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Conserved domains on  [gi|237512980|ref|NP_001153632|]
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sodium channel protein type 5 subunit alpha isoform e [Homo sapiens]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.32e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.32e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512980   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1203-1478 4.35e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 4.35e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1203 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1282 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1362 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1441
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512980  1442 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1478
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1199 5.23e-67

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 428983  Cd Length: 195  Bit Score: 224.92  E-value: 5.23e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPvsggpeappdsrtwsqvsatasseae 1106
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQL-------------------------- 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1107 asasqadwrqqwkaepqapgcgETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAP 1186
Cdd:pfam06512  125 ----------------------EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGP 182
                          250
                   ....*....|...
gi 237512980  1187 GKVWWRLRKTCYH 1199
Cdd:pfam06512  183 WKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 6.84e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 197.49  E-value: 6.84e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512980   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 6.20e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 192.10  E-value: 6.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512980   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1527-1749 3.39e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 3.39e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1527 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTG---------------------------TVLSDI 1578
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLemllkiiaagfkkryfrspwnildfvvVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1579 --IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV--KWEAG 1654
Cdd:pfam00520   82 slVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWENP 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1655 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLIVVNMY 1734
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*
gi 237512980  1735 IAIILENFSVATEES 1749
Cdd:pfam00520  223 IAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1470-1522 6.93e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.93e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512980 1470 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1522
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.32e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.32e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512980   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1203-1478 4.35e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 4.35e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1203 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1282 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1362 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1441
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512980  1442 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1478
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1199 5.23e-67

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 224.92  E-value: 5.23e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPvsggpeappdsrtwsqvsatasseae 1106
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQL-------------------------- 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1107 asasqadwrqqwkaepqapgcgETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAP 1186
Cdd:pfam06512  125 ----------------------EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGP 182
                          250
                   ....*....|...
gi 237512980  1187 GKVWWRLRKTCYH 1199
Cdd:pfam06512  183 WKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 6.84e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 197.49  E-value: 6.84e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512980   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 6.20e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 192.10  E-value: 6.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512980   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1527-1749 3.39e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 3.39e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1527 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTG---------------------------TVLSDI 1578
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLemllkiiaagfkkryfrspwnildfvvVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1579 --IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV--KWEAG 1654
Cdd:pfam00520   82 slVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWENP 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1655 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLIVVNMY 1734
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*
gi 237512980  1735 IAIILENFSVATEES 1749
Cdd:pfam00520  223 IAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1470-1522 6.93e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.93e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512980 1470 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1522
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1575-1754 1.38e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980 1575 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1654
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980 1655 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPTLPNSNGSRGdcgspAVGILFFTTYIIISFLIVVNMY 1734
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 237512980 1735 IAIILENFSVATEESTEPLS 1754
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.32e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.32e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512980   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1203-1478 4.35e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 4.35e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1203 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1282 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1362 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1441
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512980  1442 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1478
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1199 5.23e-67

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 224.92  E-value: 5.23e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPvsggpeappdsrtwsqvsatasseae 1106
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQL-------------------------- 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1107 asasqadwrqqwkaepqapgcgETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAP 1186
Cdd:pfam06512  125 ----------------------EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGP 182
                          250
                   ....*....|...
gi 237512980  1187 GKVWWRLRKTCYH 1199
Cdd:pfam06512  183 WKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 6.84e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 197.49  E-value: 6.84e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512980   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 6.20e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 192.10  E-value: 6.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512980   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1527-1749 3.39e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 3.39e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1527 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTG---------------------------TVLSDI 1578
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLemllkiiaagfkkryfrspwnildfvvVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1579 --IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV--KWEAG 1654
Cdd:pfam00520   82 slVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWENP 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1655 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLIVVNMY 1734
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*
gi 237512980  1735 IAIILENFSVATEES 1749
Cdd:pfam00520  223 IAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1470-1522 6.93e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.93e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512980 1470 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1522
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1599-1743 1.98e-04

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 46.18  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980  1599 RILRLIRGAKGIRTLLFALMMSLPALFNiglllFLVMFIYSIFGMANFAYVKWEAGIDdmfNFQTFANSMLCLFQITTSA 1678
Cdd:pfam08016  309 KLFKVLRFNKTMSLFTKTLSRAWKDLAG-----FALMFVIFFFAYAQFGYLLFGTQAP---NFSNFVKSILTLFRTILGD 380
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512980  1679 -GWDGLLSpilntgppycdptlpnsngsrgdcGSPAVGILFFTTYIIISFLIVVNMYIAIILENFS 1743
Cdd:pfam08016  381 fGYNEIFS------------------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 422
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1575-1754 1.38e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980 1575 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1654
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512980 1655 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPTLPNSNGSRGdcgspAVGILFFTTYIIISFLIVVNMY 1734
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 237512980 1735 IAIILENFSVATEESTEPLS 1754
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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