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Conserved domains on  [gi|256017124|ref|NP_001157738|]
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latent-transforming growth factor beta-binding protein 3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 297-338 6.31e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.31e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 256017124   297 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 338
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 812-854 4.62e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 256017124   812 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 854
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-273 1.12e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 256017124    238 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 273
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
627-666 2.03e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.03e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    627 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 666
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
668-708 2.49e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 256017124    668 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 543-577 5.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 5.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 256017124  543 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 577
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 370-460 1.63e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017124  370 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 447
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909

                          90
                  ....*....|...
gi 256017124  448 VEIAPTQVTETDE 460
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 982-1017 3.40e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 256017124   982 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1017
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
749-782 5.81e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 5.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 256017124    749 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 782
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
709-748 7.36e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 7.36e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    709 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 748
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
919-947 4.86e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.86e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 256017124    919 DVDECLDESNCRNG-VCENTRGGYRCACTP 947
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-619 1.82e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 256017124    586 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 619
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
499-542 2.05e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 256017124    499 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 542
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 174-204 4.40e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.40e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   174 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 204
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 297-338 6.31e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.31e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 256017124   297 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 338
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 812-854 4.62e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 256017124   812 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 854
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-273 1.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 256017124    238 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 273
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
627-666 2.03e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.03e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    627 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 666
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
668-708 2.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 256017124    668 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 543-577 5.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 5.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 256017124  543 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 577
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
543-575 8.40e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.40e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 256017124    543 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 575
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 370-460 1.63e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017124  370 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 447
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909

                          90
                  ....*....|...
gi 256017124  448 VEIAPTQVTETDE 460
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-270 2.04e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  238 DINECAMPGVCR-HGDCLNNPGSYRCVCPPGHSL 270
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 668-702 2.17e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 256017124  668 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 702
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 982-1017 3.40e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 256017124   982 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1017
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 627-657 3.94e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 256017124  627 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 657
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
749-782 5.81e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 5.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 256017124    749 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 782
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
709-748 7.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 7.36e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    709 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 748
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 749-782 9.18e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  749 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 782
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 709-748 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 256017124  709 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 748
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
919-947 4.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.86e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 256017124    919 DVDECLDESNCRNG-VCENTRGGYRCACTP 947
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
709-738 6.92e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.92e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   709 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 738
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
668-697 6.92e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.92e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   668 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 697
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 919-947 1.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 256017124  919 DVDECLDESNCRN-GVCENTRGGYRCACTP 947
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
238-267 1.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   238 DINECAMPG-VC-RHGDCLNNPGSYRCVCPPG 267
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-619 1.82e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 256017124    586 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 619
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
499-542 2.05e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 256017124    499 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 542
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 586-618 3.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  586 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYR 618
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 499-533 3.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 256017124  499 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 533
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 650-671 4.24e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.46  E-value: 4.24e-03
                           10        20
                   ....*....|....*....|..
gi 256017124   650 RCTCAQGYAPAPDGRSCLDVDE 671
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 174-204 4.40e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.40e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   174 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 204
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 297-338 6.31e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.31e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 256017124   297 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPTDGTAAFKEIC 338
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 812-854 4.62e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 4.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 256017124   812 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 854
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-273 1.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 256017124    238 DINECAMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPS 273
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
627-666 2.03e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.03e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    627 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 666
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
668-708 2.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 256017124    668 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 543-577 5.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 5.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 256017124  543 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 577
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
543-575 8.40e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.40e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 256017124    543 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 575
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 370-460 1.63e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017124  370 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 447
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909

                          90
                  ....*....|...
gi 256017124  448 VEIAPTQVTETDE 460
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-270 2.04e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  238 DINECAMPGVCR-HGDCLNNPGSYRCVCPPGHSL 270
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 668-702 2.17e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 256017124  668 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 702
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 982-1017 3.40e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 256017124   982 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1017
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 627-657 3.94e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 256017124  627 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 657
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
749-782 5.81e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 5.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 256017124    749 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 782
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
709-748 7.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 7.36e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 256017124    709 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 748
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 749-782 9.18e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  749 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 782
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 709-748 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 256017124  709 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 748
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
919-947 4.86e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.86e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 256017124    919 DVDECLDESNCRNG-VCENTRGGYRCACTP 947
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
709-738 6.92e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.92e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   709 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 738
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
668-697 6.92e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.92e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   668 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 697
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 919-947 1.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 256017124  919 DVDECLDESNCRN-GVCENTRGGYRCACTP 947
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
238-267 1.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   238 DINECAMPG-VC-RHGDCLNNPGSYRCVCPPG 267
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-619 1.82e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 256017124    586 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 619
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
499-542 2.05e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 256017124    499 DVNECEAE-PCGPGrGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 542
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF smart00181
Epidermal growth factor-like domain;
671-703 2.65e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 2.65e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 256017124    671 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 703
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 622-665 2.77e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 2.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 256017124  622 GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 665
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF smart00181
Epidermal growth factor-like domain;
241-273 2.84e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 2.84e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 256017124    241 ECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPS 273
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 586-618 3.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  586 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYR 618
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 499-533 3.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 256017124  499 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 533
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 650-671 4.24e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.46  E-value: 4.24e-03
                           10        20
                   ....*....|....*....|..
gi 256017124   650 RCTCAQGYAPAPDGRSCLDVDE 671
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 174-204 4.40e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.40e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 256017124   174 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 204
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 546-579 4.92e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 256017124  546 ECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 579
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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