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Conserved domains on  [gi|261490803|ref|NP_001159795|]
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PKHD1 like 1, tandem duplicate 2 isoform 2 precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2141-2259 1.25e-42

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 153.15  E-value: 1.25e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  2141 TWGGLSPPEEGMMVVITAGQTILLDTSTPVLKMLLIQgGRLIF-DEADIELQAENILITdGGALQIGTEQMPFQHKAIIT 2219
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 261490803  2220 LHG--HLRSQELPVYGTKTLGVRQ-GVLDLHGIPVPVPWTRLS 2259
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3003-3131 2.90e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.48  E-value: 2.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3003 NNFNVPQEGSDVIIPADVWMVVDVVVPSLNKLKIAGVLEIPDTNNdtsimqynnVVLNATYISIQGGRLIAGWPNEPFRG 3082
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKN---------ITLRARYILVQGGRLIIGSEDCPFQG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 261490803  3083 QLQIILRGShttPDWLLPYGTNQGSKVLGV--FGSLDLYGMPHNVYHTKLA 3131
Cdd:pfam10162   74 KATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2047-2134 3.03e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGSGFSSNFSEIGVTIAGSVCDIQSANETQIICVTNAGPKSQETQVRVQQGNRGIARM- 2125
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARv 80

                          90
                  ....*....|
gi 261490803 2126 -DNASFFYID 2134
Cdd:cd00603    81 lSNTTFTYVE 90
Cupredoxin super family cl19115
Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in ...
 1359-1461 3.08e-16

Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. The majority of family members contain multiple cupredoxin domain repeats: ceruloplasmin and the coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase, and the periplasmic domain of cytochrome c oxidase subunit II.


The actual alignment was detected with superfamily member cd04217:

Pssm-ID: 473140 [Multi-domain]  Cd Length: 86  Bit Score: 76.44  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1359 SDNELEVYGQGYAWSPSALITSVGDTVVWRWDAPAfvpglGYRVFSVSNPSSTDYDGISFSsgdrqtakGFFAYRFTSPG 1438
Cdd:cd04217     2 NAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQTLYYG--------KAFSYTFTEPG 68

                          90       100
                  ....*....|....*....|...
gi 261490803 1439 VYYYSSGYIDSanektLQGVVTV 1461
Cdd:cd04217    69 TYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1052-1135 9.86e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGFDGG--NVTVKTGDVECSILQVT-TSITCQVGPA-SAGVQPVSLSFSVLGN-ARY 1126
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSsTEIVCRTPAAaTPGEGPVEVTVDGANVsARV 80


                  ....*....
gi 261490803 1127 QNNTSFNFT 1135
Cdd:cd00603    81 LSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1871-1952 1.27e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGEHAGGTFPVMFNHQVKGYALTQS 1948
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 261490803  1949 VFKY 1952
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1790-1865 4.75e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1790 SINPTSGSIAGGTPLLITGNGF--VAGNTTVKLGNSLCKILDVTADTVRCLTPPRA---EGQVQVNIKVFDVVYP---PQ 1861
Cdd:cd00603     5 SISPSSGPLSGGTRLTITGSNLgsGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARvlsNT 84


                  ....
gi 261490803 1862 NFNY 1865
Cdd:cd00603    85 TFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1225-1296 8.38e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 8.38e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261490803  1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVANQG 1296
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGG 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 264-319 9.40e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 9.40e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803  264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTP 319
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTP 57
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1140-1217 1.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.24  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSGYGFSN---NIDVIIGSQPCNIVEVELFQLRCIVPA---GSEGDQTVTIGAGEMTAI--F 1211
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAaatPGEGPVEVTVDGANVSARvlS 82


                  ....*.
gi 261490803 1212 NDSFTY 1217
Cdd:cd00603    83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1617-1699 4.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 61.70  E-value: 4.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS----VMVANIPCNVVSFDYSQIVCDTSPS---VARSGDVTVYINSISSSC 1689
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSprvrVTVGGVPCKVLNVSSTEIVCRTPAAatpGEGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 261490803 1690 SSDCTFEYSD 1699
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1703-1784 1.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1703 PQVSTVSPNSVNGNS-TTVTVTGRGFGNNSADLMISADNILLAVTEVNDSSIQVLVGALPAGTYNLTVVVMSKGLATGSA 1781
Cdd:pfam01833    1 PVITSISPSSGPASGgTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 261490803  1782 TLT 1784
Cdd:pfam01833   81 TFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1312-1366 6.64e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 261490803  1312 LEVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNTVTLGDTQCRVIAASDNELEVY 1366
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCT 55
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1956-2042 6.10e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.84  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1956 LTGITPNEGSYAGGAVVAIQGSGFDPNI--TKVLICNRECTVHLqdSTSTQLNCEVPPNNGMSEALRTCTVMVMNGGDSV 2033
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSGSprVRVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*....
gi 261490803 2034 NLTSGYTYR 2042
Cdd:cd00603    81 LSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1524-1604 1.97e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1524 PTVYDITP-----GHGTThdiINIRGSGFSNITCANEVKVGDLPCSVINSSSTEINCQLSPdsgAPVGVPLPITVQINNL 1598
Cdd:cd00603     1 PVITSISPssgplSGGTR---LTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPA---AATPGEGPVEVTVDGA 74


                  ....*.
gi 261490803 1599 GNGLLT 1604
Cdd:cd00603    75 NVSARV 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 28-120 1.25e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   28 RVDKLMPKYGSLNGGTRLTIWGQgfaqasqfNLNANDPNLGNKVtlvsttRSITCDVdrDSSNSKQIMCYTRALPEDSYG 107
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGS--------NLGSGSPRVRVTV------GGVPCKV--LNVSSTEIVCRTPAAATPGEG 65

                          90
                  ....*....|....
gi 261490803  108 -VRVSVDGVPIPFS 120
Cdd:cd00603    66 pVEVTVDGANVSAR 79
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3290-3469 9.43e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 47.99  E-value: 9.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3290 SGCSFHDGFApAIGIFGTDGLSIDDNVIHhTVGEGISVKG-DSNVIQRNLVT------------LTLWpGSYNGRAEDFN 3356
Cdd:COG3420    90 SGDSLTDDDA-GIYVRGADNAVIENNRIE-NNLFGIYLEGsDNNVIRNNTISgnrdlradrgngIHLW-NSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3357 FQWNA-AIEVNEATNVTLKGNIVAGyERVGFRIdgepcpGFSeSEAQWSQNEAHGGLYGLY-MNRDGLpgcsQIQGFTVW 3434
Cdd:COG3420   167 ISGGRdGIYLEFSDNNVIRNNTIRN-LRYGIHY------MYS-NDNLVEGNTFRDNGAGIAlMYSKGN----TVRGNTIL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 261490803 3435 RSFDFGIYVQVSMNVLISNVTLIDNGMGIMslIYN 3469
Cdd:COG3420   235 GNSGYGILLKESSDSVIEGNTISGNGKGIF--IYN 267
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 142-202 2.23e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 42.83  E-value: 2.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261490803  142 PTIQSISPLSGPP--GTVVTMRGRIFTNVYGSMstssngldvklsRAYMGGMPCEFLKPNSEE 202
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRV------------RVTVGGVPCKVLNVSSTE 51
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2141-2259 1.25e-42

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 153.15  E-value: 1.25e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  2141 TWGGLSPPEEGMMVVITAGQTILLDTSTPVLKMLLIQgGRLIF-DEADIELQAENILITdGGALQIGTEQMPFQHKAIIT 2219
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 261490803  2220 LHG--HLRSQELPVYGTKTLGVRQ-GVLDLHGIPVPVPWTRLS 2259
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3003-3131 2.90e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.48  E-value: 2.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3003 NNFNVPQEGSDVIIPADVWMVVDVVVPSLNKLKIAGVLEIPDTNNdtsimqynnVVLNATYISIQGGRLIAGWPNEPFRG 3082
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKN---------ITLRARYILVQGGRLIIGSEDCPFQG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 261490803  3083 QLQIILRGShttPDWLLPYGTNQGSKVLGV--FGSLDLYGMPHNVYHTKLA 3131
Cdd:pfam10162   74 KATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2047-2134 3.03e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGSGFSSNFSEIGVTIAGSVCDIQSANETQIICVTNAGPKSQETQVRVQQGNRGIARM- 2125
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARv 80

                          90
                  ....*....|
gi 261490803 2126 -DNASFFYID 2134
Cdd:cd00603    81 lSNTTFTYVE 90
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1359-1461 3.08e-16

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 76.44  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1359 SDNELEVYGQGYAWSPSALITSVGDTVVWRWDAPAfvpglGYRVFSVSNPSSTDYDGISFSsgdrqtakGFFAYRFTSPG 1438
Cdd:cd04217     2 NAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQTLYYG--------KAFSYTFTEPG 68

                          90       100
                  ....*....|....*....|...
gi 261490803 1439 VYYYSSGYIDSanektLQGVVTV 1461
Cdd:cd04217    69 TYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1052-1135 9.86e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGFDGG--NVTVKTGDVECSILQVT-TSITCQVGPA-SAGVQPVSLSFSVLGN-ARY 1126
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSsTEIVCRTPAAaTPGEGPVEVTVDGANVsARV 80


                  ....*....
gi 261490803 1127 QNNTSFNFT 1135
Cdd:cd00603    81 LSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1871-1952 1.27e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGEHAGGTFPVMFNHQVKGYALTQS 1948
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 261490803  1949 VFKY 1952
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1871-1937 2.73e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 2.73e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGEHA-GGTFPVMFN 1937
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVT 70
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1790-1865 4.75e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1790 SINPTSGSIAGGTPLLITGNGF--VAGNTTVKLGNSLCKILDVTADTVRCLTPPRA---EGQVQVNIKVFDVVYP---PQ 1861
Cdd:cd00603     5 SISPSSGPLSGGTRLTITGSNLgsGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARvlsNT 84


                  ....
gi 261490803 1862 NFNY 1865
Cdd:cd00603    85 TFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1790-1866 6.38e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.01  E-value: 6.38e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261490803  1790 SINPTSGSIAGGTPLLITGNGFVAG--NTTVKLGNSLCKILDVTADTVRCLTPPRAEGQVQVNIKVFDVVYPPQNFNYS 1866
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPLTFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1225-1296 8.38e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 8.38e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261490803  1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVANQG 1296
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGG 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 264-319 9.40e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 9.40e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803  264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTP 319
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTP 57
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2047-2132 1.30e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 1.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  2047 PVITNITPRRGGTAGGTRLTITGSGFSSNFSEIGVTIAGSVCDIQSANETQIICVTnagPKSQETQVRVQQGNRGIARM- 2125
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTT---PPGTSGLVNVSVTVGGGGISs 77


                   ....*..
gi 261490803  2126 DNASFFY 2132
Cdd:pfam01833   78 SPLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1140-1217 1.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.24  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSGYGFSN---NIDVIIGSQPCNIVEVELFQLRCIVPA---GSEGDQTVTIGAGEMTAI--F 1211
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAaatPGEGPVEVTVDGANVSARvlS 82


                  ....*.
gi 261490803 1212 NDSFTY 1217
Cdd:cd00603    83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1617-1699 4.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 61.70  E-value: 4.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS----VMVANIPCNVVSFDYSQIVCDTSPS---VARSGDVTVYINSISSSC 1689
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSprvrVTVGGVPCKVLNVSSTEIVCRTPAAatpGEGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 261490803 1690 SSDCTFEYSD 1699
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1052-1132 5.78e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 5.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1052 PTVTGISPTEGSSSLGTVLTITGSGFDGG--NVTVKTGDVECSILQVT-TSITCQVGPASAGvqPVSLSFSVLGNARYQN 1128
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSsTTIVCTTPPGTSG--LVNVSVTVGGGGISSS 78


                   ....
gi 261490803  1129 NTSF 1132
Cdd:pfam01833   79 PLTF 82
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1703-1784 1.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1703 PQVSTVSPNSVNGNS-TTVTVTGRGFGNNSADLMISADNILLAVTEVNDSSIQVLVGALPAGTYNLTVVVMSKGLATGSA 1781
Cdd:pfam01833    1 PVITSISPSSGPASGgTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 261490803  1782 TLT 1784
Cdd:pfam01833   81 TFT 83
IPT smart00429
ig-like, plexins, transcription factors;
2047-2133 1.22e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.82  E-value: 1.22e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   2047 PVITNITPRRGGTAGGTRLTITGSGFSSnFSEIGVTI--AGSVCDIQSANETQIICVTNAGPKSQETQ--VRVQQGNRGI 2122
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvRTVGLRNGGV 80

                            90
                    ....*....|.
gi 261490803   2123 ARmDNASFFYI 2133
Cdd:smart00429   81 PS-SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 265-328 1.48e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.48e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261490803   265 VTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTPGYERKNVTV 328
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV 66
IPT smart00429
ig-like, plexins, transcription factors;
264-328 2.22e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.05  E-value: 2.22e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803    264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVL-VGGHECQIRSISNKKVVCVTPGYERKNVTV 328
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
IPT smart00429
ig-like, plexins, transcription factors;
1790-1865 2.55e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.05  E-value: 2.55e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1790 SINPTSGSIAGGTPLLITGNGFVAGNT---TVKLGNSLCKILDVTADTVRCLTPPRAEGQVQVNIKVF-----DVVYPPQ 1861
Cdd:smart00429    6 RISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVglrngGVPSSPQ 85


                    ....
gi 261490803   1862 NFNY 1865
Cdd:smart00429   86 PFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1140-1217 3.01e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 3.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1140 VTSINPTTGSVAGGTVLTVSGYGFSNNID---VIIGSQPCNIVEVELFQLRCIVPAGSEGDQTVTIGAGEMTAIFND-SF 1215
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSdlkVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlTF 82


                   ..
gi 261490803  1216 TY 1217
Cdd:pfam01833   83 TY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1225-1311 3.57e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 56.31  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLP---PAVYSVNIRVANQGYPLTS 1301
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARVLS 82

                          90
                  ....*....|
gi 261490803 1302 pdiNTTIEYV 1311
Cdd:cd00603    83 ---NTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1312-1366 6.64e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 261490803  1312 LEVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNTVTLGDTQCRVIAASDNELEVY 1366
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCT 55
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1617-1697 8.56e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 8.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS----VMVANIPCNVVSFDYSQIVCDTSPSVARSGDVTVYINsISSSCSSD 1692
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlkVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVG-GGGISSSP 79


                   ....*
gi 261490803  1693 CTFEY 1697
Cdd:pfam01833   80 LTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1313-1364 2.41e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.00  E-value: 2.41e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 261490803 1313 EVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNTVTLGDTQCRVIAASDNELE 1364
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIV 53
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1956-2042 6.10e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.84  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1956 LTGITPNEGSYAGGAVVAIQGSGFDPNI--TKVLICNRECTVHLqdSTSTQLNCEVPPNNGMSEALRTCTVMVMNGGDSV 2033
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSGSprVRVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*....
gi 261490803 2034 NLTSGYTYR 2042
Cdd:cd00603    81 LSNTTFTYV 89
IPT smart00429
ig-like, plexins, transcription factors;
1052-1135 7.09e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 7.09e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1052 PTVTGISPTEGSSSLGTVLTITGSGFDGGN---VTVKTGDVECSILQV-TTSITCQVGPASAGVQPVSLSFSVLGNARYQ 1127
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISvvfVEVGVGEAPCTFSPSsSTAIVCKTPPYHNIPGSVPVRTVGLRNGGVP 81


                    ....*...
gi 261490803   1128 NNTSfNFT 1135
Cdd:smart00429   82 SSPQ-PFT 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1956-2041 1.75e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 1.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1956 LTGITPNEGSYAGGAVVAIQGSGF--DPNITKVLICNRECTVHLqdSTSTQLNCEVPPNNGMSEALrtctVMVMNGGDSV 2033
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTVIS--VSSTTIVCTTPPGTSGLVNV----SVTVGGGGIS 76


                   ....*...
gi 261490803  2034 NLTSGYTY 2041
Cdd:pfam01833   77 SSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1871-1952 1.86e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.65  E-value: 1.86e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAV-VSLQIDSVACNISSITDTQLLCTVGEHAGGTFPV---MFNHQVKGYA 1944
Cdd:smart00429    2 PVITRISPTSGPVsgGTEITLCGKNLKSISVVfVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvrTVGLRNGGVP 81


                    ....*...
gi 261490803   1945 LTQSVFKY 1952
Cdd:smart00429   82 SSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1524-1604 1.97e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1524 PTVYDITP-----GHGTThdiINIRGSGFSNITCANEVKVGDLPCSVINSSSTEINCQLSPdsgAPVGVPLPITVQINNL 1598
Cdd:cd00603     1 PVITSISPssgplSGGTR---LTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPA---AATPGEGPVEVTVDGA 74


                  ....*.
gi 261490803 1599 GNGLLT 1604
Cdd:cd00603    75 NVSARV 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1524-1604 2.28e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 2.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1524 PTVYDITPGHGTT--HDIINIRGSGFSNITCANEVKVGDLPCSVINSSSTEINCQLspDSGAPVGVPLPITVQINNLGNG 1601
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTT--PPGTSGLVNVSVTVGGGGISSS 78


                   ...
gi 261490803  1602 LLT 1604
Cdd:pfam01833   79 PLT 81
IPT smart00429
ig-like, plexins, transcription factors;
1140-1203 8.63e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 49.73  E-value: 8.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261490803   1140 VTSINPTTGSVAGGTVLTVSGygfsNNIDVII--------GSQPCNIVEVELFQLRCIVPAGSEGDQTVTIG 1203
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCG----KNLKSISvvfvevgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVR 71
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 28-120 1.25e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   28 RVDKLMPKYGSLNGGTRLTIWGQgfaqasqfNLNANDPNLGNKVtlvsttRSITCDVdrDSSNSKQIMCYTRALPEDSYG 107
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGS--------NLGSGSPRVRVTV------GGVPCKV--LNVSSTEIVCRTPAAATPGEG 65

                          90
                  ....*....|....
gi 261490803  108 -VRVSVDGVPIPFS 120
Cdd:cd00603    66 pVEVTVDGANVSAR 79
IPT smart00429
ig-like, plexins, transcription factors;
1616-1680 1.96e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.87  E-value: 1.96e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1616 LPVVDSIFPVVGSTTGSTRLLISGSGFFSGS-----VMVANIPCNVVSFDYSQIVCDTSPSVARSGDVTV 1680
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISvvfveVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3290-3469 9.43e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 47.99  E-value: 9.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3290 SGCSFHDGFApAIGIFGTDGLSIDDNVIHhTVGEGISVKG-DSNVIQRNLVT------------LTLWpGSYNGRAEDFN 3356
Cdd:COG3420    90 SGDSLTDDDA-GIYVRGADNAVIENNRIE-NNLFGIYLEGsDNNVIRNNTISgnrdlradrgngIHLW-NSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3357 FQWNA-AIEVNEATNVTLKGNIVAGyERVGFRIdgepcpGFSeSEAQWSQNEAHGGLYGLY-MNRDGLpgcsQIQGFTVW 3434
Cdd:COG3420   167 ISGGRdGIYLEFSDNNVIRNNTIRN-LRYGIHY------MYS-NDNLVEGNTFRDNGAGIAlMYSKGN----TVRGNTIL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 261490803 3435 RSFDFGIYVQVSMNVLISNVTLIDNGMGIMslIYN 3469
Cdd:COG3420   235 GNSGYGILLKESSDSVIEGNTISGNGKGIF--IYN 267
IPT smart00429
ig-like, plexins, transcription factors;
1312-1375 1.57e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.57e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803   1312 LEVTGFSPSVGSLYGGTTITIIGSGFsLDIQDNTVTLGDTQ--CRVIAASDNELEVYGQGYAWSPS 1375
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNL-KSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPG 66
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 142-202 2.23e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 42.83  E-value: 2.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261490803  142 PTIQSISPLSGPP--GTVVTMRGRIFTNVYGSMstssngldvklsRAYMGGMPCEFLKPNSEE 202
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRV------------RVTVGGVPCKVLNVSSTE 51
IPT smart00429
ig-like, plexins, transcription factors;
1225-1293 2.91e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.41  E-value: 2.91e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGS-SVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVA 1293
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTV 73
PetE COG3794
Plastocyanin [Energy production and conversion];
1370-1442 4.56e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 41.52  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261490803 1370 YAWSPSALITSVGDTVVWRWDAPAfvpglGYRVFSVSNPSStdydgiSFSSGdRQTAKGFFAYRFTSPGVYYY 1442
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTDSV-----PHNVTSDDGPDG------AFDSG-LLAPGETFSVTFDEPGTYDY 61
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 29-121 1.74e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.12  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803    29 VDKLMPKYGSLNGGTRLTIWGQGFAQASQfnlnandpnlGNKVTLVSTTRSITcdvdrdSSNSKQIMCYTRALPEDSYGV 108
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSS----------DLKVTIGGTPCTVI------SVSSTTIVCTTPPGTSGLVNV 66

                           90
                   ....*....|...
gi 261490803   109 RVSVDGVPIPFSS 121
Cdd:pfam01833   67 SVTVGGGGISSSP 79
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3284-3390 4.88e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.85  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3284 AGESYISGCSFHDGFAPAIGIFGTDGLSIDDNVIHHTVGEGISVKGDSN-VIQRNLVtltlwpgSYNGraedfnfqwNAA 3362
Cdd:pfam13229   54 SSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAGIYLSDSSNnTIENNII-------HNNG---------GSG 117

                           90       100
                   ....*....|....*....|....*....
gi 261490803  3363 IEV-NEATNVTLKGNIVAGYERVGFRIDG 3390
Cdd:pfam13229  118 IVIeDSSNNVTISNNTVTNNKGAGILIVG 146
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2141-2259 1.25e-42

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 153.15  E-value: 1.25e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  2141 TWGGLSPPEEGMMVVITAGQTILLDTSTPVLKMLLIQgGRLIF-DEADIELQAENILITdGGALQIGTEQMPFQHKAIIT 2219
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 261490803  2220 LHG--HLRSQELPVYGTKTLGVRQ-GVLDLHGIPVPVPWTRLS 2259
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3003-3131 2.90e-32

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 123.48  E-value: 2.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3003 NNFNVPQEGSDVIIPADVWMVVDVVVPSLNKLKIAGVLEIPDTNNdtsimqynnVVLNATYISIQGGRLIAGWPNEPFRG 3082
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKN---------ITLRARYILVQGGRLIIGSEDCPFQG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 261490803  3083 QLQIILRGShttPDWLLPYGTNQGSKVLGV--FGSLDLYGMPHNVYHTKLA 3131
Cdd:pfam10162   74 KATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2047-2134 3.03e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGSGFSSNFSEIGVTIAGSVCDIQSANETQIICVTNAGPKSQETQVRVQQGNRGIARM- 2125
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARv 80

                          90
                  ....*....|
gi 261490803 2126 -DNASFFYID 2134
Cdd:cd00603    81 lSNTTFTYVE 90
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1359-1461 3.08e-16

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 76.44  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1359 SDNELEVYGQGYAWSPSALITSVGDTVVWRWDAPAfvpglGYRVFSVSNPSSTDYDGISFSsgdrqtakGFFAYRFTSPG 1438
Cdd:cd04217     2 NAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQTLYYG--------KAFSYTFTEPG 68

                          90       100
                  ....*....|....*....|...
gi 261490803 1439 VYYYSSGYIDSanektLQGVVTV 1461
Cdd:cd04217    69 TYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1052-1135 9.86e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 9.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGFDGG--NVTVKTGDVECSILQVT-TSITCQVGPA-SAGVQPVSLSFSVLGN-ARY 1126
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSsTEIVCRTPAAaTPGEGPVEVTVDGANVsARV 80


                  ....*....
gi 261490803 1127 QNNTSFNFT 1135
Cdd:cd00603    81 LSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1871-1952 1.27e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGEHAGGTFPVMFNHQVKGYALTQS 1948
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 261490803  1949 VFKY 1952
Cdd:pfam01833   81 TFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1052-1135 1.38e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 69.03  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGFD-GGNVTVK-TGDVECSILQVT-TSITCQVGP-ASAGVQPVSLSFSVLGNARYQ 1127
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGsGSNLRVTfGGGVPCSVLSVSsTAIVCTTPPyANPGPGPVEVTVDRGNGGITS 80


                  ....*...
gi 261490803 1128 NNTSFNFT 1135
Cdd:cd00102    81 SPLTFTYV 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 2047-2124 2.64e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 2.64e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGSGFSSNfSEIGVTIAGSV-CDIQSANETQIICVTNAGPKSQETQVRVQQGNRGIAR 2124
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSG-SNLRVTFGGGVpCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNGGI 78
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2047-2132 8.53e-13

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 66.48  E-value: 8.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGSGFSSNfSEIGVTIAGSVCDIQSANETQIICVTNAGPKSQETQVRVQQGNrgiARMD 2126
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAG-SSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDG---ARRL 76


                  ....*.
gi 261490803 2127 NASFFY 2132
Cdd:cd01179    77 APLVFT 82
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1871-1937 2.73e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 2.73e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGEHA-GGTFPVMFN 1937
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVT 70
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1790-1865 4.75e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1790 SINPTSGSIAGGTPLLITGNGF--VAGNTTVKLGNSLCKILDVTADTVRCLTPPRA---EGQVQVNIKVFDVVYP---PQ 1861
Cdd:cd00603     5 SISPSSGPLSGGTRLTITGSNLgsGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARvlsNT 84


                  ....
gi 261490803 1862 NFNY 1865
Cdd:cd00603    85 TFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1790-1866 6.38e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 64.01  E-value: 6.38e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261490803  1790 SINPTSGSIAGGTPLLITGNGFVAG--NTTVKLGNSLCKILDVTADTVRCLTPPRAEGQVQVNIKVFDVVYPPQNFNYS 1866
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPLTFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1225-1296 8.38e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 8.38e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261490803  1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVANQG 1296
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGG 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 264-319 9.40e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 9.40e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803  264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTP 319
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTP 57
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2047-2132 1.30e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 1.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  2047 PVITNITPRRGGTAGGTRLTITGSGFSSNFSEIGVTIAGSVCDIQSANETQIICVTnagPKSQETQVRVQQGNRGIARM- 2125
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTT---PPGTSGLVNVSVTVGGGGISs 77


                   ....*..
gi 261490803  2126 DNASFFY 2132
Cdd:pfam01833   78 SPLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1140-1217 1.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.24  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSGYGFSN---NIDVIIGSQPCNIVEVELFQLRCIVPA---GSEGDQTVTIGAGEMTAI--F 1211
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAaatPGEGPVEVTVDGANVSARvlS 82


                  ....*.
gi 261490803 1212 NDSFTY 1217
Cdd:cd00603    83 NTTFTY 88
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1052-1135 3.90e-11

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 61.86  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGFD-GGNVTVKTGDVECSILQVT-TSITCqVGPASAGVQPVSLSFSVlGNARYQNN 1129
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNaGSSVRVTVGGQPCKILSVSsSQIVC-LTPPSASPGEAPVKVLI-DGARRLAP 78


                  ....*.
gi 261490803 1130 TSFNFT 1135
Cdd:cd01179    79 LVFTYT 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1617-1699 4.52e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 61.70  E-value: 4.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS----VMVANIPCNVVSFDYSQIVCDTSPS---VARSGDVTVYINSISSSC 1689
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSprvrVTVGGVPCKVLNVSSTEIVCRTPAAatpGEGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 261490803 1690 SSDCTFEYSD 1699
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1052-1132 5.78e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 5.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1052 PTVTGISPTEGSSSLGTVLTITGSGFDGG--NVTVKTGDVECSILQVT-TSITCQVGPASAGvqPVSLSFSVLGNARYQN 1128
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSsTTIVCTTPPGTSG--LVNVSVTVGGGGISSS 78


                   ....
gi 261490803  1129 NTSF 1132
Cdd:pfam01833   79 PLTF 82
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1790-1865 2.79e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 2.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1790 SINPTSGSIAGGTPLLITGNGF-VAGNTTVKL-GNSLCKILDVTADTVRCLTPPRA---EGQVQVNIKVFDV--VYPPQN 1862
Cdd:cd00102     5 SISPSSGPVSGGTEVTITGSNFgSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnpgPGPVEVTVDRGNGgiTSSPLT 84


                  ...
gi 261490803 1863 FNY 1865
Cdd:cd00102    85 FTY 87
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2047-2120 2.89e-10

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 59.64  E-value: 2.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 2047 PVITNITPRRGGTAGGTRLTITGS--GFSSNFSEIGVTIAGSVCDIQSANE---TQIICVTN-AGPKSQETQVRVQQGNR 2120
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPEPPEYsssEKIVCTTGpAGNPVFNGPVEVTVGHG 80
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1140-1217 2.90e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 2.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSGYGFSNNIDVII---GSQPCNIVEVELFQLRCIVPAGSEGDQT---VTIGAGEMTAIFND 1213
Cdd:cd00102     3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtfgGGVPCSVLSVSSTAIVCTTPPYANPGPGpveVTVDRGNGGITSSP 82


                  ....*
gi 261490803 1214 -SFTY 1217
Cdd:cd00102    83 lTFTY 87
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1871-1952 3.36e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLQIDSVACNISSITDTQLLCTVGE-HAGGTFPVMFNHQVKGYALTQ 1947
Cdd:cd00102     1 PVITSISPSSGPVsgGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPyANPGPGPVEVTVDRGNGGITS 80


                  ....*..
gi 261490803 1948 S--VFKY 1952
Cdd:cd00102    81 SplTFTY 87
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1617-1697 6.71e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 58.63  E-value: 6.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGSVMV----ANIPCNVVSFDYSQIVCDTsPSVARSGDVTVYI---NSISSSC 1689
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRvtfgGGVPCSVLSVSSTAIVCTT-PPYANPGPGPVEVtvdRGNGGIT 79


                  ....*...
gi 261490803 1690 SSDCTFEY 1697
Cdd:cd00102    80 SSPLTFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1703-1784 1.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1703 PQVSTVSPNSVNGNS-TTVTVTGRGFGNNSADLMISADNILLAVTEVNDSSIQVLVGALPAGTYNLTVVVMSKGLATGSA 1781
Cdd:pfam01833    1 PVITSISPSSGPASGgTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 261490803  1782 TLT 1784
Cdd:pfam01833   81 TFT 83
IPT smart00429
ig-like, plexins, transcription factors;
2047-2133 1.22e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.82  E-value: 1.22e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   2047 PVITNITPRRGGTAGGTRLTITGSGFSSnFSEIGVTI--AGSVCDIQSANETQIICVTNAGPKSQETQ--VRVQQGNRGI 2122
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvRTVGLRNGGV 80

                            90
                    ....*....|.
gi 261490803   2123 ARmDNASFFYI 2133
Cdd:smart00429   81 PS-SPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 265-328 1.48e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.46  E-value: 1.48e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261490803   265 VTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTPGYERKNVTV 328
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV 66
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1790-1865 2.03e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 56.85  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1790 SINPTSGSIAGGTPLLITGNGFVAGNTT-VKLGNSLCKILDVTADTVRCLTPPRAEGQvQVNIKV-FD--VVYPPQNFNY 1865
Cdd:cd01179     5 SLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASPG-EAPVKVlIDgaRRLAPLVFTY 83
IPT smart00429
ig-like, plexins, transcription factors;
264-328 2.22e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.05  E-value: 2.22e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803    264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVL-VGGHECQIRSISNKKVVCVTPGYERKNVTV 328
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
IPT smart00429
ig-like, plexins, transcription factors;
1790-1865 2.55e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.05  E-value: 2.55e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1790 SINPTSGSIAGGTPLLITGNGFVAGNT---TVKLGNSLCKILDVTADTVRCLTPPRAEGQVQVNIKVF-----DVVYPPQ 1861
Cdd:smart00429    6 RISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVglrngGVPSSPQ 85


                    ....
gi 261490803   1862 NFNY 1865
Cdd:smart00429   86 PFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1140-1217 3.01e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 3.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1140 VTSINPTTGSVAGGTVLTVSGYGFSNNID---VIIGSQPCNIVEVELFQLRCIVPAGSEGDQTVTIGAGEMTAIFND-SF 1215
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSdlkVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlTF 82


                   ..
gi 261490803  1216 TY 1217
Cdd:pfam01833   83 TY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1225-1311 3.57e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 56.31  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLP---PAVYSVNIRVANQGYPLTS 1301
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARVLS 82

                          90
                  ....*....|
gi 261490803 1302 pdiNTTIEYV 1311
Cdd:cd00603    83 ---NTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1312-1366 6.64e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 261490803  1312 LEVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNTVTLGDTQCRVIAASDNELEVY 1366
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCT 55
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1617-1697 8.56e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 8.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS----VMVANIPCNVVSFDYSQIVCDTSPSVARSGDVTVYINsISSSCSSD 1692
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlkVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVG-GGGISSSP 79


                   ....*
gi 261490803  1693 CTFEY 1697
Cdd:pfam01833   80 LTFTY 84
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1617-1680 1.15e-08

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 55.01  E-value: 1.15e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFS------GSVMVANIPCNVVSFDYS---QIVC--DTSPSVARSGDVTV 1680
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkndvrHGVRVGGVPCNPEPPEYSsseKIVCttGPAGNPVFNGPVEV 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1313-1364 2.41e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.00  E-value: 2.41e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 261490803 1313 EVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNTVTLGDTQCRVIAASDNELE 1364
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIV 53
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 264-321 2.55e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.00  E-value: 2.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 261490803  264 EVTGVSPSAGSMLGGTLLTIQGQNFDETDQPAMVLVGGHECQIRSISNKKVVCVTPGY 321
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPY 59
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1956-2042 6.10e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.84  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1956 LTGITPNEGSYAGGAVVAIQGSGFDPNI--TKVLICNRECTVHLqdSTSTQLNCEVPPNNGMSEALRTCTVMVMNGGDSV 2033
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGSGSprVRVTVGGVPCKVLN--VSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*....
gi 261490803 2034 NLTSGYTYR 2042
Cdd:cd00603    81 LSNTTFTYV 89
IPT smart00429
ig-like, plexins, transcription factors;
1052-1135 7.09e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 7.09e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1052 PTVTGISPTEGSSSLGTVLTITGSGFDGGN---VTVKTGDVECSILQV-TTSITCQVGPASAGVQPVSLSFSVLGNARYQ 1127
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISvvfVEVGVGEAPCTFSPSsSTAIVCKTPPYHNIPGSVPVRTVGLRNGGVP 81


                    ....*...
gi 261490803   1128 NNTSfNFT 1135
Cdd:smart00429   82 SSPQ-PFT 88
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 265-319 7.46e-08

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 52.61  E-value: 7.46e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 261490803  265 VTGVSPSAGSMLGGTLLTIQGQNFDETDQPAmVLVGGHECQIRSISNKKVVCVTP 319
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNAGSSVR-VTVGGQPCKILSVSSSQIVCLTP 56
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1956-2041 1.75e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 1.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1956 LTGITPNEGSYAGGAVVAIQGSGF--DPNITKVLICNRECTVHLqdSTSTQLNCEVPPNNGMSEALrtctVMVMNGGDSV 2033
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTVIS--VSSTTIVCTTPPGTSGLVNV----SVTVGGGGIS 76


                   ....*...
gi 261490803  2034 NLTSGYTY 2041
Cdd:pfam01833   77 SSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1871-1952 1.86e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.65  E-value: 1.86e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAV-VSLQIDSVACNISSITDTQLLCTVGEHAGGTFPV---MFNHQVKGYA 1944
Cdd:smart00429    2 PVITRISPTSGPVsgGTEITLCGKNLKSISVVfVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvrTVGLRNGGVP 81


                    ....*...
gi 261490803   1945 LTQSVFKY 1952
Cdd:smart00429   82 SSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1524-1604 1.97e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1524 PTVYDITP-----GHGTThdiINIRGSGFSNITCANEVKVGDLPCSVINSSSTEINCQLSPdsgAPVGVPLPITVQINNL 1598
Cdd:cd00603     1 PVITSISPssgplSGGTR---LTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPA---AATPGEGPVEVTVDGA 74


                  ....*.
gi 261490803 1599 GNGLLT 1604
Cdd:cd00603    75 NVSARV 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1524-1604 2.28e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 2.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  1524 PTVYDITPGHGTT--HDIINIRGSGFSNITCANEVKVGDLPCSVINSSSTEINCQLspDSGAPVGVPLPITVQINNLGNG 1601
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTT--PPGTSGLVNVSVTVGGGGISSS 78


                   ...
gi 261490803  1602 LLT 1604
Cdd:pfam01833   79 PLT 81
IPT smart00429
ig-like, plexins, transcription factors;
1140-1203 8.63e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 49.73  E-value: 8.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261490803   1140 VTSINPTTGSVAGGTVLTVSGygfsNNIDVII--------GSQPCNIVEVELFQLRCIVPAGSEGDQTVTIG 1203
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCG----KNLKSISvvfvevgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVR 71
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 28-120 1.25e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   28 RVDKLMPKYGSLNGGTRLTIWGQgfaqasqfNLNANDPNLGNKVtlvsttRSITCDVdrDSSNSKQIMCYTRALPEDSYG 107
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGS--------NLGSGSPRVRVTV------GGVPCKV--LNVSSTEIVCRTPAAATPGEG 65

                          90
                  ....*....|....
gi 261490803  108 -VRVSVDGVPIPFS 120
Cdd:cd00603    66 pVEVTVDGANVSAR 79
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1140-1217 2.64e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 47.99  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSGYGFS--NNIDVIIGSQPCNIVEVELFQLRCIVPAGSEGDQ---TVTIGAGEMTAifNDS 1214
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNagSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEapvKVLIDGARRLA--PLV 80


                  ...
gi 261490803 1215 FTY 1217
Cdd:cd01179    81 FTY 83
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1617-1697 6.18e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 47.22  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1617 PVVDSIFPVVGSTTGSTRLLISGSGFFSGS---VMVANIPCNVVSFDYSQIVCDTSPSvARSGDVTVYINSISSSCSSDC 1693
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSsvrVTVGGQPCKILSVSSSQIVCLTPPS-ASPGEAPVKVLIDGARRLAPL 79


                  ....
gi 261490803 1694 TFEY 1697
Cdd:cd01179    80 VFTY 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1871-1941 6.78e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 47.31  E-value: 6.78e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261490803 1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVV--SLQIDSVACNIS---SITDTQLLCTVGehAGGTFPvmFNHQVK 1941
Cdd:cd01180     1 PVITEFFPLSGPLegGTRLTICGSNLGLRKNDVrhGVRVGGVPCNPEppeYSSSEKIVCTTG--PAGNPV--FNGPVE 74
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1871-1934 7.74e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 46.83  E-value: 7.74e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261490803 1871 PNITSVTPKTGPV--GTQITISGSGFGTDSAVVSLqIDSVACNISSITDTQLLCTVGEHA-GGTFPV 1934
Cdd:cd01179     1 PSITSLSPSYGPQsgGTRLTITGKHLNAGSSVRVT-VGGQPCKILSVSSSQIVCLTPPSAsPGEAPV 66
IPT_CGTD cd00604
IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These ...
 1871-1930 9.11e-06

IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three domains (A,B,C) but CGTase is more complex and has two additional domains (D,E). The function of the IPT/D domain is unknown.


Pssm-ID: 238338 [Multi-domain]  Cd Length: 81  Bit Score: 46.57  E-value: 9.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1871 PNITSVTPKTGPVGTQITISGSGFGTDSAVVSlqIDSVACNISSITDTQLLCTVGEHAGG 1930
Cdd:cd00604     1 PLIGSVGPVMGKPGNTVTISGEGFGSTGGTVY--FGGTAAEVLSWSDTSIVVEVPRVAPG 58
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1225-1311 1.03e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 46.69  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGSSVLIGDAECELLQWTNDSISCQLPTLP-PAVYSVNIRVANQGYPLTSPd 1303
Cdd:cd00102     3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVDRGNGGITSS- 81


                  ....*...
gi 261490803 1304 iNTTIEYV 1311
Cdd:cd00102    82 -PLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
1616-1680 1.96e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.87  E-value: 1.96e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1616 LPVVDSIFPVVGSTTGSTRLLISGSGFFSGS-----VMVANIPCNVVSFDYSQIVCDTSPSVARSGDVTV 1680
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISvvfveVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1140-1217 2.93e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 45.38  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1140 VTSINPTTGSVAGGTVLTVSG--YGFSNNID---VIIGSQPCNIVEVELF---QLRCIV-PAGSE---GDQTVTIGAGEM 1207
Cdd:cd01180     3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNDVrhgVRVGGVPCNPEPPEYSsseKIVCTTgPAGNPvfnGPVEVTVGHGSF 82

                          90
                  ....*....|
gi 261490803 1208 TAIFNDSFTY 1217
Cdd:cd01180    83 RTESSEGFSF 92
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1312-1366 6.25e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 44.37  E-value: 6.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803 1312 LEVTGFSPSVGSLYGGTTITIIGSGFSLDiQDNTVTLGDTQ-CRVIAASDNELEVY 1366
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSG-SNLRVTFGGGVpCSVLSVSSTAIVCT 55
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3290-3469 9.43e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 47.99  E-value: 9.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3290 SGCSFHDGFApAIGIFGTDGLSIDDNVIHhTVGEGISVKG-DSNVIQRNLVT------------LTLWpGSYNGRAEDFN 3356
Cdd:COG3420    90 SGDSLTDDDA-GIYVRGADNAVIENNRIE-NNLFGIYLEGsDNNVIRNNTISgnrdlradrgngIHLW-NSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 3357 FQWNA-AIEVNEATNVTLKGNIVAGyERVGFRIdgepcpGFSeSEAQWSQNEAHGGLYGLY-MNRDGLpgcsQIQGFTVW 3434
Cdd:COG3420   167 ISGGRdGIYLEFSDNNVIRNNTIRN-LRYGIHY------MYS-NDNLVEGNTFRDNGAGIAlMYSKGN----TVRGNTIL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 261490803 3435 RSFDFGIYVQVSMNVLISNVTLIDNGMGIMslIYN 3469
Cdd:COG3420   235 GNSGYGILLKESSDSVIEGNTISGNGKGIF--IYN 267
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1957-2043 9.61e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 43.99  E-value: 9.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1957 TGITPNEGSYAGGAVVAIQGSGFDPNI-TKVLI-CNRECTVhlQDSTSTQLNCEVPPNNGMSEALRTCTVmVMNGGDSVN 2034
Cdd:cd00102     4 TSISPSSGPVSGGTEVTITGSNFGSGSnLRVTFgGGVPCSV--LSVSSTAIVCTTPPYANPGPGPVEVTV-DRGNGGITS 80


                  ....*....
gi 261490803 2035 LTSGYTYRS 2043
Cdd:cd00102    81 SPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
1312-1375 1.57e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.57e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261490803   1312 LEVTGFSPSVGSLYGGTTITIIGSGFsLDIQDNTVTLGDTQ--CRVIAASDNELEVYGQGYAWSPS 1375
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNL-KSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPG 66
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 142-202 2.23e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 42.83  E-value: 2.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261490803  142 PTIQSISPLSGPP--GTVVTMRGRIFTNVYGSMstssngldvklsRAYMGGMPCEFLKPNSEE 202
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRV------------RVTVGGVPCKVLNVSSTE 51
IPT smart00429
ig-like, plexins, transcription factors;
1225-1293 2.91e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.41  E-value: 2.91e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   1225 ITSVSPQTTTVFGDRILTILGMHFGEEPNGS-SVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVA 1293
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTV 73
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 264-319 3.46e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 42.30  E-value: 3.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261490803  264 EVTGVSPSAGSMLGGTLLTIQGQNF--DETDQPAMVLVGGHECQI---RSISNKKVVCVTP 319
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPeppEYSSSEKIVCTTG 62
PetE COG3794
Plastocyanin [Energy production and conversion];
1370-1442 4.56e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 41.52  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261490803 1370 YAWSPSALITSVGDTVVWRWDAPAfvpglGYRVFSVSNPSStdydgiSFSSGdRQTAKGFFAYRFTSPGVYYY 1442
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTDSV-----PHNVTSDDGPDG------AFDSG-LLAPGETFSVTFDEPGTYDY 61
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1313-1358 1.12e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.15  E-value: 1.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 261490803 1313 EVTGFSPSVGSLYGGTTITIIGSGFSLDIQDNT--VTLGDTQCRVIAA 1358
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPCNPEPP 49
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1314-1364 1.33e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.29  E-value: 1.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 261490803 1314 VTGFSPSVGSLYGGTTITIIGSgfSLDIQDNT-VTLGDTQCRVIAASDNELE 1364
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGK--HLNAGSSVrVTVGGQPCKILSVSSSQIV 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 29-121 1.74e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.12  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803    29 VDKLMPKYGSLNGGTRLTIWGQGFAQASQfnlnandpnlGNKVTLVSTTRSITcdvdrdSSNSKQIMCYTRALPEDSYGV 108
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSS----------DLKVTIGGTPCTVI------SVSSTTIVCTTPPGTSGLVNV 66

                           90
                   ....*....|...
gi 261490803   109 RVSVDGVPIPFSS 121
Cdd:pfam01833   67 SVTVGGGGISSSP 79
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 34-118 1.96e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.90  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   34 PKYGSLNGGTRLTIWGQgfaqasqfNLNAndpnlGNKVTLvsTTRSITCDVDRDSsnSKQIMCYTRALPE-DSYGVRVSV 112
Cdd:cd01179     8 PSYGPQSGGTRLTITGK--------HLNA-----GSSVRV--TVGGQPCKILSVS--SSQIVCLTPPSASpGEAPVKVLI 70


                  ....*.
gi 261490803  113 DGVPIP 118
Cdd:cd01179    71 DGARRL 76
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 28-114 2.11e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 40.14  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   28 RVDKLMPKYGSLNGGTRLTIWGQGFAQASQfnlnandpnlgnkvTLVSTTRSITCDVdrDSSNSKQIMCYTRALPEDSYG 107
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSN--------------LRVTFGGGVPCSV--LSVSSTAIVCTTPPYANPGPG 65


                  ....*...
gi 261490803  108 -VRVSVDG 114
Cdd:cd00102    66 pVEVTVDR 73
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 28-122 2.76e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.99  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803   28 RVDKLMPKYGSLNGGTRLTIWGqgfaqaSQFNLNANDpnlgnkVTLVSTTRSITCDVDRDS-SNSKQIMCYTRALPEDSY 106
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICG------SNLGLRKND------VRHGVRVGGVPCNPEPPEySSSEKIVCTTGPAGNPVF 69

                          90
                  ....*....|....*...
gi 261490803  107 G--VRVSVDGVPIPFSSI 122
Cdd:cd01180    70 NgpVEVTVGHGSFRTESS 87
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1052-1120 3.23e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.61  E-value: 3.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261490803 1052 PTVTGISPTEGSSSLGTVLTITGSGF----DGGNVTVKTGDVECSIL----QVTTSITCQVGPASAGVQPVSLSFSV 1120
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLglrkNDVRHGVRVGGVPCNPEppeySSSEKIVCTTGPAGNPVFNGPVEVTV 77
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1369-1442 4.38e-03

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 39.29  E-value: 4.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261490803 1369 GYAWSPSALITSVGDTVVWRWDApafvPGLGYRVFSVSNPSSTdydgisFSSGDRQTAKGF-FAYRFTSPGVYYY 1442
Cdd:cd04220    11 GFAFDPAAIRVSPGTTVTWEWTG----EGGGHNVVAYEDPITA------FDSGSTDSSEGEtYEHTFEETGEYRY 75
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1524-1599 4.84e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 38.98  E-value: 4.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261490803 1524 PTVYDITP--GHGTTHDIINIRGSGFSNITCAnEVKV-GDLPCSVINSSSTEINCQLSPdSGAPVGVPLPITVQINNLG 1599
Cdd:cd00102     1 PVITSISPssGPVSGGTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCTTPP-YANPGPGPVEVTVDRGNGG 77
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3284-3390 4.88e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.85  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3284 AGESYISGCSFHDGFAPAIGIFGTDGLSIDDNVIHHTVGEGISVKGDSN-VIQRNLVtltlwpgSYNGraedfnfqwNAA 3362
Cdd:pfam13229   54 SSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAGIYLSDSSNnTIENNII-------HNNG---------GSG 117

                           90       100
                   ....*....|....*....|....*....
gi 261490803  3363 IEV-NEATNVTLKGNIVAGYERVGFRIDG 3390
Cdd:pfam13229  118 IVIeDSSNNVTISNNTVTNNKGAGILIVG 146
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3284-3391 5.36e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.47  E-value: 5.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803  3284 AGESYISGCSFHDGFAPAIGIFGTDGLSIDDNVIHHTVGEGISVKGDSNVI-------QRNLVTLTLWPGSYNgRAE--D 3354
Cdd:pfam13229    8 SSNATIKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTisnntisNNGGGGIALRGSSNN-LIEnnT 86

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 261490803  3355 FNFQWNAAIEVNEATNVTLKGNIVAGYERVGFRIDGE 3391
Cdd:pfam13229   87 ISNNGGAGIYLSDSSNNTIENNIIHNNGGSGIVIEDS 123
IPT_CGTD cd00604
IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These ...
 1224-1308 5.96e-03

IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three domains (A,B,C) but CGTase is more complex and has two additional domains (D,E). The function of the IPT/D domain is unknown.


Pssm-ID: 238338 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490803 1224 LITSVSPQTTTVfGDRIlTILGMHFGEEpnGSSVLIGDAECELLQWTNDSISCQLPTLPPAVYSVNIRVANQGyplTSPD 1303
Cdd:cd00604     2 LIGSVGPVMGKP-GNTV-TISGEGFGST--GGTVYFGGTAAEVLSWSDTSIVVEVPRVAPGNYNISVTTVDGV---TSNG 74


                  ....*
gi 261490803 1304 INTTI 1308
Cdd:cd00604    75 YNFEV 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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