNHAVSTACTTGAHAVGDSFRFIAHG---------------------------------------------------- 226
Cdd:PRK06333 163 KGPLGAPVTACAAGVQAIGDAARLIRSGeadvavcggteaaidrvslagfaaaralstrfndapeqasrpfdrdrdgfvm 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 ---------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGD 273
Cdd:PRK06333 243 gegagilvietlehalargapplaelvgygtsaDAYHMTAGPEDGEGARRAMLIALRQAGIPPEEVQHLNAHATSTPVGD 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 274 AAENKAIKHLFKdHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFD-LNYVPLKAQEWKTE 352
Cdd:PRK06333 323 LGEVAAIKKVFG-HVSGLAVSSTKSATGHLLGAAGGVEAIFTILALRDQIAPPTLNLENPDPAAEgLDVVANKARPMDMD 401
|
410
....*....|....*....
gi 223972627 353 krfIGLTNSFGFGGTNATL 371
Cdd:PRK06333 402 ---YALSNGFGFGGVNASI 417
|
|
| PTZ00050 |
PTZ00050 |
3-oxoacyl-acyl carrier protein synthase; Provisional |
51-371 |
9.81e-101 |
|
3-oxoacyl-acyl carrier protein synthase; Provisional
Pssm-ID: 240245 [Multi-domain] Cd Length: 421 Bit Score: 304.69 E-value: 9.81e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 51 LVTPLGVGTHLVWDRLIGGESGIVSLVGEEYK----------------SIPCSVAAYVPrgsdegqfNEQNFVSKSDIKS 114
Cdd:PTZ00050 1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKFlpdcipeqkalenlvaAMPCQIAAEVD--------QSEFDPSDFAPTK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 115 MSSPTI-MAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVS 193
Cdd:PTZ00050 73 RESRAThFAMAAAREALADAKLDILSEKDQERIGVNIGSGIGSLADLTDEMKTLYEKGHSRVSPYFIPKILGNMAAGLVA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 194 IRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHG----------------------------------------------- 226
Cdd:PTZ00050 153 IKHKLKGPSGSAVTACATGAHCIGEAFRWIKYGeadimicggteasitpvsfagfsrmralctkynddpqrasrpfdkdr 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 --------------------------------------DAGHITAPDPEGEGALRCMAAALKDAG-VQPEEISYINAHAT 267
Cdd:PTZ00050 233 agfvmgegagilvleelehalrrgakiyaeirgygsssDAHHITAPHPDGRGARRCMENALKDGAnININDVDYVNAHAT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 268 STPLGDAAENKAIKHLFKDH-AYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKA 346
Cdd:PTZ00050 313 STPIGDKIELKAIKKVFGDSgAPKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLENPDAECDLNLVQGKT 392
|
410 420
....*....|....*....|....*
gi 223972627 347 QEWKTEKRfIGLTNSFGFGGTNATL 371
Cdd:PTZ00050 393 AHPLQSID-AVLSTSFGFGGVNTAL 416
|
|
| PRK08722 |
PRK08722 |
beta-ketoacyl-ACP synthase II; |
42-371 |
1.36e-73 |
|
beta-ketoacyl-ACP synthase II;
Pssm-ID: 181539 [Multi-domain] Cd Length: 414 Bit Score: 234.51 E-value: 1.36e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:PRK08722 4 RRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEHFDTTNFSTRFAGLVK------DFNCEEYMSKKDARKMDLFIQY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHpQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:PRK08722 78 GIAAGIQALDDSGLE-VTEENAHRIGVAIGSGIGGLGLIEAGHQALVEKGPRKVSPFFVPSTIVNMIAGNLSIMRGLRGP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIAHGDAG---------------------------------------------------- 229
Cdd:PRK08722 157 NIAISTACTTGLHNIGHAARMIAYGDADamvaggaekastplgmagfgaakalstrndepqkasrpwdkdrdgfvlgdga 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 230 --------------------------------HITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:PRK08722 237 gmmvleeyehakargakiyaelvgfgmsgdayHMTSPSEDGSGGALAMEAAMRDAGVTGEQIGYVNAHGTSTPAGDVAEI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKH-LFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQewKTEKRFI 356
Cdd:PRK08722 317 KGIKRaLGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITVMSLVDQIVPPTINLDDPEEGLDIDLVPHTAR--KVESMEY 394
|
410
....*....|....*
gi 223972627 357 GLTNSFGFGGTNATL 371
Cdd:PRK08722 395 AICNSFGFGGTNGSL 409
|
|
| PRK08439 |
PRK08439 |
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed |
42-368 |
4.89e-70 |
|
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
Pssm-ID: 236265 [Multi-domain] Cd Length: 406 Bit Score: 225.00 E-value: 4.89e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTIM 121
Cdd:PRK08439 2 KRVVVTGIGMINSLGLNKESSFKAICNGECGIKKITLFDASDFPVQIAGEIT------DFDPTEVMDPKEVKKADRFIQL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGP 201
Cdd:PRK08439 76 GLKAAREAMKDAGFLP-EELDAERFGVSSASGIGGLPNIEKNSIICFEKGPRKISPFFIPSALVNMLGGFISIEHGLKGP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 202 NHAVSTACTTGAHAVGDSFRFIA--------------------------------------------------------- 224
Cdd:PRK08439 155 NLSSVTACAAGTHAIIEAVKTIMlggadkmlvvgaesaicpvgiggfaamkalstrnddpkkasrpfdkdrdgfvmgega 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 225 ---------------------------HGDAGHITAPDPEGegALRCMAAALKDAGVqpEEISYINAHATSTPLGDAAEN 277
Cdd:PRK08439 235 galvleeyesakkrgakiyaeiigfgeSGDANHITSPAPEG--PLRAMKAALEMAGN--PKIDYINAHGTSTPYNDKNET 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEkrfIG 357
Cdd:PRK08439 311 AALKELFGSKEKVPPVSSTKGQIGHCLGAAGAIEAVISIMAMRDGILPPTINQETPDPECDLDYIPNVARKAELN---VV 387
|
410
....*....|.
gi 223972627 358 LTNSFGFGGTN 368
Cdd:PRK08439 388 MSNSFGFGGTN 398
|
|
| PRK09185 |
PRK09185 |
beta-ketoacyl-ACP synthase; |
227-371 |
4.51e-49 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 236398 [Multi-domain] Cd Length: 392 Bit Score: 170.02 E-value: 4.51e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHayaLAVSSTKGATGHLLGA 306
Cdd:PRK09185 248 DAHHMSAPHPEGLGAILAMQQALADAGLAPADIGYINLHGTATPLNDAMESRAVAAVFGDG---VPCSSTKGLTGHTLGA 324
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223972627 307 AGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYvpLKAQEWKTEKRFIgLTNSFGFGGTNATL 371
Cdd:PRK09185 325 AGAVEAAICWLALRHGLPPHGWNTGQPDPALPPLY--LVENAQALAIRYV-LSNSFAFGGNNCSL 386
|
|
| PRK14691 |
PRK14691 |
3-oxoacyl-(acyl carrier protein) synthase II; Provisional |
136-373 |
5.11e-47 |
|
3-oxoacyl-(acyl carrier protein) synthase II; Provisional
Pssm-ID: 173154 [Multi-domain] Cd Length: 342 Bit Score: 163.36 E-value: 5.11e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 136 HPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHA 215
Cdd:PRK14691 18 HADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 216 VGDSFRFIAH---------------------------------------------------------------------- 225
Cdd:PRK14691 98 IGDAVRMIRNneadvalcggaeavidtvslagfaaaralsthfnstpekasrpfdtardgfvmgegaglliieelehala 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 226 ---------------GDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDhAYA 290
Cdd:PRK14691 178 rgakplaeivgygtsADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGE-SNA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 291 LAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFD-LNYVPLKAQewkTEKRFIGLTNSFGFGGTNA 369
Cdd:PRK14691 257 LAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKgLNIIAGNAQ---PHDMTYALSNGFGFAGVNA 333
|
....
gi 223972627 370 TLCI 373
Cdd:PRK14691 334 SILL 337
|
|
| PLN02787 |
PLN02787 |
3-oxoacyl-[acyl-carrier-protein] synthase II |
42-374 |
1.43e-46 |
|
3-oxoacyl-[acyl-carrier-protein] synthase II
Pssm-ID: 215421 [Multi-domain] Cd Length: 540 Bit Score: 166.69 E-value: 1.43e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGqfneqnFVSKSDIKSMSSPTIM 121
Cdd:PLN02787 129 RRVVVTGMGVVSPLGHDPDVFYNNLLEGVSGISEIERFDCSQFPTRIAGEIKSFSTDG------WVAPKLSKRMDKFMLY 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPQ--SEADQVATGVAIGMGMIPLEVVSEtALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLK 199
Cdd:PLN02787 203 LLTAGKKALADGGITEDvmKELDKTKCGVLIGSAMGGMKVFND-AIEALRISYRKMNPFCVPFATTNMGSAMLAMDLGWM 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 200 GPNHAVSTACTTGAHAVGDSFRFIAHG----------------------------------------------------- 226
Cdd:PLN02787 282 GPNYSISTACATSNFCILNAANHIIRGeadvmlcggsdaaiipiglggfvacralsqrnddptkasrpwdmnrdgfvmge 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAA 275
Cdd:PLN02787 362 gagvllleelehakkrganiyaeflggsftcDAYHMTEPHPEGAGVILCIEKALAQSGVSKEDVNYINAHATSTKAGDLK 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 276 ENKAIKHLFKDHAyALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNyVPLKAQEWKTEKRf 355
Cdd:PLN02787 442 EYQALMRCFGQNP-ELRVNSTKSMIGHLLGAAGAVEAIATVQAIRTGWVHPNINLENPESGVDTK-VLVGPKKERLDIK- 518
|
410
....*....|....*....
gi 223972627 356 IGLTNSFGFGGTNATLCIA 374
Cdd:PLN02787 519 VALSNSFGFGGHNSSILFA 537
|
|
| PRK07910 |
PRK07910 |
beta-ketoacyl-ACP synthase; |
44-371 |
2.33e-46 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 236129 [Multi-domain] Cd Length: 418 Bit Score: 163.36 E-value: 2.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 44 VVITGIGLVTPLGVGTHLVWDRLIGGESGIVSL---VGEEYKSiPCSVAAYVPRGSDEGqfneqnfVSKSDIKSMSSPTI 120
Cdd:PRK07910 14 VVVTGIAMTTALATDAETTWKLLLDGQSGIRTLddpFVEEFDL-PVRIGGHLLEEFDHQ-------LTRVELRRMSYLQR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAIGAAELAMKDSGwhpQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKG 200
Cdd:PRK07910 86 MSTVLGRRVWENAG---SPEVDTNRLMVSIGTGLGSAEELVFAYDDMRARGLRAVSPLAVQMYMPNGPAAAVGLERHAKA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 201 PNHAVSTACTTGAHAVGDSFRFIAHGDAG--------------------------------------------------- 229
Cdd:PRK07910 163 GVITPVSACASGSEAIAQAWRQIVLGEADiaicggvetrieavpiagfaqmrivmstnnddpagacrpfdkdrdgfvfge 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 230 ----------------------------------HITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAA 275
Cdd:PRK07910 243 ggalmvieteehakarganilarimgasitsdgfHMVAPDPNGERAGHAMTRAIELAGLTPGDIDHVNAHATGTSVGDVA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 276 ENKAIKHLFKDHayALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVplkAQEWKTEKRF 355
Cdd:PRK07910 323 EGKAINNALGGH--RPAVYAPKSALGHSVGAVGAVESILTVLALRDGVIPPTLNLENLDPEIDLDVV---AGEPRPGNYR 397
|
410
....*....|....*.
gi 223972627 356 IGLTNSFGFGGTNATL 371
Cdd:PRK07910 398 YAINNSFGFGGHNVAL 413
|
|
| PRK07967 |
PRK07967 |
beta-ketoacyl-ACP synthase I; |
42-371 |
9.87e-44 |
|
beta-ketoacyl-ACP synthase I;
Pssm-ID: 181184 [Multi-domain] Cd Length: 406 Bit Score: 156.37 E-value: 9.87e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVslVGEEYKSI--PCSVAAYVprgsdegQFNEQNFVSKSDIKSMSSPT 119
Cdd:PRK07967 2 RRVVITGLGIVSSIGNNQQEVLASLREGRSGIT--FSPEFAEMgmRSQVWGNV-------KLDPTGLIDRKVMRFMGDAS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 120 IMAIGAAELAMKDSGWhpqsEADQVA---TGVAIGMG-MIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIR 195
Cdd:PRK07967 73 AYAYLAMEQAIADAGL----SEEQVSnprTGLIAGSGgGSTRNQVEAADAMRGPRGPKRVGPYAVTKAMASTVSACLATP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 196 YKLKGPNHAVSTACTTGAHAVGDSFRFIAHG---------------------DA-------------------------- 228
Cdd:PRK07967 149 FKIKGVNYSISSACATSAHCIGNAVEQIQLGkqdivfagggeeldwemsclfDAmgalstkyndtpekasraydanrdgf 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 229 ---------------------GHITAP--------------DPEGEGALRCMAAALkdAGVQpEEISYINAHATSTPLGD 273
Cdd:PRK07967 229 viaggggvvvveelehalargAKIYAEivgygatsdgydmvAPSGEGAVRCMQMAL--ATVD-TPIDYINTHGTSTPVGD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 274 AAENKAIKHLFKDHayALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEF-DLNYVPLKAQEWKTE 352
Cdd:PRK07967 306 VKELGAIREVFGDK--SPAISATKSLTGHSLGAAGVQEAIYSLLMMEHGFIAPSANIEELDPQAaGMPIVTETTDNAELT 383
|
410
....*....|....*....
gi 223972627 353 krfIGLTNSFGFGGTNATL 371
Cdd:PRK07967 384 ---TVMSNSFGFGGTNATL 399
|
|
| PRK09116 |
PRK09116 |
beta-ketoacyl-ACP synthase; |
42-373 |
9.18e-43 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 181657 [Multi-domain] Cd Length: 405 Bit Score: 153.60 E-value: 9.18e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVG-EEYKSIPCSVAAYVPrgsdegQFNEQNFVSKSDIKSMSSPTI 120
Cdd:PRK09116 2 RRVVVTGMGGVTALGEDWQTIAARLKAGRNAVRRMPEwDRYDGLNTRLAAPID------DFELPAHYTRKKIRSMGRVSL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKG 200
Cdd:PRK09116 76 MATRASELALEDAGLLGDPILTDGRMGIAYGSSTGSTDPIGAFGTMLLEGSMSGITATTYVRMMPHTTAVNVGLFFGLKG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 201 PNHAVSTACTTGAHAVGDSFRFIAHG------------------------------------------------------ 226
Cdd:PRK09116 156 RVIPTSSACTSGSQGIGYAYEAIKYGyqtvmlaggaeelcpteaavfdtlfatstrndapeltprpfdanrdglvigega 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 -----------------------------DAGHITAPDPEGEGalRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN 277
Cdd:PRK09116 236 gtlvleelehakargatiyaeivgfgtnsDGAHVTQPQAETMQ--IAMELALKDAGLAPEDIGYVNAHGTATDRGDIAES 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 278 KAIKHLFKDHayaLAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEF-DLNYvpLKAQEWKTEKRFI 356
Cdd:PRK09116 314 QATAAVFGAR---MPISSLKSYFGHTLGACGALEAWMSIEMMNEGWFAPTLNLTQVDPACgALDY--IMGEAREIDTEYV 388
|
410
....*....|....*..
gi 223972627 357 gLTNSFGFGGTNATLCI 373
Cdd:PRK09116 389 -MSNNFAFGGINTSLIF 404
|
|
| Ketoacyl-synt_C |
pfam02801 |
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ... |
226-331 |
1.21e-41 |
|
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 426989 Cd Length: 118 Bit Score: 141.94 E-value: 1.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 226 GDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAY--ALAVSSTKGATGHL 303
Cdd:pfam02801 11 HDGRHNGLTAPNGEGQARAIRRALADAGVDPEDVDYVEAHGTGTPLGDPIEAEALKRVFGSGARkqPLAIGSVKSNIGHL 90
|
90 100
....*....|....*....|....*...
gi 223972627 304 LGAAGAVEAAFTTLACYYQKLPPTLNLD 331
Cdd:pfam02801 91 EGAAGAAGLIKVVLALRHGVIPPTLNLE 118
|
|
| elong_cond_enzymes |
cd00828 |
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ... |
42-371 |
5.18e-41 |
|
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.
Pssm-ID: 238424 [Multi-domain] Cd Length: 407 Bit Score: 149.13 E-value: 5.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLV---WDRLIGGESGIVSLVGEEYKSiPCSVAAYVPRGSDEGQFneqnfVSKSDIksMSSP 118
Cdd:cd00828 1 SRVVITGIGVVSPHGEGCDEVeefWEALREGRSGIAPVARLKSRF-DRGVAGQIPTGDIPGWD-----AKRTGI--VDRT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 119 TIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFqtkgYNKVSPFFVPK--ILVNMAAGQVSIRY 196
Cdd:cd00828 73 TLLALVATEEALADAGITDPYEVHPSEVGVVVGSGMGGLRFLRRGGKLD----ARAVNPYVSPKwmLSPNTVAGWVNILL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 197 KLK-GPNHAVSTACTTGAHAV---------------------------------------------GDSFRFIAHGD--- 227
Cdd:cd00828 149 LSShGPIKTPVGACATALEALdlaveairsgkadivvvggvedpleeglsgfanmgalstaeeepeEMSRPFDETRDgfv 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 228 ---------------------------AGHITAPDP-------EGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGD 273
Cdd:cd00828 229 eaegagvlvleraelalargapiygrvAGTASTTDGagrsvpaGGKGIARAIRTALAKAGLSLDDLDVISAHGTSTPAND 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 274 AAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEK 353
Cdd:cd00828 309 VAESRAIAEVAGALGAPLPVTAQKALFGHSKGAAGALQLIGALQSLEHGLIPPTANLDDVDPDVEHLSVVGLSRDLNLKV 388
|
410
....*....|....*...
gi 223972627 354 RfIGLTNSFGFGGTNATL 371
Cdd:cd00828 389 R-AALVNAFGFGGSNAAL 405
|
|
| PRK05952 |
PRK05952 |
beta-ketoacyl-ACP synthase; |
43-375 |
7.58e-41 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235653 [Multi-domain] Cd Length: 381 Bit Score: 147.89 E-value: 7.58e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 43 RVVITGIGLVTPLGvGTHLVWDRLIGGESGIvSLVG--EEYKSIPCSVAAYVPrgsdegqfneqnfvskSDIKSMSSPTI 120
Cdd:PRK05952 3 KVVVTGIGLVSALG-DLEQSWQRLLQGKSGI-KLHQpfPELPPLPLGLIGNQP----------------SSLEDLTKTVV 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAigaaelAMKDSGWHPqSEADqvaTGVAIGMG---------MIPLEVVSETALNFQTKGYNKVSpffvpkILVNMAAGQ 191
Cdd:PRK05952 65 TA------ALKDAGLTP-PLTD---CGVVIGSSrgcqgqwekLARQMYQGDDSPDEELDLENWLD------TLPHQAAIA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 192 VSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHG--------------------------------------------- 226
Cdd:PRK05952 129 AARQIGTQGPVLAPMAACATGLWAIAQGVELIQTGqcqrviagaveapitpltlagfqqmgalaktgaypfdrqreglvl 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 227 ---------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGD 273
Cdd:PRK05952 209 geggailvlesaelaqkrgakiygqilgfgltcDAYHMSAPEPDGKSAIAAIQQCLARSGLTPEDIDYIHAHGTATRLND 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 274 AAENKAIKHLFkdhAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLdcSEPEFDLNYVpLKAQEWKTEK 353
Cdd:PRK05952 289 QREANLIQALF---PHRVAVSSTKGATGHTLGASGALGVAFSLLALRHQQLPPCVGL--QEPEFDLNFV-RQAQQSPLQN 362
|
410 420
....*....|....*....|..
gi 223972627 354 rfiGLTNSFGFGGTNATLCIAG 375
Cdd:PRK05952 363 ---VLCLSFGFGGQNAAIALGK 381
|
|
| PRK06501 |
PRK06501 |
beta-ketoacyl-ACP synthase; |
44-375 |
2.02e-38 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235817 [Multi-domain] Cd Length: 425 Bit Score: 142.46 E-value: 2.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 44 VVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVprgsdegqfneqNFVsksDIKSMSSPTI--- 120
Cdd:PRK06501 13 VAVTGMGVVTSLGQGKADNWAALTAGESGIHTITRFPTEGLRTRIAGTV------------DFL---PESPFGASALsea 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 121 MAIGAAELAMKDSG--------------------WHPQSEADQvATGVAIGMGMIPLEVVSETalnfqtkgyNKVSPFFv 180
Cdd:PRK06501 78 LARLAAEEALAQAGigkgdfpgplflaappveleWPARFALAA-AVGDNDAPSYDRLLRAARG---------GRFDALH- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 181 PKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAV---------GDS-----------------FRF------------ 222
Cdd:PRK06501 147 ERFQFGSIADRLADRFGTRGLPISLSTACASGATAIqlgveairrGETdralciatdgsvsaealIRFsllsalstqndp 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 223 ----------------IAHG------------------------------DAGHITAPDPEGEGALRCMAAALKDAGVQP 256
Cdd:PRK06501 227 pekaskpfskdrdgfvMAEGagalvleslesavargakilgivagcgekaDSFHRTRSSPDGSPAIGAIRAALADAGLTP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 257 EEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPE 336
Cdd:PRK06501 307 EQIDYINAHGTSTPENDKMEYLGLSAVFGERLASIPVSSNKSMIGHTLTAAGAVEAVFSLLTIQTGRLPPTINYDNPDPA 386
|
410 420 430
....*....|....*....|....*....|....*....
gi 223972627 337 FDLNYVPLKAQEWKTEKRfigLTNSFGFGGTNATLCIAG 375
Cdd:PRK06501 387 IPLDVVPNVARDARVTAV---LSNSFGFGGQNASLVLTA 422
|
|
| PKS |
cd00833 |
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ... |
129-369 |
1.86e-34 |
|
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.
Pssm-ID: 238429 [Multi-domain] Cd Length: 421 Bit Score: 131.53 E-value: 1.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 129 AMKDSGWHPQSEADQvATGVAIGMGmiplevvSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTA 208
Cdd:cd00833 98 ALEDAGYSPESLAGS-RTGVFVGAS-------SSDYLELLARDPDEIDAYAATGTSRAFLANRISYFFDLRGPSLTVDTA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 209 CTTGAHAV-----------------------------------------GDSFRF------------------------I 223
Cdd:cd00833 170 CSSSLVALhlacqslrsgecdlalvggvnlilspdmfvgfskagmlspdGRCRPFdadadgyvrgegvgvvvlkrlsdaL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 224 AHGD----------------AGHITAPDPEGEGALrcMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLF--- 284
Cdd:cd00833 250 RDGDriyavirgsavnqdgrTKGITAPSGEAQAAL--IRRAYARAGVDPSDIDYVEAHGTGTPLGDPIEVEALAKVFggs 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 285 KDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLN----YVPLKAQEWK--TEKRFIGL 358
Cdd:cd00833 328 RSADQPLLIGSVKSNIGHLEAAAGLAGLIKVVLALEHGVIPPNLHFETPNPKIDFEesplRVPTEARPWPapAGPRRAGV 407
|
330
....*....|.
gi 223972627 359 tNSFGFGGTNA 369
Cdd:cd00833 408 -SSFGFGGTNA 417
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
231-369 |
2.06e-29 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 120.36 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 231 ITAPDPEGEGALrcMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYA---LAVSSTKGATGHLLGAA 307
Cdd:COG3321 277 LTAPNGPAQAAV--IRRALADAGVDPATVDYVEAHGTGTPLGDPIEAAALTAAFGQGRPAdqpCAIGSVKSNIGHLEAAA 354
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 308 GAveAAF--TTLACYYQKLPPTLNLDCSEPEFDLN----YVPLKAQEWKTEK--RFIGLtNSFGFGGTNA 369
Cdd:COG3321 355 GV--AGLikAVLALRHGVLPPTLHFETPNPHIDFEnspfYVNTELRPWPAGGgpRRAGV-SSFGFGGTNA 421
|
|
| PRK07103 |
PRK07103 |
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated |
234-374 |
4.76e-29 |
|
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated
Pssm-ID: 180839 [Multi-domain] Cd Length: 410 Bit Score: 116.28 E-value: 4.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 234 PDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYalaVSSTKGATGHLLGAAGAVEAA 313
Cdd:PRK07103 276 PDPSLEGEMRVIRAALRRAGLGPEDIDYVNPHGTGSPLGDETELAALFASGLAHAW---INATKSLTGHGLSAAGIVELI 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223972627 314 FTTLACYYQKLPPTLNLDcsEP-EFDLNYVPLKAQEWKTEkrfIGLTNSFGFGGTNATLCIA 374
Cdd:PRK07103 353 ATLLQMRAGFLHPSRNLD--EPiDERFRWVGSTAESARIR---YALSLSFGFGGINTALVLE 409
|
|
| ketoacyl-synt |
pfam00109 |
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ... |
42-228 |
3.73e-28 |
|
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.
Pssm-ID: 425468 [Multi-domain] Cd Length: 251 Bit Score: 110.42 E-value: 3.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGE-----EYKSIPCSVA--AYVPRG--SDEGQFNEQNF-VSKSD 111
Cdd:pfam00109 1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISEIPADrwdpdKLYDPPSRIAgkIYTKWGglDDIFDFDPLFFgISPRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 112 IKSMSSPTIMAIGAAELAMKDSGWHPQSEaDQVATGVAIGMGMiplEVVSETALNFQTKGYNKVSPFFVPKIlVNMAAGQ 191
Cdd:pfam00109 81 AERMDPQQRLLLEAAWEALEDAGITPDSL-DGSRTGVFIGSGI---GDYAALLLLDEDGGPRRGSPFAVGTM-PSVIAGR 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 223972627 192 VSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDA 228
Cdd:pfam00109 156 ISYFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGEA 192
|
|
| decarbox_cond_enzymes |
cd00825 |
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ... |
119-371 |
2.86e-24 |
|
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).
Pssm-ID: 238421 [Multi-domain] Cd Length: 332 Bit Score: 101.94 E-value: 2.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 119 TIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPkilvnmAAGQVSIRYKL 198
Cdd:cd00825 12 SILGFEAAERAIADAGLSREYQKNPIVGVVVGTGGGSPRFQVFGADAMRAVGPYVVTKAMFPG------ASGQIATPLGI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 199 KGPNHAVSTACTTGAHAV-------------------------------------------------------------- 216
Cdd:cd00825 86 HGPAYDVSAACAGSLHALslaadavqngkqdivlaggseelaapmdcefdamgalstpekasrtfdaaadgfvfgdgaga 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 217 ------------GDSFRFIAHGDAGHIT-----APDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKA 279
Cdd:cd00825 166 lvveelehalarGAHIYAEIVGTAATIDgagmgAFAPSAEGLARAAKEALAVAGLTVWDIDYLVAHGTGTPIGDVKELKL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 280 IKHLFKDHayALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTekrfiGLT 359
Cdd:cd00825 246 LRSEFGDK--SPAVSATKAMTGNLSSAAVVLAVDEAVLMLEHGFIPPSIHIEELDEAGLNIVTETTPRELRT-----ALL 318
|
330
....*....|..
gi 223972627 360 NSFGFGGTNATL 371
Cdd:cd00825 319 NGFGLGGTNATL 330
|
|
| CLF |
cd00832 |
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic ... |
42-342 |
2.77e-20 |
|
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.
Pssm-ID: 238428 [Multi-domain] Cd Length: 399 Bit Score: 91.27 E-value: 2.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 42 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPrGSDEGQFNEQNFVSKSDiksmsSPTIM 121
Cdd:cd00832 1 RRAVVTGIGVVAPNGLGVEEYWKAVLDGRSGLGPITRFDPSGYPARLAGEVP-DFDAAEHLPGRLLPQTD-----RMTRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 122 AIGAAELAMKDSGWHPqSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPF--FVPKILVNmaAGQVSIRYKLK 199
Cdd:cd00832 75 ALAAADWALADAGVDP-AALPPYDMGVVTASAAGGFEFGQRELQKLWSKGPRHVSAYqsFAWFYAVN--TGQISIRHGMR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 200 GPNHAVSTACTTGAHAVGDSFRFIAHGD---------------------------------------------------- 227
Cdd:cd00832 152 GPSGVVVAEQAGGLDALAQARRLVRRGTplvvsggvdsalcpwgwvaqlssgrlstsddparaylpfdaaaagyvpgegg 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 228 ----------------------AGHITAPDP-----EGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAI 280
Cdd:cd00832 232 ailvledaaaarergarvygeiAGYAATFDPppgsgRPPGLARAIRLALADAGLTPEDVDVVFADAAGVPELDRAEAAAL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223972627 281 KHLFKdhAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYV 342
Cdd:cd00832 312 AAVFG--PRGVPVTAPKTMTGRLYAGGAPLDVATALLALRDGVIPPTVNVTDVPPAYGLDLV 371
|
|
| omega_3_PfaA |
TIGR02813 |
polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this ... |
231-368 |
4.71e-17 |
|
polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.
Pssm-ID: 274311 [Multi-domain] Cd Length: 2582 Bit Score: 83.13 E-value: 4.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 231 ITAPDPEGEGalRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLF---KDHAYALAVSSTKGATGHLLGAA 307
Cdd:TIGR02813 309 IYAPRPEGQA--KALKRAYDDAGFAPHTCGLIEAHGTGTAAGDVAEFGGLVSVFsqdNDQKQHIALGSVKSQIGHTKSTA 386
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223972627 308 GAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPL----KAQEWKTEK----RFIGLTnSFGFGGTN 368
Cdd:TIGR02813 387 GTAGMIKAVLALHHKVLPPTINVDQPNPKLDIENSPFylntETRPWMQREdgtpRRAGIS-SFGFGGTN 454
|
|
| cond_enzymes |
cd00327 |
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ... |
188-373 |
6.82e-17 |
|
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.
Pssm-ID: 238201 [Multi-domain] Cd Length: 254 Bit Score: 79.41 E-value: 6.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 188 AAGQVSIRYKLK-GPNHAVSTACTTGAHAVGDSFRFIAHGDAGHITA--------------------------------- 233
Cdd:cd00327 46 AAGQLAYHLGISgGPAYSVNQACATGLTALALAVQQVQNGKADIVLAggseefvfgdgaaaavveseehalrrgahpqae 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 234 --------------PDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHayALAVSSTKGA 299
Cdd:cd00327 126 ivstaatfdgasmvPAVSGEGLARAARKALEGAGLTPSDIDYVEAHGTGTPIGDAVELALGLDPDGVR--SPAVSATLIM 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223972627 300 TGHLLGAAGAVEAAFTTLACYYQKLPPTLN-LDCsepefdlnyvplkaqewktekrfiGLTNSFGFGGTNATLCI 373
Cdd:cd00327 204 TGHPLGAAGLAILDELLLMLEHEFIPPTPRePRT------------------------VLLLGFGLGGTNAAVVL 254
|
|
| PKS_KS |
smart00825 |
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ... |
291-369 |
2.20e-11 |
|
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 214836 [Multi-domain] Cd Length: 298 Bit Score: 63.89 E-value: 2.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972627 291 LAVSSTKGATGHLLGAAGAveAAF--TTLACYYQKLPPTLNLDCSEPEFDLN----YVPLKAQEWKTE--KRFIGLtNSF 362
Cdd:smart00825 209 LLIGSVKSNIGHLEAAAGV--AGLikVVLALKHGVIPPTLHFETPNPHIDLEesplRVPTELTPWPPPgrPRRAGV-SSF 285
|
....*..
gi 223972627 363 GFGGTNA 369
Cdd:smart00825 286 GFGGTNA 292
|
|
| |
