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Conserved domains on  [gi|257471006|ref|NP_001158089|]
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glypican-3 isoform 1 precursor [Homo sapiens]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
14-600 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 696.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   14 MLLSLDFPGQAQPPPPPpDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVClPKGPTCCSRKMEEKYQLTARLNMEQLL 93
Cdd:pfam01153   1 LLLLLALPGRADPASGK-ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRIC-PQGYTCCTSEMEEKLSNQSRREFEQLV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   94 QSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDS 173
Cdd:pfam01153  79 HEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWAR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  174 LFPVIYtQLMNPG--LPDsalDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKD 251
Cdd:pfam01153 159 LLERLF-KLVNPQyhFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  252 CGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSI 331
Cdd:pfam01153 235 CTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  332 QYVQKNAGKLTTtetekkiwhfkypifflcigldlQIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRR 411
Cdd:pfam01153 315 MNMQENSMKLTA-----------------------KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGT 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  412 R------ELIQKLKSFISFYSALPGYICSHSPVAE---NDTLCWNGQElVERYSQKAARNGMKNQFNLHELKMKGPEP-- 480
Cdd:pfam01153 372 RldrlvtDVKEKLKEMKSFWSTLPDTLCSDEKMAAdptNEDKCWNGQT-KGRYLPEVMGNGLANQINNPEVEVDITKPdm 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  481 VVSQIIDKLKHINQLLRTMSMpkGRVLDknldeegFEsgdcgDDEDECiGGSGDGM----IKVKNQLRFLAELaYDLDVD 556
Cdd:pfam01153 451 VIRQQIMKLKIMTNRLKNAYP--GNDVD-------FQ-----DDSDDS-SGSGSGDgcpsDLCKGDLPFVFEL-TDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 257471006  557 DAPGNSQQATPKDNEISTfhnlGNVHSPLKLLTSMAISVVCFFF 600
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSST----GGLPSSLLLATSMLLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
14-600 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 696.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   14 MLLSLDFPGQAQPPPPPpDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVClPKGPTCCSRKMEEKYQLTARLNMEQLL 93
Cdd:pfam01153   1 LLLLLALPGRADPASGK-ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRIC-PQGYTCCTSEMEEKLSNQSRREFEQLV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   94 QSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDS 173
Cdd:pfam01153  79 HEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWAR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  174 LFPVIYtQLMNPG--LPDsalDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKD 251
Cdd:pfam01153 159 LLERLF-KLVNPQyhFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  252 CGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSI 331
Cdd:pfam01153 235 CTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  332 QYVQKNAGKLTTtetekkiwhfkypifflcigldlQIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRR 411
Cdd:pfam01153 315 MNMQENSMKLTA-----------------------KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGT 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  412 R------ELIQKLKSFISFYSALPGYICSHSPVAE---NDTLCWNGQElVERYSQKAARNGMKNQFNLHELKMKGPEP-- 480
Cdd:pfam01153 372 RldrlvtDVKEKLKEMKSFWSTLPDTLCSDEKMAAdptNEDKCWNGQT-KGRYLPEVMGNGLANQINNPEVEVDITKPdm 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  481 VVSQIIDKLKHINQLLRTMSMpkGRVLDknldeegFEsgdcgDDEDECiGGSGDGM----IKVKNQLRFLAELaYDLDVD 556
Cdd:pfam01153 451 VIRQQIMKLKIMTNRLKNAYP--GNDVD-------FQ-----DDSDDS-SGSGSGDgcpsDLCKGDLPFVFEL-TDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 257471006  557 DAPGNSQQATPKDNEISTfhnlGNVHSPLKLLTSMAISVVCFFF 600
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSST----GGLPSSLLLATSMLLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
14-600 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 696.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   14 MLLSLDFPGQAQPPPPPpDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVClPKGPTCCSRKMEEKYQLTARLNMEQLL 93
Cdd:pfam01153   1 LLLLLALPGRADPASGK-ARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRIC-PQGYTCCTSEMEEKLSNQSRREFEQLV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006   94 QSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDS 173
Cdd:pfam01153  79 HEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWAR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  174 LFPVIYtQLMNPG--LPDsalDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKD 251
Cdd:pfam01153 159 LLERLF-KLVNPQyhFSD---DYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  252 CGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSI 331
Cdd:pfam01153 235 CTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  332 QYVQKNAGKLTTtetekkiwhfkypifflcigldlQIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRR 411
Cdd:pfam01153 315 MNMQENSMKLTA-----------------------KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGT 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  412 R------ELIQKLKSFISFYSALPGYICSHSPVAE---NDTLCWNGQElVERYSQKAARNGMKNQFNLHELKMKGPEP-- 480
Cdd:pfam01153 372 RldrlvtDVKEKLKEMKSFWSTLPDTLCSDEKMAAdptNEDKCWNGQT-KGRYLPEVMGNGLANQINNPEVEVDITKPdm 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257471006  481 VVSQIIDKLKHINQLLRTMSMpkGRVLDknldeegFEsgdcgDDEDECiGGSGDGM----IKVKNQLRFLAELaYDLDVD 556
Cdd:pfam01153 451 VIRQQIMKLKIMTNRLKNAYP--GNDVD-------FQ-----DDSDDS-SGSGSGDgcpsDLCKGDLPFVFEL-TDTPAT 514

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 257471006  557 DAPGNSQQATPKDNEISTfhnlGNVHSPLKLLTSMAISVVCFFF 600
Cdd:pfam01153 515 PAKPTTQQGTGSVDGSST----GGLPSSLLLATSMLLSLVTLLV 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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