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Conserved domains on  [gi|224495959|ref|NP_001139096|]
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probable E3 ubiquitin-protein ligase HERC3 [Danio rerio]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18806229)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 699-1044 2.12e-132

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 404.25  E-value: 2.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  699 LVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSES-NLLWFSDK 777
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  778 CFV---EHNWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEFEGDvEETFCLNFA 854
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD-EDDLELTFT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  855 ITR-EYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGN 933
Cdd:cd00078   160 IELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  934 NNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVA 1011
Cdd:cd00078   240 EDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTA 319

                         330       340       350
                  ....*....|....*....|....*....|...
gi 224495959 1012 HTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFS 1044
Cdd:cd00078   320 HTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 4-339 2.47e-81

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 268.38  E-value: 2.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    4 CWGSSGAGQLGIGASEASVfEPRSccVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQLGHDKGGSR--PELVGAL 81
Cdd:COG5184    21 CWGDNSYGQLGDGTTTDRS-TPVR--VPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKVPGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   82 DAqkISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAeEAVRVPRLIKKLCEhRISQVMCGNHHCIALSKDGQLFVW 161
Cdd:COG5184    98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT-TNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCW 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  162 GENSSGQLGLGkGEPSTLSPQPLKSLCGIplTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLrs 241
Cdd:COG5184   174 GANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL-- 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  242 QKVVYISCGEEHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELmgTEVSQIACGRNHTLAfVPSTGLIYAFGC 321
Cdd:COG5184   249 TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWGD 325

                         330
                  ....*....|....*...
gi 224495959  322 NTQGQLGTGIRGSAKSPV 339
Cdd:COG5184   326 NAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
314-374 2.34e-06

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 2.34e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224495959   314 GLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIqplcignaytrtEHCTIAKIHSGGDHNFLL 374
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL------------SGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 699-1044 2.12e-132

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 404.25  E-value: 2.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  699 LVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSES-NLLWFSDK 777
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  778 CFV---EHNWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEFEGDvEETFCLNFA 854
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD-EDDLELTFT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  855 ITR-EYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGN 933
Cdd:cd00078   160 IELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  934 NNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVA 1011
Cdd:cd00078   240 EDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTA 319

                         330       340       350
                  ....*....|....*....|....*....|...
gi 224495959 1012 HTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFS 1044
Cdd:cd00078   320 HTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 723-1043 8.24e-109

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 341.52  E-value: 8.24e-109
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    723 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEH----NWFHLIGIICGLAIY 797
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    798 NSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLeFEGDVEETFCLNFAITR-EYYGITEVKELVQGGKTIA 876
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLL-LNNDTSEELDLTFSIVLtSEFGQVKVVELKPGGSNIP 159

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    877 VDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHP 956
Cdd:smart00119  160 VTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQ 239

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    957 TVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLT 1034
Cdd:smart00119  240 TIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLL 319


                    ....*....
gi 224495959   1035 QAVEQYEGF 1043
Cdd:smart00119  320 LAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 756-1046 8.36e-105

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 329.96  E-value: 8.36e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   756 MNPIYGMF-TQYSESNLLWFSDKCFVEH-----NWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSP 829
Cdd:pfam00632    8 FDPNYGLFeYETEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDP 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   830 TEGRSLQQLLEFEGDVEETFCLNFAITreYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGF 909
Cdd:pfam00632   88 ELYKSLKSLLNMDNDDDEDLGLTFTIP--VFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   910 LKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIH 989
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224495959   990 GMASL-RIVIQSTAAEEH-YLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSLV 1046
Cdd:pfam00632  246 GFKSLpKFTIVRKGGDDDdRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
379-1045 7.28e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 287.82  E-value: 7.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  379 EGLSCPDDFRILNTTKSIALINSESLDSWRMKLH-----DNSDSSITNDIILLLSSTACWNASFLDQSDdghfkTNPKVP 453
Cdd:COG5021   197 LAVSNVEKSEPDNVLFGLPYRSALTMRTNFLKLDtgnlsGEVQALLARYISIKLVIKKLYLGPGPDASS-----RISTLI 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  454 GIDFN--AVRLLFETLMKPAFarlLEQITKSFESLlipqlpcSPPDVEAMRIYLILSECPAFQDSKnyITLTIPLAMAIL 531
Cdd:COG5021   272 IRLSNtnLNRRLSYILSHSSF---EDSLLRLNSLF-------STRADSFGRTYYLDHDRILTQYSR--PLLEETLGESTS 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  532 RLDANPSKVLDNWwslmDCTVFTRLVEMYKS---------IVVFLLTGGKALLMPV----------FLESYTSaaLRLLE 592
Cdd:COG5021   340 FLVVNNDDSSSIK----DLPHQVGSNPFLEAhpefsellkNQSRGTTRDFRNKPTGwsssiedlgqFLFSDFL--TSSST 413

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  593 KLHKVNLKAHRVEYNHFYIpdiATLVDIQEDYLK-WFLRKADIKMR-----YPPVQGSVTLCAYPFILNAQakttVLQTD 666
Cdd:COG5021   414 YEDLRREQLGRESDESFYV---ASNVQQQRASREgPLLSGWKTRLNnlyrfYFVEHRKKTLTKNDSRLGSF----ISLNK 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  667 AELQmQMAVSGANLHNVFMLLTMEPLlarNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKE 746
Cdd:COG5021   487 LDIR-RIKEDKRRKLFYSLKQKAKIF---DPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTRE 562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  747 FFLLLLKELMNPIYGMFTQYSESNLLWFSDK---CFVEH-NWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLD 822
Cdd:COG5021   563 WLFLLSKEMFNPDYGLFEYITEDLYTLPINPlssINPEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLV 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  823 DLKELSPTEGRSLQQLLEFEGDvEETFCLNFAITREYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQY 902
Cdd:COG5021   643 DLESLDPELYRSLVWLLNNDID-ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQF 721

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  903 SAFSSGFLKVCGGEILSLFQPSELMAMVVG-NNNYNWEEMEKNASYKGeFSATHPTVKMFWEVFHEFSLEKKKQFLLFLT 981
Cdd:COG5021   722 SAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVT 800

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224495959  982 GSDRIPIHGMASL-------RIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSL 1045
Cdd:COG5021   801 GTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGL 871
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 4-339 2.47e-81

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 268.38  E-value: 2.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    4 CWGSSGAGQLGIGASEASVfEPRSccVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQLGHDKGGSR--PELVGAL 81
Cdd:COG5184    21 CWGDNSYGQLGDGTTTDRS-TPVR--VPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKVPGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   82 DAqkISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAeEAVRVPRLIKKLCEhRISQVMCGNHHCIALSKDGQLFVW 161
Cdd:COG5184    98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT-TNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCW 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  162 GENSSGQLGLGkGEPSTLSPQPLKSLCGIplTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLrs 241
Cdd:COG5184   174 GANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL-- 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  242 QKVVYISCGEEHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELmgTEVSQIACGRNHTLAfVPSTGLIYAFGC 321
Cdd:COG5184   249 TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWGD 325

                         330
                  ....*....|....*...
gi 224495959  322 NTQGQLGTGIRGSAKSPV 339
Cdd:COG5184   326 NAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.98e-17

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 75.25  E-value: 5.98e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 224495959   208 SGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGEEHTAAL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
314-374 2.34e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 2.34e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224495959   314 GLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIqplcignaytrtEHCTIAKIHSGGDHNFLL 374
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL------------SGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 699-1044 2.12e-132

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 404.25  E-value: 2.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  699 LVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSES-NLLWFSDK 777
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  778 CFV---EHNWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEFEGDvEETFCLNFA 854
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD-EDDLELTFT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  855 ITR-EYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGN 933
Cdd:cd00078   160 IELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  934 NNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVA 1011
Cdd:cd00078   240 EDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTA 319

                         330       340       350
                  ....*....|....*....|....*....|...
gi 224495959 1012 HTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFS 1044
Cdd:cd00078   320 HTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 723-1043 8.24e-109

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 341.52  E-value: 8.24e-109
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    723 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEH----NWFHLIGIICGLAIY 797
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    798 NSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLeFEGDVEETFCLNFAITR-EYYGITEVKELVQGGKTIA 876
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLL-LNNDTSEELDLTFSIVLtSEFGQVKVVELKPGGSNIP 159

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    877 VDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHP 956
Cdd:smart00119  160 VTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQ 239

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    957 TVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLT 1034
Cdd:smart00119  240 TIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLL 319


                    ....*....
gi 224495959   1035 QAVEQYEGF 1043
Cdd:smart00119  320 LAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 756-1046 8.36e-105

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 329.96  E-value: 8.36e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   756 MNPIYGMF-TQYSESNLLWFSDKCFVEH-----NWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSP 829
Cdd:pfam00632    8 FDPNYGLFeYETEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDP 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   830 TEGRSLQQLLEFEGDVEETFCLNFAITreYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGF 909
Cdd:pfam00632   88 ELYKSLKSLLNMDNDDDEDLGLTFTIP--VFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   910 LKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIH 989
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224495959   990 GMASL-RIVIQSTAAEEH-YLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSLV 1046
Cdd:pfam00632  246 GFKSLpKFTIVRKGGDDDdRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
379-1045 7.28e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 287.82  E-value: 7.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  379 EGLSCPDDFRILNTTKSIALINSESLDSWRMKLH-----DNSDSSITNDIILLLSSTACWNASFLDQSDdghfkTNPKVP 453
Cdd:COG5021   197 LAVSNVEKSEPDNVLFGLPYRSALTMRTNFLKLDtgnlsGEVQALLARYISIKLVIKKLYLGPGPDASS-----RISTLI 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  454 GIDFN--AVRLLFETLMKPAFarlLEQITKSFESLlipqlpcSPPDVEAMRIYLILSECPAFQDSKnyITLTIPLAMAIL 531
Cdd:COG5021   272 IRLSNtnLNRRLSYILSHSSF---EDSLLRLNSLF-------STRADSFGRTYYLDHDRILTQYSR--PLLEETLGESTS 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  532 RLDANPSKVLDNWwslmDCTVFTRLVEMYKS---------IVVFLLTGGKALLMPV----------FLESYTSaaLRLLE 592
Cdd:COG5021   340 FLVVNNDDSSSIK----DLPHQVGSNPFLEAhpefsellkNQSRGTTRDFRNKPTGwsssiedlgqFLFSDFL--TSSST 413

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  593 KLHKVNLKAHRVEYNHFYIpdiATLVDIQEDYLK-WFLRKADIKMR-----YPPVQGSVTLCAYPFILNAQakttVLQTD 666
Cdd:COG5021   414 YEDLRREQLGRESDESFYV---ASNVQQQRASREgPLLSGWKTRLNnlyrfYFVEHRKKTLTKNDSRLGSF----ISLNK 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  667 AELQmQMAVSGANLHNVFMLLTMEPLlarNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKE 746
Cdd:COG5021   487 LDIR-RIKEDKRRKLFYSLKQKAKIF---DPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTRE 562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  747 FFLLLLKELMNPIYGMFTQYSESNLLWFSDK---CFVEH-NWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLD 822
Cdd:COG5021   563 WLFLLSKEMFNPDYGLFEYITEDLYTLPINPlssINPEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLV 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  823 DLKELSPTEGRSLQQLLEFEGDvEETFCLNFAITREYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQY 902
Cdd:COG5021   643 DLESLDPELYRSLVWLLNNDID-ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQF 721

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  903 SAFSSGFLKVCGGEILSLFQPSELMAMVVG-NNNYNWEEMEKNASYKGeFSATHPTVKMFWEVFHEFSLEKKKQFLLFLT 981
Cdd:COG5021   722 SAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVT 800

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224495959  982 GSDRIPIHGMASL-------RIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSL 1045
Cdd:COG5021   801 GTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGL 871
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 4-339 2.47e-81

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 268.38  E-value: 2.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959    4 CWGSSGAGQLGIGASEASVfEPRSccVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQLGHDKGGSR--PELVGAL 81
Cdd:COG5184    21 CWGDNSYGQLGDGTTTDRS-TPVR--VPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKVPGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   82 DAqkISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAeEAVRVPRLIKKLCEhRISQVMCGNHHCIALSKDGQLFVW 161
Cdd:COG5184    98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT-TNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCW 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  162 GENSSGQLGLGkGEPSTLSPQPLKSLCGIplTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLrs 241
Cdd:COG5184   174 GANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL-- 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  242 QKVVYISCGEEHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELmgTEVSQIACGRNHTLAfVPSTGLIYAFGC 321
Cdd:COG5184   249 TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWGD 325

                         330
                  ....*....|....*...
gi 224495959  322 NTQGQLGTGIRGSAKSPV 339
Cdd:COG5184   326 NAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-377 3.76e-77

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 256.83  E-value: 3.76e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959   38 EVACGNQHSLFLLHDGSVYTCGSNSCGQLGHDKGGSR--PELVGALDaqKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQ 115
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRstPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  116 LGLGTAEEA---VRVPRLikklceHRISQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEpSTLSPQP-LKSLCGIp 191
Cdd:COG5184    80 LGDGTTTDRttpVKVPGL------TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTT-NRLTPVQvDAGLSGV- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  192 lTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSqkVVYISCGEEHTAALTKEGGLFTFGNGSK 271
Cdd:COG5184   152 -VAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  272 GQLGHDSTRNEPLPRRVmeLMGTEVSQIACGRNHTLAfVPSTGLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIQPlcign 351
Cdd:COG5184   229 GQLGDGTTTDRATPVQV--AGLTGVVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG----- 300

                         330       340
                  ....*....|....*....|....*.
gi 224495959  352 aytrtehctIAKIHSGGDHNFLLLST 377
Cdd:COG5184   301 ---------VVAVAAGSSHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 140-376 4.94e-47

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 172.08  E-value: 4.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  140 SQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEPSTlSPQPLKSLCGIplTQISAGGDHSFALSFSGAVFGWGKNSA 219
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRS-TPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224495959  220 GQLGLNDEQDRAVPCHIKFLRSqkVVYISCGEEHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVmELMGTEVSQI 299
Cdd:COG5184    78 GQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAI 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224495959  300 ACGRNHTLAfVPSTGLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIQplcignaytrtehcTIAKIHSGGDHNFLLLS 376
Cdd:COG5184   155 AAGGYHTCA-LKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS--------------GVVAVAAGGDHSCALKS 216
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.98e-17

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 75.25  E-value: 5.98e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 224495959   208 SGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGEEHTAAL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
260-308 1.45e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 71.39  E-value: 1.45e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 224495959   260 EGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELMGTEVSQIACGRNHTLA 308
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
103-152 8.33e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 8.33e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 224495959   103 GQVFAWGAGDGGQLGLGTaEEAVRVPRLIKKLCEHRISQVMCGNHHCIAL 152
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGT-TENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
155-205 1.68e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.62  E-value: 1.68e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 224495959   155 DGQLFVWGENSSGQLGLGKGEpSTLSPQPLKSLCGIPLTQISAGGDHSFAL 205
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 2.16e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 54.06  E-value: 2.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 224495959    52 DGSVYTCGSNSCGQLGHDKGGSR--PELVGALDAQKISGVSCGQAHSLAV 99
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVlvPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
37-65 3.93e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 49.73  E-value: 3.93e-08
                           10        20
                   ....*....|....*....|....*....
gi 224495959    37 KEVACGNQHSLFLLHDGSVYTCGSNSCGQ 65
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
193-221 1.53e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.19  E-value: 1.53e-07
                           10        20
                   ....*....|....*....|....*....
gi 224495959   193 TQISAGGDHSFALSFSGAVFGWGKNSAGQ 221
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
139-168 5.01e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 46.65  E-value: 5.01e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 224495959   139 ISQVMCGNHHCIALSKDGQLFVWGENSSGQ 168
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
314-374 2.34e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 2.34e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224495959   314 GLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIqplcignaytrtEHCTIAKIHSGGDHNFLL 374
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL------------SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-273 9.39e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.18  E-value: 9.39e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 224495959   244 VVYISCGEEHTAALTKEGGLFTFGNGSKGQ 273
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
4-49 1.54e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.27  E-value: 1.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 224495959     4 CWGSSGAGQLGIGaSEASVFEPRSCCVFDGRGLKEVACGNQHSLFL 49
Cdd:pfam00415    6 TWGRNDYGQLGLG-TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-326 3.23e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.64  E-value: 3.23e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224495959   296 VSQIACGRNHTLAFVpSTGLIYAFGCNTQGQ 326
Cdd:pfam13540    1 VVSVAAGDNHTLALT-SDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 8.53e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.49  E-value: 8.53e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 224495959    86 ISGVSCGQAHSLAVNEQGQVFAWGAGDGGQ 115
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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