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Conserved domains on  [gi|226493512|ref|NP_001149946|]
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coiled-coil domain-containing protein 81 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HU-CCDC81_euk_2 pfam18289
CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like ...
 103-177 6.31e-30

CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


:

Pssm-ID: 465696  Cd Length: 75  Bit Score: 112.62  E-value: 6.31e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226493512  103 PIVPLNFVMISLEGPFNRDVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSKVKMRFYKDFLCTMDGSG 177
Cdd:pfam18289   1 PVVPLNFSELALETGVSRDTVERCVKETLQALGRLLRNGKNVELTFKGIGVLSIRDRKVKMKFYEDFLRSLDGSG 75
HU-CCDC81_euk_1 pfam14908
CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like ...
 6-93 2.31e-28

CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


:

Pssm-ID: 464364  Cd Length: 89  Bit Score: 108.50  E-value: 2.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512    6 ARALQDLGRQVLPTL-PSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFIRQKLEVGNNKFILIQRPVFIMVEK 84
Cdd:pfam14908   1 AGIVAEAQKRKFSTLkPLLTEEQLLSIWDALGEYIEEQLSQGKGVHIPGFGTFTFERQKLDLGGNKNILIQRPVFVLSEK 80


                  ....*....
gi 226493512   85 LVQIHGLKQ 93
Cdd:pfam14908  81 FAQTLGLKS 89
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 356-611 1.05e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 356 QQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKpefyksflfdkrplspALNALKQEEYSRSLLKQ 435
Cdd:COG1196  213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELE----------------AELAELEAELEELRLEL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 436 MDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPpfepdssepifGKNEG 515
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE-----------ELEEE 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 516 ELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDwERSAAMKK 595
Cdd:COG1196  346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELE 424

                        250
                 ....*....|....*.
gi 226493512 596 QRDLEDKAFERASDKL 611
Cdd:COG1196  425 ELEEALAELEEEEEEE 440
 
Name Accession Description Interval E-value
HU-CCDC81_euk_2 pfam18289
CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like ...
 103-177 6.31e-30

CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


Pssm-ID: 465696  Cd Length: 75  Bit Score: 112.62  E-value: 6.31e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226493512  103 PIVPLNFVMISLEGPFNRDVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSKVKMRFYKDFLCTMDGSG 177
Cdd:pfam18289   1 PVVPLNFSELALETGVSRDTVERCVKETLQALGRLLRNGKNVELTFKGIGVLSIRDRKVKMKFYEDFLRSLDGSG 75
HU-CCDC81_euk_1 pfam14908
CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like ...
 6-93 2.31e-28

CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


Pssm-ID: 464364  Cd Length: 89  Bit Score: 108.50  E-value: 2.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512    6 ARALQDLGRQVLPTL-PSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFIRQKLEVGNNKFILIQRPVFIMVEK 84
Cdd:pfam14908   1 AGIVAEAQKRKFSTLkPLLTEEQLLSIWDALGEYIEEQLSQGKGVHIPGFGTFTFERQKLDLGGNKNILIQRPVFVLSEK 80


                  ....*....
gi 226493512   85 LVQIHGLKQ 93
Cdd:pfam14908  81 FAQTLGLKS 89
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 356-611 1.05e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 356 QQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKpefyksflfdkrplspALNALKQEEYSRSLLKQ 435
Cdd:COG1196  213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELE----------------AELAELEAELEELRLEL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 436 MDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPpfepdssepifGKNEG 515
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE-----------ELEEE 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 516 ELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDwERSAAMKK 595
Cdd:COG1196  346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELE 424

                        250
                 ....*....|....*.
gi 226493512 596 QRDLEDKAFERASDKL 611
Cdd:COG1196  425 ELEEALAELEEEEEEE 440
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 430-616 6.48e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512   430 RSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTeeLAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 509
Cdd:TIGR02168  196 NELERQLKSLERQAEKAERYKELKAELRELELA--LLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512   510 FGKNE-GELMVEKQKR------EQNYMKHQLEAAAnhKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELE-------- 574
Cdd:TIGR02168  274 LEVSElEEEIEELQKElyalanEISRLEQQKQILR--ERLANLERQLEELEAQLEELESKLDELAEELAELEekleelke 351

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 226493512   575 RVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQ 616
Cdd:TIGR02168  352 ELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393
 
Name Accession Description Interval E-value
HU-CCDC81_euk_2 pfam18289
CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like ...
 103-177 6.31e-30

CCDC81 eukaryotic HU domain 2; This is the second of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


Pssm-ID: 465696  Cd Length: 75  Bit Score: 112.62  E-value: 6.31e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226493512  103 PIVPLNFVMISLEGPFNRDVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSKVKMRFYKDFLCTMDGSG 177
Cdd:pfam18289   1 PVVPLNFSELALETGVSRDTVERCVKETLQALGRLLRNGKNVELTFKGIGVLSIRDRKVKMKFYEDFLRSLDGSG 75
HU-CCDC81_euk_1 pfam14908
CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like ...
 6-93 2.31e-28

CCDC81 eukaryotic HU domain 1; This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.


Pssm-ID: 464364  Cd Length: 89  Bit Score: 108.50  E-value: 2.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512    6 ARALQDLGRQVLPTL-PSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFIRQKLEVGNNKFILIQRPVFIMVEK 84
Cdd:pfam14908   1 AGIVAEAQKRKFSTLkPLLTEEQLLSIWDALGEYIEEQLSQGKGVHIPGFGTFTFERQKLDLGGNKNILIQRPVFVLSEK 80


                  ....*....
gi 226493512   85 LVQIHGLKQ 93
Cdd:pfam14908  81 FAQTLGLKS 89
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 356-611 1.05e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 356 QQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKpefyksflfdkrplspALNALKQEEYSRSLLKQ 435
Cdd:COG1196  213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELE----------------AELAELEAELEELRLEL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 436 MDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPpfepdssepifGKNEG 515
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE-----------ELEEE 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512 516 ELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDwERSAAMKK 595
Cdd:COG1196  346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELE 424

                        250
                 ....*....|....*.
gi 226493512 596 QRDLEDKAFERASDKL 611
Cdd:COG1196  425 ELEEALAELEEEEEEE 440
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 430-616 6.48e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512   430 RSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTeeLAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 509
Cdd:TIGR02168  196 NELERQLKSLERQAEKAERYKELKAELRELELA--LLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226493512   510 FGKNE-GELMVEKQKR------EQNYMKHQLEAAAnhKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELE-------- 574
Cdd:TIGR02168  274 LEVSElEEEIEELQKElyalanEISRLEQQKQILR--ERLANLERQLEELEAQLEELESKLDELAEELAELEekleelke 351

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 226493512   575 RVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQ 616
Cdd:TIGR02168  352 ELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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