|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
351-591 |
1.43e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.43e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 351 DWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTT-------PHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQA 423
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 FvaggagGGEPPHVPHHISDVLSDITYYVYKARRTP--RSVLCGHVR-AQWEPHEYPASMERMQN--WTPDECIPEFYTD 498
Cdd:cd06071 83 D------SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDaADRLFNSIPSSWRSASEnpSDVKELIPEFYYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 499 PSIFRSIHPD---------MPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLV 569
Cdd:cd06071 157 PEFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLT 236
|
250 260 270
....*....|....*....|....*....|....*....
gi 255759952 570 D-----------------AHTHLASYGVVQLFDQPHPQR 591
Cdd:cd06071 237 YegsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
352-591 |
2.45e-82 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 272.17 E-value: 2.45e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGrFRDLRKsKFRLnKGDKQLDFTYEMTRQA 423
Cdd:smart01026 4 WQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 fvaggAGGGEPPHvpHHISDVLSDITYYVYKARRTPR---------------SVLCGHVRAQWEPhEYPASMERMQnwtp 488
Cdd:smart01026 81 -----EDPDIPPF--HYGTHYSSAGIVLYYLIRLEPFttlflqlqggrfdhaDRLFHSVAATWRS-ASLESMTDVK---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 489 dECIPEFYTDPSIFRSIHP----------DMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKE 557
Cdd:smart01026 149 -ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAKGSpEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGKE 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 255759952 558 AVKEKNVCLHLVD-----------------AHTHLASYGVV--QLFDQPHPQR 591
Cdd:smart01026 228 AVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
352-591 |
1.21e-47 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 172.27 E-value: 1.21e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPH------GRFRDLRKSKFRLNKG-DKQLDFTYEMTrqa 423
Cdd:pfam02138 3 WQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 fvaggagggEPPHVPHHISdvlsdiTYYVykarrTPRSVLCGHVRAqwEPheYPASMERMQN--W-TPD----------- 489
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRL--EP--FTTLHIELQGgkFdHPDrlfhsieeawr 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 490 ----------ECIPEFYTDPSIFRSIH----------PDMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLT 548
Cdd:pfam02138 136 sasnstsdvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAKKSpEEFVRKHREALESDYVSENLHEWIDLI 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 255759952 549 FGYKLQGKEAVKEKNVCLHL-----VD------------AHTHLASYGVV--QLFDQPHPQR 591
Cdd:pfam02138 216 FGYKQRGEEAVEALNVFHPLtyegsVDldsikdpverdaIEAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1640-1939 |
3.32e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.47 E-value: 3.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynyGDGTsetaPRLVYTQHRKSVFFV-----GQLEApqhVVS 1714
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGK----LLRTLTGHSGAVTSVafspdGKLLA---SGS 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1715 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLGGGLnpglVRALAI 1794
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS----VRSVAF 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1795 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 1872
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 255759952 1873 H--TFDLYGSEVVTGTVSNKIGVCSLleppSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:COG2319 334 RsvAFSPDGKTLASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1641-1855 |
5.36e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.56 E-value: 5.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGdgtsetaPRLVYTQHRKSVFFVGQLEAPQHVVSC--DGA 1718
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-------CLTTLRGHTDWVNSVAFSPDGTFVASSsqDGT 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1719 VHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRlgGGLNPglVRALAISPSG 1798
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTGEV--NSVAFSPDGEKLLS-SSSDGTIKLWDLSTGKCLGTLR--GHENG--VNSVAFSPDG 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 255759952 1799 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAV-EGSVLVSSSSDHSLTVWK 1855
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1641-1675 |
1.32e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.27 E-value: 1.32e-07
10 20 30
....*....|....*....|....*....|....*
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 1675
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1641-1675 |
1.12e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.12e-06
10 20 30
....*....|....*....|....*....|....*
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 1675
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
351-591 |
1.43e-99 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 321.50 E-value: 1.43e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 351 DWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTT-------PHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQA 423
Cdd:cd06071 3 KWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTseeldlnDPSTYRDLSKPIGALNKERLQLLKERYESDSD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 FvaggagGGEPPHVPHHISDVLSDITYYVYKARRTP--RSVLCGHVR-AQWEPHEYPASMERMQN--WTPDECIPEFYTD 498
Cdd:cd06071 83 D------SDPPFHYGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDaADRLFNSIPSSWRSASEnpSDVKELIPEFYYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 499 PSIFRSIHPD---------MPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLV 569
Cdd:cd06071 157 PEFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHPLT 236
|
250 260 270
....*....|....*....|....*....|....*....
gi 255759952 570 D-----------------AHTHLASYGVVQLFDQPHPQR 591
Cdd:cd06071 237 YegsvdldsidvereaieAQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
352-591 |
2.45e-82 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 272.17 E-value: 2.45e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGrFRDLRKsKFRLnKGDKQLDFTYEMTRQA 423
Cdd:smart01026 4 WQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST-FRDLSK-PIGA-LNPERLEFFYERYEEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 fvaggAGGGEPPHvpHHISDVLSDITYYVYKARRTPR---------------SVLCGHVRAQWEPhEYPASMERMQnwtp 488
Cdd:smart01026 81 -----EDPDIPPF--HYGTHYSSAGIVLYYLIRLEPFttlflqlqggrfdhaDRLFHSVAATWRS-ASLESMTDVK---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 489 dECIPEFYTDPSIFRSIHP----------DMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKE 557
Cdd:smart01026 149 -ELIPEFFYLPEFLVNINGfdfgtrqdgeDVDDVELPPWAKGSpEEFIRKHREALESEYVSQHLHHWIDLIFGYKQRGKE 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 255759952 558 AVKEKNVCLHLVD-----------------AHTHLASYGVV--QLFDQPHPQR 591
Cdd:smart01026 228 AVEALNVFHPLTYegavdldsiedpverkaLEGQIHNFGQTpkQLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
352-591 |
1.21e-47 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 172.27 E-value: 1.21e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPH------GRFRDLRKSKFRLNKG-DKQLDFTYEMTrqa 423
Cdd:pfam02138 3 WQNGEISNFEYLMYLNTLAGRSFNDLSQYPVFPWVLaDYTSEEldlndpSTYRDLSKPIGALNEErLEKFKERYEEL--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 424 fvaggagggEPPHVPHHISdvlsdiTYYVykarrTPRSVLCGHVRAqwEPheYPASMERMQN--W-TPD----------- 489
Cdd:pfam02138 80 ---------EDDDPPFHYG------SHYS-----SPGIVLYYLIRL--EP--FTTLHIELQGgkFdHPDrlfhsieeawr 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 490 ----------ECIPEFYTDPSIFRSIH----------PDMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLT 548
Cdd:pfam02138 136 sasnstsdvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAKKSpEEFVRKHREALESDYVSENLHEWIDLI 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 255759952 549 FGYKLQGKEAVKEKNVCLHL-----VD------------AHTHLASYGVV--QLFDQPHPQR 591
Cdd:pfam02138 216 FGYKQRGEEAVEALNVFHPLtyegsVDldsikdpverdaIEAQIKNFGQTpkQLFTKPHPPR 277
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1640-1939 |
3.32e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.47 E-value: 3.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynyGDGTsetaPRLVYTQHRKSVFFV-----GQLEApqhVVS 1714
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGK----LLRTLTGHSGAVTSVafspdGKLLA---SGS 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1715 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLGGGLnpglVRALAI 1794
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS----VRSVAF 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1795 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 1872
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 255759952 1873 H--TFDLYGSEVVTGTVSNKIGVCSLleppSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:COG2319 334 RsvAFSPDGKTLASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1640-1939 |
8.15e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 112.31 E-value: 8.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFV-----GQLEApqhVVS 1714
Cdd:COG2319 70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVafspdGKTLA---SGS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1715 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRLGgglnPGLVRALAI 1794
Cdd:COG2319 140 ADGTVRLWDLATGKLLRTLTGHSGAV--TSVAFSPDGKLLAS-GSDDGTVRLWDLATGKLLRTLTGH----TGAVRSVAF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1795 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVW----KELEQKPTHHyksa 1868
Cdd:COG2319 213 SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-AFspDGRLLASGSADGTVRLWdlatGELLRTLTGH---- 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255759952 1869 SDPIHT--FDLYGSEVVTGTVSNKIGVCSLLEPPSQATtklsSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:COG2319 288 SGGVNSvaFSPDGKLLASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1641-1855 |
5.36e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.56 E-value: 5.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGdgtsetaPRLVYTQHRKSVFFVGQLEAPQHVVSC--DGA 1718
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-------CLTTLRGHTDWVNSVAFSPDGTFVASSsqDGT 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1719 VHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRlgGGLNPglVRALAISPSG 1798
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTGEV--NSVAFSPDGEKLLS-SSSDGTIKLWDLSTGKCLGTLR--GHENG--VNSVAFSPDG 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 255759952 1799 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAV-EGSVLVSSSSDHSLTVWK 1855
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1640-1854 |
6.37e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 100.37 E-value: 6.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFV-----GQLEApqhVVS 1714
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-------ATGKLLRTLTGHSGSVRSVafspdGRLLA---SGS 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1715 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLggglNPGLVRALAI 1794
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGV--NSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTG----HTGAVRSVAF 338
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 255759952 1795 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIK-AVEGSVLVSSSSDHSLTVW 1854
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1641-1939 |
1.13e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.41 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWplyNYGDGTSETaprlVYTQHRKSVFFV-----GQLEApqhVVSC 1715
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLR----TLKGHTGPVRDVaasadGTYLA---SGSS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1716 DGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRlgggLNPGLVRALAIS 1795
Cdd:cd00200 72 DKTIRLWDLETGECVRTLTGHTSYV--SSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLR----GHTDWVNSVAFS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1796 PSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVE-GSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHT 1874
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255759952 1875 --FDLYGSEVVTGTVSNKIGVCSLLEPpsQATTKLSSENfrGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:cd00200 225 vaFSPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1716-1939 |
1.27e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 78.03 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1716 DGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRLggglNPGLVRALAIS 1795
Cdd:COG2319 57 DLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLAS-ASADGTVRLWDLATGLLLRTLTG----HTGAVRSVAFS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1796 PSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIH 1873
Cdd:COG2319 130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255759952 1874 --TFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSenfrGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:COG2319 209 svAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRL 272
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1641-1675 |
1.32e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.27 E-value: 1.32e-07
10 20 30
....*....|....*....|....*....|....*
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 1675
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1641-1675 |
1.12e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 1.12e-06
10 20 30
....*....|....*....|....*....|....*
gi 255759952 1641 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 1675
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1640-1726 |
1.12e-05 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 49.91 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1640 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFVGQLEAPQHVVSC--DG 1717
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-------ATGELLRTLTGHTGAVTSVAFSPDGRTLASGsaDG 394
|
....*....
gi 255759952 1718 AVHVWDPFT 1726
Cdd:COG2319 395 TVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1786-1939 |
1.08e-03 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 43.75 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1786 PGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKA-VEGSVLVSSSSDHSLTVWKELEQKPTHH 1864
Cdd:COG2319 36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGTVRLWDLATGLLLRT 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255759952 1865 YKSASDPIHTFDLY--GSEVVTGTVSNKIGVCSLLEPPSQATTKLSSenfrGTLTSLALLPTKRHLLLGSDNGVIRL 1939
Cdd:COG2319 116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHS----GAVTSVAFSPDGKLLASGSDDGTVRL 188
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
1716-1829 |
1.78e-03 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 41.99 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759952 1716 DGAVHVWDPFTGKTLRTVEPLDSrvpLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGlnpglVRALAIS 1795
Cdd:COG3391 89 SGRVSVIDLATGKVVATIPVGGG---PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAG-----PHGIAVD 160
|
90 100 110
....*....|....*....|....*....|....*....
gi 255759952 1796 PSGRSV-VAGFSSG----FMVLLDTRTGLVLRGWPAHEG 1829
Cdd:COG3391 161 PDGKRLyVANSGSNtvsvIVSVIDTATGKVVATIPVGGG 199
|
|
| |
