|
Name |
Accession |
Description |
Interval |
E-value |
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
5-450 |
3.94e-167 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 477.45 E-value: 3.94e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 5 RRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISsnHTDDSPYSWSFPPYHPSSEKYENTKTCRGP 84
Cdd:cd16030 61 RRPDTTGVYDNNSYFRKVAPDAVTLPQYFKENGYTTAGVGKIFHPGIP--DGDDDPASWDEPPNPPGPEKYPPGKLCPGK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 85 DGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLaPDPE 164
Cdd:cd16030 139 KGGKGGGGGPAWEAADVPDEAYPDGKVADEAIEQLRKLKDSDKPFFLAVGFYKPHLPFVAPKKYFDLYPLESIPL-PNPF 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 165 VPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSD 244
Cdd:cd16030 218 DPIDLPEVAWNDLDDLPKYGDIPALNPGDPKGPLPDEQARELRQAYYASVSYVDAQVGRVLDALEELGLADNTIVVLWSD 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 245 HGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLA 324
Cdd:cd16030 298 HGWHLGEHGHWGKHTLFEEATRVPLIIRAPGVTK------------------------PGKVTDALVELVDIYPTLAELA 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 325 GLQVPPrcpvpsfhvelCREGKNLLkhfrfrdleedPYL--PGNPRELIAYSQYPRPSdipqwnsdkpslkdikIMGYSI 402
Cdd:cd16030 354 GLPAPP-----------CLEGKSLV-----------PLLknPSAKWKDAAFSQYPRPS----------------IMGYSI 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 262118210 403 RTIDYRYTVWVgfnpdeflaNFSDIHAGELYFVDSDPLQDHNMYNDSQ 450
Cdd:cd16030 396 RTERYRYTEWV---------DFDKVGAEELYDHKNDPNEWKNLANDPE 434
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
5-448 |
1.72e-53 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 183.93 E-value: 1.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 5 RRPDTTRLYDFNSYWRVH-AGNFSTIPQYFKENGYVTMSVGKVFHpgissnHTDDspyswsfppyhpssekyentktcrg 83
Cdd:COG3119 83 RYPHRTGVTDNGEGYNGGlPPDEPTLAELLKEAGYRTALFGKWHL------YLTD------------------------- 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 84 pdgELhanllcpvdvldvpegtlpdkqsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENItlapdp 163
Cdd:COG3119 132 ---LL-----------------------TDKAIDFLERQADKDKPFFLYLAFNAPHAPYQAPEEYLDKYDGKDI------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 164 EVPDGLPPVAYNPWmdirqredvqalnisvpygpipvdFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 243
Cdd:COG3119 180 PLPPNLAPRDLTEE------------------------ELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 244 DHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAG 322
Cdd:COG3119 236 DNGPSLGEHGlRGGKGTLYEGGIRVPLIVRWPGKIK------------------------AGSVSDALVSLIDLLPTLLD 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 323 LAGLQVPPRCpvpsfhvelcrEGKNLLKHFRFRDLEEDPYLpgnpreliaYSQYPRPsdipqwnsdkpslkdikIMGYSI 402
Cdd:COG3119 292 LAGVPIPEDL-----------DGRSLLPLLTGEKAEWRDYL---------YWEYPRG-----------------GGNRAI 334
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 262118210 403 RTIDYRYTVWVGFNPDEflanfsdihagELYFVDSDPLQDHNMYND 448
Cdd:COG3119 335 RTGRWKLIRYYDDDGPW-----------ELYDLKNDPGETNNLAAD 369
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
13-459 |
7.62e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 136.97 E-value: 7.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 13 YDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKvFHPGissnhTDDSPYSWSFPPYHPssekYENTKtcrgpdgelhanl 92
Cdd:cd16033 72 ENAGAYSRGLPPGVETFSEDLREAGYRNGYVGK-WHVG-----PEETPLDYGFDEYLP----VETTI------------- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 93 lcpvdvldvpEGTLpdkqsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVP-DGLPP 171
Cdd:cd16033 129 ----------EYFL-----ADRAIEMLEELAADDKPFFLRVNFWGPHDPYIPPEPYLDMYDPEDIPLPESFADDfEDKPY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 172 VAYNpwmdIRQREDVQALNISVpygpipvdfQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGE 251
Cdd:cd16033 194 IYRR----ERKRWGVDTEDEED---------WKEIIAHYWGYITLIDDAIGRILDALEELGLADDTLVIFTSDHGDALGA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 252 HGEWAK-YSNFDVATHVPLIFYVPGrtaslpeageklfpyldpfdsasqLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16033 261 HRLWDKgPFMYEETYRIPLIIKWPG------------------------VIAAGQVVDEFVSLLDLAPTILDLAGVDVPP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 331 RCpvpsfhvelcrEGKNLLKHFRfrdlEEDPylPGNPRELIAysqyprpsdipQWNSDKPSLkdikiMGYSIRTIDYRYT 410
Cdd:cd16033 317 KV-----------DGRSLLPLLR----GEQP--EDWRDEVVT-----------EYNGHEFYL-----PQRMVRTDRYKYV 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 262118210 411 vwvgFNPdeflanfSDIhaGELYFVDSDPLQDHNMYNDSQGGDLFQLLM 459
Cdd:cd16033 364 ----FNG-------FDI--DELYDLESDPYELNNLIDDPEYEEILREMR 399
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
112-350 |
1.63e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 126.91 E-value: 1.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 112 TEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLapdPEVPDGLPPVAyNPWMDIRqreDVQalni 191
Cdd:cd16155 108 ADAAIEFLEEYKDGDKPFFMYVAFTAPHDPRQAPPEYLDMYPPETIPL---PENFLPQHPFD-NGEGTVR---DEQ---- 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 192 svpYGPIPVDFQ--RKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPL 269
Cdd:cd16155 177 ---LAPFPRTPEavRQHLAEYYAMITHLDAQIGRILDALEASGELDNTIIVFTSDHGLAVGSHGLMGKQNLYEHSMRVPL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 270 IFYVPGrtasLPeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAGLQVPPRCpvpsfhvelcrEGKNLL 349
Cdd:cd16155 254 IISGPG----IP---------------------KGKRRDALVYLQDVFPTLCELAGIEIPESV-----------EGKSLL 297
|
.
gi 262118210 350 K 350
Cdd:cd16155 298 P 298
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-444 |
5.42e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 126.14 E-value: 5.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHpgISSNHTDDSPYSWSFPP-----------------YHPSSEKYENTktcrgpdgelha 90
Cdd:cd16034 81 TIADVLKDAGYRTGYIGK-WH--LDGPERNDGRADDYTPPperrhgfdywkgyecnhDHNNPHYYDDD------------ 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 91 nllcpvDVLDVPEGTLPDKQsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRY-PKEFQKLYPLENITLAPDpevpdgl 169
Cdd:cd16034 146 ------GKRIYIKGYSPDAE-TDLAIEYLENQADKDKPFALVLSWNPPHDPYTTaPEEYLDMYDPKKLLLRPN------- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 170 ppvaynpwMDIRQREDVQAlnisvpygpipvdfQRKIRQsYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL 249
Cdd:cd16034 212 --------VPEDKKEEAGL--------------REDLRG-YYAMITALDDNIGRLLDALKELGLLENTIVVFTSDHGDML 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 250 GEHGEWAKYSNFDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16034 269 GSHGLMNKQVPYEESIRVPFIIRYPGK------------------------IKAGRVVDLLINTVDIMPTLLGLCGLPIP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 330 PrcpvpsfhvelCREGKNLLKHFrfrdLEEDPYLPGNpreliAYSQYPRPSDipQWNSDKPSLKDIkimgysIRTIDYRY 409
Cdd:cd16034 325 D-----------TVEGRDLSPLL----LGGKDDEPDS-----VLLQCFVPFG--GGSARDGGEWRG------VRTDRYTY 376
|
410 420 430
....*....|....*....|....*....|....*
gi 262118210 410 TVWVGfnpDEFLanfsdihageLYFVDSDPLQDHN 444
Cdd:cd16034 377 VRDKN---GPWL----------LFDNEKDPYQLNN 398
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
28-330 |
9.06e-32 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 126.71 E-value: 9.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKV-FHPGIS----SNHTDDSPYSWSFPPYHPSseKYENTKTCR--------GPDGEL------ 88
Cdd:PRK13759 87 TLPQEFRDAGYYTQCIGKMhVFPQRNllgfHNVLLHDGYLHSGRNEDKS--QFDFVSDYLawlrekapGKDPDLtdigwd 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 89 -HANLLCPvdvLDVPEGTLPDKQSTEQAIQLLEKmKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENItlaPDPEVPD 167
Cdd:PRK13759 165 cNSWVARP---WDLEERLHPTNWVGSESIEFLRR-RDPTKPFFLKMSFARPHSPYDPPKRYFDMYKDADI---PDPHIGD 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 168 glppvaynpWmDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGW 247
Cdd:PRK13759 238 ---------W-EYAEDQDPEGGSIDALRGNLGEEYARRARAAYYGLITHIDHQIGRFLQALKEFGLLDNTIILFVSDHGD 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 248 ALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEageklfpyldpfdsasqlmepGRQSMDLVELVSLFPTLAGLAGLQ 327
Cdd:PRK13759 308 MLGDHYLFRKGYPYEGSAHIPFIIYDPGGLLAGNR---------------------GTVIDQVVELRDIMPTLLDLAGGT 366
|
...
gi 262118210 328 VPP 330
Cdd:PRK13759 367 IPD 369
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
100-439 |
9.48e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 123.81 E-value: 9.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 100 DVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYplenitlapdpevpdglppvaynpwmd 179
Cdd:cd16037 104 DQRHGFRYDRDVTEAAVDWLREEAADDKPWFLFVGFVAPHFPLIAPQEFYDLY--------------------------- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 180 irqredvqalnisvpygpipvdfQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYS 259
Cdd:cd16037 157 -----------------------VRRARAAYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHGDMLGERGLWGKST 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 260 NFDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlmEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPvpsfhv 339
Cdd:cd16037 214 MYEESVRVPMIISGPGI-------------------------PAGKRVKTPVSLVDLAPTILEAAGAPPPPDLD------ 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 340 elcreGKNLLkhfrfrDLEEDPYlpgnPRELIAYSQYprpsdipqwnsdkpSLKDIKIMGYSIRTIDYRYTVWVGFNPde 419
Cdd:cd16037 263 -----GRSLL------PLAEGPD----DPDRVVFSEY--------------HAHGSPSGAFMLRKGRWKYIYYVGYPP-- 311
|
330 340
....*....|....*....|
gi 262118210 420 flanfsdihagELYFVDSDP 439
Cdd:cd16037 312 -----------QLFDLENDP 320
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
28-458 |
4.81e-30 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 121.10 E-value: 4.81e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHPGISSNHTDDSPYSWSFPPYHPSSEKYENtKTCRGPDGEL-HANLLCpvdvldvpegtl 106
Cdd:cd16031 83 TYPKLLRKAGYQTAFIGK-WHLGSGGDLPPPGFDYWVSFPGQGSYYDPEF-IENGKRVGQKgYVTDII------------ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 107 pdkqsTEQAIQLLEKMKTSaSPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAP--DPEVPDGLPPVAYNPWMDIRQRE 184
Cdd:cd16031 149 -----TDKALDFLKERDKD-KPFCLSLSFKAPHRPFTPAPRHRGLYEDVTIPEPEtfDDDDYAGRPEWAREQRNRIRGVL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 185 DVQALNisvpygpiPVDFQRKIRQsYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGeWA-KYSNFDV 263
Cdd:cd16031 223 DGRFDT--------PEKYQRYMKD-YLRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGFFLGEHG-LFdKRLMYEE 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 264 ATHVPLIFYVPGRTaslpeageklfpyldpfdsasqlmEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCpvpsfhvelcr 343
Cdd:cd16031 293 SIRVPLIIRDPRLI------------------------KAGTVVDALVLNIDFAPTILDLAGVPIPEDM----------- 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 344 EGKNLLKHFRFRDleedpylPGNPRE--LIAYSQYPRPSDIPQWnsdkpslkdikimgYSIRTIDYRYTVWVGFNPDEfl 421
Cdd:cd16031 338 QGRSLLPLLEGEK-------PVDWRKefYYEYYEEPNFHNVPTH--------------EGVRTERYKYIYYYGVWDEE-- 394
|
410 420 430
....*....|....*....|....*....|....*..
gi 262118210 422 anfsdihagELYFVDSDPLQDHNMYNDSQGGDLFQLL 458
Cdd:cd16031 395 ---------ELYDLKKDPLELNNLANDPEYAEVLKEL 422
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
128-376 |
2.96e-29 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 116.91 E-value: 2.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 128 PFFLAVGYHKPHIPFRYPKEFQKLYplenitlapdpevpdglppvaynpwmdirqredvqalnisvpygpipvdfQRKIR 207
Cdd:cd16032 134 PFFLTVSFTHPHDPYVIPQEYWDLY--------------------------------------------------VRRAR 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 208 QSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTAslpeagekl 287
Cdd:cd16032 164 RAYYGMVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHGDMLGERGLWYKMSFFEGSARVPLIISAPGRFA--------- 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 288 fpyldpfdsasqlmePGRQSmDLVELVSLFPTLAGLAGLQVPPRCPVPsfhvelcrEGKNLLKHFRFRDleedpylPGNP 367
Cdd:cd16032 235 ---------------PRRVA-EPVSLVDLLPTLVDLAGGGTAPHVPPL--------DGRSLLPLLEGGD-------SGGE 283
|
....*....
gi 262118210 368 REliAYSQY 376
Cdd:cd16032 284 DE--VISEY 290
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
105-450 |
1.45e-28 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 116.95 E-value: 1.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 105 TLPDKQSTEQAIQLLEKMKTSAsPFFLAVGYHKPHIPFRYPKEFQKLYPLEnitLAPdPEVPDGLPpvAYNPWMDIRQRE 184
Cdd:cd16150 111 CDSDEACVRTAIDWLRNRRPDK-PFCLYLPLIFPHPPYGVEEPWFSMIDRE---KLP-PRRPPGLR--AKGKPSMLEGIE 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 185 DvQALNisvpygPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSN-F-D 262
Cdd:cd16150 184 K-QGLD------RWSEERWRELRATYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDHGDYTGDYGLVEKWPNtFeD 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 263 VATHVPLIFYVPGRTaslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAGLQVPPrcpvPSFhvelc 342
Cdd:cd16150 257 CLTRVPLIIKPPGGP-------------------------AGGVSDALVELVDIPPTLLDLAGIPLSH----THF----- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 343 reGKNLLKHFRFRDLEEDPY-------LPGNPReliAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYtVWVGF 415
Cdd:cd16150 303 --GRSLLPVLAGETEEHRDAvfseggrLHGEEQ---AMEGGHGPYDLKWPRLLQQEEPPEHTKAVMIRTRRYKY-VYRLY 376
|
330 340 350
....*....|....*....|....*....|....*
gi 262118210 416 NPDeflanfsdihagELYFVDSDPLQDHNMYNDSQ 450
Cdd:cd16150 377 EPD------------ELYDLEADPLELHNLIGDPA 399
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
5-329 |
2.15e-27 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 109.45 E-value: 2.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 5 RRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKvfhpgissNHtddspyswsfppyhpssekyentktcrgp 84
Cdd:cd16022 60 RYPHRHGVRGNVGNGGGLPPDEPTLAELLKEAGYRTALIGK--------WH----------------------------- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 85 dgelhanllcpvdvldvpegtlpdkqstEQAIQLLEKMKTSAsPFFLAVGYHKPHIPFRYpkefqklyplenitlapdpe 164
Cdd:cd16022 103 ----------------------------DEAIDFIERRDKDK-PFFLYVSFNAPHPPFAY-------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 165 vpdglppvaynpwmdirqredvqalnisvpygpipvdfqrkirqsyFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSD 244
Cdd:cd16022 134 ----------------------------------------------YAMVSAIDDQIGRILDALEELGLLDNTLIVFTSD 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 245 HGWALGEHGE-WAKYSNFDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGL 323
Cdd:cd16022 168 HGDMLGDHGLrGKKGSLYEGGIRVPFIVRWPGK------------------------IPAGQVSDALVSLLDLLPTLLDL 223
|
....*.
gi 262118210 324 AGLQVP 329
Cdd:cd16022 224 AGIEPP 229
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
28-330 |
4.79e-27 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 111.45 E-value: 4.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKVFHPGissnhtdDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANllcpvdvldvpegtlP 107
Cdd:cd16027 82 TLPELLREAGYYTGLIGKTHYNP-------DAVFPFDDEMRGPDDGGRNAWDYASNAADFLNRA---------------K 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 108 DKQsteqaiqllekmktsasPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAP----DPEVpdglppvaynpwmdirqR 183
Cdd:cd16027 140 KGQ-----------------PFFLWFGFHDPHRPYPPGDGEEPGYDPEKVKVPPylpdTPEV-----------------R 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 184 EDVQAlnisvpygpipvdfqrkirqsYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGehgeWAKYSNFDV 263
Cdd:cd16027 186 EDLAD---------------------YYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGMPFP----RAKGTLYDS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262118210 264 ATHVPLIFYVPGRTaslpeageklfpyldpfdsasqlmEPGRQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16027 241 GLRVPLIVRWPGKI------------------------KPGSVSDALVSFIDLAPTLLDLAGIEPPE 283
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
15-331 |
5.83e-27 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 109.17 E-value: 5.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 15 FNSYWRVHAG----NFSTIPQYFKENGYVTMSVGkvfhpgissnhtdDSPYSWSFPPYHPSSEKYENTktcRGPDGElha 90
Cdd:cd16148 61 YPFYHGVWGGplepDDPTLAEILRKAGYYTAAVS-------------SNPHLFGGPGFDRGFDTFEDF---RGQEGD--- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 91 nllcpvdvlDVPEGTLPDKQSTEQAIQLLEKMKTSaSPFFLAVGYHKPHIPFRYpkefqklyplenitlapdpevpdglp 170
Cdd:cd16148 122 ---------PGEEGDERAERVTDRALEWLDRNADD-DPFFLFLHYFDPHEPYLY-------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 171 pvaynpwmdirqredvqalnisvpygpipvDfqrkirqsyfASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALG 250
Cdd:cd16148 166 ------------------------------D----------AEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHGEEFG 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 251 EHGEWAK-YSNF-DVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlmEPGRQSMDLVELVSLFPTLAGLAGLQV 328
Cdd:cd16148 206 EHGLYWGhGSNLyDEQLHVPLIIRWPGK-------------------------EPGKRVDALVSHIDIAPTLLDLLGVEP 260
|
...
gi 262118210 329 PPR 331
Cdd:cd16148 261 PDY 263
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
128-379 |
6.57e-24 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 103.49 E-value: 6.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 128 PFFLAVGYHKPHIPFRYPKEFQKLYPLENITL---APDPEVPDGLPPVaYNPWMDIRQREDVQALNISVPYGPIPVdfQR 204
Cdd:cd16028 158 PWFLHLSYIRPHPPFVAPAPYHALYDPADVPPpirAESLAAEAAQHPL-LAAFLERIESLSFSPGAANAADLDDEE--VA 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 205 KIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTAslpeag 284
Cdd:cd16028 235 QMRATYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQLGDHWLWGKDGFFDQAYRVPLIVRDPRREA------ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 285 eklfpyldpfDSASqlmepGRQSMDLVELVSLFPTLAGLAGLQVPPRCpvpsfhvelcrEGKNLLKHfrfrdLEEDPylP 364
Cdd:cd16028 309 ----------DATR-----GQVVDAFTESVDVMPTILDWLGGEIPHQC-----------DGRSLLPL-----LAGAQ--P 355
|
250
....*....|....*
gi 262118210 365 GNPRELIAYSQYPRP 379
Cdd:cd16028 356 SDWRDAVHYEYDFRD 370
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
5-328 |
2.03e-22 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 96.68 E-value: 2.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 5 RRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKvfhpgissnhtddspyswsfppyhpssEKYENtktcrgp 84
Cdd:cd16153 71 RYPHRTGVYGFEAAHPALDHGLPTFPEVLKKAGYQTASFGK---------------------------SHLEA------- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 85 dgelhanllcPVDVLDVPEgtlpdkQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFqklyplenitlapdpe 164
Cdd:cd16153 117 ----------FQRYLKNAN------QSYKSFWGKIAKGADSDKPFFVRLSFLQPHTPVLPPKEF---------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 165 vpdglppvaynpwmdiRQREDvqalnisvpygpipvdfqrkirqsYFASVSYLDTQVGRLLSALDDLQLAN---STIIAF 241
Cdd:cd16153 165 ----------------RDRFD------------------------YYAFCAYGDAQVGRAVEAFKAYSLKQdrdYTIVYV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 242 TSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRtaslpeageKLFPyldpfdsasqlmePGRQSMDLVELVSLFPTLA 321
Cdd:cd16153 205 TGDHGWHLGEQGILAKFTFWPQSHRVPLIVVSSDK---------LKAP-------------AGKVRHDFVEFVDLAPTLL 262
|
....*..
gi 262118210 322 GLAGLQV 328
Cdd:cd16153 263 AAAGVDV 269
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
2-330 |
6.55e-22 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 97.61 E-value: 6.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 2 PLRRRPDTTRLYDFNSYWRVHAGNFsTIPQYFKENGYVTMSVGKvFHPGISSNHT--------DDSPYSWSFPPYHPSSE 73
Cdd:cd16144 73 GRRGPPDNTKLIPPPSTTRLPLEEV-TIAEALKDAGYATAHFGK-WHLGGEGGYGpedqgfdvNIGGTGNGGPPSYYFPP 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 74 KYENTKTCRGPDGElHanllcPVDVLdvpegtlpdkqsTEQAIQLLEKmkTSASPFFLAVGYHKPHIPFRYPKEFQKLYP 153
Cdd:cd16144 151 GKPNPDLEDGPEGE-Y-----LTDRL------------TDEAIDFIEQ--NKDKPFFLYLSHYAVHTPIQARPELIEKYE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 154 lenitlapdpEVPDGLPPVAYNPwmdirqredvqalnisvpygpipvdfqrkirqSYFASVSYLDTQVGRLLSALDDLQL 233
Cdd:cd16144 211 ----------KKKKGLRKGQKNP--------------------------------VYAAMIESLDESVGRILDALEELGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 234 ANSTIIAFTSDHGwALGEHGEWA---------KYSNFDVATHVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePG 304
Cdd:cd16144 249 ADNTLVIFTSDNG-GLSTRGGPPtsnaplrggKGSLYEGGIRVPLIVRWPGVIK------------------------PG 303
|
330 340
....*....|....*....|....*.
gi 262118210 305 RQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16144 304 SVSDVPVIGTDLYPTFLELAGGPLPP 329
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
28-329 |
1.44e-21 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 96.09 E-value: 1.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHPGISSNH--TD---DS----PYS---WSFPPYHPSSEKYEntktcrgpdgelhANLLCP 95
Cdd:cd16026 87 TIAEVLKKAGYRTALVGK-WHLGHQPEFlpTRhgfDEyfgiPYSndmWPFPLYRNDPPGPL-------------PPLMEN 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 96 VDVLDVPegtlPD-----KQSTEQAIQLLEKMKTSasPFFLAVGYHKPHIPFRYPKEFqklyplENITLApdpevpdGLp 170
Cdd:cd16026 153 EEVIEQP----ADqssltQRYTDEAVDFIERNKDQ--PFFLYLAHTMPHVPLFASEKF------KGRSGA-------GL- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 171 pvaynpwmdirqredvqalnisvpYGpipvdfqrkirqsyfASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALG 250
Cdd:cd16026 213 ------------------------YG---------------DVVEELDWSVGRILDALKELGLEENTLVIFTSDNGPWLE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 251 EHGEW--------AKYSNFDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAG 322
Cdd:cd16026 254 YGGHGgsagplrgGKGTTWEGGVRVPFIAWWPGV------------------------IPAGTVSDELASTMDLLPTLAA 309
|
....*..
gi 262118210 323 LAGLQVP 329
Cdd:cd16026 310 LAGAPLP 316
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
28-444 |
1.96e-20 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 93.00 E-value: 1.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHPGissnhtDDSPY----------------SWSFPPYHPSSEKYENTKTCRGP----DGe 87
Cdd:cd16146 82 TLAEVFKDAGYRTGIFGK-WHLG------DNYPYrpqdrgfdevlghgggGIGQYPDYWGNDYFDDTYYHNGKfvktEG- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 88 lhanlLCPvDVLdvpegtlpdkqsTEQAIQLLEKMKTSasPFFLAVGYHKPHIPFRYPKEFQKLYPlenitlapDPEVPD 167
Cdd:cd16146 154 -----YCT-DVF------------FDEAIDFIEENKDK--PFFAYLATNAPHGPLQVPDKYLDPYK--------DMGLDD 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 168 GlppvaynpwmdirqredvqalnisvpygpipvdfqrkiRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGW 247
Cdd:cd16146 206 K--------------------------------------LAAFYGMIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 248 ALGEHGEW------AKYSNFDVATHVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLA 321
Cdd:cd16146 248 AGGVPKRFnagmrgKKGSVYEGGHRVPFFIRWPGKIL------------------------AGKDVDTLTAHIDLLPTLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 322 GLAGLQVPPrcpvpsfHVELcrEGKNLLKhfrfrdLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSdkpslkdikimgyS 401
Cdd:cd16146 304 DLCGVKLPE-------GIKL--DGRSLLP------LLKGESDPWPERTLFTHSGRWPPPPKKKRNA-------------A 355
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 262118210 402 IRTIDYRYTVWVGFNPdeflanfsdihagELYFVDSDPLQDHN 444
Cdd:cd16146 356 VRTGRWRLVSPKGFQP-------------ELYDIENDPGEEND 385
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
210-337 |
6.12e-20 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 88.84 E-value: 6.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 210 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAK------YSNFDVATHVPLIFYVPGRTaslpea 283
Cdd:cd16149 144 YFAAVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGFNMGHHGIWGKgngtfpLNMYDNSVKVPFIIRWPGVV------ 217
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 262118210 284 geklfpyldpfdsasqlmEPGRQSMDLVELVSLFPTLAGLAGLQVP--PRCPVPSF 337
Cdd:cd16149 218 ------------------PAGRVVDSLVSAYDFFPTLLELAGVDPPadPRLPGRSF 255
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
23-326 |
5.37e-19 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 87.09 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 23 AGNFSTIPQYFKENGYVTMSVGKvFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDgelhanllcpvdvldvP 102
Cdd:pfam00884 76 PRTEPSLPDLLKRAGYNTGAIGK-WHLGWYNNQSPCNLGFDKFFGRNTGSDLYADPPDVPYNC----------------S 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 103 EGTLPDKQSTEQAIQLLEKmktSASPFFLAVGYHKPHIPFRYPKEFQKLYPlenitlapdpevpdglppvaynpwmdirq 182
Cdd:pfam00884 139 GGGVSDEALLDEALEFLDN---NDKPFFLVLHTLGSHGPPYYPDRYPEKYA----------------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 183 redvqalnISVPYGpipvDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFD 262
Cdd:pfam00884 187 --------TFKPSS----CSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGEGGGYLHGGKYD 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262118210 263 VA----THVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAGL 326
Cdd:pfam00884 255 NApeggYRVPLLIWSPGGKA------------------------KGQKSEALVSHVDLFPTILDLAGI 298
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
25-362 |
8.06e-19 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 88.59 E-value: 8.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 25 NFSTIPQYFKENGYVTMSVGK-------VFHPGISSNHTDdSPYSWSFPPYHPSSEKYENTKTCRGPDgELHANllcpvd 97
Cdd:cd16156 77 NVKTIGQRLSDNGIHTAYIGKwhldggdYFGNGICPQGWD-PDYWYDMRNYLDELTEEERRKSRRGLT-SLEAE------ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 98 vlDVPEGTLPDKQSTEQAIQLLEKMKTSasPFFLAVGYHKPHIPFRYPKEFQKLYplENITLAPDPEVPDGLP--PVAYN 175
Cdd:cd16156 149 --GIKEEFTYGHRCTNRALDFIEKHKDE--DFFLVVSYDEPHHPFLCPKPYASMY--KDFEFPKGENAYDDLEnkPLHQR 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 176 PWMDIRQREDVQALNISVPYgpipvdfqrkirqsYFASVSYLDTQVGRLLSALDDLqLANSTIIaFTSDHGWALGEHGEW 255
Cdd:cd16156 223 LWAGAKPHEDGDKGTIKHPL--------------YFGCNSFVDYEIGRVLDAADEI-AEDAWVI-YTSDHGDMLGAHKLW 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 256 AK-YSNFDVATHVPLIFYVPGrtaslpeaGEKLFPYLD-PfdsasqlmepgrqsmdlVELVSLFPTLAGLAGLQVPPRCP 333
Cdd:cd16156 287 AKgPAVYDEITNIPLIIRGKG--------GEKAGTVTDtP-----------------VSHIDLAPTILDYAGIPQPKVLE 341
|
330 340 350
....*....|....*....|....*....|...
gi 262118210 334 ----VPSFHVELCREGKNLLKHFRFRDLEEDPY 362
Cdd:cd16156 342 gesiLATIEDPEIPENRGVFVEFGRYEVDHDGF 374
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
108-326 |
4.06e-18 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 84.57 E-value: 4.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 108 DKQSTEQAIQLLEKMKTSAS---PFFLAVGYHKPHipfrypkefqklyplenitlapdpevpdglppvaynpwmdirqre 184
Cdd:cd16035 116 DPGIAAQAVEWLRERGAKNAdgkPWFLVVSLVNPH--------------------------------------------- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 185 DVQalnisvpYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSN-FDV 263
Cdd:cd16035 151 DIM-------FPPDDEERWRRFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHGEMGGAHGLRGKGFNaYEE 223
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262118210 264 ATHVPLIFYVPGrtaslpeagekLFPyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAGL 326
Cdd:cd16035 224 ALHVPLIISHPD-----------LFG-------------TGQTTDALTSHIDLLPTLLGLAGV 262
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
27-362 |
1.41e-17 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 84.14 E-value: 1.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 27 STIPQYFKENGYVTMSVGKVFHpGISSNHTDDSP---YSWSFPPYHPSseKYENTKTCRGPDGELHANllCPV----DVL 99
Cdd:cd16147 85 STLPVWLQEAGYRTAYAGKYLN-GYGVPGGVSYVppgWDEWDGLVGNS--TYYNYTLSNGGNGKHGVS--YPGdyltDVI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 100 dvpegtlpdkqsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPleNITLAP-----DPEVPDG------ 168
Cdd:cd16147 160 ------------ANKALDFLRRAAADDKPFFLVVAPPAPHGPFTPAPRYANLFP--NVTAPPrpppnNPDVSDKphwlrr 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 169 --LPPVAYNPWMDIRQREDVQALnisvpygpipvdfqrkirqsyfASVsylDTQVGRLLSALDDLQLANSTIIAFTSDHG 246
Cdd:cd16147 226 lpPLNPTQIAYIDELYRKRLRTL----------------------QSV---DDLVERLVNTLEATGQLDNTYIIYTSDNG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 247 WALGEHG-EWAKYSNFDVATHVPLIFYVPGrtasLPeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAG 325
Cdd:cd16147 281 YHLGQHRlPPGKRTPYEEDIRVPLLVRGPG----IP---------------------AGVTVDQLVSNIDLAPTILDLAG 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 262118210 326 LQVPP--------RCPVPSFH-VELCREGKNLLKHF---RFR---DLEEDPY 362
Cdd:cd16147 336 APPPSdmdgrscgDSNNNTYKcVRTVDDTYNLLYFEwctGFRelyDLTTDPY 387
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-331 |
4.56e-17 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 83.03 E-value: 4.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKVfhpGISSNHTDDSPYS----------------WSFPPYhpsseKYENTKTcrgpdgELHAN 91
Cdd:cd16145 85 TLAEVLKKAGYATAAFGKW---GLGGPGTPGHPTKqgfdyfygyldqvhahNYYPEY-----LWRNGEK------VPLPN 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 92 LLCPVDVLDVPEGTLPDKQS----TEQAIQLLEKMKtsASPFFLAVGYHKPHIPFRYPKefqklyplenitLAPDPEVPD 167
Cdd:cd16145 151 NVIPPLDEGNNAGGGGGTYShdlfTDEALDFIRENK--DKPFFLYLAYTLPHAPLQVPD------------DGPYKYKPK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 168 GLPPVAYNPWMDIRQRedvqalnisvpygpipvdfqrkirqsYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGw 247
Cdd:cd16145 217 DPGIYAYLPWPQPEKA--------------------------YAAMVTRLDRDVGRILALLKELGIDENTLVVFTSDNG- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 248 ALGEHGEWAKYSNFDVA--------------THVPLIFYVPGRTaslpeageklfpyldpfdsasqlmEPGRQSMDLVEL 313
Cdd:cd16145 270 PHSEGGSEHDPDFFDSNgplrgykrslyeggIRVPFIARWPGKI------------------------PAGSVSDHPSAF 325
|
330
....*....|....*...
gi 262118210 314 VSLFPTLAGLAGLQVPPR 331
Cdd:cd16145 326 WDFMPTLADLAGAEPPED 343
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
192-444 |
2.83e-16 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 79.95 E-value: 2.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 192 SVPYGPIPVDFQRkiRQSYF-ASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEW-------AKYSNFDV 263
Cdd:cd16151 190 SPDWDPDDKRKKD--DPEYFpDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGTHRPITSRTngrevrgGKGKTTDA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 264 ATHVPLIFYVPGrtaslpeageklfpyldpfdsasqLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVpsfhvelcr 343
Cdd:cd16151 268 GTHVPLIVNWPG------------------------LIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPL--------- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 344 EGKNLLkhfrfrdleedPYL---PGNPRELIAYsqyprpsdipqWNSDKPSLKDIKimgYSIRTIDYRYtvwvgfnpdef 420
Cdd:cd16151 315 DGRSFA-----------PQLlgkTGSPRREWIY-----------WYYRNPHKKFGS---RFVRTKRYKL----------- 358
|
250 260
....*....|....*....|....
gi 262118210 421 lanFSDihaGELYFVDSDPLQDHN 444
Cdd:cd16151 359 ---YAD---GRFFDLREDPLEKNP 376
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
204-330 |
3.05e-16 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 79.89 E-value: 3.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 204 RKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGrtaslpea 283
Cdd:cd16171 192 RNIRAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHGELAMEHRQFYKMSMYEGSSHVPLLIMGPG-------- 263
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 262118210 284 geklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16171 264 -----------------IKAGQQVSDVVSLVDIYPTMLDIAGVPQPQ 293
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
25-334 |
7.26e-16 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 79.13 E-value: 7.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 25 NFSTIPQYFKENGYVTMSVGKvFHPGISS-NHTD-----DSPYSwsfppYHPSSEKYENTKTCRGPDgelhanllCPVDV 98
Cdd:cd16029 82 NETLLPQYLKELGYATHLVGK-WHLGFYTwEYTPtnrgfDSFYG-----YYGGAEDYYTHTSGGAND--------YGNDD 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 99 LDVPEGTLPDKQS-------TEQAIQLLEKMKTSaSPFFLAVGYHKPHIPFRYPKEFQKLYPlenitlapdpevpdglpp 171
Cdd:cd16029 148 LRDNEEPAWDYNGtystdlfTDRAVDIIENHDPS-KPLFLYLAFQAVHAPLQVPPEYADPYE------------------ 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 172 vaynpwmdirqredVQALNISvpygpipvDFQRKIrqsYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGwALGE 251
Cdd:cd16029 209 --------------DKFAHIK--------DEDRRT---YAAMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNG-GPTG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 252 HGEWAkySNFdvathvPLifyvPGRTASLPEAGEKlfpyLDPFDSASQL-MEPGRQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16029 263 GGDGG--SNY------PL----RGGKNTLWEGGVR----VPAFVWSPLLpPKRGTVSDGLMHVTDWLPTLLSLAGGDPDD 326
|
....
gi 262118210 331 RCPV 334
Cdd:cd16029 327 LPPL 330
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-330 |
9.75e-16 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 78.34 E-value: 9.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvfhpgissNHTDDSPYSWsfppyhPssekyentkTCRGPDgELHANLLcpvdvldvpegTLP 107
Cdd:cd16142 87 TLAELLKDAGYATAQFGK--------WHLGDEDGRL------P---------TDHGFD-EFYGNLY-----------HTI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 108 DKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPlenitlapdpevpdglppvAYNPWMDirqredvq 187
Cdd:cd16142 132 DEEIVDKAIDFIKRNAKADKPFFLYVNFTKMHFPTLPSPEFEGKSS-------------------GKGKYAD-------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 188 alnisvpygpipvdfqrkirqsyfaSVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG-----WALGEHGEW--AKYSN 260
Cdd:cd16142 185 -------------------------SMVELDDHVGQILDALDELGIADNTIVIFTTDNGpeqdvWPDGGYTPFrgEKGTT 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 261 FDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 330
Cdd:cd16142 240 WEGGVRVPAIVRWPGK------------------------IKPGRVSNEIVSHLDWFPTLAALAGAPDPK 285
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-329 |
1.06e-14 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 75.32 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDgelHANLLCPVDVLDvpegTLp 107
Cdd:cd16143 87 TLAKMLKQAGYRTAMVGK-WHLGLDWKKKDGKKAATGTGKDVDYSKPIKGGPLDHGFD---YYFGIPASEVLP----TL- 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 108 dkqsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKlyplenitlapdpevpdglppvaynpwmdirqredVQ 187
Cdd:cd16143 158 ----TDKAVEFIDQHAKKDKPFFLYFALPAPHTPIVPSPEFQG-----------------------------------KS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 188 ALNisvPYGpipvDFqrkIRQsyfasvsyLDTQVGRLLSALDDLQLANSTIIAFTSDHG-------WALGEHGEWA---- 256
Cdd:cd16143 199 GAG---PYG----DF---VYE--------LDWVVGRILDALKELGLAENTLVIFTSDNGpspyadyKELEKFGHDPsgpl 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262118210 257 ---KYSNFDVATHVPLIFYVPGRTAslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16143 261 rgmKADIYEGGHRVPFIVRWPGKIP------------------------AGSVSDQLVSLTDLFATLAAIVGQKLP 312
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
112-449 |
1.69e-14 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 74.57 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 112 TEQAIQLLEKmKTSASPFFLAVGYHKPHIP---FRY--PKEFQKLYPlenitlapDPEVPdglppvaynpwmdirqrEDV 186
Cdd:cd16152 110 TDFAIDYLDN-RQKDKPFFLFLSYLEPHHQndrDRYvaPEGSAERFA--------NFWVP-----------------PDL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 187 QALnisvpygpiPVDFQRKIrQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHgwalGEH-----GEWaKYSNF 261
Cdd:cd16152 164 AAL---------PGDWAEEL-PDYLGCCERLDENVGRIRDALKELGLYDNTIIVFTSDH----GCHfrtrnAEY-KRSCH 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 262 DVATHVPLIFYVPGrtaslpeageklfpyldpFDSasqlmepGRQSMDLVELVSLFPTLAGLAGLQVPprcpvPSFHvel 341
Cdd:cd16152 229 ESSIRVPLVIYGPG------------------FNG-------GGRVEELVSLIDLPPTLLDAAGIDVP-----EEMQ--- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 342 creGKNLLkhfrfrdleedpylpgnprELIAYSQYPRPSDIPqwnsdkpslkdIKI----MGYSIRTIDYRYTVwVGFNP 417
Cdd:cd16152 276 ---GRSLL-------------------PLVDGKVEDWRNEVF-----------IQIsesqVGRAIRTDRWKYSV-AAPDK 321
|
330 340 350
....*....|....*....|....*....|...
gi 262118210 418 DEFLANFSDIHAGE-LYFVDSDPLQDHNMYNDS 449
Cdd:cd16152 322 DGWKDSGSDVYVEDyLYDLEADPYELVNLIGRP 354
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
28-329 |
4.73e-12 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 67.47 E-value: 4.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvfhpgissnhtddspysW--SFPPYHpSSEKYentktcrgpdgelhanllcpvdvldvpegt 105
Cdd:cd16025 90 TIAEVLKDAGYHTYMSGK-----------------WhlGPDDYY-STDDL------------------------------ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 106 lpdkqsTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEF----------------------QK---LYPlENITLA 160
Cdd:cd16025 122 ------TDKAIEYIDEQKAPDKPFFLYLAFGAPHAPLQAPKEWidkykgkydagwdalreerlerQKelgLIP-ADTKLT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 161 P-DPEVPdglppvaynPWMDIRQRE-DVQALNISVpygpipvdfqrkirqsYFASVSYLDTQVGRLLSALDDLQLANSTI 238
Cdd:cd16025 195 PrPPGVP---------AWDSLSPEEkKLEARRMEV----------------YAAMVEHMDQQIGRLIDYLKELGELDNTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 239 IAFTSDHGwALGEHGeWAKYSN-----FDVATH-----VPLIfyvpgrtASLPEAGEKlfpyldpfdsasqlmePGRQSM 308
Cdd:cd16025 250 IIFLSDNG-ASAEPG-WANASNtpfrlYKQASHeggirTPLI-------VSWPKGIKA----------------KGGIRH 304
|
330 340
....*....|....*....|.
gi 262118210 309 DLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16025 305 QFAHVIDIAPTILELAGVEYP 325
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
207-324 |
7.46e-12 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 65.13 E-value: 7.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 207 RQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYS----NFDVATHVPLIFYVPGRTAslpe 282
Cdd:cd00016 141 TPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDKGHGGDPKADgkadKSHTGMRVPFIAYGPGVKK---- 216
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 262118210 283 ageklfpyldpfdsasqlmepGRQSMDLVELVSLFPTLAGLA 324
Cdd:cd00016 217 ---------------------GGVKHELISQYDIAPTLADLL 237
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
25-330 |
8.18e-11 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 63.64 E-value: 8.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 25 NFSTIPQYFKENGYVTMSVGKvFHPGissnHTDDspyswsfppYHPSSekyentktcRGPDgelhanllcpvDVLDVP-- 102
Cdd:cd16161 84 NETTLAEVLRQAGYATGMIGK-WHLG----QREA---------YLPNS---------RGFD-----------YYFGIPfs 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 103 -EGTLPDKQStEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQklyplenitlapdpevpdglppvaynpwmdir 181
Cdd:cd16161 130 hDSSLADRYA-QFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRFQ-------------------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 182 qredvQALNISVPYGpipvdfqrkirqsyfASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG-WALG-------EHG 253
Cdd:cd16161 177 -----SPTSGRGPYG---------------DALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpWEVKcelavgpGTG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 254 EW--------AKYSNFDVATHVPLIFYVPGRtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAG 325
Cdd:cd16161 237 DWqgnlggsvAKASTWEGGHREPAIVYWPGR------------------------IPANSTSAALVSTLDIFPTVVALAG 292
|
....*
gi 262118210 326 LQVPP 330
Cdd:cd16161 293 ASLPP 297
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
25-349 |
9.21e-10 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 60.82 E-value: 9.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 25 NFSTIPQYFKENGYVTMsvgkVFHPGissnhtddSPYSWSFPPYHP--------SSEKYENTKTcrGPDGelhanllcpv 96
Cdd:COG1368 310 NFPSLPSILKKQGYETS----FFHGG--------DGSFWNRDSFYKnlgfdefyDREDFDDPFD--GGWG---------- 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 97 dvldvpegtLPDKQSTEQAIQLLEKMKtsaSPFFLAV----GyhkpHIPFRYPKEFQKLYPLENITLapdpevpdglppv 172
Cdd:COG1368 366 ---------VSDEDLFDKALEELEKLK---KPFFAFLitlsN----HGPYTLPEEDKKIPDYGKTTL------------- 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 173 aynpwmdirqredvqalnisvpygpipvdfqrkirQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGwalGEH 252
Cdd:COG1368 417 -----------------------------------NNYLNAVRYADQALGEFIEKLKKSGWYDNTIFVIYGDHG---PRS 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 253 GEWAKYSNFDVATHVPLIFYVPGRTAslPEAGEKLfpyldpfdsASQlmepgrqsMDlvelvsLFPTLAGLAGLQVPPRc 332
Cdd:COG1368 459 PGKTDYENPLERYRVPLLIYSPGLKK--PKVIDTV---------GSQ--------ID------IAPTLLDLLGIDYPSY- 512
|
330
....*....|....*..
gi 262118210 333 pvPSFhvelcreGKNLL 349
Cdd:COG1368 513 --YAF-------GRDLL 520
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
25-325 |
7.10e-09 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 56.92 E-value: 7.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 25 NFSTIPQYFKENGYVTMSvgkvFHPGissnhtddSPYSWSFPPYHP--------SSEKYENTKTCRGPDGelhanllcpv 96
Cdd:cd16015 79 PLPSLPSILKEQGYETIF----IHGG--------DASFYNRDSVYPnlgfdefyDLEDFPDDEKETNGWG---------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 97 dvldvpegtLPDKQSTEQAIQLLEKMKtsASPFFLAV----GyhkpHIPFRYPKEFQKLyplenitlapdpevpdglppv 172
Cdd:cd16015 137 ---------VSDESLFDQALEELEELK--KKPFFIFLvtmsN----HGPYDLPEEKKDE--------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 173 aynpwmdirqredvqalnisvpygPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEH 252
Cdd:cd16015 181 ------------------------PLKVEEDKTELENYLNAIHYTDKALGEFIEKLKKSGLYENTIIVIYGDHLPSLGSD 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262118210 253 GEWAKYSNFDvATHVPLIFYVPGrtaslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAG 325
Cdd:cd16015 237 YDETDEDPLD-LYRTPLLIYSPG-------------------------LKKPKKIDRVGSQIDIAPTLLDLLG 283
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
210-329 |
7.15e-09 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 57.68 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 210 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL------GEHGEW-------AKYSNFDVATHVPLIFYVPGR 276
Cdd:cd16159 281 YGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLeeisvgGEYGGGnggiyggKKMGGWEGGIRVPTIVRWPGV 360
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 262118210 277 tasLPeageklfpyldpfdSASQLMEPGRQsMDlvelvsLFPTLAGLAGLQVP 329
Cdd:cd16159 361 ---IP--------------PGSVIDEPTSL-MD------IFPTVAALAGAPLP 389
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
207-329 |
4.55e-07 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 52.08 E-value: 4.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 207 RQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL-------GEHGEW--AKYSNFDVATHVPLIFYVPGRt 277
Cdd:cd16157 223 RGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAALisapeqgGSNGPFlcGKQTTFEGGMREPAIAWWPGH- 301
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 262118210 278 aslpeageklfpyldpfdsasqlMEPGRQSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16157 302 -----------------------IKPGQVSHQLGSLMDLFTTSLALAGLPIP 330
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
110-329 |
7.95e-07 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 50.81 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 110 QSTEQAIQLLEKmktSASPFFLAVGYHKPHIPFRYPkefqklyP--LENITLAPDpevpdgLPPVAYNPwmdirqredvq 187
Cdd:cd16154 153 KLTNLAIDWIDQ---QTKPWFLWLAYNAPHTPFHLP-------PaeLHSRSLLGD------SADIEANP----------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 188 alnisvpygpipvdfqrkiRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIaFTSDHG--------WALGEHgewAKYS 259
Cdd:cd16154 206 -------------------RPYYLAAIEAMDTEIGRLLASIDEEERENTIII-FIGDNGtpgqvvdlPYTRNH---AKGS 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 260 NFDVATHVPLIFyvpgrtaslpeageklfpyldpfdSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16154 263 LYEGGINVPLIV------------------------SGAGVERANERESALVNATDLYATIAELAGVDAA 308
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
212-275 |
2.83e-06 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 48.74 E-value: 2.83e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262118210 212 ASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWA-LGEHGewakYSNFDVATHVPLIFYVPG 275
Cdd:cd16018 183 EALKRVDRRLGYLIEALKERGLLDDTNIIVVSDHGMTdVGTHG----YDNELPDMRAIFIARGPA 243
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
28-329 |
1.65e-05 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 47.04 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 28 TIPQYFKENGYVTMSVGKvFHPGISSNHTDDSPYswsFPPYH---------PssekYENTKTCrgPDGELHanllcpVDV 98
Cdd:cd16160 89 TMAEALKEAGYTTGMVGK-WHLGINENNHSDGAH---LPSHHgfdfvgtnlP----FTNSWAC--DDTGRH------VDF 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 99 LDVPEGTLPDK-QSTEQAIQ---LLEKMKTSA---------SPFFLAVGYHKPHIPFRYPKEFQklyplenitlapdpev 165
Cdd:cd16160 153 PDRSACFLYYNdTIVEQPIQhehLTETLVGDAksfiednqeNPFFLYFSFPQTHTPLFASKRFK---------------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 166 pdglppvaynpwmdirqredvqalNISVpygpipvdfqrkiRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDH 245
Cdd:cd16160 217 ------------------------GKSK-------------RGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDH 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 246 GWAL---GEHGEWA-----KYSNFDVATHVPLIFYVPGRTaslpeageklfpyldpfdsasqlmePGRQSMDLVELVSLF 317
Cdd:cd16160 260 GPHVeycLEGGSTGglkggKGNSWEGGIRVPFIAYWPGTI-------------------------KPRVSHEVVSTMDIF 314
|
330
....*....|..
gi 262118210 318 PTLAGLAGLQVP 329
Cdd:cd16160 315 PTFVDLAGGTLP 326
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
204-329 |
6.44e-05 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 45.13 E-value: 6.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 204 RKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL------GEHG--EWAKYSNFDVATHVPLIFYVPG 275
Cdd:cd16158 222 RSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPSTmrksrgGNAGllKCGKGTTYEGGVREPAIAYWPG 301
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 262118210 276 RTAslpeageklfpyldpfdsasqlmePGRqSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16158 302 RIK------------------------PGV-THELASTLDILPTIAKLAGAPLP 330
|
|
| LptA |
cd16017 |
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ... |
139-327 |
1.12e-04 |
|
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.
Pssm-ID: 293741 [Multi-domain] Cd Length: 288 Bit Score: 43.77 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 139 HIPF--RYPKEFQKLYPlenitlapdpevpdglppvaynpwmdirqredvqalnisVPYGPIPVDFQRKIRQSYFASVSY 216
Cdd:cd16017 154 HGPYydRYPEEFAKFTP---------------------------------------DCDNELQSCSKEELINAYDNSILY 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 217 LDTQVGRLLSALDDLQlaNSTIIAFTSDHGWALGEHGEW--AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPF 294
Cdd:cd16017 195 TDYVLSQIIERLKKKD--KDAALIYFSDHGESLGENGLYlhGAPYAPKEQYHVPFIIWSSDSYKQRYPVERLRANKDRPF 272
|
170 180 190
....*....|....*....|....*....|...
gi 262118210 295 dsasqlmepgrqSMDLvelvsLFPTLAGLAGLQ 327
Cdd:cd16017 273 ------------SHDN-----LFHTLLGLLGIK 288
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
210-246 |
4.28e-04 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 42.43 E-value: 4.28e-04
10 20 30
....*....|....*....|....*....|....*..
gi 262118210 210 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 246
Cdd:COG1524 207 YRAALREVDAALGRLLDALKARGLYEGTLVIVTADHG 243
|
|
| GPI_EPT_2 |
cd16024 |
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ... |
216-329 |
2.29e-03 |
|
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293748 [Multi-domain] Cd Length: 274 Bit Score: 39.86 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262118210 216 YLDTQVGRLLSALDDLQLANSTIIAFTSDHGW-ALGEHGEwAKYSNfdvaTHVPLIFYVPGrtaslpeageklfpyldpF 294
Cdd:cd16024 175 EMDDVIKRIYESLEEQSSNNPTLLVVCGDHGMtDAGNHGG-SSPGE----TSVPLLFISPK------------------F 231
|
90 100 110
....*....|....*....|....*....|....*
gi 262118210 295 DSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 329
Cdd:cd16024 232 SSKPSNADGELSYYETVQQVDLAPTLALLLGLPIP 266
|
|
| |
