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Conserved domains on  [gi|224177558|ref|NP_001138909|]
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lanosterol synthase isoform 3 [Homo sapiens]

Protein Classification

squalene_cyclas family protein( domain architecture ID 11493165)

squalene_cyclas family protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-641 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


:

Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1001.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:TIGR01787   6 VEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:TIGR01787  85 LKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  161 SYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQRAVQKL 239
Cdd:TIGR01787 165 SYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKRALQWL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  240 YEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQALLEA 319
Cdd:TIGR01787 237 YEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRES 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  320 GGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvTEH 397
Cdd:TIGR01787 310 GDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE-----DEH 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  398 IPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHRAAEIR 477
Cdd:TIGR01787 385 VKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHRADEIR 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  478 ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCE 557
Cdd:TIGR01787 460 NVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGEDCFSYE 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  558 ERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIFPIWAL 636
Cdd:TIGR01787 537 DPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWAL 616

                  ....*
gi 224177558  637 GRFSQ 641
Cdd:TIGR01787 617 GRYRQ 621
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-641 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1001.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:TIGR01787   6 VEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:TIGR01787  85 LKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  161 SYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQRAVQKL 239
Cdd:TIGR01787 165 SYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKRALQWL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  240 YEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQALLEA 319
Cdd:TIGR01787 237 YEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRES 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  320 GGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvTEH 397
Cdd:TIGR01787 310 GDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE-----DEH 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  398 IPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHRAAEIR 477
Cdd:TIGR01787 385 VKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHRADEIR 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  478 ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCE 557
Cdd:TIGR01787 460 NVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGEDCFSYE 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  558 ERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIFPIWAL 636
Cdd:TIGR01787 537 DPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWAL 616

                  ....*
gi 224177558  637 GRFSQ 641
Cdd:TIGR01787 617 GRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
1-639 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 934.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:cd02892    5 LEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:cd02892   85 LRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLY 240
Cdd:cd02892  165 SYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAY 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 241 EHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAG 320
Cdd:cd02892  243 EWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAG 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 321 GHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTEHIPR 400
Cdd:cd02892  323 LA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GEKVSR 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 401 ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEIRETL 480
Cdd:cd02892  400 ERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAI 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 481 TQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCEERR 560
Cdd:cd02892  479 RRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSYEDKS 555
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 561 YLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:cd02892  556 YAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
PLN03012 PLN03012
Camelliol C synthase
3-644 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 589.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   3 FYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:PLN03012 105 FFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNY 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  79 VSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:PLN03012 184 ICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCRL 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 156 VYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH----- 230
Cdd:PLN03012 264 VYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfnk 343
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 -LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWDT 309
Cdd:PLN03012 344 lLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDS 421
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 310 AFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQ 388
Cdd:PLN03012 422 GFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLFS 499
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 389 EKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKR 467
Cdd:PLN03012 500 MIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQL 579
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 468 FPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADG 547
Cdd:PLN03012 580 YPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDNG 656
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 548 GWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN03012 657 GWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCL 734
                        650       660
                 ....*....|....*....|...
gi 224177558 622 ISYTSYRNIFPIWALGRFSQLYP 644
Cdd:PLN03012 735 LHYAAYRNIFPLWALAEYRARVP 757
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
4-643 0e+00

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 562.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   4 YVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRI 83
Cdd:COG1657   31 LLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  84 LGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYC 163
Cdd:COG1657  111 LGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 164 YAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHI 243
Cdd:COG1657  191 YARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKPLRRRALRKAEDWI 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 244 vaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQIWDTAFAIQALLEA 319
Cdd:COG1657  264 --LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEA 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQekcpHVTEHIP 399
Cdd:COG1657  340 G---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLRLR----LPDEPRY 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhkrfpEHRAAEIRET 479
Cdd:COG1657  412 REAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG-------QLGLTEDHPA 482
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:COG1657  483 IRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNADGGWGEDCRSYEDP 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSYRNIFPIWALGR 638
Cdd:COG1657  559 RYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALAR 638

                 ....*
gi 224177558 639 FSQLY 643
Cdd:COG1657  639 YRNLR 643
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
304-639 3.20e-51

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 179.84  E-value: 3.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  304 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  384 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 459
Cdd:pfam13243  78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  460 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 539
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  540 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 618
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
                         330       340
                  ....*....|....*....|.
gi 224177558  619 SCAISYTSYRNIFPIWALGRF 639
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-641 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1001.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:TIGR01787   6 VEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:TIGR01787  85 LKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  161 SYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQRAVQKL 239
Cdd:TIGR01787 165 SYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKRALQWL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  240 YEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQALLEA 319
Cdd:TIGR01787 237 YEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRES 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  320 GGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvTEH 397
Cdd:TIGR01787 310 GDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE-----DEH 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  398 IPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHRAAEIR 477
Cdd:TIGR01787 385 VKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHRADEIR 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  478 ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCE 557
Cdd:TIGR01787 460 NVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGEDCFSYE 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  558 ERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIFPIWAL 636
Cdd:TIGR01787 537 DPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWAL 616

                  ....*
gi 224177558  637 GRFSQ 641
Cdd:TIGR01787 617 GRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
1-639 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 934.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:cd02892    5 LEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:cd02892   85 LRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLY 240
Cdd:cd02892  165 SYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAY 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 241 EHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAG 320
Cdd:cd02892  243 EWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAG 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 321 GHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTEHIPR 400
Cdd:cd02892  323 LA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GEKVSR 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 401 ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEIRETL 480
Cdd:cd02892  400 ERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAI 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 481 TQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCEERR 560
Cdd:cd02892  479 RRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSYEDKS 555
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 561 YLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:cd02892  556 YAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
7-639 0e+00

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 617.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    7 LQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGV 86
Cdd:TIGR03463   4 LQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLLGL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   87 GPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYA 165
Cdd:TIGR03463  84 GKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  166 VRLSAAE-DPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIV 244
Cdd:TIGR03463 164 RGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQIL 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  245 ADDRFTKSISIGPISKTINMLVrWYVDGPASTAFQEHVSRIPDYLWMGLD-GMKMQGTNGSQIWDTAFAIQALLEAG--- 320
Cdd:TIGR03463 244 AEDEATHYICIGPINGLLNCLA-IFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGeld 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  321 GHHRpefsSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK-CPHVTEHIP 399
Cdd:TIGR03463 323 EEAK----HALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRET 479
Cdd:TIGR03463 399 AARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAA 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:TIGR03463 479 IRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD----MALQAAAAFLLEKQRADGAWGEHVESCLEA 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:TIGR03463 555 RWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
PLN03012 PLN03012
Camelliol C synthase
3-644 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 589.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   3 FYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:PLN03012 105 FFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNY 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  79 VSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:PLN03012 184 ICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCRL 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 156 VYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH----- 230
Cdd:PLN03012 264 VYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfnk 343
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 -LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWDT 309
Cdd:PLN03012 344 lLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDS 421
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 310 AFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQ 388
Cdd:PLN03012 422 GFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLFS 499
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 389 EKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKR 467
Cdd:PLN03012 500 MIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQL 579
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 468 FPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADG 547
Cdd:PLN03012 580 YPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDNG 656
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 548 GWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN03012 657 GWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCL 734
                        650       660
                 ....*....|....*....|...
gi 224177558 622 ISYTSYRNIFPIWALGRFSQLYP 644
Cdd:PLN03012 735 LHYAAYRNIFPLWALAEYRARVP 757
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
4-643 0e+00

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 562.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   4 YVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRI 83
Cdd:COG1657   31 LLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  84 LGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYC 163
Cdd:COG1657  111 LGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 164 YAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHI 243
Cdd:COG1657  191 YARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKPLRRRALRKAEDWI 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 244 vaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQIWDTAFAIQALLEA 319
Cdd:COG1657  264 --LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEA 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQekcpHVTEHIP 399
Cdd:COG1657  340 G---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLRLR----LPDEPRY 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhkrfpEHRAAEIRET 479
Cdd:COG1657  412 REAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG-------QLGLTEDHPA 482
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:COG1657  483 IRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNADGGWGEDCRSYEDP 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSYRNIFPIWALGR 638
Cdd:COG1657  559 RYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALAR 638

                 ....*
gi 224177558 639 FSQLY 643
Cdd:COG1657  639 YRNLR 643
PLN02993 PLN02993
lupeol synthase
1-639 0e+00

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 559.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   1 MTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 76
Cdd:PLN02993 103 VSFFSALQASDGHWpgeiTGPLFFLPPLVFCLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIESKSVMFCTVL 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  77 NYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHC 153
Cdd:PLN02993 182 NYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLCYT 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 154 RQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH--- 230
Cdd:PLN02993 262 RMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRwpl 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 ---LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIW 307
Cdd:PLN02993 342 nklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQLW 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 308 DTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 386
Cdd:PLN02993 420 DTGFAIQALLAS--DLSDETDDVLRRGHNYIKKSQVRENPSgDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCCML 497
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 387 LQEKCPHVT-EHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFH 465
Cdd:PLN02993 498 LSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLFK 577
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 466 KRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMA 545
Cdd:PLN02993 578 QLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQRD 654
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 546 DGGWGEDFESCEERRY--LQSAQSQIHNTCWAMMGLMAVRHP--DIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN02993 655 DGGWGESYLSCPEQRYipLEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTCM 734
                        650
                 ....*....|....*...
gi 224177558 622 ISYTSYRNIFPIWALGRF 639
Cdd:PLN02993 735 LHYATYRNTFPLWALAEY 752
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
304-639 1.87e-175

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 502.52  E-value: 1.87e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 304 SQIWDTAFAIQALLEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:cd02889   23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 384 VLLLQEKCPHvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELlnPSEVFGDIMIDYTYVECTSAVMQALKY 463
Cdd:cd02889  101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 464 FHKRFPEHRAaEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRdgtaCAEVSRACDFLLSRQ 543
Cdd:cd02889  178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGEDEN----SPYVRKACDWLLSKQ 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 544 MADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAIS 623
Cdd:cd02889  253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
                        330
                 ....*....|....*.
gi 224177558 624 YTSYRNIFPIWALGRF 639
Cdd:cd02889  333 YHNYRNYFPLWALGRY 348
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
3-642 3.74e-63

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 220.92  E-value: 3.74e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    3 FYVGLQAEDGHWTGDYGGPLFLLPGLLITCH----VARIPLpagyrEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:TIGR01507  24 YLLSCQKDEGYWWGELESNVTIEAEYVLLCHildrVDRDRM-----EKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAY 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   79 VSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYL 158
Cdd:TIGR01507  99 VALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVV 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  159 PMSYCYAVRLSAaedPLVQSLR-QELYVEDfasidwlaqrnnVAPDELYTPHS---W-LLRVVYALLNLYEHHHSAHLRQ 233
Cdd:TIGR01507 179 PLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgtgWgIFDALDRALHGYEKLSVHPFRR 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  234 RAVQKLYEHIVAddRFTKSISIGPISKT-INMLVRWYVDG-PASTAF-QEHVSRIPDYLWMGLDGMKMQGTNgSQIWDTA 310
Cdd:TIGR01507 244 AAEIRALDWLLE--RQAGDGSWGGIQPAmFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDTA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  311 FAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVpDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK 390
Cdd:TIGR01507 321 LAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWALNGLRLP 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  391 cphvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNpsevFGDI--MIDYTYVECTSAVMQALKYFHKRF 468
Cdd:TIGR01507 397 ----DERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDD 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  469 PehraaeiRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 548
Cdd:TIGR01507 469 A-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPDGG 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  549 WGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSY 627
Cdd:TIGR01507 538 WGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMY 617
                         650
                  ....*....|....*
gi 224177558  628 RNIFPIWALGRFSQL 642
Cdd:TIGR01507 618 RHVFPLLALARYKQA 632
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
294-639 1.20e-56

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 193.92  E-value: 1.20e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 294 DGMKMQGTNGSQIWDTAFAIQALLEAGGH--HRPEFSSCLQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDcGW 371
Cdd:cd00688   15 DGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD--------------GGFSGWGGN-DY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 372 IVSDCTAEALKAVLLLQEkcphvTEHIPRERLCDAVAVLLNMRNPDGGFATYEtkrgghllellnpsEVFGDIMIDYTYV 451
Cdd:cd00688   80 PSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG--------------PGNHRIGGDESDV 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 452 ECTSAVMQALKYFHKRFPehraaeiRETLTQGLEFCRRQQRADGSWeGSWGVCFTYGTWFGLEAFACMGQTYRDgtacaE 531
Cdd:cd00688  141 RLTAYALIALALLGKLDP-------DPLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDLDSP-----D 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 532 VSRACDFLLSRQMADGGWGedfesceERRYLQSAQSQIHNTCWAMMGLMA-VRHPDIEAQERGVRCLLEKQLPNGDWPQE 610
Cdd:cd00688  208 AKKALRWLLSRQRPDGGWG-------EGRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKWLLSQQNEDGGFSSK 280
                        330       340
                 ....*....|....*....|....*....
gi 224177558 611 NIagvfnkscaISYTSYRNIFPIWALGRF 639
Cdd:cd00688  281 PG---------KSYDTQHTVFALLALSLY 300
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
304-639 3.20e-51

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 179.84  E-value: 3.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  304 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  384 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 459
Cdd:pfam13243  78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  460 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 539
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  540 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 618
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
                         330       340
                  ....*....|....*....|.
gi 224177558  619 SCAISYTSYRNIFPIWALGRF 639
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
6-245 4.07e-41

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 151.10  E-value: 4.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558    6 GLQAEDGHWTGD----------YggplfllpgllITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 75
Cdd:pfam13249  10 SLQHPDGHWVGEleanvtitaeY-----------ILLRHFLGPDDPELEAKIARYLRSQQREDGGWPLFHGGPGDLSTTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   76 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:pfam13249  79 EAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWART 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  156 VYLPMSYCYAVRLSAAEDPlvQSLRQELYVEDFASIDWlaqrnnvaPDELYTPHSW--LLRVVYALLNLYEHHHSAHLRQ 233
Cdd:pfam13249 159 TIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRY--------YPRPHRLFSWtnLFLGLDRVLKLYERLPPKPLRR 228
                         250
                  ....*....|..
gi 224177558  234 RAVQKLYEHIVA 245
Cdd:pfam13249 229 RALRKAEEWILE 240
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
51-639 4.56e-19

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 91.23  E-value: 4.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558   51 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVSLRILGVGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSW 125
Cdd:TIGR04277  77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  126 EGLntLFPEMWLFPDWAPAHPSTLWCHCRQ-VYLPMSYCYAVRLSAAEDPLVQSLRQELYvedfasIDWLAQRNNVAPDE 204
Cdd:TIGR04277 156 EDL--FKIPLFIFKKKGIFKPLYIKDITAQwVYPHLTALAYLQNQRIIFNVAVADIRELW------INKAKKGIKHQKKE 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  205 LYT--PHSWLLRVVYALLNLYEHHHSahLRQRAVQKLYEHIVADDrFTksisigpiSKTINMlvrwyvdgpastafqeHV 282
Cdd:TIGR04277 228 RPSffIDNDLLILMDEIFKLKQPLGS--FGAYTISTLLSLLAFKD-FQ--------GKHPHK----------------HK 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  283 SRIPDYLWMGLDGMKM------QGTNGS----QIWDTAFAIQALLEAGGHH---RPEFSSCLQKAHEflrlsqvPDNPPD 349
Cdd:TIGR04277 281 NEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESGEDKekiFPIVENMLKEGLQ-------PKGGIE 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  350 YQKYYrqmrkgGFSFSTLDCGwivsdctaealkavLLLQEKCPHVTEHipRERLCDAVAVLLNMRNPDGGFATYET-KRG 428
Cdd:TIGR04277 354 YGYDF------EYAPDADDTG--------------LLLQVLSYYGEAF--ADAIDEGAEFLFSMQNDDGGFPAFDKgKME 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  429 GHLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKYFHKRfPEHraaeirETLTQGLEFCRRQQRADGSWEGS 500
Cdd:TIGR04277 412 DNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEFGDQ-ANH------DQIQKMIKYFMDTQEKFGSWEAR 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558  501 WGVCFTYGTWFGLEAFACMGQTYRDGTacaeVSRACDFLLSRQMADGGWGEDFESCEE-RRYLQSAQSQIHNTCWAMMGL 579
Cdd:TIGR04277 480 WGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYNDpEKWNGIGKSTVTQTSWGLLAL 555
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224177558  580 MAVR-HPDI--EAQERGVRCLLEK-QLPNGDWPQENIAGVFNKSCA-ISYTSYRNIFPIWALGRF 639
Cdd:TIGR04277 556 LAVEdHNDQikEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
44-85 5.86e-10

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 54.82  E-value: 5.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 224177558   44 REEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILG 85
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
410-605 2.85e-08

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 55.48  E-value: 2.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 410 LLNMRNPDGGFATYETkrgghllellnPSEVFgdimidYTYVECTSAVMQALKYFHkrfpEHRAAEIRETLtqglefcrr 489
Cdd:COG5029   28 LRASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESPKW----RDRVADLLSSL--------- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 490 qQRADGSW----EGSWGvcFTYGTWFGLEAFACMGQTYRDgtacaeVSRACDFLLSRQMADGGWGEDFesceerrylqSA 565
Cdd:COG5029   78 -RVEDGGFakapEGGAG--STYHTYLATLLAELLGRPPPD------PDRLVRFLISQQNDDGGFEISP----------GR 138
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 224177558 566 QSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNG 605
Cdd:COG5029  139 RSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
484-520 3.15e-07

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 47.12  E-value: 3.15e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224177558  484 LEFCRRQQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 520
Cdd:pfam00432   7 VDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
40-100 2.86e-06

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 49.32  E-value: 2.86e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224177558  40 PAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGpDDPDLVRARNIL 100
Cdd:COG5029  111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVIRFL 170
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
532-578 1.50e-05

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 42.50  E-value: 1.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 224177558  532 VSRACDFLLSRQMADGGWGEDFESCeerryLQSAQSQIHNTCWAMMG 578
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
331-580 1.78e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 40.86  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 331 LQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSF-----STLdcgwivSDcTAEALKAVLLLQEKCPHVTEHIprerlcd 405
Cdd:COG1689    8 LARTIEYVLKRQNED--------------GGFCAypglpSTL------AD-TYYAVRILKLLGEEVPNRDKTI------- 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 406 avAVLLNMRNPDGG-FATYETKRGGHLLELLnpsevfGDIMIDYtyvectsavMQALKYFHKRFPEHRAAE---IRET-- 479
Cdd:COG1689   60 --EFLESCQDEEGGgFALYTTSYGLMALALL------GIDPPDE---------QEALEYLSDALPTKFAGGasdLEETyl 122
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLE--------------FCRRQQRADGSWEGSWGVcfTYGTWFGLEAFACMGQTYRDGtacaevSRACDFLLSRQMA 545
Cdd:COG1689  123 AVALLEalgaseperekireFLLSLRRPDGGFGGKKPN--LEDTYWALAALRRLGRDLPPA------DRVIAFILACQNE 194
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 224177558 546 DGGWGedfesceerrYLQSAQSQIHNTCWAMMGLM 580
Cdd:COG1689  195 DGGFS----------KTPGSYSDLEATYYALRALK 219
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
308-496 3.20e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 40.09  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 308 DTAFAIQALLEAGG-------------HHRPEFSSCLQKAHEFLR---LSQVPDNPPDYQK---YYR-----QMRKGGFS 363
Cdd:COG1689   37 DTYYAVRILKLLGEevpnrdktiefleSCQDEEGGGFALYTTSYGlmaLALLGIDPPDEQEaleYLSdalptKFAGGASD 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 364 FSTLDCgwivsdcTAEALKAVLLLQEKCPhvtehiprerlcDAVAVLLNMRNPDGGFA-----TYETkrgGHLLELL--- 435
Cdd:COG1689  117 LEETYL-------AVALLEALGASEPERE------------KIREFLLSLRRPDGGFGgkkpnLEDT---YWALAALrrl 174
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 436 -----NPSEV-------------FGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAeiretltqgLEFCRRQQRADGS 496
Cdd:COG1689  175 grdlpPADRViafilacqnedggFSKTPGSYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQNSDGG 244
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
534-607 6.71e-03

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 39.13  E-value: 6.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224177558 534 RACDFLLSRQMADGGWGEDFesceerrylqsaqSQIHNTCWAMMGLMA--VRHPDIEAQERGVRCLLEKQLP-NGDW 607
Cdd:cd02889    3 RALDFLLSLQAPDGHWPGEY-------------SQVWDTALALQALLEagLAPEFDPALKKALEWLLKSQIRdNPDD 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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