NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|228008410|ref|NP_001153019|]
View 

BEN domain-containing protein 4 isoform b [Homo sapiens]

Protein Classification

bZIP transcription factor( domain architecture ID 10646641)

basic leucine zipper (bZIP) transcription factor binds to the promoter regions of genes to control their expression

CATH:  1.20.5.170
Gene Ontology:  GO:0046983|GO:0006355|GO:0003700|GO:0003677
PubMed:  23661758|7780801|11017199
SCOP:  4003836

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BRLZ smart00338
basic region leucin zipper;
325-362 2.28e-03

basic region leucin zipper;


:

Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.39  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 228008410   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
 
Name Accession Description Interval E-value
BRLZ smart00338
basic region leucin zipper;
325-362 2.28e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.39  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 228008410   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 321-368 6.36e-03

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 34.72  E-value: 6.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 228008410 321 GYCPRCQELEQEVISLQQENEELRRKLESipvpCQTVLDYLKMVLQHH 368
Cdd:cd22290    5 LRKPTYQELEKENSNLKAENEALKIQLKD----AQRRIEALRLELRKH 48
 
Name Accession Description Interval E-value
BRLZ smart00338
basic region leucin zipper;
325-362 2.28e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.39  E-value: 2.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 228008410   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 321-368 6.36e-03

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 34.72  E-value: 6.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 228008410 321 GYCPRCQELEQEVISLQQENEELRRKLESipvpCQTVLDYLKMVLQHH 368
Cdd:cd22290    5 LRKPTYQELEKENSNLKAENEALKIQLKD----AQRRIEALRLELRKH 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH