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Conserved domains on  [gi|254553334|ref|NP_001156956|]
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DDB1- and CUL4-associated factor 11 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 9.94e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 9.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS-------RQAATqQNWD 406
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgKLLAS-GSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 407 YRWqqvpkKAWRklkLPGDSSLMTYRGHGVLHTLIrcRFSPihsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACV 486
Cdd:COG2319  310 GTV-----RLWD---LATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        330       340
                 ....*....|....*....|....*
gi 254553334 487 RDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 9.94e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 9.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS-------RQAATqQNWD 406
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgKLLAS-GSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 407 YRWqqvpkKAWRklkLPGDSSLMTYRGHGVLHTLIrcRFSPihsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACV 486
Cdd:COG2319  310 GTV-----RLWD---LATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        330       340
                 ....*....|....*....|....*
gi 254553334 487 RDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-511 3.81e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 133.61  E-value: 3.81e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 169 DSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIY 248
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 249 GEGDTHTALDLRPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGD 328
Cdd:cd00200   79 DLETGECVRTLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 329 DAICKVWDRRTMreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrqaatqqnwdyr 408
Cdd:cd00200  156 DGTIKLWDLRTG-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 409 wqqvpkkawrklklpGDSSLMTYRGHgvLHTLIRCRFSPihstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRD 488
Cdd:cd00200  208 ---------------TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                        330       340
                 ....*....|....*....|...
gi 254553334 489 VSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:cd00200  267 LAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 1.33e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 141 GLCHRGSFSlgeQSRVISHFLPNDLgftdSYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfrkfKSI--KARDV 217
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 254553334 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 2.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254553334   472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 3.66e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.66e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 254553334  473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 9.94e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 9.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICNIyGEGDTHTALDL 259
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  161 HSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS-------RQAATqQNWD 406
Cdd:COG2319  236 -----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgKLLAS-GSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 407 YRWqqvpkKAWRklkLPGDSSLMTYRGHGVLHTLIrcRFSPihsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKACV 486
Cdd:COG2319  310 GTV-----RLWD---LATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        330       340
                 ....*....|....*....|....*
gi 254553334 487 RDVSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-511 3.81e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 133.61  E-value: 3.81e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 169 DSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICNIY 248
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 249 GEGDTHTALDLRPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGD 328
Cdd:cd00200   79 DLETGECVRTLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 329 DAICKVWDRRTMreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrqaatqqnwdyr 408
Cdd:cd00200  156 DGTIKLWDLRTG-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 409 wqqvpkkawrklklpGDSSLMTYRGHgvLHTLIRCRFSPihstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRD 488
Cdd:cd00200  208 ---------------TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                        330       340
                 ....*....|....*....|...
gi 254553334 489 VSWHPFEEKIVSSSWDGNLRLWQ 511
Cdd:cd00200  267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-513 3.60e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 3.60e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 220 SVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTaldLRpdERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT---LK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 300 TLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTI 379
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 380 KLWDIRrfssregmeasrqaatqqnwdyrwqqvpkkawrklklpGDSSLMTYRGH--GVLHtlirCRFSPihsTGQQFIy 457
Cdd:cd00200  160 KLWDLR--------------------------------------TGKCVATLTGHtgEVNS----VAFSP---DGEKLL- 193

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254553334 458 SGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYR 513
Cdd:cd00200  194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
219-510 1.21e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.79  E-value: 1.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 219 WSVLDVAFTPDGNHFLYSSWSDYIHICNIygegdTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNR 298
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDL-----ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 299 RTLQIESHEDDVNAVAF-ADisSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQ 377
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFsPD--GKLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 378 TIKLWDIRRFSSREGMEASRQAATQQNW--DYRW-------QQVpkKAWRklkLPGDSSLMTYRGHGvlHTLIRCRFSPi 448
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLlasgsadGTV--RLWD---LATGELLRTLTGHS--GGVNSVAFSP- 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254553334 449 hsTGQQFIySGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:COG2319  299 --DGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
180-385 3.36e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 3.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKardvGWSVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 259
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH----SGSVRSVAFSPDGRLLASGSADGTVRLWDL----ATGELLRT 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 260 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  284 LTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 254553334 340 mreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 385
Cdd:COG2319  362 -----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 6.40e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 6.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKV 334
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS-------RQAAT 401
Cdd:COG2319  147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgklLRTLTGHTGAVRSvafspdgKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 402 qQNWDyrwQQVpkKAWRklkLPGDSSLMTYRGHGVLHTLIrcRFSPihstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTN 481
Cdd:COG2319  222 -GSAD---GTV--RLWD---LATGKLLRTLTGHSGSVRSV--AFSP----DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260
                 ....*....|....*....|....*....
gi 254553334 482 HKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 302-516 3.27e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 3.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 302 QIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTMReddpkPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 381
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 382 WDIRrfssregmeasrqaatqqnwdyrwqqvpkkawrklklpGDSSLMTYRGH--GVLHtlirCRFSPIHstgqQFIYSG 459
Cdd:cd00200   78 WDLE--------------------------------------TGECVRTLTGHtsYVSS----VAFSPDG----RILSSS 111

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 254553334 460 CSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAE 516
Cdd:cd00200  112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
180-339 2.95e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 2.95e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 180 YSKDGQIFMSACQDQTIRLYDCRYGRFRKfksIKARDVGWsVLDVAFTPDGNHFLYSSWSDYIHICNIygegDTHTALDL 259
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRT 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 260 RPDERRfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319  326 LTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 9.77e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 9.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcKV 334
Cdd:COG2319   26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssregmeasrqaatqqnwdyrwqqvpk 414
Cdd:COG2319  105 WDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT---------------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 415 kaWRKLKlpgdsslmTYRGHGvlHTLIRCRFSPihsTGQqFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF 494
Cdd:COG2319  152 --GKLLR--------TLTGHS--GAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                        250
                 ....*....|....*.
gi 254553334 495 EEKIVSSSWDGNLRLW 510
Cdd:COG2319  216 GKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-510 8.67e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 8.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 347 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDirrfssregmeasrqaatqqnwdyrwqqvpkkawrklkLPGDS 426
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD--------------------------------------LETGE 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 427 SLMTYRGHgvLHTLIRCRFSPIHstgqQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGN 506
Cdd:cd00200   43 LLRTLKGH--TGPVRDVAASADG----TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116


                 ....
gi 254553334 507 LRLW 510
Cdd:cd00200  117 IKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
272-510 1.86e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 272 AVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddpKPVGAL 351
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG------ALLATL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 352 AGHQDGITFIDSKGDARYLISNSKDQTIKLWDirrfssregmeasrqaatqqnwdyrwqqvpkkawrklkLPGDSSLMTY 431
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWD--------------------------------------LATGLLLRTL 116

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254553334 432 RGHGvlHTLIRCRFSPihstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:COG2319  117 TGHT--GAVRSVAFSP----DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 1.33e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 141 GLCHRGSFSlgeQSRVISHFLPNDLgftdSYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfrkfKSI--KARDV 217
Cdd:PLN00181 458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICNIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181 523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181 601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                        250
                 ....*....|....*.
gi 254553334 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181 674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 2.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254553334   472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 3.66e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.66e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 254553334  473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
346-383 2.66e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.66e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 254553334  346 KPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-383 1.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 254553334   344 DPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 244-384 1.25e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 244 ICNIYGEGDTHTALDLRPDERRFAVFSIAVSSD----GREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADIS 319
Cdd:PTZ00420   7 IKNLYPDPSNNLFDDLRICSRVIDSCGIACSSGfvavPWEVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254553334 320 SQILFSGGDDAICKVWDRRTMRED-----DPKPVgaLAGHQDGITFIDSKGDARYLISNSK-DQTIKLWDI 384
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPHNDESvkeikDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-336 4.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 254553334   303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:smart00320   8 LKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
303-336 7.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 254553334  303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 301-403 2.67e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553334 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIK 380
Cdd:PTZ00421 119 VHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193

                         90       100
                 ....*....|....*....|...
gi 254553334 381 LWDIRRFSSREGMEASRQAATQQ 403
Cdd:PTZ00421 194 IIDPRDGTIVSSVEAHASAKSQR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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