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Conserved domains on  [gi|225579152|ref|NP_001139478|]
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insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 20807514)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-574 9.14e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 132 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 211
Cdd:COG4886   22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 212 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 291
Cdd:COG4886  100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 292 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 371
Cdd:COG4886  171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 372 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 451
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 225579152 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 574
Cdd:COG4886  371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRRNT smart00013
Leucine rich repeat N-terminal domain;
78-116 1.03e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 225579152    78 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 116
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
574-618 8.91e-05

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 8.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 225579152   574 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 618
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-574 9.14e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 132 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 211
Cdd:COG4886   22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 212 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 291
Cdd:COG4886  100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 292 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 371
Cdd:COG4886  171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 372 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 451
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 225579152 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 574
Cdd:COG4886  371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-561 1.78e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 1.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAhtPALASLGLSNNRLS 197
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 198 ---RLEDGLFEglgSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA----------------YLQ--------PA 250
Cdd:PLN00113 154 geiPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiYLGynnlsgeiPY 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 251 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllgl 330
Cdd:PLN00113 231 EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI---------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 331 rvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ-EVKAGafLG-LTNVAVMNLS 408
Cdd:PLN00113 301 --------------PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN--LGkHNNLTVLDLS 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 409 GNCLR-NLPEQVFRGlGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
Cdd:PLN00113 365 TNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152 488 PHRLFQGLGKLEYLLLSRNR-LAELPaDALGPlQRAFWLDVSHNRL-EALPNSLLApLGRLRYLSLRNNSLRTFTP 561
Cdd:PLN00113 444 INSRKWDMPSLQMLSLARNKfFGGLP-DSFGS-KRLENLDLSRNQFsGAVPRKLGS-LSELMQLKLSENKLSGEIP 516
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-294 2.70e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 117 LWLDGNNLSSVP-PAAFQNLSSLgflNLQGGQLGSLEpqALLGLENLCHLHLERNQLRSlaLGTFAHTPALASLGLSNNR 195
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVL---YLYDNKITKIE--NLEFLTNLTHLYLQNNQIEK--IENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 196 LSRLEdGLfEGLGSLWDLNLGW------NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALR 269
Cdd:cd21340   80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*..
gi 225579152 270 AIK--ANVFVQLPRLQKLYLDRNLIAA 294
Cdd:cd21340  156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
257-316 6.05e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.05e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
78-116 1.03e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 225579152    78 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 116
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 78-111 1.34e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 1.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 225579152   78 ACPAACVCSydddadELSVFCSSRNLTRLPDGVP 111
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
574-618 8.91e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 8.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 225579152   574 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 618
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-574 9.14e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 132 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 211
Cdd:COG4886   22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 212 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 291
Cdd:COG4886  100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 292 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 371
Cdd:COG4886  171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 372 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 451
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 225579152 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 574
Cdd:COG4886  371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-321 3.20e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 115 QALWLDGNNLSSVpPAAFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQLRSLAlGTFAHTPALASLGLSNN 194
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 195 RLSRLEDGLfEGLGSLWDLNLGWNSLAVLPDaAFRGLGSLRELVLAGNRLAYLqPALfSGLAELRELDLSRNALRAIKAN 274
Cdd:COG4886  193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL-PEL-GNLTNLEELDLSNNQLTDLPPL 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 225579152 275 vfVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 321
Cdd:COG4886  269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
348-595 4.17e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 4.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 348 FKDLHFLEELQLGHNRIRQLAErSFEGLGQLEVLTLDHNQLQEVKAgAFLGLTNVAVMNLSGNCLRNLPEqVFRGLGKLH 427
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 428 SLHLEGSCLGRIrPHTFTGLSGLRRLFLKDNGLVGIEEqSLWGLAELLELDLTSNQLTHLPHrlFQGLGKLEYLLLSRNR 507
Cdd:COG4886  186 ELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 508 LAELPAdaLGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRD 587
Cdd:COG4886  262 LTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339


                 ....*...
gi 225579152 588 FALQNPSA 595
Cdd:COG4886  340 LALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-375 1.44e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  99 SSRNLTRLPDGVPGGT--QALWLDGNNLSSVPPAaFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQLRSLA 176
Cdd:COG4886  121 SGNQLTDLPEELANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 177 LgTFAHTPALASLGLSNNRLSRLEDGLfEGLGSLWDLNLGWNSLAVLPDaaFRGLGSLRELVLAGNRLAYLQPAlfSGLA 256
Cdd:COG4886  199 E-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG-AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRL 335
Cdd:COG4886  273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLiLLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 225579152 336 SHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
Cdd:COG4886  353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-561 1.78e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 1.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAhtPALASLGLSNNRLS 197
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 198 ---RLEDGLFEglgSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA----------------YLQ--------PA 250
Cdd:PLN00113 154 geiPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiYLGynnlsgeiPY 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 251 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllgl 330
Cdd:PLN00113 231 EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI---------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 331 rvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ-EVKAGafLG-LTNVAVMNLS 408
Cdd:PLN00113 301 --------------PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN--LGkHNNLTVLDLS 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 409 GNCLR-NLPEQVFRGlGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
Cdd:PLN00113 365 TNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152 488 PHRLFQGLGKLEYLLLSRNR-LAELPaDALGPlQRAFWLDVSHNRL-EALPNSLLApLGRLRYLSLRNNSLRTFTP 561
Cdd:PLN00113 444 INSRKWDMPSLQMLSLARNKfFGGLP-DSFGS-KRLENLDLSRNQFsGAVPRKLGS-LSELMQLKLSENKLSGEIP 516
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-556 1.77e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  99 SSRNLT-RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 177
Cdd:PLN00113 126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 178 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 257
Cdd:PLN00113 206 RELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQK 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 258 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLST 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLrnlpe 417
Cdd:PLN00113 366 NNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL----- 440

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 418 qvfrgLGKLHSLHLEgsclgrirphtftgLSGLRRLFLKDNGLVGiEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
Cdd:PLN00113 441 -----QGRINSRKWD--------------MPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 225579152 498 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
Cdd:PLN00113 501 LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
347-574 3.59e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 427 HSLHLEGSClgrirphTFTGLSGLRRLFLKDNGLVGIEEqSLWGLAELLELDLTSNQLTHLPHRLFQgLGKLEYLLLSRN 506
Cdd:COG4886   99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNN 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225579152 507 RLAELPAdALGPLQRAFWLDVSHNRLEALPNSlLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGN 574
Cdd:COG4886  170 QLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEplaNLTNLETLDLSNN 238
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 182-569 2.99e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 2.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 182 HTPALASLGLSNNRLS-RLEDGLFEGLGSLWDLNLGWNSLA-VLPDAAFRGLGSLRelvLAGNRLAYLQPALFSGLAELR 259
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD---LSNNMLSGEIPNDIGSFSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 260 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllglrvlrlshna 339
Cdd:PLN00113 168 VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI------------------- 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 340 iaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR-NLPEQ 418
Cdd:PLN00113 229 -----PYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPEL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 419 VFRgLGKLHSLHLEGSCL-GRIrPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT-HLPHRLFQGlG 496
Cdd:PLN00113 304 VIQ-LQNLEILHLFSNNFtGKI-PVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSS-G 380

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 497 KLEYLLLSRNRL-------------------------AELPADaLGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSL 551
Cdd:PLN00113 381 NLFKLILFSNSLegeipkslgacrslrrvrlqdnsfsGELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459

                        410
                 ....*....|....*...
gi 225579152 552 RNNSLRTFTPQPPGLERL 569
Cdd:PLN00113 460 ARNKFFGGLPDSFGSKRL 477
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-294 2.70e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 117 LWLDGNNLSSVP-PAAFQNLSSLgflNLQGGQLGSLEpqALLGLENLCHLHLERNQLRSlaLGTFAHTPALASLGLSNNR 195
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVL---YLYDNKITKIE--NLEFLTNLTHLYLQNNQIEK--IENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 196 LSRLEdGLfEGLGSLWDLNLGW------NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALR 269
Cdd:cd21340   80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*..
gi 225579152 270 AIK--ANVFVQLPRLQKLYLDRNLIAA 294
Cdd:cd21340  156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
453-634 2.98e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 2.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 453 LFLKDNGLVGIEEQSLwglAELLELDLTSNQLTHLPHRLFQGLGKLEyllLSRNRLAELPADALGPLQRafwLDVSHNRL 532
Cdd:PRK15370 204 LILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPSALQS---LDLFHNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 533 EALPNSLlaPLGrLRYLSLRNNSLRTFTPQ-PPGLERLWLEGNpwdcgcPLKALrdfalqnPSAVPRFVQAICEGDdcqp 611
Cdd:PRK15370 275 SCLPENL--PEE-LRYLSVYDNSIRTLPAHlPSGITHLNVQSN------SLTAL-------PETLPPGLKTLEAGE---- 334

                        170       180
                 ....*....|....*....|....*.
gi 225579152 612 paytyNNITC---ASPPEVVGLDLRD 634
Cdd:PRK15370 335 -----NALTSlpaSLPPELQVLDVSK 355
LRR_8 pfam13855
Leucine rich repeat;
257-316 6.05e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.05e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-321 1.24e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 103 LTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSlgfLNLQGGQLGSLePQALlgLENLCHLHLERNQLRSLAlgtfAH 182
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQGNIKT---LYANSNQLTSI-PATL--PDTIQEMELSINRITELP----ER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 183 TP-ALASLGLSNNRLSRLEDGLFEGL------------------GSLWDLNLGWNSLAVLPDAAFRGlgsLRELVLAGNR 243
Cdd:PRK15370 260 LPsALQSLDLFHNKISCLPENLPEELrylsvydnsirtlpahlpSGITHLNVQSNSLTALPETLPPG---LKTLEAGENA 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 244 LAYLQPALfsgLAELRELDLSRNALRAIKANVfvqLPRLQKLYLDRNLIAAVA---PGaflglkALRWLDLSHNRVAGLL 320
Cdd:PRK15370 337 LTSLPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPenlPA------ALQIMQASRNNLVRLP 404


                 .
gi 225579152 321 E 321
Cdd:PRK15370 405 E 405
LRR_8 pfam13855
Leucine rich repeat;
233-292 1.43e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.43e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  233 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 292
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-410 1.75e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNN 194
Cdd:PLN00113 335 QVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 195 RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFsGLAELRELDLSRNALRAIKAN 274
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPR 493

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 275 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllglrvlrlshnaiaslrPRTFKDLHFL 354
Cdd:PLN00113 494 KLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI------------------------PASFSEMPVL 549

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225579152 355 EELQLGHNrirQLAERSFEGLGQLEVL---TLDHNQLQEV--KAGAFLGLTNVAVmnlSGN 410
Cdd:PLN00113 550 SQLDLSQN---QLSGEIPKNLGNVESLvqvNISHNHLHGSlpSTGAFLAINASAV---AGN 604
LRR_8 pfam13855
Leucine rich repeat;
184-244 5.04e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 5.04e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225579152  184 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRL 244
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-325 7.78e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 7.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  95 SVFCSSRNLTRLPDGVPGGT--QALWLDGNNLSSVPpAAFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQL 172
Cdd:COG4886  163 SLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 173 RSLAlgTFAHTPALASLGLSNNRLSRLEDGLfeGLGSLWDLNLGWNSLAVLpdaafrglgSLRELVLAGNRLAYLQPALF 252
Cdd:COG4886  241 TDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL---------KLKELELLLGLNSLLLLLLL 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225579152 253 SGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFP 325
Cdd:COG4886  308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
338-575 1.19e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 338 NAIASLrPRTFKDLhfLEELQLGHNRIRQLAERSFEGLgqlEVLTLDHNQLQEVKAGAFLGLTNVAVMNlsgNCLRNLPE 417
Cdd:PRK15370 230 NQLTSI-PATLPDT--IQEMELSINRITELPERLPSAL---QSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPA 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 418 qvfrglgklhslHLEgsclgrirphtftglSGLRRLFLKDNGLVGIEEQSLWGLaELLELDltSNQLTHLPHRLFQGLGK 497
Cdd:PRK15370 301 ------------HLP---------------SGITHLNVQSNSLTALPETLPPGL-KTLEAG--ENALTSLPASLPPELQV 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 498 LEyllLSRNRLAELPaDALGPLQRAfwLDVSHNRLEALPNSLLAPLGRLRylSLRNN------SLRTFTPQPPGLERLWL 571
Cdd:PRK15370 351 LD---VSKNQITVLP-ETLPPTITT--LDVSRNALTNLPENLPAALQIMQ--ASRNNlvrlpeSLPHFRGEGPQPTRIIV 422


                 ....
gi 225579152 572 EGNP 575
Cdd:PRK15370 423 EYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 233-412 3.95e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 233 SLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALRAIkaNVFVQLPRLQKLYLDRNLIAAVApgAFLGLKALRWLDLS 312
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 313 HNRVA---GLLEDTFpgllglrvlrlshnAIASLRPRtfkdlhfLEELQLGHNRIRQLAErsFEGLGQLEVLTLDHNQLQ 389
Cdd:cd21340   99 NQRLPpgeKLTFDPR--------------SLAALSNS-------LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....*
gi 225579152 390 EVK--AGAFLGLTNVAVMNLSGNCL 412
Cdd:cd21340  156 DLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
425-484 4.29e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 4.29e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
448-508 4.78e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 4.78e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225579152  448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
336-388 6.11e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 6.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 225579152  336 SHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 388
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
377-433 1.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 225579152  377 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG 433
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 159-386 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 159 LENLCHLHLERNQLRSLalGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLWDLNLGWNSLAVLPDaaFRGLGSLRELV 238
Cdd:cd21340    1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 239 LAGNRLAYLqpalfSGLA---ELRELDLSRNalraikanvfvQLPRLQKLYLDRNLIAAVApgaflglKALRWLDLSHNR 315
Cdd:cd21340   75 LGGNRISVV-----EGLEnltNLEELHIENQ-----------RLPPGEKLTFDPRSLAALS-------NSLRVLNISGNN 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225579152 316 vaglledtfpgllglrvlrlshnaIASLRPrtFKDLHFLEELQLGHNRIRQLAE--RSFEGLGQLEVLTLDHN 386
Cdd:cd21340  132 ------------------------IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
280-364 3.66e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRvaglledtfpgllglrvlrlshnaIASLRPRTFKDLHFLEELQL 359
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL------------------------LTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 225579152  360 GHNRI 364
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
213-268 6.45e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 6.45e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152  213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNAL 268
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
354-410 1.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 225579152  354 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
161-220 1.80e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.80e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
476-532 1.95e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.95e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 225579152  476 ELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
141-196 2.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.83e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152  141 LNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRL 196
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
119-172 3.48e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.48e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 225579152  119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 172
Cdd:pfam13855   8 LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
103-307 4.42e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.24  E-value: 4.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 103 LTRLPDGVPGGTQALWLDGNNLSSVPPAAfqnlSSLGFLNLQGGQLGSLE--PQALLGL--------------ENLCHLH 166
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPvlPPGLLELsifsnplthlpalpSGLCKLW 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 167 LERNQLRSLALgtfaHTPALASLGLSNNRLSRLEdGLFEGLGSLWDLNLGWNSLAVLPDAafrglgsLRELVLAGNRLAY 246
Cdd:PRK15387 289 IFGNQLTSLPV----LPPGLQELSVSDNQLASLP-ALPSELCKLWAYNNQLTSLPTLPSG-------LQELSVSDNQLAS 356

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152 247 LqPALFSGLAELRELDLSRNALRA---------IKANVFVQLP----RLQKLYLDRNLIAAVA--PGAFLGLKALR 307
Cdd:PRK15387 357 L-PTLPSELYKLWAYNNRLTSLPAlpsglkeliVSGNRLTSLPvlpsELKELMVSGNRLTSLPmlPSGLLSLSVYR 431
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 423-575 9.78e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 9.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 423 LGKLHSLHLEGSCLGRIrpHTFTGLSGLRRLFLKDNGLVGIEeqSLWGLAELLELDLTSNQLTHLPHrlFQGLGKLEYLL 502
Cdd:cd21340    1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 503 LSRNR------------LAEL----------------PA--DALGP-LQRafwLDVSHNRLEALpnSLLAPLGRLRYLSL 551
Cdd:cd21340   75 LGGNRisvveglenltnLEELhienqrlppgekltfdPRslAALSNsLRV---LNISGNNIDSL--EPLAPLRNLEQLDA 149

                        170       180       190
                 ....*....|....*....|....*....|
gi 225579152 552 RNNSLRTFT------PQPPGLERLWLEGNP 575
Cdd:cd21340  150 SNNQISDLEelldllSSWPSLRELDLTGNP 179
LRRNT smart00013
Leucine rich repeat N-terminal domain;
78-116 1.03e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 225579152    78 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 116
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-530 1.03e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 351 LHFLEELQLGHNRIRQLaeRSFEGLGQLEVLTLDHNQLQEVKagaflGLTNvavmnlsgncLRNLPEqvfrglgklhsLH 430
Cdd:cd21340   45 LTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE-----GLEN----------LTNLEE-----------LH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 431 LEGSCLGRirPHTFTglsglrrlflkdnglvgIEEQSLWGLAELLE-LDLTSNQLTHLphRLFQGLGKLEYLLLSRNRLA 509
Cdd:cd21340   97 IENQRLPP--GEKLT-----------------FDPRSLAALSNSLRvLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155

                        170       180
                 ....*....|....*....|....
gi 225579152 510 ELpADALGPLQRAFWL---DVSHN 530
Cdd:cd21340  156 DL-EELLDLLSSWPSLrelDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
94-257 1.12e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152  94 LSVFCSSrnLTRLPDGVPGGTQALWLDGNNLSSVPpaafQNL-SSLGFLNLQGGQLGSLEPQALLGLENlchLHLERNQL 172
Cdd:PRK15370 267 LDLFHNK--ISCLPENLPEELRYLSVYDNSIRTLP----AHLpSGITHLNVQSNSLTALPETLPPGLKT---LEAGENAL 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 173 RSLALGTfahTPALASLGLSNNRLSRLEDGLFEglgSLWDLNLGWNSLAVLPD---AAFRGLGSLRelvlagNRLAYLQP 249
Cdd:PRK15370 338 TSLPASL---PPELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLPEnlpAALQIMQASR------NNLVRLPE 405


                 ....*...
gi 225579152 250 ALFSGLAE 257
Cdd:PRK15370 406 SLPHFRGE 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-592 1.17e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT-FKDLHFLEELQLGHNRIRQLAERSFegLGQLEVLTLDHNQ 387
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 388 L-----QEVkaGAFlglTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462
Cdd:PLN00113 152 LsgeipNDI--GSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSG 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAP 542
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQ 306

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 225579152 543 LGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPlkalRDFALQN 592
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVAltslPRLQVLQLWSNKFSGEIP----KNLGKHN 356
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 78-111 1.34e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 1.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 225579152   78 ACPAACVCSydddadELSVFCSSRNLTRLPDGVP 111
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
574-618 8.91e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.49  E-value: 8.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 225579152   574 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 618
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
LRR_8 pfam13855
Leucine rich repeat;
524-575 5.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 225579152  524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----PPGLERLWLEGNP 575
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPSLRYLDLSGNR 60
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
474-574 4.75e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 4.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225579152 474 LLELDLTSNQLTHLPhRLFQGLGKleyLLLSRNRLAELPADALGpLQRafwLDVSHNRLEALPnsllAPLGRLRYLSLRN 553
Cdd:PRK15387 264 LLELSIFSNPLTHLP-ALPSGLCK---LWIFGNQLTSLPVLPPG-LQE---LSVSDNQLASLP----ALPSELCKLWAYN 331

                         90       100
                 ....*....|....*....|.
gi 225579152 554 NSLRTFTPQPPGLERLWLEGN 574
Cdd:PRK15387 332 NQLTSLPTLPSGLQELSVSDN 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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