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Conserved domains on  [gi|238550212|ref|NP_001153891|]
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Z-DNA-binding protein 1 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
z-alpha super family cl02659
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 14-66 5.55e-10

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


The actual alignment was detected with superfamily member smart00550:

Pssm-ID: 295419  Cd Length: 68  Bit Score: 54.26  E-value: 5.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 238550212    14 LEQRILQVLTEAGSP-VKLAQLVKECQAPKRELNQVLYRMKKELKVS--LTSPATW 66
Cdd:smart00550   7 LEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCkqGGTPPLW 62
z-alpha super family cl02659
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 110-153 1.13e-04

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


The actual alignment was detected with superfamily member smart00550:

Pssm-ID: 295419  Cd Length: 68  Bit Score: 39.24  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 238550212   110 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 153
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 14-66 5.55e-10

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 54.26  E-value: 5.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 238550212    14 LEQRILQVLTEAGSP-VKLAQLVKECQAPKRELNQVLYRMKKELKVS--LTSPATW 66
Cdd:smart00550   7 LEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCkqGGTPPLW 62
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 110-153 1.13e-04

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 39.24  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 238550212   110 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 153
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
z-alpha pfam02295
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 15-66 2.75e-04

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


Pssm-ID: 280459  Cd Length: 67  Bit Score: 38.26  E-value: 2.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 238550212   15 EQRILQVLTEAG--SPVKLAQLVKECQAPKRELNQVLYRMKKELKV--SLTSPATW 66
Cdd:pfam02295   6 AEKILELLENLGegKAATAIALERGLSTPKREINRVLYDLERKGDVyrEDGTPPRW 61
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 14-66 5.55e-10

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 54.26  E-value: 5.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 238550212    14 LEQRILQVLTEAGSP-VKLAQLVKECQAPKRELNQVLYRMKKELKVS--LTSPATW 66
Cdd:smart00550   7 LEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCkqGGTPPLW 62
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 110-153 1.13e-04

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 39.24  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 238550212   110 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 153
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
z-alpha pfam02295
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 15-66 2.75e-04

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


Pssm-ID: 280459  Cd Length: 67  Bit Score: 38.26  E-value: 2.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 238550212   15 EQRILQVLTEAG--SPVKLAQLVKECQAPKRELNQVLYRMKKELKV--SLTSPATW 66
Cdd:pfam02295   6 AEKILELLENLGegKAATAIALERGLSTPKREINRVLYDLERKGDVyrEDGTPPRW 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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