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Conserved domains on  [gi|241896889|ref|NP_001154924|]
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lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2 [Homo sapiens]

Protein Classification

cytochrome b family protein( domain architecture ID 10171794)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 19-188 2.77e-97

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176492  Cd Length: 179  Bit Score: 281.76  E-value: 2.77e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  19 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 98
Cdd:cd08762   10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  99 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK 178
Cdd:cd08762   90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIASCISGINEK 169

                        170
                 ....*....|
gi 241896889 179 LFFSLKNTTR 188
Cdd:cd08762  170 LFFSLKNTTN 179
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 19-188 2.77e-97

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 281.76  E-value: 2.77e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  19 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 98
Cdd:cd08762   10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  99 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK 178
Cdd:cd08762   90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIASCISGINEK 169

                        170
                 ....*....|
gi 241896889 179 LFFSLKNTTR 188
Cdd:cd08762  170 LFFSLKNTTN 179
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 46-182 3.96e-48

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 155.46  E-value: 3.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889   46 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896889  126 FLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFS 182
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
PLN02680 PLN02680
carbon-monoxide oxygenase
 23-215 2.16e-37

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 130.69  E-value: 2.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  23 FTIYWMQYWRGGFAW--NGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQswvGPKLPWKLLHAALHLMAFVLTVVGLVA 100
Cdd:PLN02680  24 LVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVP---GTKNLKKLVHLTLQFLAFCLSLIGVWA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 101 VFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK-L 179
Cdd:PLN02680 101 ALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATATTGILEKaT 180

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 241896889 180 FFSLKNTTRPYhslPSEAVFANSTGMLVVAFGLLVL 215
Cdd:PLN02680 181 FLQSNKVISRY---STEAMLVNSLGILIVVLGGFVI 213
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 46-175 5.74e-33

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 116.18  E-value: 5.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889    46 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 125
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 241896889   126 FLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGI 175
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
 
Name Accession Description Interval E-value
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 19-188 2.77e-97

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 281.76  E-value: 2.77e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  19 MCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGL 98
Cdd:cd08762   10 ACVVLVVHWNQMWRGGFAWDGSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLPWKLLHAGLLLLAFILTVIGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  99 VAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK 178
Cdd:cd08762   90 CAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIASCISGINEK 169

                        170
                 ....*....|
gi 241896889 179 LFFSLKNTTR 188
Cdd:cd08762  170 LFFSLKNTTN 179
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 21-240 3.38e-68

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 209.11  E-value: 3.38e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  21 ILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVgpKLPWKLLHAALHLMAFVLTVVGLVA 100
Cdd:cd08764    1 VVLVGIWLGKFRGGFSWTGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTR--KKRLKLLHAVLHLLAFILAVIGLKA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 101 VFTFHNHGR--TANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK 178
Cdd:cd08764   79 VFDSHNLAKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEK 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241896889 179 LFFSLKNttrpYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGilTDRQPLLHD 240
Cdd:cd08764  159 AFFSLNK----YSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELP--EEEELLIQN 214
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 46-182 3.96e-48

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 155.46  E-value: 3.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889   46 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 241896889  126 FLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFS 182
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 34-185 5.95e-45

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 147.74  E-value: 5.95e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  34 GFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANL 113
Cdd:cd08765    2 GLGWDGGAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNM 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 241896889 114 YSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKN 185
Cdd:cd08765   82 YSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLKS 153
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 43-175 7.84e-41

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 136.26  E-value: 7.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  43 MFNWHPVLMVAGMVVFYGGASLVYRLPqsWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGI 122
Cdd:cd08554    1 EFNWHPLLMVIGFVFLMGEALLVYRVF--RLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 241896889 123 TTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGI 175
Cdd:cd08554   79 ATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
PLN02680 PLN02680
carbon-monoxide oxygenase
 23-215 2.16e-37

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 130.69  E-value: 2.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  23 FTIYWMQYWRGGFAW--NGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQswvGPKLPWKLLHAALHLMAFVLTVVGLVA 100
Cdd:PLN02680  24 LVLTWTVHYRGGLALssDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVP---GTKNLKKLVHLTLQFLAFCLSLIGVWA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 101 VFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEK-L 179
Cdd:PLN02680 101 ALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATATTGILEKaT 180

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 241896889 180 FFSLKNTTRPYhslPSEAVFANSTGMLVVAFGLLVL 215
Cdd:PLN02680 181 FLQSNKVISRY---STEAMLVNSLGILIVVLGGFVI 213
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 37-181 1.92e-36

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 125.70  E-value: 1.92e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  37 WNGSIyMFNWHPVLMVAGMVVFYGGASLVYRLPQSwvGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSL 116
Cdd:cd08763    1 WSGPL-QFNVHPLCMVLGLVFLCGEALLVYRVFRN--ETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 241896889 117 HSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFF 181
Cdd:cd08763   78 HSWCGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 44-181 4.88e-36

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 124.73  E-value: 4.88e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  44 FNWHPVLMVAGMVVFYGGASLVYRlpqSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGIT 123
Cdd:cd08766    8 FNVHPVLMVIGFIFLAGEAILAYK---TVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLGIG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 241896889 124 TVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFF 181
Cdd:cd08766   85 TISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 46-175 5.74e-33

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 116.18  E-value: 5.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889    46 WHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTV 125
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARPLTRFLSKPT-WFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 241896889   126 FLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGI 175
Cdd:smart00665  80 VLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02810 PLN02810
carbon-monoxide oxygenase
 27-222 3.41e-30

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 112.22  E-value: 3.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  27 WMQYWRGGFAWNGS--IYMFNWHPVLMVAGMVVFYGGASLVYrlpQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTF 104
Cdd:PLN02810  28 WSIYYRGGLAWEATnkNLIFNLHPVLMLIGLIIIGGEAIMSY---KSLPLKKEVKKLIHLVLHAIALILGIFGICAAFKN 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 105 HNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLK 184
Cdd:PLN02810 105 HNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKLTFLES 184

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 241896889 185 NTTRPYHslpSEAVFANSTGMLVVAFGLLVLYILLASS 222
Cdd:PLN02810 185 GGLDKYG---SEALLVNFTAIITILYGAFVVLTALAQS 219
PLN02351 PLN02351
cytochromes b561 family protein
 47-221 8.56e-16

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 74.17  E-value: 8.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  47 HPVLMVAGMVVFYGGASLVYR-LPqswvGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFhNHGRTANLYSLHSWLGITTV 125
Cdd:PLN02351  54 HPLLMVIGFILISGEAILVHRwLP----GSRKTKKSVHLWLQGLALASGVFGIWTKFHG-QDGIVANFYSLHSWMGLICV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 126 FLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSlpSEAVFANSTGm 205
Cdd:PLN02351 129 SLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVFLGLYTYGLAVATAETGLLEKLTFLQTKRNVSKHG--SESMVVNGLG- 205

                        170
                 ....*....|....*.
gi 241896889 206 lvVAFGLLVLYILLAS 221
Cdd:PLN02351 206 --LGLALLSGIVILAA 219
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 30-175 1.41e-10

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 58.51  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  30 YWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLpqSWVGPKLpWKLLHAALHLMAFVLTVVGLVAVFtFHNHGR 109
Cdd:cd08760   22 LLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALLARY--FLLGDPV-WFYLHAGLQLLAVLLAIAGFVLGI-VLVQGG 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241896889 110 TANLYSLHSWLGITTVFLFACQWFLGfavFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGI 175
Cdd:cd08760   98 GGSLNNAHAILGIIVLALAILQPLLG---LLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGL 160
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 34-180 1.15e-08

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 53.06  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889  34 GFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKL-LHAALHLMAFVLTVVGLVAVFTFHNHGRTAN 112
Cdd:cd08761   11 LYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTKLARKTKVrLHWILQLLALLCILAGLVAIYYNKERNGKPH 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241896889 113 LYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSL--LKPIHVFFGAAILSLSIASVISGINEKLF 180
Cdd:cd08761   91 FTSWHGILGLVTVILIVLQALGGLALLYPPGLRRGESKAkkLKKYHRLSGYVAYLLGLATLVLGLETRWF 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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