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Conserved domains on  [gi|261337185|ref|NP_001159740|]
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WD repeat-containing protein 82 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 5.48e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 5.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  12 RVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  92 LSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 170 MVKLYDLRSFDkgPFATFKLQYERTcewTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 261337185 250 DSQFIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 5.48e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 5.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  12 RVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  92 LSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 170 MVKLYDLRSFDkgPFATFKLQYERTcewTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 261337185 250 DSQFIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-300 1.34e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 1.34e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  15 KVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSL 94
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  95 HDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAAGVNSEMVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 173 LYDLRSFdkGPFATFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTPDSQ 252
Cdd:cd00200  161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG---VNSVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 261337185 253 FIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASA 300
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 20-301 6.81e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 6.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  20 NSDKINC-FDFSSNGETVISSSDDDSIVLYDCQE-GKPKRTLY------SKKYGVDLIRYTHAANTVVYSSNkIDDTIRY 91
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESiIKDGRDIHypvvelASRSKLSGICWNSYIKSQVASSN-FEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  92 LSLHDNKYIRYFPGHNKRVVALSMSPVDDTFI-SGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPE--GLIFAAGVNS 168
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSesGRSLAFGSAD 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 169 EMVKLYDLRSfDKGPFATFkLQYERTCEWtgLKFSNDGKLILVSTNGgTLRVLD------AFKGAVLHSFGGYNNSKGVI 242
Cdd:PLN00181 640 HKVYYYDLRN-PKLPLCTM-IGHSKTVSY--VRFVDSSTLVSSSTDN-TLKLWDlsmsisGINETPLHSFMGHTNVKNFV 714

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261337185 243 leaSFTPDSQFIMIGSEDGKIHVWNAESGMKVALLDGKHTGPVTCLQFNPKFMTFASAC 301
Cdd:PLN00181 715 ---GLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVDDASQFISSVC 770
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 5.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.49e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 261337185    96 DNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-135 8.10e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 8.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 261337185   97 NKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-302 5.48e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 5.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  12 RVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRY 91
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  92 LSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSE 169
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLLASGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 170 MVKLYDLRSFDkgPFATFKLQYERTcewTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTP 249
Cdd:COG2319  269 TVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---VRSVAFSP 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 261337185 250 DSQFIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACS 302
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-300 1.34e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 1.34e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  15 KVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSL 94
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  95 HDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAAGVNSEMVK 172
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 173 LYDLRSFdkGPFATFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTPDSQ 252
Cdd:cd00200  161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG---VNSVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 261337185 253 FIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASA 300
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
8-303 8.91e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 8.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185   8 LRSFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA--DG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  88 TIRYLSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSvaFSPDGKLLASG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 166 VNSEMVKLYDLRSfdKGPFATFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNnskGVILEA 245
Cdd:COG2319  223 SADGTVRLWDLAT--GKLLRTLT---GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS---GGVNSV 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 261337185 246 SFTPDSQFIMIGSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACSN 303
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD 351
WD40 COG2319
WD40 repeat [General function prediction only];
8-270 1.95e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 1.95e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185   8 LRSFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA--DG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  88 TIRYLSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAG 165
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSvaFSPDGKLLASG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 166 VNSEMVKLYDLRSFDkgPFATFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEA 245
Cdd:COG2319  307 SDDGTVRLWDLATGK--LLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---VTSV 378

                        250       260
                 ....*....|....*....|....*
gi 261337185 246 SFTPDSQFIMIGSEDGKIHVWNAES 270
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
28-303 4.88e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 4.88e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  28 DFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDDTIRYLSLHDNKYIRYFPGHN 107
Cdd:COG2319   43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 108 KRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEGLIFAAGVNSEMVKLYDLRSFDkgPFA 185
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSvaFSPDGKLLASGSDDGTVRLWDLATGK--LLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 186 TFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTPDSQFIMIGSEDGKIHV 265
Cdd:COG2319  199 TLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS---VRSVAFSPDGRLLASGSADGTVRL 272

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 261337185 266 WNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACSN 303
Cdd:COG2319  273 WDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDD 309
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-308 1.46e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 1.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 100 IRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLM--HLQGKPVCSFDPEG-LIFAAGVNSeMVKLYDL 176
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgHTGPVRDVAASADGtYLASGSSDK-TIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 177 RSFDKgpFATFKlqyERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASFTPDSQFIMI 256
Cdd:cd00200   81 ETGEC--VRTLT---GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 261337185 257 GSEDGKIHVWNAESGMKVALLDGkHTGPVTCLQFNPKFMTFASACSNMAFWL 308
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-267 1.06e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185   8 LRSFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNkiDD 87
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ--DG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  88 TIRYLSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSfdpeglifaagvn 167
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS------------- 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 168 semvklydlrsfdkgpfatfklqyertcewtgLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSkgvILEASF 247
Cdd:cd00200  225 --------------------------------VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS---VTSLAW 269

                        250       260
                 ....*....|....*....|
gi 261337185 248 TPDSQFIMIGSEDGKIHVWN 267
Cdd:cd00200  270 SPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 20-301 6.81e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 6.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  20 NSDKINC-FDFSSNGETVISSSDDDSIVLYDCQE-GKPKRTLY------SKKYGVDLIRYTHAANTVVYSSNkIDDTIRY 91
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESiIKDGRDIHypvvelASRSKLSGICWNSYIKSQVASSN-FEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  92 LSLHDNKYIRYFPGHNKRVVALSMSPVDDTFI-SGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPE--GLIFAAGVNS 168
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSesGRSLAFGSAD 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185 169 EMVKLYDLRSfDKGPFATFkLQYERTCEWtgLKFSNDGKLILVSTNGgTLRVLD------AFKGAVLHSFGGYNNSKGVI 242
Cdd:PLN00181 640 HKVYYYDLRN-PKLPLCTM-IGHSKTVSY--VRFVDSSTLVSSSTDN-TLKLWDlsmsisGINETPLHSFMGHTNVKNFV 714

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261337185 243 leaSFTPDSQFIMIGSEDGKIHVWNAESGMKVALLDGKHTGPVTCLQFNPKFMTFASAC 301
Cdd:PLN00181 715 ---GLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVDDASQFISSVC 770
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-135 5.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.49e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 261337185    96 DNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-135 8.10e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 8.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 261337185   97 NKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKTIRLWD 135
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 198-294 1.53e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.57  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261337185  198 TGLKFSNDGKLILVSTNGGTLRVLDAFKGA---VLHSfgGYNNSkgvILEASFTPDSQFI----MIGSEDGKIHVWNAES 270
Cdd:COG4946   392 FNPVWSPDGKKIAFTDNRGRLWVVDLASGKvrkVDTD--GYGDG---ISDLAWSPDSKWLayskPGPNQLSQIFLYDVET 466

                          90       100
                  ....*....|....*....|....
gi 261337185  271 GMKVALLDGKHTGpvtclqFNPKF 294
Cdd:COG4946   467 GKTVQLTDGRYDD------GSPAF 484
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-232 4.35e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 4.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 261337185  192 ERTCEWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSF 232
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-49 3.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 261337185    10 SFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYD 49
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
15-49 5.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 261337185   15 KVFRENSDKINCFDFSSNGETVISSSDDDSIVLYD 49
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-267 5.51e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 261337185   225 KGAVLHSFGGYNNSkgvILEASFTPDSQFIMIGSEDGKIHVWN 267
Cdd:smart00320   1 SGELLKTLKGHTGP---VTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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