NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|269996004|ref|NP_001161797|]
View 

calcineurin B homologous protein 3 isoform 2 [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 87-115 8.97e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 8.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 269996004  87 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 115
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
54-123 1.72e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269996004  54 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 123
Cdd:COG5126   48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 87-115 8.97e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 8.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 269996004  87 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 115
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
54-123 1.72e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269996004  54 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 123
Cdd:COG5126   48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
EF-hand_7 pfam13499
EF-hand domain pair;
85-130 1.86e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 35.31  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269996004   85 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSI 130
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEEL 45
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 87-115 8.97e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 8.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 269996004  87 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 115
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
54-123 1.72e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269996004  54 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 123
Cdd:COG5126   48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
EF-hand_7 pfam13499
EF-hand domain pair;
85-130 1.86e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 35.31  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269996004   85 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSI 130
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEEL 45
EF-hand_6 pfam13405
EF-hand domain;
87-115 3.27e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 33.69  E-value: 3.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 269996004   87 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 115
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSL 29
EFh_CREC_RCN3 cd16230
EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3); RCN-3, also termed EF-hand ...
 83-110 7.73e-03

EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3); RCN-3, also termed EF-hand calcium-binding protein RLP49, is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal His-Asp-Glu-Leu (HDEL) tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.


Pssm-ID: 320028 [Multi-domain]  Cd Length: 268  Bit Score: 36.11  E-value: 7.73e-03
                         10        20
                 ....*....|....*....|....*...
gi 269996004  83 SRKEKLRFLFHMYDSDSDGRITLEEYRN 110
Cdd:cd16230   70 HIRDSVSAAWQTYDTDRDGRVGWEELRN 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH