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Conserved domains on  [gi|260763999|ref|NP_001159610|]
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armadillo repeat-containing protein 8 isoform 2 [Mus musculus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
49-212 1.33e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999  49 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 127
Cdd:COG5064  273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999 128 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSP 200
Cdd:COG5064  350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                        170
                 ....*....|..
gi 260763999 201 SYKVRMQALKCF 212
Cdd:COG5064  427 DNKIIEVALDAI 438
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
49-212 1.33e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999  49 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 127
Cdd:COG5064  273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999 128 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSP 200
Cdd:COG5064  350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                        170
                 ....*....|..
gi 260763999 201 SYKVRMQALKCF 212
Cdd:COG5064  427 DNKIIEVALDAI 438
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
49-212 1.33e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999  49 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 127
Cdd:COG5064  273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999 128 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSP 200
Cdd:COG5064  350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                        170
                 ....*....|..
gi 260763999 201 SYKVRMQALKCF 212
Cdd:COG5064  427 DNKIIEVALDAI 438
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
28-118 9.86e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.03  E-value: 9.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999  28 LFDPDPQKVLQGVIDMKNAV-IGNNKQKANLIVLGAVPRLLYLLQqETSSTELKTECAVVLGSLAMGTENNVKSLLDCHI 106
Cdd:COG5064   80 LFSDDIEQQLQAVYKFRKLLsKETSPPIQPVIDAGVVPRFVEFMD-EIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGA 158

                         90
                 ....*....|..
gi 260763999 107 IPALLQGLLSPD 118
Cdd:COG5064  159 VPLFIQLLSSTE 170
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
22-125 2.12e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 40.26  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763999  22 RHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLqqETSSTELKTECAVVLGSLAMGTENNVKSL 101
Cdd:COG5064  288 GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLL--SSPKENIRKEACWTISNITAGNTEQIQAV 365

                         90       100
                 ....*....|....*....|....*
gi 260763999 102 LDCHIIPALLQGLLSPDLKF-IEAC 125
Cdd:COG5064  366 IDANLIPPLIHLLSSAEYKIkKEAC 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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