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Conserved domains on  [gi|261245046|ref|NP_001159694|]
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carnosine synthase 1 isoform 1 [Homo sapiens]

Protein Classification

acetyl-CoA carboxylase biotin carboxylase subunit family protein( domain architecture ID 11418417)

acetyl-CoA carboxylase biotin carboxylase subunit family protein similar to Bacillus subtilis alanine--anticapsin ligase that is part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 573-847 8.11e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 151.18  E-value: 8.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 573 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 652
Cdd:COG0439    3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 653 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 732
Cdd:COG0439   73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 733 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 811
Cdd:COG0439  145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 261245046 812 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 847
Cdd:COG0439  224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 573-847 8.11e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 151.18  E-value: 8.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 573 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 652
Cdd:COG0439    3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 653 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 732
Cdd:COG0439   73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 733 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 811
Cdd:COG0439  145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 261245046 812 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 847
Cdd:COG0439  224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
PRK02186 PRK02186
argininosuccinate lyase; Provisional
 536-936 1.09e-21

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 101.46  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 536 ARDYGLQLHLVESDPNH--FASQLVQTFIHFDMtehRRDEENARLLAELVRARGLkldgcFSYWDDCLVLTALLCQELGL 613
Cdd:PRK02186  23 ALLRGFTPYFLTANRGKypFLDAIRVVTISADT---SDPDRIHRFVSSLDGVAGI-----MSSSEYFIEVASEVARRLGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 614 PCSSPAAMRLAKQKsLTQLHLLHHHGPPwpAPSLHAvpccpLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQ 693
Cdd:PRK02186  95 PAANTEAIRTCRDK-KRLARTLRDHGID--VPRTHA-----LALRAVALDALDGLTYPVVVKPRMGSGSVGVRLCASVAE 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 694 CHEHFSRITRDLqgeadhpgiglgwGNAMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAP 773
Cdd:PRK02186 167 AAAHCAALRRAG-------------TRAALVQAYVEGDEYSVETLTVARGHQVLGITRKHLGPPPHFVEIGHDFPAPLSA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 774 EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRPALPTRP 853
Cdd:PRK02186 234 PQRERIVRTVLRALDAVGYAFGPAHTELRVRGDTVVIIEINPRLAGGMIPVLLEEAFGVDLLDHVIDLHLGVAAFADPTA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 854 RARGHLVGVMCLVSQHLQALSstASRETLQALHDRGLLRLNLLEEALVP-GEYEEPYCSVACAGPSPTEARLRLLGLCQG 932
Cdd:PRK02186 314 KRYGAIRFVLPARSGVLRGLL--FLPDDIAARPELRFHPLKQPGDALRLeGDFRDRIAAVVCAGDHRDSVAAAAERAVAG 391


                 ....
gi 261245046 933 LGID 936
Cdd:PRK02186 392 LSID 395
ATPgrasp_Ter pfam15632
ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to ...
 721-854 2.27e-13

ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434824 [Multi-domain]  Cd Length: 131  Bit Score: 68.02  E-value: 2.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  721 AMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFtetaacmptglapEQEAQMVQAAFRCCLGCGLlDGVFNVE 800
Cdd:pfam15632   4 PLLVMEYLPGPEYSVDCLAGHGELIAAVPRRKGDGGIQTL-------------EDDPELIEAARRLAEAFGL-DGLFNVQ 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 261245046  801 LKLTGAGPRLIEINPRM-GGFYLrdwiLELYGVDLLLAAVMVACGLRPALPTRPR 854
Cdd:pfam15632  70 FRYDGDGPKLLEINPRMsGGIGY----SCLAGVNLPYLALKLLLGLETPDPVEPR 120
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 573-847 8.11e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 151.18  E-value: 8.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 573 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 652
Cdd:COG0439    3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 653 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 732
Cdd:COG0439   73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 733 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 811
Cdd:COG0439  145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 261245046 812 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 847
Cdd:COG0439  224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
PRK02186 PRK02186
argininosuccinate lyase; Provisional
 536-936 1.09e-21

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 101.46  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 536 ARDYGLQLHLVESDPNH--FASQLVQTFIHFDMtehRRDEENARLLAELVRARGLkldgcFSYWDDCLVLTALLCQELGL 613
Cdd:PRK02186  23 ALLRGFTPYFLTANRGKypFLDAIRVVTISADT---SDPDRIHRFVSSLDGVAGI-----MSSSEYFIEVASEVARRLGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 614 PCSSPAAMRLAKQKsLTQLHLLHHHGPPwpAPSLHAvpccpLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQ 693
Cdd:PRK02186  95 PAANTEAIRTCRDK-KRLARTLRDHGID--VPRTHA-----LALRAVALDALDGLTYPVVVKPRMGSGSVGVRLCASVAE 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 694 CHEHFSRITRDLqgeadhpgiglgwGNAMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAP 773
Cdd:PRK02186 167 AAAHCAALRRAG-------------TRAALVQAYVEGDEYSVETLTVARGHQVLGITRKHLGPPPHFVEIGHDFPAPLSA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 774 EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRPALPTRP 853
Cdd:PRK02186 234 PQRERIVRTVLRALDAVGYAFGPAHTELRVRGDTVVIIEINPRLAGGMIPVLLEEAFGVDLLDHVIDLHLGVAAFADPTA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 854 RARGHLVGVMCLVSQHLQALSstASRETLQALHDRGLLRLNLLEEALVP-GEYEEPYCSVACAGPSPTEARLRLLGLCQG 932
Cdd:PRK02186 314 KRYGAIRFVLPARSGVLRGLL--FLPDDIAARPELRFHPLKQPGDALRLeGDFRDRIAAVVCAGDHRDSVAAAAERAVAG 391


                 ....
gi 261245046 933 LGID 936
Cdd:PRK02186 392 LSID 395
ATPgrasp_Ter pfam15632
ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to ...
 721-854 2.27e-13

ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434824 [Multi-domain]  Cd Length: 131  Bit Score: 68.02  E-value: 2.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  721 AMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFtetaacmptglapEQEAQMVQAAFRCCLGCGLlDGVFNVE 800
Cdd:pfam15632   4 PLLVMEYLPGPEYSVDCLAGHGELIAAVPRRKGDGGIQTL-------------EDDPELIEAARRLAEAFGL-DGLFNVQ 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 261245046  801 LKLTGAGPRLIEINPRM-GGFYLrdwiLELYGVDLLLAAVMVACGLRPALPTRPR 854
Cdd:pfam15632  70 FRYDGDGPKLLEINPRMsGGIGY----SCLAGVNLPYLALKLLLGLETPDPVEPR 120
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 668-819 9.63e-09

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 55.37  E-value: 9.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  668 VPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGIGLGWGNAMLLMEFVEGTEHDVDlVLFG--GRLL 745
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFAAIREEIEQWKEMYPEAVVDGGSFLVEEYIEGEEFAVD-AYFDenGEPV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245046  746 AAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGP-RLIEINP-RMGG 819
Cdd:pfam13535  80 ILNILKHDFASSEDVSDRIYVTSASIIRETQAAFTEFLKRINALLGLKNFPVHIELRVDEDGQiIPIEVNPlRFAG 155
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 617-834 1.30e-08

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 57.26  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 617 SPAAMRLAKQKSLTQLhllhhhgppwpAPSLHAVPCCP---LESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDApq 693
Cdd:COG0189   87 DPEAIRRARDKLFTLQ-----------LLARAGIPVPPtlvTRDPDDLRAFLEELGGPVVLKPLDGSGGRGVFLVEDE-- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 694 chEHFSRITRDLQGEADHPgiglgwgnaMLLMEFVEGTE-HDVDLVLFGGRLLAAF--VSDNGPTR----LPGFTETAAc 766
Cdd:COG0189  154 --DALESILEALTELGSEP---------VLVQEFIPEEDgRDIRVLVVGGEPVAAIrrIPAEGEFRtnlaRGGRAEPVE- 221

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261245046 767 mptglAPEQEAQMVQAAFRCclgcgLLDGVFNVELKLTGAGPRLIEINPRMGgfyLRdWILELYGVDL 834
Cdd:COG0189  222 -----LTDEERELALRAAPA-----LGLDFAGVDLIEDDDGPLVLEVNVTPG---FR-GLERATGVDI 275
ATPgrasp_N pfam18130
ATP-grasp N-terminal domain; This is the N-terminal domain found in BL00235 present in ...
 534-614 1.74e-06

ATP-grasp N-terminal domain; This is the N-terminal domain found in BL00235 present in Bacillus licheniformis. BL00235 is a ATP-grasp superfamily protein that catalyzes the formation of an alpha-peptide bond between two L-amino acids in an ATP-dependent manner. BL00235 has a highly restricted substrate specificity: the N-terminal substrate is confined to L-methionine an L-leucine, while the C-terminal substrates include small residues such as L-alanine, L-serine, L-threonine and L-cysteine.


Pssm-ID: 407962 [Multi-domain]  Cd Length: 81  Bit Score: 46.49  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  534 EAARDYGLQLHLV----ESDPNHFASqlVQTFIHFDMTEhrrDEENA-RLLAELVRARGLklDGCFSYWDDCLVLTALLC 608
Cdd:pfam18130   2 EAARALGIDVTVVdepgEWAPGHLPA--VEEFIPLDLAD---DPDRAlEIVRALHRARPV--DGVVTFTDPFLPFVARAA 74


                  ....*.
gi 261245046  609 QELGLP 614
Cdd:pfam18130  75 EALGLP 80
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 647-830 3.30e-06

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 50.27  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 647 LHAVPCCPLESEADVERA--VHQVPLPGVMKLEFGAGAVGVRLVEDapqchehFSRITRDLQGEADhpgiglgwgnaMLL 724
Cdd:PRK12767 124 IPTPKSYLPESLEDFKAAlaKGELQFPLFVKPRDGSASIGVFKVND-------KEELEFLLEYVPN-----------LII 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 725 MEFVEGTEHDVD-LVLFGGRLLAAFVSDNGPTRlPGFTETAAcmpTGLAPEQEAQMVQAAFRccLGCgllDGVFNVELKL 803
Cdd:PRK12767 186 QEFIEGQEYTVDvLCDLNGEVISIVPRKRIEVR-AGETSKGV---TVKDPELFKLAERLAEA--LGA---RGPLNIQCFV 256

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 261245046 804 TGAGPRLIEINPRMGG-FYLR--------DWILELY 830
Cdd:PRK12767 257 TDGEPYLFEINPRFGGgYPLSymaganepDWIIRNL 292
ATP-grasp_3 pfam02655
ATP-grasp domain; No functional information or experimental verification of function is known ...
 650-819 8.73e-06

ATP-grasp domain; No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).


Pssm-ID: 396979 [Multi-domain]  Cd Length: 160  Bit Score: 46.99  E-value: 8.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  650 VPCCPLESEADVEravhqvPLPGVMKLEFGAGAVGVRLVEDapqchehfsritrdlqGEADHPGIglgwgNAMLLMEFVE 729
Cdd:pfam02655  18 TPETLQAEELLRE------EKKYVVKPRDGCGGEGVRKVEN----------------GREDEAFI-----ENVLVQEFIE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  730 GTEHDVDLVLFGGRllAAFVSDNgpTRLPGFTETAACMPTGLAP---EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGA 806
Cdd:pfam02655  71 GEPLSVSLLSDGEK--ALPLSVN--RQYIDNGGSGFVYAGNVTPsrtELKEEIIELAEEVVECLPGLRGYVGVDLVLKDN 146

                         170
                  ....*....|...
gi 261245046  807 GPRLIEINPRMGG 819
Cdd:pfam02655 147 EPYVIEVNPRITT 159
PylC COG2232
Pyrrolysine biosynthesis ligase PylC and related enzymes, ATP-grasp superfamily [Amino acid ...
 748-926 1.19e-04

Pyrrolysine biosynthesis ligase PylC and related enzymes, ATP-grasp superfamily [Amino acid transport and metabolism];


Pssm-ID: 441833 [Multi-domain]  Cd Length: 370  Bit Score: 45.30  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 748 FVSDNGPTRLPGFTE----TAACM---------PTGLAPEQEAQMVQAAFRCCLGCGLLdGVFNVELKLTGAGPRLIEIN 814
Cdd:COG2232  182 FLADGSDARVLGFNRqligPAGERpfryggnigPLALPPALAEEMRAIAEALVAALGLV-GLNGVDFILDGDGPYVLEVN 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 815 PRMGGfylrdwILELYGVDL---LLAAVMVACglRPALPTRPRARGHLVGVMCLV-SQHlqALSSTASRETLQALHDRGl 890
Cdd:COG2232  261 PRPQA------SLDLYEDATggnLFDAHLRAC--RGELPEVPRPKPRRVAAKAILyAPR--DLTIPDDLSWPPWVADIP- 329

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 261245046 891 lrlnlleealVPGEY---EEPYCSVACAGPSPTEARLRL 926
Cdd:COG2232  330 ----------APGTRiekGEPVCTVLAEGPTAEAARALL 358
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
655-860 1.59e-03

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 41.84  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 655 LESEADVERAVHQVPLPGVMK--------LEFGAGAVGVRLVEDAPQCHEHFSRITrdlqgEADHPgiglgwgnaMLLME 726
Cdd:COG3919  138 LDSADDLDALAEDLGFPVVVKpadsvgydELSFPGKKKVFYVDDREELLALLRRIA-----AAGYE---------LIVQE 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046 727 FVEGTEhDVDLVLFG-----GRLLAAFVSdngpTRL----PGFTETAACMPTGlapeqEAQMVQAAFRcclgcgLLD--- 794
Cdd:COG3919  204 YIPGDD-GEMRGLTAyvdrdGEVVATFTG----RKLrhypPAGGNSAARESVD-----DPELEEAARR------LLEalg 267

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261245046 795 --GVFNVELKL---TGAgPRLIEINPRMGG-FYLrdwiLELYGVDLLLAAVMVACG--LRPALPTRPRARGHLV 860
Cdd:COG3919  268 yhGFANVEFKRdprDGE-YKLIEINPRFWRsLYL----ATAAGVNFPYLLYDDAVGrpLEPVPAYREGVLWRVL 336
carB PRK12815
carbamoyl phosphate synthase large subunit; Reviewed
 722-818 8.16e-03

carbamoyl phosphate synthase large subunit; Reviewed


Pssm-ID: 237215 [Multi-domain]  Cd Length: 1068  Bit Score: 39.95  E-value: 8.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245046  722 MLLMEFVEGTEHDVDLvlfggrllaafVSDNGPTRLPGFTE------------TAACMPTGLAPEQEAQMVQAAFRCCLG 789
Cdd:PRK12815  744 ILIDQFIDGKEYEVDA-----------ISDGEDVTIPGIIEhieqagvhsgdsIAVLPPQSLSEEQQEKIRDYAIKIAKK 812

                          90       100
                  ....*....|....*....|....*....
gi 261245046  790 CGLLdGVFNVELKLTGAGPRLIEINPRMG 818
Cdd:PRK12815  813 LGFR-GIMNIQFVLANDEIYVLEVNPRAS 840
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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