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Conserved domains on  [gi|262527269|ref|NP_001161074|]
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sialidase-4 isoform 3 [Homo sapiens]

Protein Classification

sialidase family protein( domain architecture ID 10202570)

sialidase (glycoside hydrolase 33) family protein such as non-viral exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides

CATH:  2.120.10.10
CAZY:  GH33
EC:  3.2.1.-
PubMed:  7934919|8994884
SCOP:  3001607

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
10-456 2.73e-61

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


:

Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 203.84  E-value: 2.73e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  10 TVLFERERTG-LTYRVPSLLPVPPGpTLLAFVEQRL--SPDDSHAHRLVLRRGTLAGGSvrWGA-LHVLGTAALAEHRSM 85
Cdd:cd15482    1 VLLFVPGDEGsDSYRIPSLVTTPNG-TLLAFADGRYegAGDLGGDIDIVVRRSTDGGKT--WSEpVTVVDGGGSGGASYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  86 NPCPVHDAGTGTVFLFFIAVLGHTPEAvqiATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGavqDWATFAVGPGHGV 165
Cdd:cd15482   78 DPSLVVDPDTGRIFLFYTSGPGGGGEA---LTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGI 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 166 QLPSGRLLVPAYTYRVDRRecfgkicrtSPHSFAFYSDDHGRTWRCGGLVPNLRSG--ECQLAAVDGGQagsfLYCNARS 243
Cdd:cd15482  152 QLSDGRLVFPAYARNGGGG---------GDGAVVIYSDDGGKTWTRGGGVPSSGAGgdEPSIVELSDGR----LLMNARN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 244 --PLGSRVQALSTDEGTSFLPAERVASLPEtaWGCQGSIVGFPAPAPNrprddswsvgpgsplqppllgpgvheppeeaa 321
Cdd:cd15482  219 sgGGGGRAVAESTDGGETWSEPVPTPSLPD--PGCQGSLIRLPDGGRK-------------------------------- 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 322 vdprggqvpggpfsrlqprgdgprqpgprpgvsgdvgswtlalpmpfaappqsptWLLYSHPVGRRA-RLHMGIRLSQsp 400
Cdd:cd15482  265 -------------------------------------------------------VLLFSNPASPGKgRTNLTLRLSD-- 287
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 262527269 401 LDPRSWTEPWVIYEGP-SGYSDLASIgpaPEGglVFACLYESGARTSYDEISFCTFS 456
Cdd:cd15482  288 DGGKTWPDVRVLEDGPgSGYSSLTQL---PDG--TIGLLYEEGRGGGYEGIKFARLT 339
PHA03247 super family cl33720
large tegument protein UL36; Provisional
241-375 7.12e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  241 ARSPLGSRVQALSTDEGTSFLPAERVASLPETAwgcqgsiVGFPAPAPNRPRDDSWSVGPGSPLQPPL----LGPGVHEP 316
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP-------ADPPAAVLAPAAALPPAASPAGPLPPPTsaqpTAPPPPPG 2844
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262527269  317 PEEAAVDPRGGQVPGGPFSRLQPrgdgPRQPGPRPGVSGDVGSWTLALP------MPFAAPPQSP 375
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPARPPVRRLARPavsrstESFALPPDQP 2905
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
10-456 2.73e-61

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 203.84  E-value: 2.73e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  10 TVLFERERTG-LTYRVPSLLPVPPGpTLLAFVEQRL--SPDDSHAHRLVLRRGTLAGGSvrWGA-LHVLGTAALAEHRSM 85
Cdd:cd15482    1 VLLFVPGDEGsDSYRIPSLVTTPNG-TLLAFADGRYegAGDLGGDIDIVVRRSTDGGKT--WSEpVTVVDGGGSGGASYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  86 NPCPVHDAGTGTVFLFFIAVLGHTPEAvqiATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGavqDWATFAVGPGHGV 165
Cdd:cd15482   78 DPSLVVDPDTGRIFLFYTSGPGGGGEA---LTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGI 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 166 QLPSGRLLVPAYTYRVDRRecfgkicrtSPHSFAFYSDDHGRTWRCGGLVPNLRSG--ECQLAAVDGGQagsfLYCNARS 243
Cdd:cd15482  152 QLSDGRLVFPAYARNGGGG---------GDGAVVIYSDDGGKTWTRGGGVPSSGAGgdEPSIVELSDGR----LLMNARN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 244 --PLGSRVQALSTDEGTSFLPAERVASLPEtaWGCQGSIVGFPAPAPNrprddswsvgpgsplqppllgpgvheppeeaa 321
Cdd:cd15482  219 sgGGGGRAVAESTDGGETWSEPVPTPSLPD--PGCQGSLIRLPDGGRK-------------------------------- 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 322 vdprggqvpggpfsrlqprgdgprqpgprpgvsgdvgswtlalpmpfaappqsptWLLYSHPVGRRA-RLHMGIRLSQsp 400
Cdd:cd15482  265 -------------------------------------------------------VLLFSNPASPGKgRTNLTLRLSD-- 287
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 262527269 401 LDPRSWTEPWVIYEGP-SGYSDLASIgpaPEGglVFACLYESGARTSYDEISFCTFS 456
Cdd:cd15482  288 DGGKTWPDVRVLEDGPgSGYSSLTQL---PDG--TIGLLYEEGRGGGYEGIKFARLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
9-463 1.94e-51

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 178.59  E-value: 1.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269   9 RTVLFERERTGL-TYRVPSLLPVPPGpTLLAFVEQRL-SPDDSHAH-RLVLRRGTLAGGSvrWGALHVL---GTAALAEH 82
Cdd:COG4409   23 ETAVFTSGDDGYaSYRIPALVTTPKG-TLLAFADARYnGSGDLPGDiDIVMRRSTDGGKT--WSPPQVIldyGEGGGLSA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  83 RSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQ-IATGRNAARLCCVA---SRDAGLSWGSARDLTEEAiggAVQDWATFA 158
Cdd:COG4409  100 GVGDPAPVVDRKTGRIFLLADWMPGNDGEGWSgSEPGTDPKGTRQLWvtySDDDGKTWSEPRNITPQV---KDPDWRFLA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 159 VGPGHGVQLPS----GRLLVPAYTyrvdrrecfgkICRTSPHSFAFYSDDHGRTWRCGGLV-PNLRSGECQLAAVDGGQa 233
Cdd:COG4409  177 TGPGHGIQLKNgehkGRLVFPAYY-----------SDGGKPSAAVIYSDDHGKTWKLGESAnDKANTNEAQVVELSDGR- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 234 gsfLYCNAR--SPLGSRVQALSTDEGTSFLPAERVASLPETawGCQGSIVgfpapapnrprddswsvgpgsplqppllgp 311
Cdd:COG4409  245 ---LMLNMRnqSGGGKRAVATSKDGGETWSEVTFDPALPEP--VCQASII------------------------------ 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 312 gvheppeeaAVDPRGGQvpggpfsrlqprgdgprqpgprpgvsgdvgswtlalpmpfaappqspTWLLYSHPVGRRARLH 391
Cdd:COG4409  290 ---------RYDKGDGK-----------------------------------------------DVLLFSNPASPKGRKN 313
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262527269 392 MGIRLSQSplDPRSWTEPWVIYEGPSGYSDLASIgpaPEGGlvFACLYESGArtsYDEISFCTFSLREVLEN 463
Cdd:COG4409  314 GTVRLSYD--DGKTWPYSKVIEPGGSAYSCLTVL---DDGT--IGLLYERGD---AGNIVFARFPLDWLTQK 375
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
64-270 3.36e-19

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 87.38  E-value: 3.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269   64 GSVRWGALHVLGTAALAE---HRSMNPCPVHDAGtGTVFLFFIAvlghTPEAVQIATGRNAARLccvaSRDAGLSWGSAR 140
Cdd:pfam13088  28 GSNKWSAPQVVADGEQLGryiRKLGNPVLFRDPG-GTLVLFYKV----GVSPGGWAGSKIYRIT----SSDNGRTWSAPR 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  141 DLTEeaiggavqDWATFAVGPGHG--VQLPSGRLLVPAYTyrvdrrECFGKicrtsPHSFAFYSDDHGRTWRCGGLVPNL 218
Cdd:pfam13088  99 RLPP--------GPFLNISGPVKNkpVQLADGRLLLPSYH------ELAGK-----WAAHLELSDDGGVTWRKGRPDNAI 159
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 262527269  219 rSGECQLAAV--DGGQagsfLYCNARSPLGSRVQALSTDEGTSFLPAErVASLP 270
Cdd:pfam13088 160 -SGELQPSVLvlADGR----LVMLFRSQEGAILASESTDGGLTWSPPE-PTNLP 207
PHA03247 PHA03247
large tegument protein UL36; Provisional
241-375 7.12e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  241 ARSPLGSRVQALSTDEGTSFLPAERVASLPETAwgcqgsiVGFPAPAPNRPRDDSWSVGPGSPLQPPL----LGPGVHEP 316
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP-------ADPPAAVLAPAAALPPAASPAGPLPPPTsaqpTAPPPPPG 2844
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262527269  317 PEEAAVDPRGGQVPGGPFSRLQPrgdgPRQPGPRPGVSGDVGSWTLALP------MPFAAPPQSP 375
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPARPPVRRLARPavsrstESFALPPDQP 2905
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
10-456 2.73e-61

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 203.84  E-value: 2.73e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  10 TVLFERERTG-LTYRVPSLLPVPPGpTLLAFVEQRL--SPDDSHAHRLVLRRGTLAGGSvrWGA-LHVLGTAALAEHRSM 85
Cdd:cd15482    1 VLLFVPGDEGsDSYRIPSLVTTPNG-TLLAFADGRYegAGDLGGDIDIVVRRSTDGGKT--WSEpVTVVDGGGSGGASYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  86 NPCPVHDAGTGTVFLFFIAVLGHTPEAvqiATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGavqDWATFAVGPGHGV 165
Cdd:cd15482   78 DPSLVVDPDTGRIFLFYTSGPGGGGEA---LTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGI 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 166 QLPSGRLLVPAYTYRVDRRecfgkicrtSPHSFAFYSDDHGRTWRCGGLVPNLRSG--ECQLAAVDGGQagsfLYCNARS 243
Cdd:cd15482  152 QLSDGRLVFPAYARNGGGG---------GDGAVVIYSDDGGKTWTRGGGVPSSGAGgdEPSIVELSDGR----LLMNARN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 244 --PLGSRVQALSTDEGTSFLPAERVASLPEtaWGCQGSIVGFPAPAPNrprddswsvgpgsplqppllgpgvheppeeaa 321
Cdd:cd15482  219 sgGGGGRAVAESTDGGETWSEPVPTPSLPD--PGCQGSLIRLPDGGRK-------------------------------- 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 322 vdprggqvpggpfsrlqprgdgprqpgprpgvsgdvgswtlalpmpfaappqsptWLLYSHPVGRRA-RLHMGIRLSQsp 400
Cdd:cd15482  265 -------------------------------------------------------VLLFSNPASPGKgRTNLTLRLSD-- 287
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 262527269 401 LDPRSWTEPWVIYEGP-SGYSDLASIgpaPEGglVFACLYESGARTSYDEISFCTFS 456
Cdd:cd15482  288 DGGKTWPDVRVLEDGPgSGYSSLTQL---PDG--TIGLLYEEGRGGGYEGIKFARLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
9-463 1.94e-51

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 178.59  E-value: 1.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269   9 RTVLFERERTGL-TYRVPSLLPVPPGpTLLAFVEQRL-SPDDSHAH-RLVLRRGTLAGGSvrWGALHVL---GTAALAEH 82
Cdd:COG4409   23 ETAVFTSGDDGYaSYRIPALVTTPKG-TLLAFADARYnGSGDLPGDiDIVMRRSTDGGKT--WSPPQVIldyGEGGGLSA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  83 RSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQ-IATGRNAARLCCVA---SRDAGLSWGSARDLTEEAiggAVQDWATFA 158
Cdd:COG4409  100 GVGDPAPVVDRKTGRIFLLADWMPGNDGEGWSgSEPGTDPKGTRQLWvtySDDDGKTWSEPRNITPQV---KDPDWRFLA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 159 VGPGHGVQLPS----GRLLVPAYTyrvdrrecfgkICRTSPHSFAFYSDDHGRTWRCGGLV-PNLRSGECQLAAVDGGQa 233
Cdd:COG4409  177 TGPGHGIQLKNgehkGRLVFPAYY-----------SDGGKPSAAVIYSDDHGKTWKLGESAnDKANTNEAQVVELSDGR- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 234 gsfLYCNAR--SPLGSRVQALSTDEGTSFLPAERVASLPETawGCQGSIVgfpapapnrprddswsvgpgsplqppllgp 311
Cdd:COG4409  245 ---LMLNMRnqSGGGKRAVATSKDGGETWSEVTFDPALPEP--VCQASII------------------------------ 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 312 gvheppeeaAVDPRGGQvpggpfsrlqprgdgprqpgprpgvsgdvgswtlalpmpfaappqspTWLLYSHPVGRRARLH 391
Cdd:COG4409  290 ---------RYDKGDGK-----------------------------------------------DVLLFSNPASPKGRKN 313
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262527269 392 MGIRLSQSplDPRSWTEPWVIYEGPSGYSDLASIgpaPEGGlvFACLYESGArtsYDEISFCTFSLREVLEN 463
Cdd:COG4409  314 GTVRLSYD--DGKTWPYSKVIEPGGSAYSCLTVL---DDGT--IGLLYERGD---AGNIVFARFPLDWLTQK 375
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
64-270 3.36e-19

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 87.38  E-value: 3.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269   64 GSVRWGALHVLGTAALAE---HRSMNPCPVHDAGtGTVFLFFIAvlghTPEAVQIATGRNAARLccvaSRDAGLSWGSAR 140
Cdd:pfam13088  28 GSNKWSAPQVVADGEQLGryiRKLGNPVLFRDPG-GTLVLFYKV----GVSPGGWAGSKIYRIT----SSDNGRTWSAPR 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  141 DLTEeaiggavqDWATFAVGPGHG--VQLPSGRLLVPAYTyrvdrrECFGKicrtsPHSFAFYSDDHGRTWRCGGLVPNL 218
Cdd:pfam13088  99 RLPP--------GPFLNISGPVKNkpVQLADGRLLLPSYH------ELAGK-----WAAHLELSDDGGVTWRKGRPDNAI 159
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 262527269  219 rSGECQLAAV--DGGQagsfLYCNARSPLGSRVQALSTDEGTSFLPAErVASLP 270
Cdd:pfam13088 160 -SGELQPSVLvlADGR----LVMLFRSQEGAILASESTDGGLTWSPPE-PTNLP 207
COG4692 COG4692
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane ...
86-264 2.46e-07

Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443727 [Multi-domain]  Cd Length: 353  Bit Score: 52.62  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  86 NPCPVHDAGtGTVFLFFIAVLGHTPEAvqiatgrnaARLCCVASRDAGLSWGSARDLTEE--AIGGAVQdwatfavgpGH 163
Cdd:COG4692  104 NPVLFLAPD-GRLWLFYKVPSPGGWWG---------SLIRVRTSTDGGKTWSPPERLPEGpfLIGGPVR---------NK 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269 164 GVQLPSGRLLVPAYTyrvdrreCFGkicrtsPHSFAF--YSDDHGRTWRC-------GGLVPN-LRSGECQLAAvdggqa 233
Cdd:COG4692  165 PVVLSDGRILLPSYT-------ESG------GKWRSHveISDDGGKTWTKspipkgfGAIQPSiLELKDGRLQA------ 225
                        170       180       190
                 ....*....|....*....|....*....|.
gi 262527269 234 gsflYCNARSPlGSRVQALSTDEGTSFLPAE 264
Cdd:COG4692  226 ----LMRSRGA-GRIYRSESTDGGKTWSPPE 251
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
9-436 6.91e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 42.55  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269    9 RTVLFERERTGLT---YRVpsLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGT--------------LAGGSVRWGAL 71
Cdd:COG3321   775 QPVRFADAVEALLadgVRV--FLEVGPGPVLTGLVRQCLAAAGDAVVLPSLRRGEdelaqlltalaqlwVAGVPVDWSAL 852
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269   72 HVLGTAALA-------EHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTE 144
Cdd:COG3321   853 YPGRGRRRVplptypfQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLAL 932
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  145 EAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRecfgkicrtsPHSFAFYSDDHGRTWRCGGLVPNLRSGECQ 224
Cdd:COG3321   933 VALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAA----------AAAAAAAAAAAAAAAAAAAAAAALAAAAAL 1002
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  225 LAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPL 304
Cdd:COG3321  1003 ALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAA 1082
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  305 QPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPV 384
Cdd:COG3321  1083 ALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAA 1162
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262527269  385 GRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFA 436
Cdd:COG3321  1163 LAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALA 1214
PHA03247 PHA03247
large tegument protein UL36; Provisional
241-375 7.12e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262527269  241 ARSPLGSRVQALSTDEGTSFLPAERVASLPETAwgcqgsiVGFPAPAPNRPRDDSWSVGPGSPLQPPL----LGPGVHEP 316
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP-------ADPPAAVLAPAAALPPAASPAGPLPPPTsaqpTAPPPPPG 2844
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262527269  317 PEEAAVDPRGGQVPGGPFSRLQPrgdgPRQPGPRPGVSGDVGSWTLALP------MPFAAPPQSP 375
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPP----SRSPAAKPAAPARPPVRRLARPavsrstESFALPPDQP 2905
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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