|
Name |
Accession |
Description |
Interval |
E-value |
| DUF3668 |
pfam12416 |
Cep120 protein; This family includes the Cep120 protein which is associated with centriole ... |
92-314 |
4.62e-127 |
|
Cep120 protein; This family includes the Cep120 protein which is associated with centriole structure and function.
Pssm-ID: 463569 Cd Length: 226 Bit Score: 383.21 E-value: 4.62e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 92 KYTKFKSEIQISIALETDTKPP---VDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSV 168
Cdd:pfam12416 1 KYTKQKPELLLSLALEKDSKPHtkdFDSFKAKPAPPRQSPGHSILANLLPSKLIPYLNEEEGYHQIGPADLCCDIFVLSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 169 TIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLC 248
Cdd:pfam12416 81 TIAFATNLEQLVPSSMKLPEEKPGFFFYYSLLGNDVTNEPFKNLLNPNFEPERASVRIRSSLRVLRAYLSSQPYLQIHLC 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 249 CGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQR 314
Cdd:pfam12416 161 CGNQSLGSTEVSLQGLLPDNSTELERKPVTIEGAFVLNPPNRAKQDLPEVPLELKPTVGVTVTLRR 226
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
643-897 |
1.70e-16 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 84.60 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 643 ENQL----KQKELAH-MQALAEEWKKRDREReslvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 717
Cdd:COG1196 199 ERQLepleRQAEKAErYRELKEELKELEAEL------LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEEL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 718 RQRnLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEIN 795
Cdd:COG1196 273 RLE-LEELELELEEAQA----EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEelEELEEELE 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 796 LLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELL 875
Cdd:COG1196 348 EAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE 427
|
250 260
....*....|....*....|..
gi 261245061 876 DIRNELNRLRQQEQKQYQDSTE 897
Cdd:COG1196 428 EALAELEEEEEEEEEALEEAAE 449
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
624-925 |
4.24e-15 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 79.98 E-value: 4.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 624 EYKAALELEMWKEMQEDIfenQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASV 703
Cdd:COG1196 224 ELEAELLLLKLRELEAEL---EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 704 ESELQREKKELQsERQRNLQELQDSIRRAKEDCI-HQVELERL--KIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKD 780
Cdd:COG1196 301 EQDIARLEERRR-ELEERLEELEEELAELEEELEeLEEELEELeeELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 781 QQN--NKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRY 858
Cdd:COG1196 380 ELEelAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 859 LAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYqDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEE 925
Cdd:COG1196 460 ALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEGVKAALLLAGLRGLAGA 525
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
692-929 |
1.17e-13 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 75.36 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 692 DLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKIL 771
Cdd:COG1196 221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 772 EKEFQQFKDQQnnkpeIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEEL 851
Cdd:COG1196 301 EQDIARLEERR-----RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261245061 852 EQMRLRylaAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDgphgsvLEEGLDDYLTRLIEERDTL 929
Cdd:COG1196 376 EAEEEL---EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE------LEEALAELEEEEEEEEEAL 444
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
649-954 |
6.95e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 73.18 E-value: 6.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 649 KELAHMQALAEEWKKRDRERESLVKKKvaeyTILEGKLQKTLIDLEKREQQLASVESELQR--EKKELQSERQRNLQELQ 726
Cdd:TIGR02169 671 SEPAELQRLRERLEGLKRELSSLQSEL----RRIENRLDELSQELSDASRKIGEIEKEIEQleQEEEKLKERLEELEEDL 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 727 DSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYkiLEKEFQQFKDQQNNKPEIRlqSEINLLTlekVELER 806
Cdd:TIGR02169 747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV--SRIEARL---REIEQ 819
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 807 KLEsatksKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELeQMRLRYLAAEEKDTVKTERQ---ELLDIRNELNR 883
Cdd:TIGR02169 820 KLN-----RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL-NGKKEELEEELEELEAALRDlesRLGDLKKERDE 893
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261245061 884 ----LRQQEQKQYQDSTEIASGKKdgpHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILA 954
Cdd:TIGR02169 894 leaqLRELERKIEELEAQIEKKRK---RLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEE 965
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
629-929 |
3.85e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 70.47 E-value: 3.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 629 LELEMwKEMQEDIFENQLKQKELAH-MQALAEEWKKRDRERESLVKKKVAEYTILEgKLQKTLIDLEKREQQLASVESEL 707
Cdd:TIGR02168 682 LEEKI-EELEEKIAELEKALAELRKeLEELEEELEQLRKELEELSRQISALRKDLA-RLEAEVEQLEERIAQLSKELTEL 759
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 708 QREKKELQSERQ----------RNLQELQDSIRRAKEDC---IHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 774
Cdd:TIGR02168 760 EAEIEELEERLEeaeeelaeaeAEIEELEAQIEQLKEELkalREALDELRAELTLLNEEAANLRERLESLERRIAATERR 839
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 775 FQQFKDQ--QNNKPEIRLQSEINLLTLEKVELERKLESATKSKlhykqqwgRALKELARLKQREQESQMARLkkQQEELE 852
Cdd:TIGR02168 840 LEDLEEQieELSEDIESLAAEIEELEELIEELESELEALLNER--------ASLEEALALLRSELEELSEEL--RELESK 909
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 853 QMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSvlEEGLDDYLTRLIEERDTL 929
Cdd:TIGR02168 910 RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDD--EEEARRRLKRLENKIKEL 984
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
644-890 |
4.45e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 70.47 E-value: 4.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 644 NQLKQKELAhmqALAEEWKKRDRERESLvKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSErqrnLQ 723
Cdd:TIGR02168 220 AELRELELA---LLVLRLEELREELEEL-QEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKE----LY 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 724 ELQDSIRRAKEDCIHQVElerlKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVE 803
Cdd:TIGR02168 292 ALANEISRLEQQKQILRE----RLANLERQLEELEAQLEELESKLDELAEELAELEEKLE-----ELKEELESLEAELEE 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 804 LERKLESATKSKLHYKQQWGRALKELARLKQRE--QESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNEL 881
Cdd:TIGR02168 363 LEAELEELESRLEELEEQLETLRSKVAQLELQIasLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEL 442
|
....*....
gi 261245061 882 NRLRQQEQK 890
Cdd:TIGR02168 443 EELEEELEE 451
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
649-948 |
4.06e-11 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 67.07 E-value: 4.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 649 KELAHMQALAEEWKKRDRERESL-----VKKKVAEYTILEGKlqKTLIDLEKREQQLASVESELQREKKELQSERQRNLQ 723
Cdd:pfam17380 221 KEVQGMPHTLAPYEKMERRKESFnlaedVTTMTPEYTVRYNG--QTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQ 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 724 ElqdSIRRAKEDCIHQVELERlkikQLEEDKHRLQQQLND-----AENKYKILEKEFQ----QFKDQQNNKPEIRlQSEI 794
Cdd:pfam17380 299 E---RLRQEKEEKAREVERRR----KLEEAEKARQAEMDRqaaiyAEQERMAMEREREleriRQEERKRELERIR-QEEI 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 795 -----NLLTLEKVELERK---------LESATKSKLhykqqwgraLKELARLKQREQESQMARLKKQQEELEQMRLRYLA 860
Cdd:pfam17380 371 ameisRMRELERLQMERQqknervrqeLEAARKVKI---------LEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE 441
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 861 AEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGS-----VLEEGLDDYLTRLIEE---RDTLMR- 931
Cdd:pfam17380 442 EERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEeqrrkILEKELEERKQAMIEEerkRKLLEKe 521
|
330 340
....*....|....*....|..
gi 261245061 932 -----TGVYNHEDRIISELDRQ 948
Cdd:pfam17380 522 meerqKAIYEEERRREAEEERR 543
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
614-858 |
4.27e-11 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 67.39 E-value: 4.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 614 EIQTEPRETLEYKAALELEMwKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDL 693
Cdd:TIGR02168 257 ELTAELQELEEKLEELRLEV-SELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDEL 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcihQVELERL--KIKQLEEDKHRLQQQLNDAENKYKIL 771
Cdd:TIGR02168 336 AEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL---EEQLETLrsKVAQLELQIASLNNEIERLEARLERL 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 772 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQMARLKKQQE 849
Cdd:TIGR02168 413 EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDaaERELAQLQARLD 492
|
....*....
gi 261245061 850 ELEQMRLRY 858
Cdd:TIGR02168 493 SLERLQENL 501
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
683-897 |
6.15e-11 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 66.62 E-value: 6.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 683 EGKLQKTLIDLEKREQQLASVESELqrEKKELQSERQRNLQELQDSIRRAkedcihQVELERLKIKQLEEDKHRLQQQLN 762
Cdd:TIGR02168 178 ERKLERTRENLDRLEDILNELERQL--KSLERQAEKAERYKELKAELREL------ELALLVLRLEELREELEELQEELK 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 763 DAENKYKILEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQ 840
Cdd:TIGR02168 250 EAEEELEELTAELQE------------LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLAnlERQ 317
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245061 841 MARLKKQQEELEQMRLRYLA-----AEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTE 897
Cdd:TIGR02168 318 LEELEAQLEELESKLDELAEelaelEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
640-893 |
1.04e-10 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 66.09 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 640 DIFENQLKQKElAHMQALAEEWKKRDRERESLVKKKVAEYTILEgkLQKTLIDLEKREQQLASVESELQR------EKKE 713
Cdd:COG4913 613 AALEAELAELE-EELAEAEERLEALEAELDALQERREALQRLAE--YSWDEIDVASAEREIAELEAELERldassdDLAA 689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 714 LQSERQRnLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKI-----LEKEFQQFKDQQNNKpEI 788
Cdd:COG4913 690 LEEQLEE-LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLelralLEERFAAALGDAVER-EL 767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 789 R--LQSEINLLTLEKVELERKLESATKSklhYKQQW--------------GRALKELARLKQR---EQESQMARLKKQQE 849
Cdd:COG4913 768 RenLEERIDALRARLNRAEEELERAMRA---FNREWpaetadldadleslPEYLALLDRLEEDglpEYEERFKELLNENS 844
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 261245061 850 ELEQMRLRYLAAEEKDTVkteRQELLDIRNELNRLRQQEQKQYQ 893
Cdd:COG4913 845 IEFVADLLSKLRRAIREI---KERIDPLNDSLKRIPFGPGRYLR 885
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
614-876 |
2.80e-10 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 63.01 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 614 EIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYtiLEGKLQKTLIDL 693
Cdd:pfam13868 95 EKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEY--LKEKAEREEERE 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKELQSERQRnlQELQDSIRRAKEDCIHQVElERLKIKQLEEDKHRLQQQLNDAENKYKILEK 773
Cdd:pfam13868 173 AEREEIEEEKEREIARLRAQQEKAQDE--KAERDELRAKLYQEEQERK-ERQKEREEAEKKARQRQELQQAREEQIELKE 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 774 EFQQFkdqqnnkpEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQwgralkELAR--LKQREQESQMARLKKQQEEL 851
Cdd:pfam13868 250 RRLAE--------EAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRL------EHRRelEKQIEEREEQRAAEREEELE 315
|
250 260
....*....|....*....|....*
gi 261245061 852 EQMRLRYLAAEEKDTVKTERQELLD 876
Cdd:pfam13868 316 EGERLREEEAERRERIEEERQKKLK 340
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
626-959 |
4.55e-10 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 63.93 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 626 KAALELEmwkEMQEDIFENQLKQKELA-HMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVE 704
Cdd:TIGR02169 174 KALEELE---EVEENIERLDLIIDEKRqQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 705 SELQREKKELQ------SERQRNLQELQDSIRRAKEDCIHQV--ELERLK--IKQLEEDKHRLQQQLNDAENKYKILEKE 774
Cdd:TIGR02169 251 EELEKLTEEISelekrlEEIEQLLEELNKKIKDLGEEEQLRVkeKIGELEaeIASLERSIAEKERELEDAEERLAKLEAE 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 775 FQQFKDQ---------QNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKqREQESQMARLK 845
Cdd:TIGR02169 331 IDKLLAEieelereieEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLK-REINELKRELD 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 846 KQQEELEQMrlrylaaeekdtvkteRQELLDIRNELNRLRQQeQKQYQDSTE--IASGKKDGPHGSVLEEGLDDYLTRLI 923
Cdd:TIGR02169 410 RLQEELQRL----------------SEELADLNAAIAGIEAK-INELEEEKEdkALEIKKQEWKLEQLAADLSKYEQELY 472
|
330 340 350
....*....|....*....|....*....|....*.
gi 261245061 924 EERDTLMRTgvynhEDRiISELDRQIREILAKSNAS 959
Cdd:TIGR02169 473 DLKEEYDRV-----EKE-LSKLQRELAEAEAQARAS 502
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
644-960 |
1.18e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 62.85 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 644 NQLKQKELAHMQA----LAEEWKKRDRERESLVKKKVAEYTILEgklQKTLIDLEKREQQLASVESELQREKKELQSERQ 719
Cdd:PTZ00121 1500 DEAKKAAEAKKKAdeakKAEEAKKADEAKKAEEAKKADEAKKAE---EKKKADELKKAEELKKAEEKKKAEEAKKAEEDK 1576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 720 RNLQELQDSIRRAKEDCIHQV-----ELERLKIKQL--EEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQS 792
Cdd:PTZ00121 1577 NMALRKAEEAKKAEEARIEEVmklyeEEKKMKAEEAkkAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 793 EINllTLEKVELERKLESATKSKlhykqqwgralkELARLKQREQESQMARLKKQQEELEQM-RLRYLAAEEK---DTVK 868
Cdd:PTZ00121 1657 EEN--KIKAAEEAKKAEEDKKKA------------EEAKKAEEDEKKAAEALKKEAEEAKKAeELKKKEAEEKkkaEELK 1722
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 869 TERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRlieERDTLMRTGVYNHEDRIISELDRQ 948
Cdd:PTZ00121 1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKK 1799
|
330
....*....|..
gi 261245061 949 IREIlaKSNASN 960
Cdd:PTZ00121 1800 IKDI--FDNFAN 1809
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
713-960 |
1.25e-09 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 61.32 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 713 ELQSERQRNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQ--QNNKPEIRL 790
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEK----ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAElaELEKEIAEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 791 QSEINLLtleKVELERKLESATKSKLHYK-------QQWGRALKELARLKQ--REQESQMARLKKQQEELEQmrLRYLAA 861
Cdd:COG4942 96 RAELEAQ---KEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYlaPARREQAEELRADLAELAA--LRAELE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 862 EEKDTVKTERQELLDIRNELNRLRQQEQKQyqdsteIASGKKDgphgsvlEEGLDDYLTRLIEERDTLmrtgvynheDRI 941
Cdd:COG4942 171 AERAELEALLAELEEERAALEALKAERQKL------LARLEKE-------LAELAAELAELQQEAEEL---------EAL 228
|
250
....*....|....*....
gi 261245061 942 ISELDRQIREILAKSNASN 960
Cdd:COG4942 229 IARLEAEAAAAAERTPAAG 247
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
634-886 |
1.41e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 62.00 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 634 WKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERE---SLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQRE 710
Cdd:PRK03918 164 YKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEkelEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEEL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 711 KKELQSERQrNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAEnKYKILEKEFQQFKDQQNN--KPEI 788
Cdd:PRK03918 244 EKELESLEG-SKRKLEEKIRELEE----RIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREieKRLS 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 789 RLQSEINLLTLEKVELERKLESATKSKLHYKQqwgrALKELARLKQREQESQMARLKKqqEELEQMRLRyLAAEEKDTVK 868
Cdd:PRK03918 318 RLEEEINGIEERIKELEEKEERLEELKKKLKE----LEKRLEELEERHELYEEAKAKK--EELERLKKR-LTGLTPEKLE 390
|
250 260
....*....|....*....|..
gi 261245061 869 TERQEL----LDIRNELNRLRQ 886
Cdd:PRK03918 391 KELEELekakEEIEEEISKITA 412
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
704-891 |
2.04e-09 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 61.32 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 704 ESELQREKKELQSERQRNLQELQDSIRRAKEDcIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQN 783
Cdd:COG4717 48 LERLEKEADELFKPQGRKPELNLKELKELEEE-LKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 784 NKPEI----RLQSEINLLTLEKVELERKLE---SATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRL 856
Cdd:COG4717 127 LLPLYqeleALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
|
170 180 190
....*....|....*....|....*....|....*
gi 261245061 857 RYLAAEEKdtVKTERQELLDIRNELNRLRQQEQKQ 891
Cdd:COG4717 207 RLAELEEE--LEEAQEELEELEEELEQLENELEAA 239
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
613-888 |
2.90e-09 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 61.14 E-value: 2.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEwkKRDRERESLVKKKVAEYTILEGKLQKTLID 692
Cdd:pfam02463 732 DKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEE--REKTEKLKVEEEKEEKLKAQEEELRALEEE 809
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQ-----VELERLKIKQLEEDKHRLQQQLNDAENK 767
Cdd:pfam02463 810 LKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELerleeEITKEELLQELLLKEEELEEQKLKDELE 889
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKIL----EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHykqqwGRALKELARLKQREQESQMAR 843
Cdd:pfam02463 890 SKEEkekeEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLE-----EADEKEKEENNKEEEEERNKR 964
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 261245061 844 LKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQE 888
Cdd:pfam02463 965 LLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
634-887 |
2.92e-09 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 61.24 E-value: 2.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 634 WKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKR----------------- 696
Cdd:TIGR02169 725 IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsripeiqaelskle 804
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 697 ------EQQLASVESELQR---EKKELQSERQrNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 767
Cdd:TIGR02169 805 eevsriEARLREIEQKLNRltlEKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR 883
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKILEKEFQQFKDQQNNkpeirLQSEINLLTLEkVELERKLESATKSKLHYKQQwgrALKELARLKQREQES-------- 839
Cdd:TIGR02169 884 LGDLKKERDELEAQLRE-----LERKIEELEAQ-IEKKRKRLSELKAKLEALEE---ELSEIEDPKGEDEEIpeeelsle 954
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261245061 840 --QMARLKKQQ-------------EELEQMRLRYLAAEEK-DTVKTERQELLDIRNELNRLRQQ 887
Cdd:TIGR02169 955 dvQAELQRVEEeiralepvnmlaiQEYEEVLKRLDELKEKrAKLEEERKAILERIEEYEKKKRE 1018
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
687-868 |
3.50e-09 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 58.40 E-value: 3.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 687 QKTLIDLEKREQQLASVESELQREKKELQsERQRNLQELQDSIRRAKEDcIHQVELER----LKIKQLEEDKHRLQQQLN 762
Cdd:COG1579 6 LRALLDLQELDSELDRLEHRLKELPAELA-ELEDELAALEARLEAAKTE-LEDLEKEIkrleLEIEEVEARIKKYEEQLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 763 DAENkykilEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELE-------RKLESATKSKLHYKQQWGRALKELARLKQr 835
Cdd:COG1579 84 NVRN-----NKEYEA------------LQKEIESLKRRISDLEdeilelmERIEELEEELAELEAELAELEAELEEKKA- 145
|
170 180 190
....*....|....*....|....*....|...
gi 261245061 836 EQESQMARLKKQQEELEQMRLRYLAAEEKDTVK 868
Cdd:COG1579 146 ELDEELAELEAELEELEAEREELAAKIPPELLA 178
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
664-952 |
4.71e-09 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 60.70 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 664 RDRERESLV-----KKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQ-----SERQRNLQELQDSIRRAK 733
Cdd:COG4913 595 RRRIRSRYVlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlaeySWDEIDVASAEREIAELE 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 734 EdcihqvELERLK--IKQLEEdkhrLQQQLNDAENKYKILEKEFQQFKDQQnnkpeIRLQSEINLLTLEKVELERKLESA 811
Cdd:COG4913 675 A------ELERLDasSDDLAA----LEEQLEELEAELEELEEELDELKGEI-----GRLEKELEQAEEELDELQDRLEAA 739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 812 TKSKLHYKQQwgRALKELARLKQREQESQMAR-LKKQQEELEQMRLRylaaeekdtvkterqelldIRNELNRLRQQEQK 890
Cdd:COG4913 740 EDLARLELRA--LLEERFAAALGDAVERELREnLEERIDALRARLNR-------------------AEEELERAMRAFNR 798
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261245061 891 QYQDST-EIASGKKDGP-----HGSVLEEGLDDYLTRLIEERDTLMRTGVynheDRIISELDRQIREI 952
Cdd:COG4913 799 EWPAETaDLDADLESLPeylalLDRLEEDGLPEYEERFKELLNENSIEFV----ADLLSKLRRAIREI 862
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
618-928 |
5.45e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 60.54 E-value: 5.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 618 EPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKRE 697
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAR 1593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 698 QQLAsveSELQREKKELQSERQRNLQElqdsiRRAKEDCIHQVELERLKIKQL---EEDKHRLQQQLNDAENKYKILEKE 774
Cdd:PTZ00121 1594 IEEV---MKLYEEEKKMKAEEAKKAEE-----AKIKAEELKKAEEEKKKVEQLkkkEAEEKKKAEELKKAEEENKIKAAE 1665
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 775 FQQFKDQQNNKPEIRLQSEinlltlekvELERKLESATKSKLHYKqqwgRALKELArlKQREQESQMARLKKQQEELEQM 854
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAE---------EDEKKAAEALKKEAEEA----KKAEELK--KKEAEEKKKAEELKKAEEENKI 1730
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 855 RLRYLAAEEKDTvKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKdgphgSVLEEGLD--DYLTRLIEERDT 928
Cdd:PTZ00121 1731 KAEEAKKEAEED-KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE-----AVIEEELDeeDEKRRMEVDKKI 1800
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
665-889 |
1.13e-08 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 59.01 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 665 DRERESLVKKKVAEYTILEGKLQktliDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEDcihQVELER 744
Cdd:COG4717 52 EKEADELFKPQGRKPELNLKELK----ELEEELKEAEEKEEEYAELQEELEELEEE-LEELEAELEELREE---LEKLEK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 745 LK-IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEinlltlekvELERKLESA-TKSKLHYKQQW 822
Cdd:COG4717 124 LLqLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELA---------ELQEELEELlEQLSLATEEEL 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 823 GRALKELARLKQREQESQmARLKKQQEELEQMRlrylaaeekdtvkterQELLDIRNELNRLRQQEQ 889
Cdd:COG4717 195 QDLAEELEELQQRLAELE-EELEEAQEELEELE----------------EELEQLENELEAAALEER 244
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
632-891 |
3.91e-08 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 57.38 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 632 EMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKvAEYTILEGKLQKTLIDLEKREQQLASVESELqREK 711
Cdd:PRK03918 266 ERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDEL-REIEKRLSRLEEEINGIEERIKELEEKEERL-EEL 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 712 KELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQ 791
Cdd:PRK03918 344 KKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKE 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 792 SEINLLTLEKVELE-----RKLESATKSKL--HYKQQWGRALKELARLKQREQEsqmarLKKQQEELEQMRLRylaAEEK 864
Cdd:PRK03918 424 LKKAIEELKKAKGKcpvcgRELTEEHRKELleEYTAELKRIEKELKEIEEKERK-----LRKELRELEKVLKK---ESEL 495
|
250 260
....*....|....*....|....*..
gi 261245061 865 DTVKTERQELLDIRNELNRLRQQEQKQ 891
Cdd:PRK03918 496 IKLKELAEQLKELEEKLKKYNLEELEK 522
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
672-955 |
4.93e-08 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 56.06 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 672 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQsERQRNLQELQDSIRRAKEDCIHQVElerlKIKQLE 751
Cdd:COG4372 33 LRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELE-QLEEELEELNEQLQAAQAELAQAQE----ELESLQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 752 EDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESAtksklhykqqwgraLKELAR 831
Cdd:COG4372 108 EEAEELQEELEELQKERQDLEQQRKQLEAQIA-----ELQSEIAEREEELKELEEQLESL--------------QEELAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 832 LKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVL 911
Cdd:COG4372 169 LEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDK 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 261245061 912 EEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAK 955
Cdd:COG4372 249 EELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAA 292
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
655-897 |
5.04e-08 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 56.80 E-value: 5.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 655 QALAEEWKKRDRER-----ESLVKKKVAEYTILEGKL----QKTLIDLEKRE--QQLASVESELQREKKELQSERQRNLQ 723
Cdd:pfam02029 62 EAFLDRTAKREERRqkrlqEALERQKEFDPTIADEKEsvaeRKENNEEEENSswEKEEKRDSRLGRYKEEETEIREKEYQ 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 724 E--LQDSIRRAKEDCIHQvELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEK 801
Cdd:pfam02029 142 EnkWSTEVRQAEEEGEEE-EDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 802 VELERKleSATKSKLHYKQQWGRALKE----LARLKQREQEsqmarlkKQQEELEQMRLRYLAAE-EKDTVKTERQELLD 876
Cdd:pfam02029 221 VTTKRR--QGGLSQSQEREEEAEVFLEaeqkLEELRRRRQE-------KESEEFEKLRQKQQEAElELEELKKKREERRK 291
|
250 260
....*....|....*....|.
gi 261245061 877 IRNELNRLRQQEQKQYQDSTE 897
Cdd:pfam02029 292 LLEEEEQRRKQEEAERKLREE 312
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
637-875 |
6.96e-08 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 56.06 E-value: 6.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 637 MQEDIFENQLKQKELAHMQALAEEWKKRDRERESlvkkKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQS 716
Cdd:pfam07888 47 LQAQEAANRQREKEKERYKRDREQWERQRRELES----RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 717 ERQRNLQ---ELQDSIRRAKEDCI-HQVELERLK---------IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQN 783
Cdd:pfam07888 123 QRAAHEArirELEEDIKTLTQRVLeRETELERMKerakkagaqRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 784 NKPE--IRLQSEINLLTL-------EKVELERKLE--SATKSKLHYKQQ----WGRALKELARLKQREQ-ESQMARLKKQ 847
Cdd:pfam07888 203 QRDTqvLQLQDTITTLTQklttahrKEAENEALLEelRSLQERLNASERkvegLGEELSSMAAQRDRTQaELHQARLQAA 282
|
250 260
....*....|....*....|....*...
gi 261245061 848 QEELEQMRLRYLAAEEKDTVKTERQELL 875
Cdd:pfam07888 283 QLTLQLADASLALREGRARWAQERETLQ 310
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
630-874 |
1.02e-07 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 56.28 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 630 ELEMWKEMQEDIFENQLKQKELAHMQaLAEEWKKRDREREslvkkkvaEYTILEGKLQKTLIDLEKREQQLaSVESELQR 709
Cdd:pfam15921 332 ELREAKRMYEDKIEELEKQLVLANSE-LTEARTERDQFSQ--------ESGNLDDQLQKLLADLHKREKEL-SLEKEQNK 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 710 E---------------KKELqSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 774
Cdd:pfam15921 402 RlwdrdtgnsitidhlRREL-DDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV 480
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 775 FQQFKDQQnnkpeIRLQSE---INLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQEsqmarLKKQQEEL 851
Cdd:pfam15921 481 VEELTAKK-----MTLESSertVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDH-----LRNVQTEC 550
|
250 260
....*....|....*....|...
gi 261245061 852 EQMRLRylAAEEKDTVKTERQEL 874
Cdd:pfam15921 551 EALKLQ--MAEKDKVIEILRQQI 571
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
676-900 |
1.58e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 55.69 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 676 VAEYTILEGkLQKTLIDLEKREQQLASVEsELQREKKELQseRQRNLQELQDSIRRAKEDcIHQVELERLKIKQLEEDKH 755
Cdd:COG4913 231 VEHFDDLER-AHEALEDAREQIELLEPIR-ELAERYAAAR--ERLAELEYLRAALRLWFA-QRRLELLEAELEELRAELA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 756 RLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQseinlltlekvELERKLESATKSKLHYKQQWGRALKELARLKQR 835
Cdd:COG4913 306 RLEAELERLEARLDALREELDELEAQIRGNGGDRLE-----------QLEREIERLERELEERERRRARLEALLAALGLP 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 836 EQESQmarlkkqqEELEQMRLRylAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQD-STEIAS 900
Cdd:COG4913 375 LPASA--------EEFAALRAE--AAALLEALEEELEALEEALAEAEAALRDLRRELRElEAEIAS 430
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
647-814 |
2.04e-07 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 53.00 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 647 KQKELAHMQALAEEWKKRDRERESLvKKKVAEytiLEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQR--NLQE 724
Cdd:COG1579 5 DLRALLDLQELDSELDRLEHRLKEL-PAELAE---LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARikKYEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 725 LQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKpEIRLQSEINLLTLEKV 802
Cdd:COG1579 81 QLGNVRNNKEyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEK-KAELDEELAELEAELE 159
|
170
....*....|..
gi 261245061 803 ELERKLESATKS 814
Cdd:COG1579 160 ELEAEREELAAK 171
|
|
| CCDC22 |
pfam05667 |
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ... |
692-854 |
3.19e-07 |
|
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 54.26 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 692 DLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcIHQVELER----LKIKQLEEDKHRLQQQLNDAENK 767
Cdd:pfam05667 307 QFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESS-IQELEKEIkkleSSIKQVEEELEELKEQNEELEKQ 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKILEKEFQQFKDQQNNkpeirlqseinlltLEKveLERKLESATKSKLHYKQQWG----------RALKELARLKQREQ 837
Cdd:pfam05667 386 YKVKKKTLDLLPDAEEN--------------IAK--LQALVDASAQRLVELAGQWEkhrvplieeyRALKEAKSNKEDES 449
|
170
....*....|....*..
gi 261245061 838 ESQMARLKKQQEELEQM 854
Cdd:pfam05667 450 QRKLEEIKELREKIKEV 466
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
663-929 |
1.04e-06 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 53.05 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 663 KRDRERESLVKKKVAEY----TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDcIH 738
Cdd:pfam02463 168 KRKKKEALKKLIEETENlaelIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE-LL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 739 QVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER----------KL 808
Cdd:pfam02463 247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEklkesekekkKA 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 809 ESATKSKLHYK--QQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYL---------AAEEKDTVKTERQELLDI 877
Cdd:pfam02463 327 EKELKKEKEEIeeLEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKkleserlssAAKLKEEELELKSEEEKE 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 261245061 878 RNELNRLRQQEQKQYQDSTEIASGKKdgphgSVLEEGLDDYLTRLIEERDTL 929
Cdd:pfam02463 407 AQLLLELARQLEDLLKEEKKEELEIL-----EEEEESIELKQGKLTEEKEEL 453
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
635-881 |
1.14e-06 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 52.72 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 635 KEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKEL 714
Cdd:TIGR04523 349 KELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 715 QSERQRNLQeLQDSIRRAKEDcIHQVElerLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKpeirlQSEI 794
Cdd:TIGR04523 429 ERLKETIIK-NNSEIKDLTNQ-DSVKE---LIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK-----EKEL 498
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 795 NLLTLEKVELERKLESATK--SKLHYKQ--------QWGRALKELAR-LKQREQESQMARLKKQ----QEELEQMRLRYL 859
Cdd:TIGR04523 499 KKLNEEKKELEEKVKDLTKkiSSLKEKIeklesekkEKESKISDLEDeLNKDDFELKKENLEKEidekNKEIEELKQTQK 578
|
250 260
....*....|....*....|....*..
gi 261245061 860 AAEEKDTVKTER-----QELLDIRNEL 881
Cdd:TIGR04523 579 SLKKKQEEKQELidqkeKEKKDLIKEI 605
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
616-890 |
1.32e-06 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 52.67 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 616 QTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAE---YTILEGKL---QKT 689
Cdd:pfam02463 243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLerrKVDDEEKLkesEKE 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 690 LIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRakedcihQVELERLKIKQLeeDKHRLQQQLNDAENKYK 769
Cdd:pfam02463 323 KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL-------QEKLEQLEEELL--AKKKLESERLSSAAKLK 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 770 ILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKlhykqqwgraLKELARLKQREQESQMARLKKQQE 849
Cdd:pfam02463 394 EEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESI----------ELKQGKLTEEKEELEKQELKLLKD 463
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 261245061 850 ELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK 890
Cdd:pfam02463 464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESK 504
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
614-782 |
1.33e-06 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 52.08 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 614 EIQTEPRETLEYKAALElEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLvkkkvAEYTILEGKLQKTLIDL 693
Cdd:COG4717 85 EKEEEYAELQEELEELE-EELEELEAELEELREELEKLEKLLQLLPLYQELEALEAEL-----AELPERLEELEERLEEL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqvELERL--KIKQLEEDKHRLQQQLNDAENKYKIL 771
Cdd:COG4717 159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAE------ELEELqqRLAELEEELEEAQEELEELEEELEQL 232
|
170
....*....|.
gi 261245061 772 EKEFQQFKDQQ 782
Cdd:COG4717 233 ENELEAAALEE 243
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
643-891 |
2.14e-06 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 50.69 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 643 ENQLKQKELAHMQALAEEwKKRDRERESLVKKKVAEYTILEGKLQktlidlEKREQQLASVESELQREKKELQSERQRNL 722
Cdd:pfam13868 25 DAQIAEKKRIKAEEKEEE-RRLDEMMEEERERALEEEEEKEEERK------EERKRYRQELEEQIEEREQKRQEEYEEKL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 723 QElqdsiRRAKEDCIHQVELERLKIKQLeedKHRLQQQLNdaenkykileKEFQQFKDQQNNKPEIRLQSEinlltlekV 802
Cdd:pfam13868 98 QE-----REQMDEIVERIQEEDQAEAEE---KLEKQRQLR----------EEIDEFNEEQAEWKELEKEEE--------R 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 803 ELERKLESATKSKLHYKQQWGRALKELARLKQREQE---SQMARLKKQQEELEQMRL-RYLAAEEKDTVKTERQELLDIR 878
Cdd:pfam13868 152 EEDERILEYLKEKAEREEEREAEREEIEEEKEREIArlrAQQEKAQDEKAERDELRAkLYQEEQERKERQKEREEAEKKA 231
|
250
....*....|...
gi 261245061 879 NELNRLRQQEQKQ 891
Cdd:pfam13868 232 RQRQELQQAREEQ 244
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
697-894 |
2.17e-06 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 51.56 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 697 EQQLASVESELQREKKELQSERQRN-LQELQDsirrakedcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEkef 775
Cdd:COG3206 181 EEQLPELRKELEEAEAALEEFRQKNgLVDLSE-----------EAKLLLQQLSELESQLAEARAELAEAEARLAALR--- 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 776 QQFKDQQNNKPEIRLQSEINLLTLEKVELERKL--ESATKSKLHYK-QQWGRALKELARLKQREQESQMARLKKQQEELE 852
Cdd:COG3206 247 AQLGSGPDALPELLQSPVIQQLRAQLAELEAELaeLSARYTPNHPDvIALRAQIAALRAQLQQEAQRILASLEAELEALQ 326
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 261245061 853 QmRLRYLAAEEkDTVKTERQELLDIRNELNRLRQQ---EQKQYQD 894
Cdd:COG3206 327 A-REASLQAQL-AQLEARLAELPELEAELRRLEREvevARELYES 369
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
651-887 |
2.34e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 51.84 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 651 LAHMQALAEEWKKRDRERESLVKKKvAEYTILEG------KLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQE 724
Cdd:COG4913 224 FEAADALVEHFDDLERAHEALEDAR-EQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 725 lqdsirrakedcihqvelerlKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQnnkpEIRLQSEINLLTLEKVEL 804
Cdd:COG4913 303 ---------------------ELARLEAELERLEARLDALREELDELEAQIRGNGGDR----LEQLEREIERLERELEER 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 805 ERKLESAtksklhykQQWGRALKELARLKQREQESQMARLKKQQEELEQMR--LRYLAAEEKDTVKTERQELLDIRNELN 882
Cdd:COG4913 358 ERRRARL--------EALLAALGLPLPASAEEFAALRAEAAALLEALEEELeaLEEALAEAEAALRDLRRELRELEAEIA 429
|
....*
gi 261245061 883 RLRQQ 887
Cdd:COG4913 430 SLERR 434
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
694-891 |
2.88e-06 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 51.11 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKelQSERQRnLQELQDSIRRakedcihqVELERlKIKQLEEDKHRLQQQLNDAENKYKILEK 773
Cdd:pfam15709 313 EERSEEDPSKALLEKREQE--KASRDR-LRAERAEMRR--------LEVER-KRREQEEQRRLQQEQLERAEKMREELEL 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 774 EfqqfkdQQNNKPEIRL----QSEINLLTLEKVELERKLESATKSKLHYKQQ-WGRALKELARLKQREQESQMARLKKQQ 848
Cdd:pfam15709 381 E------QQRRFEEIRLrkqrLEEERQRQEEEERKQRLQLQAAQERARQQQEeFRRKLQELQRKKQQEEAERAEAEKQRQ 454
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 261245061 849 EEL------EQMRLRYLAAEEKDTVKTERQELLD-IRNELNRLRQQEQKQ 891
Cdd:pfam15709 455 KELemqlaeEQKRLMEMAEEERLEYQRQKQEAEEkARLEAEERRQKEEEA 504
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
620-832 |
3.29e-06 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 51.09 E-value: 3.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 620 RETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQ 699
Cdd:COG1196 308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 700 LASVESELQREKKELQS---------ERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKI 770
Cdd:COG1196 388 LLEALRAAAELAAQLEEleeaeeallERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245061 771 LEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARL 832
Cdd:COG1196 468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVL 529
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
638-891 |
5.18e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.76 E-value: 5.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 638 QEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSE 717
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 718 RQRNLQELQDSIRRAkedcihqvelerLKIKQLEEDKHRLQQQ-LNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINL 796
Cdd:COG4942 99 LEAQKEELAELLRAL------------YRLGRQPPLALLLSPEdFLDAVRRLQYLKYLAPARREQAE-----ELRADLAE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 797 LTlekvELERKLESATKSKLHYKQQWGRALKELARLKQrEQESQMARLKKQQEELEQmRLRYLAAEEKdtvkterqellD 876
Cdd:COG4942 162 LA----ALRAELEAERAELEALLAELEEERAALEALKA-ERQKLLARLEKELAELAA-ELAELQQEAE-----------E 224
|
250
....*....|....*
gi 261245061 877 IRNELNRLRQQEQKQ 891
Cdd:COG4942 225 LEALIARLEAEAAAA 239
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
590-903 |
7.36e-06 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 49.48 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 590 SDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWK---EMQEDIFENQLKQKELAHMQALAEE-WKKRD 665
Cdd:pfam02029 25 EEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKreeRRQKRLQEALERQKEFDPTIADEKEsVAERK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 666 RERESLVKKKVAEYTILEGKLQKTLID----LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVE 741
Cdd:pfam02029 105 ENNEEEENSSWEKEEKRDSRLGRYKEEeteiREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 742 LERLKIKqlEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQS-EINLLTLEKVELERKLESATKS------ 814
Cdd:pfam02029 185 KKEKKVK--YESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSqEREEEAEVFLEAEQKLEELRRRrqekes 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 815 ----KLHYKQQwgRALKELARLKQREQESQMARlkkqqEELEQMRlrylAAEEKDTVKTERQELLDIRNELNRLRQQ--E 888
Cdd:pfam02029 263 eefeKLRQKQQ--EAELELEELKKKREERRKLL-----EEEEQRR----KQEEAERKLREEEEKRRMKEEIERRRAEaaE 331
|
330
....*....|....*
gi 261245061 889 QKQYQDSTEIASGKK 903
Cdd:pfam02029 332 KRQKLPEDSSSEGKK 346
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
618-913 |
8.61e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.14 E-value: 8.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 618 EPRETLEYKAALELEMWKEMQEdifENQLKQKelAHMQALAEEWKKRDREreslvKKKVAEYTILEGKLQKTLIDLEKRE 697
Cdd:PTZ00121 1282 ELKKAEEKKKADEAKKAEEKKK---ADEAKKK--AEEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAE 1351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 698 QQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELErlkiKQLEEDKHRLQQQLNDAENKYKilekefqq 777
Cdd:PTZ00121 1352 AEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK----KKAEEDKKKADELKKAAAAKKK-------- 1419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 778 fKDQQNNKPEIRLQSEinlltlekvELERKLESATKS-KLHYKQQWGRALKELArlKQREQESQMARLKKQQEELEQMRL 856
Cdd:PTZ00121 1420 -ADEAKKKAEEKKKAD---------EAKKKAEEAKKAdEAKKKAEEAKKAEEAK--KKAEEAKKADEAKKKAEEAKKADE 1487
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 857 RYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEE 913
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
643-769 |
8.72e-06 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 49.39 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 643 ENQLKQKELahmQAlAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELqSERQRNL 722
Cdd:PRK12704 52 EAIKKEALL---EA-KEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKEL-EQKQQEL 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 261245061 723 QELQDSIRRAKEDciHQVELERLKIKQLEEDKHRLqqqLNDAENKYK 769
Cdd:PRK12704 127 EKKEEELEELIEE--QLQELERISGLTAEEAKEIL---LEKVEEEAR 168
|
|
| ATG16 |
pfam08614 |
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ... |
699-876 |
1.57e-05 |
|
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
Pssm-ID: 462536 [Multi-domain] Cd Length: 176 Bit Score: 46.46 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 699 QLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDK---HR----LQQQLNDAENKYKIL 771
Cdd:pfam08614 11 RLLDRTALLEAENAKLQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELaelYRsrgeLAQRLVDLNEELQEL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 772 EKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATksklhykqqwgRALKELARLKQReqesqmarlkkQQEEL 851
Cdd:pfam08614 91 EKKLRE------------DERRLAALEAERAQLEEKLKDRE-----------EELREKRKLNQD-----------LQDEL 136
|
170 180
....*....|....*....|....*.
gi 261245061 852 EQMRLRYLAAEEK-DTVKTERQELLD 876
Cdd:pfam08614 137 VALQLQLNMAEEKlRKLEKENRELVE 162
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
617-945 |
1.67e-05 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 48.95 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 617 TEPRETLEYKAALELEMwKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKR 696
Cdd:pfam05483 391 SELEEMTKFKNNKEVEL-EELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHY 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 697 EQQLASVESELQREK----------KELQSERQRNLQELQD---SIRRAKEDCIHQVELERLKIKQLEEdkhrLQQQLND 763
Cdd:pfam05483 470 LKEVEDLKTELEKEKlknieltahcDKLLLENKELTQEASDmtlELKKHQEDIINCKKQEERMLKQIEN----LEEKEMN 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 764 AENKYKILEKEFQQFKDQ--------QNNKPEIR---LQSEINLLTLEKV--ELERKLESATKSkLHYKQQWGRALKELA 830
Cdd:pfam05483 546 LRDELESVREEFIQKGDEvkckldksEENARSIEyevLKKEKQMKILENKcnNLKKQIENKNKN-IEELHQENKALKKKG 624
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 831 RLKQREQESQMARLKKQQEELEQMRLRYlaAEEKDTVKTE------RQELLDIRNELNRLRQQEQKQYQDSTEIASGKKD 904
Cdd:pfam05483 625 SAENKQLNAYEIKVNKLELELASAKQKF--EEIIDNYQKEiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKI 702
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 261245061 905 GPHGSVLEEGLDDYlTRLIEERDTLMrtGVYNHEDRIISEL 945
Cdd:pfam05483 703 AEMVALMEKHKHQY-DKIIEERDSEL--GLYKNKEQEQSSA 740
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
580-928 |
2.03e-05 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 48.89 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 580 GLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDI-----FENQLKQKELAHM 654
Cdd:TIGR00606 730 GLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimerFQMELKDVERKIA 809
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 655 QALAE-----------EWKKRDRERESLVKKKVAEYTILegklQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQ 723
Cdd:TIGR00606 810 QQAAKlqgsdldrtvqQVNQEKQEKQHELDTVVSKIELN----RKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQ 885
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 724 ELQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQ----LNDAENKYKILEKEFQQFKDQ---------------Q 782
Cdd:TIGR00606 886 FEEQLVELSTEvqSLIREIKDAKEQDSPLETFLEKDQQEkeelISSKETSNKKAQDKVNDIKEKvknihgymkdienkiQ 965
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 783 NNKPEIRLQSEINLLTLEKvelerKLESATKSKLHYKQQWGRALKELARLKQREQ--ESQMARLKKQQE--ELEQMRLRY 858
Cdd:TIGR00606 966 DGKDDYLKQKETELNTVNA-----QLEECEKHQEKINEDMRLMRQDIDTQKIQERwlQDNLTLRKRENElkEVEEELKQH 1040
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 859 LAAEEKDTVKTERQELLDIRNELNRLRQQE------QKQYQDSTEIASGKKDGPHGSVLEEgldDYLTRLIEERDT 928
Cdd:TIGR00606 1041 LKEMGQMQVLQMKQEHQKLEENIDLIKRNHvlalgrQKGYEKEIKHFKKELREPQFRDAEE---KYREMMIVMRTT 1113
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
643-883 |
2.06e-05 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 48.58 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 643 ENQLKQKELAHMQALAEewkkrdRERESLVKKKVAEYTILEGK-LQKTLIDLEKRE---QQLASVESELQREKKELQSER 718
Cdd:pfam05557 15 QNEKKQMELEHKRARIE------LEKKASALKRQLDRESDRNQeLQKRIRLLEKREaeaEEALREQAELNRLKKKYLEAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 719 QRNLQELQDSIRRAKE--DCI--------HQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQ--NNKP 786
Cdd:pfam05557 89 NKKLNEKESQLADAREviSCLknelselrRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQssLAEA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 787 EIRLQseinlltlekvELERKLESATKSKLHYKQqwgrALKELARLKQREQEsqmarLKKQQEELEQMRlrylaaEEKDT 866
Cdd:pfam05557 169 EQRIK-----------ELEFEIQSQEQDSEIVKN----SKSELARIPELEKE-----LERLREHNKHLN------ENIEN 222
|
250
....*....|....*..
gi 261245061 867 VKTERQELLDIRNELNR 883
Cdd:pfam05557 223 KLLLKEEVEDLKRKLER 239
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
685-903 |
2.18e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.90 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 685 KLQKTLIDLEKREQQLASVESELQREKKELQSErqrnLQELQDSIRRAKEdcihqvelerlKIKQLEEDKHRLQQQLNDA 764
Cdd:COG3883 20 AKQKELSELQAELEAAQAELDALQAELEELNEE----YNELQAELEALQA-----------EIDKLQAEIAEAEAEIEER 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 765 ENKYKilekefQQFKDQQNNKpeiRLQSEINLLT--------LEKVELERKLESATKSKLhyKQQwgRALKELARLKQRE 836
Cdd:COG3883 85 REELG------ERARALYRSG---GSVSYLDVLLgsesfsdfLDRLSALSKIADADADLL--EEL--KADKAELEAKKAE 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 837 QESQMARLKKQQEELEQMRlrylaaEEKDTVKTERQELldirneLNRLRQQEQKQYQDSTEIASGKK 903
Cdd:COG3883 152 LEAKLAELEALKAELEAAK------AELEAQQAEQEAL------LAQLSAEEAAAEAQLAELEAELA 206
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
618-952 |
2.24e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.60 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 618 EPRETLEYKAALELEmwKEMQEDIFENQLKQKelahmqalAEEWKKRDRE--RESLVKKKVAEYTILEGKLQKTLIDLEK 695
Cdd:PTZ00121 1294 EAKKAEEKKKADEAK--KKAEEAKKADEAKKK--------AEEAKKKADAakKKAEEAKKAAEAAKAEAEAAADEAEAAE 1363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 696 REQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERL--------KIKQLEEDKHRLQQQLNDAENK 767
Cdd:PTZ00121 1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAaaakkkadEAKKKAEEKKKADEAKKKAEEA 1443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKI--LEKEFQQFKDQQNNKPEIRLQSEINLLTlEKVELERKLESATKSKLHYKQQwGRALKELARLKQREQESQMARLK 845
Cdd:PTZ00121 1444 KKAdeAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKADEAKKKAEEAKKK-ADEAKKAAEAKKKADEAKKAEEA 1521
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 846 KQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNR---LRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRL 922
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY 1601
|
330 340 350
....*....|....*....|....*....|
gi 261245061 923 IEERDTLMRTGVYNHEDRIISELDRQIREI 952
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEE 1631
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
626-804 |
2.51e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 48.37 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 626 KAALELEMWKEMQE--DIFENQLKQKEL-AHMQALAEEWKKRDRERESLVKKKVAeytiLEGKLQKTLIDLEKRE-QQLA 701
Cdd:COG4913 266 AARERLAELEYLRAalRLWFAQRRLELLeAELEELRAELARLEAELERLEARLDA----LREELDELEAQIRGNGgDRLE 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 702 SVESELQREKKELQsERQRNLQELQDSIR--------------RAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 767
Cdd:COG4913 342 QLEREIERLERELE-ERERRRARLEALLAalglplpasaeefaALRAEAAALLEALEEELEALEEALAEAEAALRDLRRE 420
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 261245061 768 YKILEKEFQQFKDQQNNKPE--IRLQSEIN-LLTLEKVEL 804
Cdd:COG4913 421 LRELEAEIASLERRKSNIPArlLALRDALAeALGLDEAEL 460
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
613-900 |
2.56e-05 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 48.14 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKElahmqALAEEWKKRDRERE---SLVKKKVAEYTILEGKLQKT 689
Cdd:PRK03918 487 KVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKA-----EEYEKLKEKLIKLKgeiKSLKKELEKLEELKKKLAEL 561
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 690 LIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKE--DCIHQVELERLKIKQLEEDKHRLQQQLNDAENK 767
Cdd:PRK03918 562 EKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLElkDAEKELEREEKELKKLEEELDKAFEELAETEKR 641
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKILEKEFQQFKdQQNNKPEIRLQSEinlltlEKVELERKLEsatksklhykqqwgRALKELARLKQREQESqMARLKKQ 847
Cdd:PRK03918 642 LEELRKELEELE-KKYSEEEYEELRE------EYLELSRELA--------------GLRAELEELEKRREEI-KKTLEKL 699
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 261245061 848 QEELEQMRlryLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQ-YQDSTEIAS 900
Cdd:PRK03918 700 KEELEERE---KAKKELEKLEKALERVEELREKVKKYKALLKERaLSKVGEIAS 750
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
717-887 |
3.34e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 48.13 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 717 ERQRNLQELQDSIRRAKEDC-IHQVELERLK---------IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkp 786
Cdd:TIGR02168 674 ERRREIEELEEKIEELEEKIaELEKALAELRkeleeleeeLEQLRKELEELSRQISALRKDLARLEAEVEQLEERIA--- 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 787 eiRLQSEINLLTLEKVELERKLESATKsklhykqqwgrALKELARLKQrEQESQMARLkkqQEELEQMRLRYLAAEEKdt 866
Cdd:TIGR02168 751 --QLSKELTELEAEIEELEERLEEAEE-----------ELAEAEAEIE-ELEAQIEQL---KEELKALREALDELRAE-- 811
|
170 180
....*....|....*....|.
gi 261245061 867 VKTERQELLDIRNELNRLRQQ 887
Cdd:TIGR02168 812 LTLLNEEAANLRERLESLERR 832
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
676-853 |
3.42e-05 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 47.47 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 676 VAEYTILEGKLQKTLIDLEKREQQLasveseLQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEdkh 755
Cdd:PRK12704 19 VIGYFVRKKIAEAKIKEAEEEAKRI------LEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEK--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 756 RLQQqlndaenKYKILEKefqqfKDQQNNKPEIRLQSEINLLTLEKVELERKLESAtkSKLHYKQQwgRALKELARLKQR 835
Cdd:PRK12704 90 RLLQ-------KEENLDR-----KLELLEKREEELEKKEKELEQKQQELEKKEEEL--EELIEEQL--QELERISGLTAE 153
|
170
....*....|....*...
gi 261245061 836 EQESQMarLKKQQEELEQ 853
Cdd:PRK12704 154 EAKEIL--LEKVEEEARH 169
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
613-890 |
3.46e-05 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 47.58 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALELEMWKEMQEDIfeNQLKQKELAHMQALaEEWKKRDRERESLVKKKVAEYTILEGKLQKTlid 692
Cdd:pfam07888 110 SEELSEEKDALLAQRAAHEARIRELEEDI--KTLTQRVLERETEL-ERMKERAKKAGAQRKEEEAERKQLQAKLQQT--- 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 lekrEQQLASVESELQrEKKELQSERQRNLQELQDSIRRA--KEDCIHQVELERlkiKQLEEDKHRLQQQLNDAENKYKI 770
Cdd:pfam07888 184 ----EEELRSLSKEFQ-ELRNSLAQRDTQVLQLQDTITTLtqKLTTAHRKEAEN---EALLEELRSLQERLNASERKVEG 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 771 LEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWG---------------RALK---ELARL 832
Cdd:pfam07888 256 LGEELSSMAAQRD-----RTQAELHQARLQAAQLTLQLADASLALREGRARWAqeretlqqsaeadkdRIEKlsaELQRL 330
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 833 KQREQESQMARLKKQQE-----------------ELEQMR--LRyLAAEEKDTVKTERQELLDirnelnRLRQQEQK 890
Cdd:pfam07888 331 EERLQEERMEREKLEVElgrekdcnrvqlsesrrELQELKasLR-VAQKEKEQLQAEKQELLE------YIRQLEQR 400
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
672-951 |
3.90e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 47.20 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 672 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRrakedcihQVELERLKIKQLE 751
Cdd:COG4372 8 VGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEE--------ELEQARSELEQLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 752 EDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELAR 831
Cdd:COG4372 80 EELEELNEQLQAAQAELAQAQEELESLQEEAE-----ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 832 LkqreqESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVL 911
Cdd:COG4372 155 L-----EEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEA 229
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 261245061 912 EEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIRE 951
Cdd:COG4372 230 KLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
616-897 |
3.97e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 616 QTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQAlaEEWKKRDRERESL--VKKKVAEYTILEGKLQKTLIDL 693
Cdd:PTZ00121 1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA--EELKKAEEEKKKVeqLKKKEAEEKKKAEELKKAEEEN 1659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEK 773
Cdd:PTZ00121 1660 KIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 774 EFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQwgrALKELARLKQREQESQMARLKKQQEELEQ 853
Cdd:PTZ00121 1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE---ELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 261245061 854 --MRLRYLAAEEKDTVKTERQELLDIRN-ELNRLRQQEQKQYQDSTE 897
Cdd:PTZ00121 1813 ggKEGNLVINDSKEMEDSAIKEVADSKNmQLEEADAFEKHKFNKNNE 1859
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
674-894 |
4.06e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.32 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 674 KKVAEYtilegKLQKTLIDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRakedcihQVELERLKIKQLEED 753
Cdd:COG3206 196 AALEEF-----RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAE-AEARLAALRA-------QLGSGPDALPELLQS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 754 KH--RLQQQLNDAENKYKILEKEFqqfkdqQNNKPEIR-LQSEINlltlekvELERKLESATksklhyKQQWGRALKELA 830
Cdd:COG3206 263 PViqQLRAQLAELEAELAELSARY------TPNHPDVIaLRAQIA-------ALRAQLQQEA------QRILASLEAELE 323
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 831 RLKQREQE--SQMARLKKQQEELEQMRLRYLAAEEKdtVKTERQELLDIRNELNRLRQQEQKQYQD 894
Cdd:COG3206 324 ALQAREASlqAQLAQLEARLAELPELEAELRRLERE--VEVARELYESLLQRLEEARLAEALTVGN 387
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
666-919 |
4.74e-05 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 47.35 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 666 RERESLVKKKVAEYTILEGK--LQKTLIDLEKRE-----QQLASVESELQREKKELqsERQRNLQELQDSIRRAKEDCIH 738
Cdd:TIGR00606 712 KSTESELKKKEKRRDEMLGLapGRQSIIDLKEKEipelrNKLQKVNRDIQRLKNDI--EEQETLLGTIMPEEESAKVCLT 789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 739 QVELERLKIKQLEEDKHRLQQQLndAENKYKILEKEFQQFKDQQNNKpeirlQSEINLLTlEKVELERKLESATKSKLHY 818
Cdd:TIGR00606 790 DVTIMERFQMELKDVERKIAQQA--AKLQGSDLDRTVQQVNQEKQEK-----QHELDTVV-SKIELNRKLIQDQQEQIQH 861
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 819 KQQWGRALK----ELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQD 894
Cdd:TIGR00606 862 LKSKTNELKseklQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941
|
250 260 270
....*....|....*....|....*....|.
gi 261245061 895 STEIASGKKDGPHG------SVLEEGLDDYL 919
Cdd:TIGR00606 942 KVNDIKEKVKNIHGymkdieNKIQDGKDDYL 972
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
658-929 |
5.04e-05 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 47.34 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 658 AEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESEL------------QREK-----KELQSERQR 720
Cdd:PRK02224 344 AESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIeelrerfgdapvDLGNaedflEELREERDE 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 721 ----------NLQELQDSIRRAK------------------------EDCIHQVELERLKIKQLEEDKHRLQQQLNDAEn 766
Cdd:PRK02224 424 lrereaeleaTLRTARERVEEAEalleagkcpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEERLERAE- 502
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 767 KYKILEKEFQQFKDQQNNKPEIRLQSEINL---------LTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQ 837
Cdd:PRK02224 503 DLVEAEDRIERLEERREDLEELIAERRETIeekreraeeLRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLA 582
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 838 EsqmarLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELN------------RLRQQEQKQYQDSTEIASGKKDg 905
Cdd:PRK02224 583 E-----LKERIESLERIRTLLAAIADAEDEIERLREKREALAELNderrerlaekreRKRELEAEFDEARIEEAREDKE- 656
|
330 340
....*....|....*....|....
gi 261245061 906 pHGSVLEEGLDDYLTRLIEERDTL 929
Cdd:PRK02224 657 -RAEEYLEQVEEKLDELREERDDL 679
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
648-931 |
5.68e-05 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 47.27 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 648 QKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQktlidLEKREQQLASVESELQREKKELQSERQRNLQELQD 727
Cdd:TIGR00618 552 TSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQN-----ITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQD 626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 728 SIRRAKEDCIHQVELErlkikQLEEDKHRLQQQLNDAENKYKILE-KEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER 806
Cdd:TIGR00618 627 LQDVRLHLQQCSQELA-----LKLTALHALQLTLTQERVREHALSiRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQ 701
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 807 K-------LESATKSKLHYKQQWGRALKELARLKQRE----------QESQMARLKKQQEELEQMRLRYLAAEEKDtvkT 869
Cdd:TIGR00618 702 CqtllrelETHIEEYDREFNEIENASSSLGSDLAAREdalnqslkelMHQARTVLKARTEAHFNNNEEVTAALQTG---A 778
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245061 870 ERQELldIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMR 931
Cdd:TIGR00618 779 ELSHL--AAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLE 838
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
628-887 |
5.80e-05 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 47.04 E-value: 5.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 628 ALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKlQKTLIDL----EKREQQLASV 703
Cdd:pfam15921 437 AMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS-ERTVSDLtaslQEKERAIEAT 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 704 ESELQRekkeLQSERQRNLQELQ------DSIRRAKEDCihqvelERLKIKQLEEDK--HRLQQQLndaENKYKILEKEF 775
Cdd:pfam15921 516 NAEITK----LRSRVDLKLQELQhlknegDHLRNVQTEC------EALKLQMAEKDKviEILRQQI---ENMTQLVGQHG 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 776 QQFKDQQNNKPEirLQSEINLLTLEKVELerklesatksklhykqqwgRALKELARLKQREQESQMARLkkqqeELEQMR 855
Cdd:pfam15921 583 RTAGAMQVEKAQ--LEKEINDRRLELQEF-------------------KILKDKKDAKIRELEARVSDL-----ELEKVK 636
|
250 260 270
....*....|....*....|....*....|..
gi 261245061 856 LRYLAAEEKDTVKTERQELLDIRNELNRLRQQ 887
Cdd:pfam15921 637 LVNAGSERLRAVKDIKQERDQLLNEVKTSRNE 668
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
696-863 |
6.77e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.87 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 696 REQQLASVESELQrEKKELQSERQRNLQELQdsirRAKEDcihqveLERLKIKQL--------EEDKHRLQQQLNDAENK 767
Cdd:PRK04863 784 REKRIEQLRAERE-ELAERYATLSFDVQKLQ----RLHQA------FSRFIGSHLavafeadpEAELRQLNRRRVELERA 852
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 768 YKILEKEFQQFKDQ-QNNKPEI----RLQSEINLL---TLEK--VELERKLESATKSKLhYKQQWGRALKELarlkqreq 837
Cdd:PRK04863 853 LADHESQEQQQRSQlEQAKEGLsalnRLLPRLNLLadeTLADrvEEIREQLDEAEEAKR-FVQQHGNALAQL-------- 923
|
170 180
....*....|....*....|....*.
gi 261245061 838 ESQMARLKKQQEELEQMRLRYLAAEE 863
Cdd:PRK04863 924 EPIVSVLQSDPEQFEQLKQDYQQAQQ 949
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
617-891 |
7.49e-05 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 46.71 E-value: 7.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 617 TEPRETLEYKAALELEMWKEMQED---IFENQLKQKELAHMQA---LAEEWKKRDRERESLVKKKVAeytiLEGKLQKTL 690
Cdd:pfam01576 315 TAAQQELRSKREQEVTELKKALEEetrSHEAQLQEMRQKHTQAleeLTEQLEQAKRNKANLEKAKQA----LESENAELQ 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 691 IDLekREQQLASVESELQREKKELQ----------SERQRnlQELQDSIRRAkedcihQVELERLK--IKQLEEDKHRLQ 758
Cdd:pfam01576 391 AEL--RTLQQAKQDSEHKRKKLEGQlqelqarlseSERQR--AELAEKLSKL------QSELESVSslLNEAEGKNIKLS 460
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 759 QQLNDAENKYKILEKEFQQFKDQQNNkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQE 838
Cdd:pfam01576 461 KDVSSLESQLQDTQELLQEETRQKLN-----LSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEE 535
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261245061 839 SQMA------RLKKQQEELEQMRLRY----LAAEEKDTVKTE-RQELLDIRNELNRLRQ----QEQKQ 891
Cdd:pfam01576 536 DAGTlealeeGKKRLQRELEALTQQLeekaAAYDKLEKTKNRlQQELDDLLVDLDHQRQlvsnLEKKQ 603
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
614-893 |
7.70e-05 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 46.74 E-value: 7.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 614 EIQTEPRETLEYKAALELEMwKEMQE--DIFENQLKQKE------LAHMQALAEEWKKRDRERESL---VKKKVAEYTIL 682
Cdd:pfam10174 458 QREREDRERLEELESLKKEN-KDLKEkvSALQPELTEKEsslidlKEHASSLASSGLKKDSKLKSLeiaVEQKKEECSKL 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 683 EGKLQKTlidlekreQQLASVEselqREKKELQSErqrnLQELQDSIRRAKEDCIH-QVELERL--KIKQLEEDKHrlqq 759
Cdd:pfam10174 537 ENQLKKA--------HNAEEAV----RTNPEINDR----IRLLEQEVARYKEESGKaQAEVERLlgILREVENEKN---- 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 760 qlnDAENKYKILEK-EFQQFKDQQNNKPEIR-LQSEINLLTLEKVELERKLESATKSKlHYKQQWGRALKELARLKQrEQ 837
Cdd:pfam10174 597 ---DKDKKIAELESlTLRQMKEQNKKVANIKhGQQEMKKKGAQLLEEARRREDNLADN-SQQLQLEELMGALEKTRQ-EL 671
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 838 ESQMARL---------------------KKQQEELEQMRLRYL--AAEEKDT-----------VKTERQELLDIRNELNR 883
Cdd:pfam10174 672 DATKARLsstqqslaekdghltnlraerRKQLEEILEMKQEALlaAISEKDAniallelssskKKKTQEEVMALKREKDR 751
|
330
....*....|
gi 261245061 884 LRQQEQKQYQ 893
Cdd:pfam10174 752 LVHQLKQQTQ 761
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
757-889 |
7.97e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 46.55 E-value: 7.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 757 LQQQLNDAENKYKILEKEFQQFKdQQNNkpEIRLQSEINLLTLEKVELERKLESAT------KSKLHY-KQQWGRALKEL 829
Cdd:COG3206 180 LEEQLPELRKELEEAEAALEEFR-QKNG--LVDLSEEAKLLLQQLSELESQLAEARaelaeaEARLAAlRAQLGSGPDAL 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261245061 830 ARLKQREQESQM-ARLKKQQEELEQMRLRYLAA--------EEKDTVKTERQE-----LLDIRNELNRLRQQEQ 889
Cdd:COG3206 257 PELLQSPVIQQLrAQLAELEAELAELSARYTPNhpdvialrAQIAALRAQLQQeaqriLASLEAELEALQAREA 330
|
|
| CEP63 |
pfam17045 |
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ... |
636-891 |
8.20e-05 |
|
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.
Pssm-ID: 465338 [Multi-domain] Cd Length: 264 Bit Score: 45.58 E-value: 8.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 636 EMQE-----DIFENQLKQKELAHMQALaeEWKKRDRERESLVKKKVAEYTILE-GKLQKTLIDLE--------KREQQLA 701
Cdd:pfam17045 7 ELQElmkqiDIMVAHKKSEWEGQTRAL--ETRLDIREEELLSARNTLERKHKEiGLLRQQLEELEkgkqelvaKYEQQLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 702 SVESELQREKKELQSERQRNLQELQDSIRRAKEDcihQVELERLKIKQ-------LEEDKHRL--QQQLNDAENKYKILE 772
Cdd:pfam17045 85 KLQEELSKLKRSYEKLQRKQLKEAREEAKSREED---RSELSRLNGKLeefrqksLEWEQQRLqyQQQVASLEAQRKALA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 773 KEFQQFK-----DQQNNKPEI--RLQSEINLLTlekveleRKLESATKSkLHykqqwgralkelarlkqreqesqmarlk 845
Cdd:pfam17045 162 EQSSLIQsaayqVQLEGRKQCleASQSEIQRLR-------SKLERAQDS-LC---------------------------- 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 846 kqQEELEQMRLRYLAAEEKDTVKT---ERQELLD-----------IRNELNRLRQQEQKQ 891
Cdd:pfam17045 206 --AQELELERLRMRVSELGDSNRKlleEQQRLLEelrmsqrqlqvLQNELMELKATLQSQ 263
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
620-899 |
9.22e-05 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 45.68 E-value: 9.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 620 RETLEYKAALELEMWKEMQEDIF-----ENQLKQKELAHMQALAEEWKKRDRERESlvkkkvaeytilegKLQKTLIDLE 694
Cdd:pfam13868 36 AEEKEEERRLDEMMEEERERALEeeeekEEERKEERKRYRQELEEQIEEREQKRQE--------------EYEEKLQERE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 695 KREQQLASVESELQREKKELQSERQRNLQELQDSIR---RAKEDCIHQVELERLKIKQLEEDKHRLQQQLnDAENKYKIL 771
Cdd:pfam13868 102 QMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEeqaEWKELEKEEEREEDERILEYLKEKAEREEER-EAEREEIEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 772 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELErklesatksklhYKQQWGRALKELARLKQREQESQMARLKKQQEEL 851
Cdd:pfam13868 181 EKEREIARLRAQQEKAQDEKAERDELRAKLYQEE------------QERKERQKEREEAEKKARQRQELQQAREEQIELK 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 261245061 852 EQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIA 899
Cdd:pfam13868 249 ERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELE 296
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
613-960 |
9.81e-05 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 46.26 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEyKAALELEMWKEMQEDIFEN------QLKQKELAHMQALAEEWK----------KRDRERESLvkkKV 676
Cdd:pfam15921 137 SQSQEDLRNQLQ-NTVHELEAAKCLKEDMLEDsntqieQLRKMMLSHEGVLQEIRSilvdfeeasgKKIYEHDSM---ST 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 677 AEYTILEGKLQKTLIDLEKR----EQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDciHQVELERLKIK---- 748
Cdd:pfam15921 213 MHFRSLGSAISKILRELDTEisylKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISE--HEVEITGLTEKassa 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 749 ---------QLE--EDKHRLQ-----QQLNDAENKYKILEKEFQQFKDQQNNKPEiRLQSEINLLTLEKVE--LERKLES 810
Cdd:pfam15921 291 rsqansiqsQLEiiQEQARNQnsmymRQLSDLESTVSQLRSELREAKRMYEDKIE-ELEKQLVLANSELTEarTERDQFS 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 811 ATKSKLHYKQQwgralKELARLKQREQEsqmARLKKQQEEleqmRLRYLAAEEKDTVKTERQELLDIRNELNRL------ 884
Cdd:pfam15921 370 QESGNLDDQLQ-----KLLADLHKREKE---LSLEKEQNK----RLWDRDTGNSITIDHLRRELDDRNMEVQRLeallka 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 885 -RQQEQKQYQDSTEIASGKKDGPHG----SVLEEGLDDYLTRLIEERdTLMRTGVYNHEdRIISELDRQIREILAKSNAS 959
Cdd:pfam15921 438 mKSECQGQMERQMAAIQGKNESLEKvsslTAQLESTKEMLRKVVEEL-TAKKMTLESSE-RTVSDLTASLQEKERAIEAT 515
|
.
gi 261245061 960 N 960
Cdd:pfam15921 516 N 516
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
657-850 |
1.14e-04 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 45.71 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 657 LAEEWKKRDRERESLVKKKVAEytiLEGKLQKtliDLEKREQQLASVESElQREKKELQSERQRNLQELQDSIRRAKEDC 736
Cdd:pfam15709 328 REQEKASRDRLRAERAEMRRLE---VERKRRE---QEEQRRLQQEQLERA-EKMREELELEQQRRFEEIRLRKQRLEEER 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 737 IHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQfKDQQNNKPEIRLQSEINLLTLEkvELERKLESATKSKL 816
Cdd:pfam15709 401 QRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQ-EEAERAEAEKQRQKELEMQLAE--EQKRLMEMAEEERL 477
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 261245061 817 HYKQQWGRAlKELARLK---QREQESQMARL-----KKQQEE 850
Cdd:pfam15709 478 EYQRQKQEA-EEKARLEaeeRRQKEEEAARLaleeaMKQAQE 518
|
|
| DUF4686 |
pfam15742 |
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ... |
626-808 |
1.37e-04 |
|
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.
Pssm-ID: 464838 [Multi-domain] Cd Length: 384 Bit Score: 45.44 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 626 KAALELEMwKEMQED-------IFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTI----LEGKLQKTLIDLE 694
Cdd:pfam15742 153 KKQLEERI-KEASENeaklkqqYQEEQQKRKLLDQNVNELQQQVRSLQDKEAQLEMTNSQQQLriqqQEAQLKQLENEKR 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 695 KREQQLASVE------SELQREKKELQSERQRNLQELQDSIR--------------RAKEDCIHQVELERLKIKQLEEDK 754
Cdd:pfam15742 232 KSDEHLKSNQelseklSSLQQEKEALQEELQQVLKQLDVHVRkynekhhhhkaklrRAKDRLVHEVEQRDERIKQLENEI 311
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 261245061 755 HRLQQQLNdaenkykiLEKEFQQFKDQQNNKpeirlqseinlLTLEKVELERKL 808
Cdd:pfam15742 312 GILQQQSE--------KEKAFQKQVTAQNEI-----------LLLEKRKLLEQL 346
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
612-925 |
1.61e-04 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 45.51 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 612 PSEIqtePRETLEYKAALELEMWKEMQED-------IFENQLKQKELAHMQALAEEWKKR-----DRERESLVKKKVAEY 679
Cdd:pfam07111 232 PPEV---HSQTWELERQELLDTMQHLQEDradlqatVELLQVRVQSLTHMLALQEEELTRkiqpsDSLEPEFPKKCRSLL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 680 TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQElQDSIRRAKEDCIHQVELERLKIKQL-------EE 752
Cdd:pfam07111 309 NRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQE-QAILQRALQDKAAEVEVERMSAKGLqmelsraQE 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 753 DKHRLQQQLNDAENKYKI-----------LEKEFQQFKDQQNNKPE--------IRLQSEINLLTLEKVELER-KLESAT 812
Cdd:pfam07111 388 ARRRQQQQTASAEEQLKFvvnamsstqiwLETTMTRVEQAVARIPSlsnrlsyaVRKVHTIKGLMARKVALAQlRQESCP 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 813 KSKL-------------HYKQQWGRALKEL---ARLKQreQESQMARlkkQQEELEQMRLRYLAAEEKDTVKTERQELLD 876
Cdd:pfam07111 468 PPPPappvdadlsleleQLREERNRLDAELqlsAHLIQ--QEVGRAR---EQGEAERQQLSEVAQQLEQELQRAQESLAS 542
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 261245061 877 IRNELNRLRQQEQKQYQDSTEIAS--GKKDGPHGSVLEEGLDDYLTRLIEE 925
Cdd:pfam07111 543 VGQQLEVARQGQQESTEEAASLRQelTQQQEIYGQALQEKVAEVETRLREQ 593
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
693-890 |
1.66e-04 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 45.23 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 LEKREQQLASVESELQREK---KELQSERQRNLQELQDSIRRAKEDCIH------QVELERLKiKQLEEDKHRLQQ-QLN 762
Cdd:pfam06160 181 LEKLEEETDALEELMEDIPplyEELKTELPDQLEELKEGYREMEEEGYAlehlnvDKEIQQLE-EQLEENLALLENlELD 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 763 DAENK-----------YKILEKEFQQFKDQQNNKPEIRlqSEINLLTLEKVELERKLEsatksklHYKQQWGRALKELAR 831
Cdd:pfam06160 260 EAEEAleeieeridqlYDLLEKEVDAKKYVEKNLPEIE--DYLEHAEEQNKELKEELE-------RVQQSYTLNENELER 330
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 832 lkQREQESQMARLKKQQEELEQ-----------MRLRYLAAEEKDTVKTERQEllDIRNELNRLRQQEQK 890
Cdd:pfam06160 331 --VRGLEKQLEELEKRYDEIVErleekevayseLQEELEEILEQLEEIEEEQE--EFKESLQSLRKDELE 396
|
|
| Granin |
pfam01271 |
Granin (chromogranin or secretogranin); |
613-916 |
1.74e-04 |
|
Granin (chromogranin or secretogranin);
Pssm-ID: 279595 [Multi-domain] Cd Length: 584 Bit Score: 45.41 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQ-ALAEEWKKRDRERESLVKKKVAEYTilegklQKTLI 691
Cdd:pfam01271 98 NEPGGHSRENQPYALQVEKEFKTDHSDDYETQQWEEEKLKHMRfPLRYEENSEEKHSEREGELSEVFEN------PRSQA 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 692 DLEKREQQLASVESElQREKKELQSERQRNLQELQDSIRRAKEdciHQVELERLKIKQlEEDKHRLQQQLNDAENKYKIL 771
Cdd:pfam01271 172 TLKKVFEEVSRLDTP-SKQKREKSDEREKSSQESGEDTYRQEN---IPQEDQVGPEDQ-EPSEEGEEDATQEEVKRSRPR 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 772 EKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQ--QE 849
Cdd:pfam01271 247 THHGRSLPDESSRGGQLGLEEEASEEEEEYGEESRGLSAVQTYLLRLVNARGRGRSEKRAERERSEESEEEELKRAspYE 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 850 ELEQMRLRYL--AAEEKDTVKTERQ-----------ELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLD 916
Cdd:pfam01271 327 ELEITANLQIppSEEERMLKKAGRSprgrvdeagalEALEALEEKRKLDLDHSRVFESSEDGAPRAPQGAWVEALRNYLS 406
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
672-844 |
2.17e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.14 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 672 VKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQS-ERQRNLQELQDSIRRAKE------DCIHQVELER 744
Cdd:COG4717 76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKlEKLLQLLPLYQELEALEAelaelpERLEELEERL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 745 LKIKQLEEDKHRLQQQLNDAENKykiLEKEFQQFkDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR 824
Cdd:COG4717 156 EELRELEEELEELEAELAELQEE---LEELLEQL-SLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
|
170 180
....*....|....*....|
gi 261245061 825 ALKELARLKQREQESQMARL 844
Cdd:COG4717 232 LENELEAAALEERLKEARLL 251
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
680-953 |
2.24e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 45.31 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 680 TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDkhrlqq 759
Cdd:COG1196 581 KIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGE------ 654
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 760 QLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQES 839
Cdd:COG1196 655 GGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAER 734
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 840 QMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRL------------RQQEQKQYqdsteiasgkkdgph 907
Cdd:COG1196 735 EELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALgpvnllaieeyeELEERYDF--------------- 799
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 261245061 908 gsvLEEGLDDyltrLIEERDTLMrtgvynhedRIISELDRQIREIL 953
Cdd:COG1196 800 ---LSEQRED----LEEARETLE---------EAIEEIDRETRERF 829
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
706-904 |
2.26e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 44.89 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 706 ELQREKKELQSER---QRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILE-------KEF 775
Cdd:pfam07888 38 ECLQERAELLQAQeaaNRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSasseelsEEK 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 776 QQFKDQQ-NNKPEIR-LQSEINLLTLEKVELERKLESATKsklhykqqwgRALKELARLKQREQESQMARLKKQQEELEQ 853
Cdd:pfam07888 118 DALLAQRaAHEARIReLEEDIKTLTQRVLERETELERMKE----------RAKKAGAQRKEEEAERKQLQAKLQQTEEEL 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 261245061 854 MRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKD 904
Cdd:pfam07888 188 RSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEE 238
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
697-897 |
2.44e-04 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 45.04 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 697 EQQLASVESELQREKKELQSERQRnLQELQDSIrrakedcihqvelerLKIKQLEEDKHRlqqQLNDAENKYKILEKEFQ 776
Cdd:PRK10929 108 EQEILQVSSQLLEKSRQAQQEQDR-AREISDSL---------------SQLPQQQTEARR---QLNEIERRLQTLGTPNT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 777 QFKDQQNnkpeIRLQSEINLLTLEKVELERKLESAtksklHYKQqwgralkELARLkqreqesQMARLKKQQEELEQmrl 856
Cdd:PRK10929 169 PLAQAQL----TALQAESAALKALVDELELAQLSA-----NNRQ-------ELARL-------RSELAKKRSQQLDA--- 222
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 261245061 857 rylaaeekdtvkterqELLDIRNELNRLRQQEQKQYQDSTE 897
Cdd:PRK10929 223 ----------------YLQALRNQLNSQRQREAERALESTE 247
|
|
| CCDC34 |
pfam13904 |
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ... |
642-786 |
2.48e-04 |
|
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.
Pssm-ID: 464032 [Multi-domain] Cd Length: 221 Bit Score: 43.54 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 642 FENQLKQKELAHMQ-ALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESElQREKKELQSERQR 720
Cdd:pfam13904 57 YENWLAAKQRQRQKeLQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAE-SASKSLAKPERKV 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 721 nlqeLQDSIRRAKEDCIhQVELERLKIKQLEEDKHRLQQQLNDAENKyKILEKEFQQFKDQQNNKP 786
Cdd:pfam13904 136 ----SQEEAKEVLQEWE-RKKLEQQQRKREEEQREQLKKEEEEQERK-QLAEKAWQKWMKNVKNKP 195
|
|
| PRK12705 |
PRK12705 |
hypothetical protein; Provisional |
693-883 |
2.62e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 237178 [Multi-domain] Cd Length: 508 Bit Score: 44.70 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 LEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEdkhRLQQQLNDAENKYKile 772
Cdd:PRK12705 25 LKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEE---RLVQKEEQLDARAE--- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 773 kefqqfkdqqnnkpeirlqsEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEElE 852
Cdd:PRK12705 99 --------------------KLDNLENQLEEREKALSARELELEELEKQLDNELYRVAGLTPEQARKLLLKLLDAELE-E 157
|
170 180 190
....*....|....*....|....*....|.
gi 261245061 853 QMRLRYLAAEEKDTVKTERQELLDIRNELNR 883
Cdd:PRK12705 158 EKAQRVKKIEEEADLEAERKAQNILAQAMQR 188
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
682-864 |
2.67e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.44 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 682 LEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEdcihqvELERLKiKQLEEDKHRLQQQL 761
Cdd:COG3883 21 KQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE-LEALQAEIDKLQA------EIAEAE-AEIEERREELGERA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 762 NDAenkYK----------ILE-KEFQQFKDQ---------QNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQ 821
Cdd:COG3883 93 RAL---YRsggsvsyldvLLGsESFSDFLDRlsalskiadADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA 169
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 261245061 822 wgraLKELARlKQREQESQMARLKKQQEELEQMRLRYLAAEEK 864
Cdd:COG3883 170 ----KAELEA-QQAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
576-929 |
3.29e-04 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 44.57 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 576 LEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPretlEYKAALELEMwKEMQEDIFENQLKQKELAHMQ 655
Cdd:TIGR00618 175 LDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYH----ERKQVLEKEL-KHLREALQQTQQSHAYLTQKR 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 656 ALAEEWKKRDRERESLVKKkVAEYTILEGKLQKTLIDLEKR----------------EQQLASVESELQREKKELQSERQ 719
Cdd:TIGR00618 250 EAQEEQLKKQQLLKQLRAR-IEELRAQEAVLEETQERINRArkaaplaahikavtqiEQQAQRIHTELQSKMRSRAKLLM 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 720 R---------NLQELQDSIRRAKEDCIH----------------QVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKE 774
Cdd:TIGR00618 329 KraahvkqqsSIEEQRRLLQTLHSQEIHirdahevatsireiscQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQRE 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 775 F--QQFKDQQNNKPEIRL---------------------QSEINLLTLEKVELE------RKLESATKSKLHYKQQWGRA 825
Cdd:TIGR00618 409 QatIDTRTSAFRDLQGQLahakkqqelqqryaelcaaaiTCTAQCEKLEKIHLQesaqslKEREQQLQTKEQIHLQETRK 488
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 826 LKELARLKQREQESQmARLKKQQEELEQ---------------MRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK 890
Cdd:TIGR00618 489 KAVVLARLLELQEEP-CPLCGSCIHPNParqdidnpgpltrrmQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQE 567
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 261245061 891 QYQDSTEIA----SGKKDGPHGSVLEEGLDDYLTRLIEERDTL 929
Cdd:TIGR00618 568 IQQSFSILTqcdnRSKEDIPNLQNITVRLQDLTEKLSEAEDML 610
|
|
| CCDC34 |
pfam13904 |
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ... |
687-863 |
3.45e-04 |
|
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.
Pssm-ID: 464032 [Multi-domain] Cd Length: 221 Bit Score: 43.15 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 687 QKTLIDLEKREQQLASVESELQREKKELQSERQRNLQElqdsirRAKEDcihqvelerlkikQLEEDKHRLqqqlndAEN 766
Cdd:pfam13904 41 ARKLEGLKLERQPLEAYENWLAAKQRQRQKELQAQKEE------REKEE-------------QEAELRKRL------AKE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 767 KYK--ILEKEFQQFKDQQNNKPeirlQSEINLLTLEKVELERKlESATKSKLHYKQQWgraLKELARLKQREQESQMARL 844
Cdd:pfam13904 96 KYQewLQRKARQQTKKREESHK----QKAAESASKSLAKPERK-VSQEEAKEVLQEWE---RKKLEQQQRKREEEQREQL 167
|
170
....*....|....*....
gi 261245061 845 KKQQEELEQMRLRYLAAEE 863
Cdd:pfam13904 168 KKEEEEQERKQLAEKAWQK 186
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
685-904 |
3.46e-04 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 44.63 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 685 KLQKTLIDLEKREQQLASVES---ELQREKKELQSERQRNLQELQDsirraKEDCIHQVELERLK-------IKQLEEDK 754
Cdd:TIGR04523 139 NIDKFLTEIKKKEKELEKLNNkynDLKKQKEELENELNLLEKEKLN-----IQKNIDKIKNKLLKlelllsnLKKKIQKN 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 755 HRLQQQLNDAENKYKILEKEFQQfkdqqnnkpeirLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQ 834
Cdd:TIGR04523 214 KSLESQISELKKQNNQLKDNIEK------------KQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK 281
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245061 835 R--EQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNrlrQQEQKQYQDSTEIASGKKD 904
Cdd:TIGR04523 282 KikELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQIS---QNNKIISQLNEQISQLKKE 350
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
613-774 |
3.86e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 44.67 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALElEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQktliD 692
Cdd:TIGR02169 301 AEIASLERSIAEKERELE-DAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELE----E 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 LEKREQQLASVESELQREKKELQSER---QRNLQELQDSIRRA------------------------KEDCIHQVELERL 745
Cdd:TIGR02169 376 VDKEFAETRDELKDYREKLEKLKREInelKRELDRLQEELQRLseeladlnaaiagieakineleeeKEDKALEIKKQEW 455
|
170 180
....*....|....*....|....*....
gi 261245061 746 KIKQLEEDKHRLQQQLNDAENKYKILEKE 774
Cdd:TIGR02169 456 KLEQLAADLSKYEQELYDLKEEYDRVEKE 484
|
|
| Lebercilin |
pfam15619 |
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ... |
744-897 |
5.21e-04 |
|
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Pssm-ID: 464776 [Multi-domain] Cd Length: 193 Bit Score: 42.20 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 744 RLKIKQLEEDKHRLQQQLNDAENKYKIL-------EKEFQQFKDQQNNKPEI--RLQSEINLLTLEKVELERKLESATKS 814
Cdd:pfam15619 10 LHKIKELQNELAELQSKLEELRKENRLLkrlqkrqEKALGKYEGTESELPQLiaRHNEEVRVLRERLRRLQEKERDLERK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 815 KLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKdTVKTERQ-ELLDirNELNRLRQQEQKQYQ 893
Cdd:pfam15619 90 LKEKEAELLRLRDQLKRLEKLSEDKNLAEREELQKKLEQLEAKLEDKDEK-IQDLERKlELEN--KSFRRQLAAEKKKHK 166
|
....
gi 261245061 894 DSTE 897
Cdd:pfam15619 167 EAQE 170
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
617-890 |
5.36e-04 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 44.01 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 617 TEPRETLEYKAAlELEMWKEMQEDiFENQLKQKELAH-------------MQALAEEWKKRDRERESLVKKKvaeytile 683
Cdd:pfam01576 1 TRQEEEMQAKEE-ELQKVKERQQK-AESELKELEKKHqqlceeknalqeqLQAETELCAEAEEMRARLAARK-------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 684 GKLQKTLIDLEKREQQLASVESELQREKKELQSerqrNLQELQDSIRrAKEDCIHQVELERL----KIKQLEEDKHRLQQ 759
Cdd:pfam01576 71 QELEEILHELESRLEEEEERSQQLQNEKKKMQQ----HIQDLEEQLD-EEEAARQKLQLEKVtteaKIKKLEEDILLLED 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 760 QLNDAENKYKILEKEFQQFKDQQNNKPE--IRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQR-- 835
Cdd:pfam01576 146 QNSKLSKERKLLEERISEFTSNLAEEEEkaKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQia 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261245061 836 EQESQMARLK----KQQEELE--QMRLRYLAAEEKDTVKTERQ---ELLDIRNELNRLRQQEQK 890
Cdd:pfam01576 226 ELQAQIAELRaqlaKKEEELQaaLARLEEETAQKNNALKKIREleaQISELQEDLESERAARNK 289
|
|
| MscS_porin |
pfam12795 |
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ... |
665-897 |
5.39e-04 |
|
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.
Pssm-ID: 432790 [Multi-domain] Cd Length: 238 Bit Score: 42.67 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 665 DRERESLVKKKVAEYtilegkLQKTLIDLEKRE---QQLASVESELQREKKELQsERQRNLQELQDSIRRAKedcihQVE 741
Cdd:pfam12795 7 KAKLDEAAKKKLLQD------LQQALSLLDKIDaskQRAAAYQKALDDAPAELR-ELRQELAALQAKAEAAP-----KEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 742 LERLKIKQLEedkhrlqQQLNDAENKYKILEKEFQQFKDQ---QNNKPEiRLQSEINLLTLEKVELERKLESATKSKlhy 818
Cdd:pfam12795 75 LASLSLEELE-------QRLLQTSAQLQELQNQLAQLNSQlieLQTRPE-RAQQQLSEARQRLQQIRNRLNGPAPPG--- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 819 kQQWGRALKELARLKQREQESQMARLKKQQE------ELEQMRLRYLAAEekdtVKTERQELLDIRNELNRLRQQEQKQY 892
Cdd:pfam12795 144 -EPLSEAQRWALQAELAALKAQIDMLEQELLsnnnrqDLLKARRDLLTLR----IQRLEQQLQALQELLNEKRLQEAEQA 218
|
....*
gi 261245061 893 QDSTE 897
Cdd:pfam12795 219 VAQTE 223
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
648-904 |
6.13e-04 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 43.10 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 648 QKELAHMQALAEEWKKRDRERESLvkkkvaEYTILEGKLQKTLIDLEKRE---QQLASVESELQREKKELQSERQRNLQE 724
Cdd:pfam15558 37 LRRRDQKRQETLERERRLLLQQSQ------EQWQAEKEQRKARLGREERRradRREKQVIEKESRWREQAEDQENQRQEK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 725 LQDSIRRAKEDCIHQVelERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLeKVEL 804
Cdd:pfam15558 111 LERARQEAEQRKQCQE--QRLKEKEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENNLSELLNHQAR-KVLV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 805 ERK-----------LE-SATKSKLHYKQQWGRALKEL-ARLKQREQESQMARLK-KQQEELEQMRLRYLAAEEK------ 864
Cdd:pfam15558 188 DCQakaeellrrlsLEqSLQRSQENYEQLVEERHRELrEKAQKEEEQFQRAKWRaEEKEEERQEHKEALAELADrkiqqa 267
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 261245061 865 -----DTVKTERQELLDIRNE------LNRLR-QQEQKQYQDSTEIASGKKD 904
Cdd:pfam15558 268 rqvahKTVQDKAQRARELNLEreknhhILKLKvEKEEKCHREGIKEAIKKKE 319
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
635-850 |
6.56e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 43.21 E-value: 6.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 635 KEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLasvESELQREKKEL 714
Cdd:COG4942 30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL---RAELEAQKEEL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 715 --------QSERQRNLQEL------QDSIRRAKEdcIHQVELERLK-IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFK 779
Cdd:COG4942 107 aellralyRLGRQPPLALLlspedfLDAVRRLQY--LKYLAPARREqAEELRADLAELAALRAELEAERAELEALLAELE 184
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261245061 780 DQQNnkpeiRLQSEINlltlEKVELERKLESATKSKlhykqqwgraLKELARLKQREQ--ESQMARLKKQQEE 850
Cdd:COG4942 185 EERA-----ALEALKA----ERQKLLARLEKELAEL----------AAELAELQQEAEelEALIARLEAEAAA 238
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
617-949 |
7.78e-04 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 43.67 E-value: 7.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 617 TEPRETLEYKAALE----LEMWKEMQEDIFENQLKQKELA--HMQALAEEW-------KKRDRERESLVKKKVAEYTIL- 682
Cdd:pfam12128 374 TAKYNRRRSKIKEQnnrdIAGIKDKLAKIREARDRQLAVAedDLQALESELreqleagKLEFNEEEYRLKSRLGELKLRl 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 683 -------EGKLQKTLIDL------EKREQQLASVESeLQREKKELQSERQRNLQELQDSIRRAKEdciHQVELERLKiKQ 749
Cdd:pfam12128 454 nqatatpELLLQLENFDErierarEEQEAANAEVER-LQSELRQARKRRDQASEALRQASRRLEE---RQSALDELE-LQ 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 750 LEEDKHRLQQQLND-----AENKYKILEKEFQQFKDQQnnkPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR 824
Cdd:pfam12128 529 LFPQAGTLLHFLRKeapdwEQSIGKVISPELLHRTDLD---PEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRER 605
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 825 ALK-----ELARLKQREQESQMARLKKQQEEL---------------------------EQMRLRYLAAEEKDTVKTERQ 872
Cdd:pfam12128 606 LDKaeealQSAREKQAAAEEQLVQANGELEKAsreetfartalknarldlrrlfdekqsEKDKKNKALAERKDSANERLN 685
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 873 ElLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLmRTGVYNHEDRIISELDRQI 949
Cdd:pfam12128 686 S-LEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAAR-RSGAKAELKALETWYKRDL 760
|
|
| Spc7 |
smart00787 |
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ... |
629-853 |
8.46e-04 |
|
Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.
Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 42.70 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 629 LELEMW--KEMQEDI-----FENQLKQKELAHMQALAEEWKKRDRERESLVKKK---VAEYTILEGK---------LQKT 689
Cdd:smart00787 65 LELYQFscKELKKYIsegrdLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQfqlVKTFARLEAKkmwyewrmkLLEG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 690 LIDlekreqQLASVESELQREKKELQSERQRnLQELQDSIRRAKEDCIHQVELERlkikQLEEDKHRLQQ-QLNDAENKY 768
Cdd:smart00787 145 LKE------GLDENLEGLKEDYKLLMKELEL-LNSIKPKLRDRKDALEEELRQLK----QLEDELEDCDPtELDRAKEKL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 769 KILEKEFQQFKDQQNNkpeirlqseinlLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREqESQMARLKKQQ 848
Cdd:smart00787 214 KKLLQEIMIKVKKLEE------------LEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFT-FKEIEKLKEQL 280
|
....*
gi 261245061 849 EELEQ 853
Cdd:smart00787 281 KLLQS 285
|
|
| BRE1 |
pfam08647 |
BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a ... |
648-765 |
1.67e-03 |
|
BRE1 E3 ubiquitin ligase; BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.
Pssm-ID: 462547 [Multi-domain] Cd Length: 95 Bit Score: 38.72 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 648 QKELAHMQAlaeEWKKRDrereSLVKKKVAEYTILEGKLQKTLIDLEKREQQLAsvesELQREKKELQSERqRNLQelqd 727
Cdd:pfam08647 2 QTELVKLEQ---AFEELS----EQLDKKVKDLTILEEKKLRLEAEKAKADQKYF----AAMRSKDALENEN-KKLN---- 65
|
90 100 110
....*....|....*....|....*....|....*...
gi 261245061 728 sirrakedciHQVELERLKIKQLEEDKHRLQQQLNDAE 765
Cdd:pfam08647 66 ----------TLLSKSSELIEQLKETEKEFVRKLKNLE 93
|
|
| COG2433 |
COG2433 |
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]; |
701-832 |
1.90e-03 |
|
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 42.15 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 701 ASVESELQREKKELQSERQRNLQELQDSIRRAKEDciHQVELERL--KIKQLEEDKHRLQQQLNDAENKYKILEKEFQQF 778
Cdd:COG2433 376 LSIEEALEELIEKELPEEEPEAEREKEHEERELTE--EEEEIRRLeeQVERLEAEVEELEAELEEKDERIERLERELSEA 453
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 779 KDQQNNkpEIRLQSEINLLTLEKVELERKLESA--TKSKLHYKQQwgrALKELARL 832
Cdd:COG2433 454 RSEERR--EIRKDREISRLDREIERLERELEEEreRIEELKRKLE---RLKELWKL 504
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
682-784 |
2.18e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 41.74 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 682 LEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQEL----QDSIRRAKE--DCIHQVELERLKIKQLEEDKH 755
Cdd:PRK00409 528 LERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAekeaQQAIKEAKKeaDEIIKELRQLQKGGYASVKAH 607
|
90 100
....*....|....*....|....*....
gi 261245061 756 RLQQQLNDAENKYKILEKEFQQFKDQQNN 784
Cdd:PRK00409 608 ELIEARKRLNKANEKKEKKKKKQKEKQEE 636
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
597-895 |
2.25e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 41.82 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 597 SAVQQKPSSLPPAPCPSEIQTEPRETLEyKAALELEMWKEMQEDIfeNQLKQK------ELAHMQALAEEWKKRDRE--R 668
Cdd:PRK11281 39 ADVQAQLDALNKQKLLEAEDKLVQQDLE-QTLALLDKIDRQKEET--EQLKQQlaqapaKLRQAQAELEALKDDNDEetR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 669 ESLVKKKVAEytiLEGKLQKTLIDLEKREQQLASVESEL--QREKKE-LQSERQRNLQELQdsirrakedcihqvELERL 745
Cdd:PRK11281 116 ETLSTLSLRQ---LESRLAQTLDQLQNAQNDLAEYNSQLvsLQTQPErAQAALYANSQRLQ--------------QIRNL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 746 KIKQLEEDK---HRLQQQLNdAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLEsatksklhykqqw 822
Cdd:PRK11281 179 LKGGKVGGKalrPSQRVLLQ-AEQALLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQ------------- 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261245061 823 grALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQ--KQYQDS 895
Cdd:PRK11281 245 --LLQEAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRLLKATEKLNTLTQQNLrvKNWLDR 317
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
658-899 |
2.27e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 658 AEEWKKRDRERESLVKKKVAEYTILEgklQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQElqdsIRRAKEDCI 737
Cdd:PTZ00121 1190 AEELRKAEDARKAEAARKAEEERKAE---EARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEE----IRKFEEARM 1262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 738 HQVELERLKIKQLEEDKhrlQQQLNDAENKYKilekefqqfKDQQNNKPEIRLQSEINlltlEKVELERKLESATKSKLH 817
Cdd:PTZ00121 1263 AHFARRQAAIKAEEARK---ADELKKAEEKKK---------ADEAKKAEEKKKADEAK----KKAEEAKKADEAKKKAEE 1326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 818 YKQQwGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTE 897
Cdd:PTZ00121 1327 AKKK-ADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKK 1405
|
..
gi 261245061 898 IA 899
Cdd:PTZ00121 1406 KA 1407
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
745-901 |
2.33e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.68 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 745 LKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDqqnnkpeirlqsEINLLTLEKVELERKLESATKSKLHYKQQWG- 823
Cdd:COG1579 17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKT------------ELEDLEKEIKRLELEIEEVEARIKKYEEQLGn 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 824 -RALKELARLkQREQESQMARLKK-QQEELEQM----RLRYLAAEEKDTVKTERQELLDIRNELN----RLRQQEQKQYQ 893
Cdd:COG1579 85 vRNNKEYEAL-QKEIESLKRRISDlEDEILELMerieELEEELAELEAELAELEAELEEKKAELDeelaELEAELEELEA 163
|
....*...
gi 261245061 894 DSTEIASG 901
Cdd:COG1579 164 EREELAAK 171
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
615-886 |
2.37e-03 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 41.96 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 615 IQTEPRETLEYKAALE-LEMWKEMQEDIfENQLKQKElAHMQALAEEWKKRDRERESLVK--KKVAEYTILEGKLQKTLI 691
Cdd:TIGR00606 195 RQTQGQKVQEHQMELKyLKQYKEKACEI-RDQITSKE-AQLESSREIVKSYENELDPLKNrlKEIEHNLSKIMKLDNEIK 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 692 DLEKREQQLASVESEL----------------------QREKKELQSERQRNLQELQDSIRRAKEDCIHQVELE-RLKIK 748
Cdd:TIGR00606 273 ALKSRKKQMEKDNSELelkmekvfqgtdeqlndlyhnhQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLvEQGRL 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 749 QLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRlqseiNLLTLEKVELERKLESATK------SKLHYKQQW 822
Cdd:TIGR00606 353 QLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK-----NFHTLVIERQEDEAKTAAQlcadlqSKERLKQEQ 427
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261245061 823 GRALKELARLKQREQESQMARLKKQQEELEQMR--LRYLAAEEKDTVKTErQELLDIRNELNRLRQ 886
Cdd:TIGR00606 428 ADEIRDEKKGLGRTIELKKEILEKKQEELKFVIkeLQQLEGSSDRILELD-QELRKAERELSKAEK 492
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
634-797 |
2.61e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 41.02 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 634 WKEMQEDIFE--NQLKQKELAHMQALAEEWKKrdrereslvKKKVAEyTILEGKLQKTLIDLEKREQQLASVESELQREK 711
Cdd:cd16269 147 YLEDREKLVEkyRQVPRKGVKAEEVLQEFLQS---------KEAEAE-AILQADQALTEKEKEIEAERAKAEAAEQERKL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 712 KElqsERQRNL-QELQDSIRRakedciHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNkpeiRL 790
Cdd:cd16269 217 LE---EQQRELeQKLEDQERS------YEEHLRQLKEKMEEERENLLKEQERALESKLKEQEALLEEGFKEQAE----LL 283
|
....*..
gi 261245061 791 QSEINLL 797
Cdd:cd16269 284 QEEIRSL 290
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
618-891 |
2.64e-03 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 41.75 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 618 EPRETLEYKAAL------ELEMWKEMQEDIFENQLKQKELaHMQALAEEWK-KRDRERESL------VKKKVAEYTILEG 684
Cdd:pfam12128 251 NTLESAELRLSHlhfgykSDETLIASRQEERQETSAELNQ-LLRTLDDQWKeKRDELNGELsaadaaVAKDRSELEALED 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 685 KLQKTL-IDLEKREQ---QLASVESEL--QREKKELQSERQRNLQELQDSiRRAKEDCIHQVELERLKiKQLEEDKHRLQ 758
Cdd:pfam12128 330 QHGAFLdADIETAAAdqeQLPSWQSELenLEERLKALTGKHQDVTAKYNR-RRSKIKEQNNRDIAGIK-DKLAKIREARD 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 759 QQLNDAENKYKILEKEFQQFKDQQNNkpEIRLQSEINLLTLEkvELERKLESATKSKlhykqqwgrALKElarlkqrEQE 838
Cdd:pfam12128 408 RQLAVAEDDLQALESELREQLEAGKL--EFNEEEYRLKSRLG--ELKLRLNQATATP---------ELLL-------QLE 467
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 261245061 839 SQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQ 891
Cdd:pfam12128 468 NFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQS 520
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
647-872 |
2.96e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 41.29 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 647 KQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQseRQRNLQELQ 726
Cdd:COG4717 296 EKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ--LEELEQEIA 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 727 DSIRRAKEDCIHQVeleRLKIKQLEEdKHRLQQQLNDAENKykiLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELER 806
Cdd:COG4717 374 ALLAEAGVEDEEEL---RAALEQAEE-YQELKEELEELEEQ---LEELLGELEELLEALDEEELEEELEELEEELEELEE 446
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261245061 807 KLESATKSKLHYKQQWgRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAA---EEKDTVKTERQ 872
Cdd:COG4717 447 ELEELREELAELEAEL-EQLEEDGELAELLQELEELKAELRELAEEWAALKLALElleEAREEYREERL 514
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
620-816 |
3.69e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.90 E-value: 3.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 620 RETLEYKAALELEMWKEMQEDIFENQLKQKELAhmQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLI------DL 693
Cdd:COG4942 57 LAALERRIAALARRIRALEQELAALEAELAELE--KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLspedflDA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 694 EKREQQLASVESELQREKKELQSERQRnLQELQDSIRRAKEdcihqvELERLKiKQLEEDKHRLQQQLNDAENKYKILEK 773
Cdd:COG4942 135 VRRLQYLKYLAPARREQAEELRADLAE-LAALRAELEAERA------ELEALL-AELEEERAALEALKAERQKLLARLEK 206
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 261245061 774 EFQQFKDQ--QNNKPEIRLQSEINLLTLEKVELERKLESATKSKL 816
Cdd:COG4942 207 ELAELAAElaELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
|
|
| CCCAP |
pfam15964 |
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ... |
685-880 |
4.38e-03 |
|
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.
Pssm-ID: 435040 [Multi-domain] Cd Length: 703 Bit Score: 41.04 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 685 KLQKTL-IDLEKREQQLASVESELQREKKELQ------SERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHR- 756
Cdd:pfam15964 371 RLEKELaSQQEKRAQEKEALRKEMKKEREELGatmlalSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDVTKv 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 757 ---LQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQsEINLLTLEKVELERKLESAtksklhyKQQWGRALKELAR-- 831
Cdd:pfam15964 451 cgeMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKDQ-EIEKLGLELSESKQRLEQA-------QQDAARAREECLKlt 522
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 261245061 832 --LKQREQESQMARLKK---QQEELEQMRLRYLAAEEKDTVKTERQELLDIRNE 880
Cdd:pfam15964 523 elLGESEHQLHLTRLEKesiQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHD 576
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
626-915 |
4.67e-03 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 40.80 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 626 KAALELEMWK------EMQEDIFEN-----QLKQKELAHMQalaEEWKKRDRERESLVKKKvAEYTILEGKLQ------- 687
Cdd:TIGR00606 285 NSELELKMEKvfqgtdEQLNDLYHNhqrtvREKERELVDCQ---RELEKLNKERRLLNQEK-TELLVEQGRLQlqadrhq 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 688 --KTLIDLEKREQQLasvESELQREKKELQSERQ-RNLQEL-----QDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQ 759
Cdd:TIGR00606 361 ehIRARDSLIQSLAT---RLELDGFERGPFSERQiKNFHTLvierqEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKG 437
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 760 QLNDAENKYKILEKEFQQFKDqqnnkpeirlqseinlltleKVELERKLESATKSKLHYKQQWGRALKELARL-KQREQE 838
Cdd:TIGR00606 438 LGRTIELKKEILEKKQEELKF--------------------VIKELQQLEGSSDRILELDQELRKAERELSKAeKNSLTE 497
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 839 SQMARLKKQQEE----LEQMRLRYLAAEEKDTVKTERQELLDI-RNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEE 913
Cdd:TIGR00606 498 TLKKEVKSLQNEkadlDRKLRKLDQEMEQLNHHTTTRTQMEMLtKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 577
|
..
gi 261245061 914 GL 915
Cdd:TIGR00606 578 WL 579
|
|
| HlpA |
COG2825 |
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ... |
654-740 |
4.69e-03 |
|
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442073 [Multi-domain] Cd Length: 171 Bit Score: 39.05 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 654 MQALAEEWKKRDRERESLVKKKVAEYTILEGKLQK-----TLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDS 728
Cdd:COG2825 41 GKAAQKKLEKEFKKRQAELQKLEKELQALQEKLQKeaatlSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQP 120
|
90
....*....|..
gi 261245061 729 IRRAKEDCIHQV 740
Cdd:COG2825 121 ILEKIQKAIKEV 132
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
651-956 |
4.74e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.10 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 651 LAHMQALAEEWKKRDRERESLV--KKKVAEYTILEGKLQktlIDLEKREQQLASV-ESELQREK----------KELQSE 717
Cdd:PRK04863 289 LELRRELYTSRRQLAAEQYRLVemARELAELNEAESDLE---QDYQAASDHLNLVqTALRQQEKieryqadleeLEERLE 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 718 RQRNLQELQDSirrakedcihQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLL 797
Cdd:PRK04863 366 EQNEVVEEADE----------QQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQLCGLPDL 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 798 TLEKV-----ELERKLESATKSKLHYKQ----------QWGRALKELARL-----------KQREQESQMARLKKQQEEL 851
Cdd:PRK04863 436 TADNAedwleEFQAKEQEATEELLSLEQklsvaqaahsQFEQAYQLVRKIagevsrseawdVARELLRRLREQRHLAEQL 515
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 852 EQMRLRyLAAEEKDTVKTERQELLdirneLNRLRQQEQKQYQDSTEIASGKKDgpHGSVLEEgLDDYLTRLIEERDTLmr 931
Cdd:PRK04863 516 QQLRMR-LSELEQRLRQQQRAERL-----LAEFCKRLGKNLDDEDELEQLQEE--LEARLES-LSESVSEARERRMAL-- 584
|
330 340
....*....|....*....|....*
gi 261245061 932 tgvynheDRIISELDRQIREILAKS 956
Cdd:PRK04863 585 -------RQQLEQLQARIQRLAARA 602
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
613-887 |
4.86e-03 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 40.88 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALEL--EMWKEMQEDIFENQLKQKELA-HMQALAE-EWKKRDRERESLVKKKVAEYTILEGKLQK 688
Cdd:pfam05557 125 LELQSTNSELEELQERLDLlkAKASEAEQLRQNLEKQQSSLAeAEQRIKElEFEIQSQEQDSEIVKNSKSELARIPELEK 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 689 TLIDLEKR--------------EQQLASVESELQREKK------ELQSERQRNLQELQDSIRRAKEDCIHQV--ELERLK 746
Cdd:pfam05557 205 ELERLREHnkhlnenienklllKEEVEDLKRKLEREEKyreeaaTLELEKEKLEQELQSWVKLAQDTGLNLRspEDLSRR 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 747 IKQLEEDKHRLQQQLNDAENKYKILEK---EFQQFKDQQNNKPE-------------IRLQSEINLLTLEKVELERKLES 810
Cdd:pfam05557 285 IEQLQQREIVLKEENSSLTSSARQLEKarrELEQELAQYLKKIEdlnkklkrhkalvRRLQRRVLLLTKERDGYRAILES 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 811 ATK--SKLHYKQQWGRALKELARLKQREQ---ESQMARLKKQQEELEQMRLRYLAAE-----------------EKDTVK 868
Cdd:pfam05557 365 YDKelTMSNYSPQLLERIEEAEDMTQKMQahnEEMEAQLSVAEEELGGYKQQAQTLErelqalrqqesladpsySKEEVD 444
|
330
....*....|....*....
gi 261245061 869 TERQELLDIRNELNRLRQQ 887
Cdd:pfam05557 445 SLRRKLETLELERQRLREQ 463
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
675-959 |
4.98e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 40.71 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 675 KVAEYTILEGKLQKTLIDLEKREQQLASVE--SELQREKKELQSERQRNLQELQDSIR---------------------- 730
Cdd:PRK04863 339 LVQTALRQQEKIERYQADLEELEERLEEQNevVEEADEQQEENEARAEAAEEEVDELKsqladyqqaldvqqtraiqyqq 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 731 ------RAKEDC------IHQVE--LERLKIKQLEEDKHRLQ--QQLNDAENKYKILEKEFQQFKdqqnnkpeiRLQSEI 794
Cdd:PRK04863 419 avqaleRAKQLCglpdltADNAEdwLEEFQAKEQEATEELLSleQKLSVAQAAHSQFEQAYQLVR---------KIAGEV 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 795 NLLTLEKV--ELERKLESAtKSKLHYKQQWGRALKELAR--LKQREQESQMARLKKQ--------------QEELEQMR- 855
Cdd:PRK04863 490 SRSEAWDVarELLRRLREQ-RHLAEQLQQLRMRLSELEQrlRQQQRAERLLAEFCKRlgknlddedeleqlQEELEARLe 568
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 856 -LRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQK--QYQDSTEiasgkKDGPH-GSVLE--EGLDDYLTRLIE-ERDT 928
Cdd:PRK04863 569 sLSESVSEARERRMALRQQLEQLQARIQRLAARAPAwlAAQDALA-----RLREQsGEEFEdsQDVTEYMQQLLErEREL 643
|
330 340 350
....*....|....*....|....*....|....
gi 261245061 929 LMrtgvynHEDRI---ISELDRQIREILAKSNAS 959
Cdd:PRK04863 644 TV------ERDELaarKQALDEEIERLSQPGGSE 671
|
|
| GAS |
pfam13851 |
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ... |
659-764 |
5.01e-03 |
|
Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.
Pssm-ID: 464001 [Multi-domain] Cd Length: 200 Bit Score: 39.12 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 659 EEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLAsvesELQREKKELQSERQRnLQELQDSIRRAKEDciH 738
Cdd:pfam13851 36 AELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLE----NYEKDKQSLKNLKAR-LKVLEKELKDLKWE--H 108
|
90 100
....*....|....*....|....*.
gi 261245061 739 QVELERLkiKQLEEDKHRLQQQLNDA 764
Cdd:pfam13851 109 EVLEQRF--EKVERERDELYDKFEAA 132
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
635-907 |
5.24e-03 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 40.83 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 635 KEMQEDIFENQLKQKELAHMQALAEEWK-KRDRERESLVKKKVAEYtilegKLQKTLIDLEKreqqlasveSELQREKKE 713
Cdd:COG5022 810 KEYRSYLACIIKLQKTIKREKKLRETEEvEFSLKAEVLIQKFGRSL-----KAKKRFSLLKK---------ETIYLQSAQ 875
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 714 LQSERQRNLQELQDSIRRAKEDCIHQVELERLKI---KQLEEDkhrLQQQLNDAENKYKILEK-------EFQQFKDQQN 783
Cdd:COG5022 876 RVELAERQLQELKIDVKSISSLKLVNLELESEIIelkKSLSSD---LIENLEFKTELIARLKKllnnidlEEGPSIEYVK 952
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 784 NKPEIRLQSEINLLTLEKVELERKLESATKSKLHYK------QQWGRALKELARLKQREQESqmarlKKQQEELEQMRLR 857
Cdd:COG5022 953 LPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNkanselKNFKKELAELSKQYGALQES-----TKQLKELPVEVAE 1027
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 261245061 858 YLAAEEKD-TVKTERQELLDIRnELNRLRQQEQKQYQDSTEIASGKKDGPH 907
Cdd:COG5022 1028 LQSASKIIsSESTELSILKPLQ-KLKGLLLLENNQLQARYKALKLRRENSL 1077
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
673-887 |
5.33e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 40.52 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 673 KKKVAEYTILEGKLQKTLIDLEKREQQ----LASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqveleRLKIK 748
Cdd:COG4717 296 EKASLGKEAEELQALPALEELEEEELEellaALGLPPDLSPEELLELLDRIEELQELLREAEELEE---------ELQLE 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 749 QLEEDKHRLQQQLN-DAENKYKILEKEFQQFKDQQNNKPEIRLQseinlLTLEKVELERKLESATKSKLhyKQQWGRALK 827
Cdd:COG4717 367 ELEQEIAALLAEAGvEDEEELRAALEQAEEYQELKEELEELEEQ-----LEELLGELEELLEALDEEEL--EEELEELEE 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 828 ELARLkQREQESQMARLKKQQEELEQMrlrylaaEEKDTVKTERQELLDIRNELNRLRQQ 887
Cdd:COG4717 440 ELEEL-EEELEELREELAELEAELEQL-------EEDGELAELLQELEELKAELRELAEE 491
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
620-951 |
5.45e-03 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 40.79 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 620 RETLEyKAALELEMWKEMQEDIFEnqLKQkELAHMQALAEEwkkRDRERESLvKKKVAEytilegkLQKTLIDLEKREQQ 699
Cdd:PRK02224 233 RETRD-EADEVLEEHEERREELET--LEA-EIEDLRETIAE---TEREREEL-AEEVRD-------LRERLEELEEERDD 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 700 LASvESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFqqfk 779
Cdd:PRK02224 298 LLA-EAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESEL---- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 780 dqQNNKPEIRLQSEinlltlEKVELERKLESATKSKLHYKQQWGRA-------LKELARLKQREQESQmARLKKQQEELE 852
Cdd:PRK02224 373 --EEAREAVEDRRE------EIEELEEEIEELRERFGDAPVDLGNAedfleelREERDELREREAELE-ATLRTARERVE 443
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 853 QMRlRYLAA-------------EEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDyL 919
Cdd:PRK02224 444 EAE-ALLEAgkcpecgqpvegsPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERRED-L 521
|
330 340 350
....*....|....*....|....*....|..
gi 261245061 920 TRLIEERdtlmRTGVYNHEDRiISELDRQIRE 951
Cdd:PRK02224 522 EELIAER----RETIEEKRER-AEELRERAAE 548
|
|
| F-BAR_PACSIN |
cd07655 |
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein ... |
713-891 |
6.38e-03 |
|
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins, also called Synaptic dynamin-associated proteins (Syndapins), act as regulators of cytoskeletal and membrane dynamics. They bind both dynamin and Wiskott-Aldrich syndrome protein (WASP), and may provide direct links between the actin cytoskeletal machinery through WASP and dynamin-dependent endocytosis. Vetebrates harbor three isoforms with distinct expression patterns and specific functions. PACSINs contain an N-terminal F-BAR domain and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Pssm-ID: 153339 [Multi-domain] Cd Length: 258 Bit Score: 39.60 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 713 ELQSERQRNLQ-ELQDSIRRAKEDCIHQVELERLK-IKQLEEDKHRLQQQ-------LNDAENKYKILEKEFQQFKDQQN 783
Cdd:cd07655 78 ELHLSIRDKLLnDVVEEVKTWQKENYHKSMMGGFKeTKEAEDGFAKAQKPwakllkkVEKAKKAYHAACKAEKSAQKQEN 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 784 NKpeirlQSEINLLTlEKV-ELERKLESATKSKLHYKQQWGRALKELARLKQREQESqMARLKKQQEELEQMRLRYLaae 862
Cdd:cd07655 158 NA-----KSDTSLSP-DQVkKLQDKVEKCKQEVSKTKDKYEKALEDLNKYNPRYMED-MEQVFDKCQEFEEKRLDFF--- 227
|
170 180
....*....|....*....|....*....
gi 261245061 863 ekdtvkteRQELLDIRNELNRLRQQEQKQ 891
Cdd:cd07655 228 --------KEILLSYHRHLDLSTNPSFKA 248
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
654-806 |
6.77e-03 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 39.79 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 654 MQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAK 733
Cdd:pfam15905 154 MSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSC 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 734 EdcIHQVELERLKIKQLEED------------------KHRLQQQLNDAENKYKILEKEFQQfKDQQNNKPEIRLQSEIN 795
Cdd:pfam15905 234 V--SEQVEKYKLDIAQLEELlkekndeieslkqsleekEQELSKQIKDLNEKCKLLESEKEE-LLREYEEKEQTLNAELE 310
|
170
....*....|.
gi 261245061 796 LLTlEKVELER 806
Cdd:pfam15905 311 ELK-EKLTLEE 320
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
613-893 |
7.02e-03 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 39.88 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 613 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEwKKRDRERESLVKKKVAEYTILEGKLQKtlid 692
Cdd:pfam07888 80 SRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAH-EARIRELEEDIKTLTQRVLERETELER---- 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 693 LEKREQQLASVESELQREKKELQS------------------------ERQRNLQELQDSIRR--AKEDCIHQVELErlk 746
Cdd:pfam07888 155 MKERAKKAGAQRKEEEAERKQLQAklqqteeelrslskefqelrnslaQRDTQVLQLQDTITTltQKLTTAHRKEAE--- 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 747 IKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNnkpeiRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGR-- 824
Cdd:pfam07888 232 NEALLEELRSLQERLNASERKVEGLGEELSSMAAQRD-----RTQAELHQARLQAAQLTLQLADASLALREGRARWAQer 306
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261245061 825 ------ALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDT----VKTERQELLDIRNELnRLRQQEQKQYQ 893
Cdd:pfam07888 307 etlqqsAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCnrvqLSESRRELQELKASL-RVAQKEKEQLQ 384
|
|
| COG5644 |
COG5644 |
U3 small nucleolar RNA-associated protein 14 [Function unknown]; |
602-917 |
7.88e-03 |
|
U3 small nucleolar RNA-associated protein 14 [Function unknown];
Pssm-ID: 227931 [Multi-domain] Cd Length: 869 Bit Score: 40.07 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 602 KPSSLPPAPCPSEIQTEPRETLEYKaaleleMWKEMQEDIFENQ---LKQKELAHMQALAEEWKKRDRE---------RE 669
Cdd:COG5644 315 ETARPVPSNNGLASSFEPRTESERK------MHQALLDAGLENEsalKKQEELALNKLSVEEVAERTRQlrfmrelmfRE 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 670 SLVKKKVAEytILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEdcihqvELERLkiKQ 749
Cdd:COG5644 389 ERKAKRVAK--IKSKTYRKIRKNRKEKEMALIPKSEDLENEKSEEARALERMTQRHKNTSSWTRK------MLERA--SH 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 750 LEEDKHRLQQQLNDAEN-KYKILEKEFQQFKDqqnnkpeIRLQSEINLLTLEKVELERKlesATKSKLHYKQQWGRALKE 828
Cdd:COG5644 459 GEGTREAVNEQIRKGDElMQRIHGKEIMDGED-------VSEFSDSDYDTNEQVSTAFE---KIRNEEELKGVLGMKFMR 528
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 829 LARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTV--KTERQELLDIRNELNRL--RQQEQKQYQDST-------E 897
Cdd:COG5644 529 DASNRQMAASKISVADLVKVENGDDIDVGELDEVGGDAIyaNAGRREVFPVVEQRRKLapRKRKEDFVTPSTsleksmdR 608
|
330 340
....*....|....*....|
gi 261245061 898 IASGKKDGPHGSVLEEGLDD 917
Cdd:COG5644 609 ILHGQKKRAEGAVVFEKPLE 628
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
642-960 |
8.29e-03 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 40.09 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 642 FENQLKQKE-LAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVEselqrEKKELQSERQR 720
Cdd:pfam05483 211 LEMHFKLKEdHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-----EKTKLQDENLK 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 721 NLQELQDSIRRAKEDCIHQVELERLKIKQLEED---------------------------KHRL---------------- 757
Cdd:pfam05483 286 ELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDlqiatkticqlteekeaqmeelnkakaAHSFvvtefeattcsleell 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 758 ---QQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKV-------------------------------- 802
Cdd:pfam05483 366 rteQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKIlaedeklldekkqfekiaeelkgkeqelifll 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 803 --------ELERKLESATKSKLHYKQQWGRALKEL--ARLKQREQESQMARLKKQQEELEQ----MRLRyLAAEEKDTVK 868
Cdd:pfam05483 446 qarekeihDLEIQLTAIKTSEEHYLKEVEDLKTELekEKLKNIELTAHCDKLLLENKELTQeasdMTLE-LKKHQEDIIN 524
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 869 TERQE-------------LLDIRNELNRLRqQEQKQYQDSTEIASGKKDGPHGSVLEEGL-DDYLTRLIEERDTLMRTGV 934
Cdd:pfam05483 525 CKKQEermlkqienleekEMNLRDELESVR-EEFIQKGDEVKCKLDKSEENARSIEYEVLkKEKQMKILENKCNNLKKQI 603
|
410 420
....*....|....*....|....*.
gi 261245061 935 YNhEDRIISELDRQIREILAKSNASN 960
Cdd:pfam05483 604 EN-KNKNIEELHQENKALKKKGSAEN 628
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
706-887 |
8.69e-03 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 39.12 E-value: 8.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 706 ELQREKKELQSERQRNLQELQDSIRRAKEdcihqvelERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNk 785
Cdd:COG1340 12 ELEEKIEELREEIEELKEKRDELNEELKE--------LAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDE- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 786 peirLQSEINLLTLEKVELERKLESATKSKLHYKQqwgrALKELARLKQREQES------------QMARLKKQQEELEQ 853
Cdd:COG1340 83 ----LNEKLNELREELDELRKELAELNKAGGSIDK----LRKEIERLEWRQQTEvlspeeekelveKIKELEKELEKAKK 154
|
170 180 190
....*....|....*....|....*....|....
gi 261245061 854 MRlrylaaEEKDTVKTERQELLDIRNELNRLRQQ 887
Cdd:COG1340 155 AL------EKNEKLKELRAELKELRKEAEEIHKK 182
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
652-910 |
8.95e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 39.43 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 652 AHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESE---LQREKKELQSERQRNLQELQDS 728
Cdd:COG3883 12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEidkLQAEIAEAEAEIEERREELGER 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 729 IRRAKEDCIHQVELERL--------------KIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQqnnkpeirLQSEI 794
Cdd:COG3883 92 ARALYRSGGSVSYLDVLlgsesfsdfldrlsALSKIADADADLLEELKADKAELEAKKAELEAKLAE--------LEALK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 795 NLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQEL 874
Cdd:COG3883 164 AELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
|
250 260 270
....*....|....*....|....*....|....*.
gi 261245061 875 LDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSV 910
Cdd:COG3883 244 ASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGAAAA 279
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
676-887 |
9.02e-03 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 39.88 E-value: 9.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 676 VAEYTILEGKLQKTLIDLEKREQQLA---SVESELQREKKELQSERQ-------------RNLQELQDSIRRAKEDC--- 736
Cdd:PRK01156 182 ISNIDYLEEKLKSSNLELENIKKQIAddeKSHSITLKEIERLSIEYNnamddynnlksalNELSSLEDMKNRYESEIkta 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 737 ---IHQVELERLKIKQLEEdkhRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEI--RLQSEINlltlEKVELERKLESA 811
Cdd:PRK01156 262 esdLSMELEKNNYYKELEE---RHMKIINDPVYKNRNYINDYFKYKNDIENKKQIlsNIDAEIN----KYHAIIKKLSVL 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 812 TKSKLHY---KQQWGRALKELARLKQREQESQMA-------RLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNEL 881
Cdd:PRK01156 335 QKDYNDYikkKSRYDDLNNQILELEGYEMDYNSYlksieslKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEI 414
|
....*.
gi 261245061 882 NRLRQQ 887
Cdd:PRK01156 415 NVKLQD 420
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
627-856 |
9.99e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 39.94 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 627 AALELEMWKEMQEDIFENQLkqkELAHMQALAEEWKKRDRERESLVKKKVAEYTILEG-----KLQKTLIDLEKREQQLA 701
Cdd:COG3096 439 AEDYLAAFRAKEQQATEEVL---ELEQKLSVADAARRQFEKAYELVCKIAGEVERSQAwqtarELLRRYRSQQALAQRLQ 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245061 702 SVESELQREKKELqsERQRNLQELQDSI-RRAKEDCIHQVELERLKiKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKD 780
Cdd:COG3096 516 QLRAQLAELEQRL--RQQQNAERLLEEFcQRIGQQLDAAEELEELL-AELEAQLEELEEQAAEAVEQRSELRQQLEQLRA 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261245061 781 QQNnkpEIRLQSEINLLTLEKVElerKLESATKSKLHYKQQWGRALKELA-RLKQREQESQMARLKKQQEELEQMRL 856
Cdd:COG3096 593 RIK---ELAARAPAWLAAQDALE---RLREQSGEALADSQEVTAAMQQLLeREREATVERDELAARKQALESQIERL 663
|
|
| |
