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Conserved domains on  [gi|237512982|ref|NP_001153633|]
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sodium channel protein type 5 subunit alpha isoform f [Homo sapiens]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1146 1.16e-71

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 428983  Cd Length: 195  Bit Score: 238.01  E-value: 1.16e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ-----TPEDSCSEGSTADMTNTAELLEQIP 1101
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQqeqleDDDSSSSEGSTVDLQDPEEELEKIP 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 237512982  1102 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
Cdd:pfam06512  151 EEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.23e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.23e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512982   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1150-1425 1.20e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 225.61  E-value: 1.20e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1150 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1228
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1229 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1309 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1388
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512982  1389 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1425
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1474-1728 2.35e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 201.73  E-value: 2.35e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1474 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTGECIVKLAA--LRHYYFTNSWNIFDFVVVILSIV 1550
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1551 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1628
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1629 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLI 1708
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 237512982  1709 VVNMYIAIILENFSVATEES 1728
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 1.04e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 194.02  E-value: 1.04e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512982   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 1.23e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 188.24  E-value: 1.23e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512982   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1417-1469 6.86e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.86e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512982 1417 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1469
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1146 1.16e-71

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 238.01  E-value: 1.16e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ-----TPEDSCSEGSTADMTNTAELLEQIP 1101
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQqeqleDDDSSSSEGSTVDLQDPEEELEKIP 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 237512982  1102 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
Cdd:pfam06512  151 EEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.23e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.23e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512982   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1150-1425 1.20e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 225.61  E-value: 1.20e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1150 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1228
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1229 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1309 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1388
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512982  1389 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1425
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1474-1728 2.35e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 201.73  E-value: 2.35e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1474 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTGECIVKLAA--LRHYYFTNSWNIFDFVVVILSIV 1550
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1551 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1628
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1629 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLI 1708
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 237512982  1709 VVNMYIAIILENFSVATEES 1728
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 1.04e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 194.02  E-value: 1.04e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512982   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 1.23e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 188.24  E-value: 1.23e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512982   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1417-1469 6.86e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.86e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512982 1417 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1469
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1554-1733 1.36e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982 1554 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1633
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982 1634 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPTLPNSNGSRGdcgspAVGILFFTTYIIISFLIVVNMY 1713
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 237512982 1714 IAIILENFSVATEESTEPLS 1733
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
953-1146 1.16e-71

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 238.01  E-value: 1.16e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   953 DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRqRPQKPAALA------AQGQLPSCIATpysppppETEKVPPtrKET 1026
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCL-EPQLPEKKPldeskdARSKLTNQIAN-------HTKKAPG--GGG 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ-----TPEDSCSEGSTADMTNTAELLEQIP 1101
Cdd:pfam06512   71 KYELDEGHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQqeqleDDDSSSSEGSTVDLQDPEEELEKIP 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 237512982  1102 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
Cdd:pfam06512  151 EEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
507-667 8.23e-71

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 234.27  E-value: 8.23e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   507 NHLSLTRGLSRTsmkPRSSRGSIFTFRRR--DLGSEADFADDENSTAGESESHHTSLLVPWP-LRRTSAQGQPSPG-TSA 582
Cdd:pfam11933    1 SLLSIPGSPFSP---RRSSRGSIFSFRGRgrDAGSENDFADDENSTFEDSESRRGSLFVPRRhERRSSYQSQASRSsRSH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   583 PGHALHGKKNSTVDCNGVVSLLGaGDPEATSPGSHLLRPVMLE--HPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
Cdd:pfam11933   78 PGLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGLLLPEVIIDkaGTGDSTTTTEEELRKRRSSSYQLSMDYLEEPFQRQ 156

                   ....*..
gi 237512982   661 RALSAVS 667
Cdd:pfam11933  157 RAVSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1150-1425 1.20e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 225.61  E-value: 1.20e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1150 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1228
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1229 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1309 CINQTEGDlplnytivnnksqceslnltgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwey 1388
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 237512982  1389 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1425
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1474-1728 2.35e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 201.73  E-value: 2.35e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1474 QAFDVTIMFLICLNMVTMMVETDDQSPEKIN-ILAKINLLFVAIFTGECIVKLAA--LRHYYFTNSWNIFDFVVVILSIV 1550
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1551 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1628
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1629 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdptlpnsngsrgdcgsPAVGILFFTTYIIISFLI 1708
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 237512982  1709 VVNMYIAIILENFSVATEES 1728
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-927 1.04e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 194.02  E-value: 1.04e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   716 DPFTDLTITMCIVLNTLFMALEHYNMTSE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   794 MELGLSRM---SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 237512982   871 SDSgllPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Cdd:pfam00520  161 PDN---GRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 1.23e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 188.24  E-value: 1.23e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   130 HSLFNMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   203 MAYVS----ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982   279 kcvrnftalngtngsveadglvwesldlylsdpenyllkngtsdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 237512982   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1417-1469 6.86e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 6.86e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 237512982 1417 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1469
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1511-1722 2.55e-10

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 64.67  E-value: 2.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1511 LLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS--------DIIQKYFFSPTLF----RVIRLARIGR 1578
Cdd:pfam08016  217 VVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLNiyrdflvdRLIKSVEASPVTFidfdRVAQLDNLYR 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982  1579 I-------------LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWeagiddmfNFQTFAN 1645
Cdd:pfam08016  297 IilaflvfltwlklFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAP--------NFSNFVK 368
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 237512982  1646 SMLCLFQITTSA-GWDGLLSpilntgppycdptlpnsngsrgdcGSPAVGILFFTTYIIISFLIVVNMYIAIILENFS 1722
Cdd:pfam08016  369 SILTLFRTILGDfGYNEIFS------------------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 422
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1554-1733 1.36e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982 1554 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1633
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237512982 1634 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPTLPNSNGSRGdcgspAVGILFFTTYIIISFLIVVNMY 1713
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 237512982 1714 IAIILENFSVATEESTEPLS 1733
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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