|
Name |
Accession |
Description |
Interval |
E-value |
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
386-768 |
4.34e-38 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 155.20 E-value: 4.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 386 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDSP--------VLRLSNLdpgnySF 456
Cdd:NF038112 1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTAtpsftapeVTADTVL-----TF 1256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 457 RLTVTDSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQ 536
Cdd:NF038112 1257 QLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGAT 1331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 537 TPYLHLSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFY 613
Cdd:NF038112 1332 TATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTY 1408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 614 HWEHVRGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNS 690
Cdd:NF038112 1409 AWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGST 1485
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 691 ITLDGSRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 768
Cdd:NF038112 1486 VTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
359-675 |
7.16e-31 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 132.09 E-value: 7.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 359 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 436
Cdd:NF038112 1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 437 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 511
Cdd:NF038112 1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 512 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 587
Cdd:NF038112 1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 588 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 664
Cdd:NF038112 1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555
|
330
....*....|.
gi 270265857 665 AVKKENNSPPR 675
Cdd:NF038112 1556 TVKNVNRAPDG 1566
|
|
| MANEC |
smart00765 |
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ... |
4-57 |
2.33e-15 |
|
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.
Pssm-ID: 129004 Cd Length: 93 Bit Score: 72.48 E-value: 2.33e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270265857 4 SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKENCepkKMGPIRSYLTF 57
Cdd:smart00765 35 IAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKEVC---KFKPHEGYTSY 93
|
|
| REJ |
pfam02010 |
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ... |
501-781 |
3.60e-10 |
|
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Pssm-ID: 366875 [Multi-domain] Cd Length: 448 Bit Score: 63.29 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 501 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 572
Cdd:pfam02010 1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 573 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 630
Cdd:pfam02010 80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 631 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 702
Cdd:pfam02010 157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 703 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 769
Cdd:pfam02010 235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313
|
330
....*....|..
gi 270265857 770 SGLVELTLQVGV 781
Cdd:pfam02010 314 GGTCSVTPTEGT 325
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
390-476 |
6.93e-10 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 56.31 E-value: 6.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 390 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 469
Cdd:smart00089 1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71
|
....*..
gi 270265857 470 TTAALIV 476
Cdd:smart00089 72 ATVTVVV 78
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
581-666 |
2.10e-08 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 52.11 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 581 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 660
Cdd:cd00146 1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75
|
....*.
gi 270265857 661 TLTVAV 666
Cdd:cd00146 76 TTTVVV 81
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
436-773 |
6.70e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.92 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 436 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 514
Cdd:COG3401 186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 515 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 593
Cdd:COG3401 262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 594 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 662
Cdd:COG3401 334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 663 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 742
Cdd:COG3401 412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490
|
330 340 350
....*....|....*....|....*....|.
gi 270265857 743 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 773
Cdd:COG3401 491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
|
|
| MANEC |
pfam07502 |
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ... |
11-42 |
6.37e-04 |
|
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.
Pssm-ID: 462186 Cd Length: 90 Bit Score: 39.60 E-value: 6.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 270265857 11 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 42
Cdd:pfam07502 38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
353-580 |
6.51e-04 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 43.92 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 353 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 424
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 425 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 491
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 492 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 554
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445
|
250 260
....*....|....*....|....*.
gi 270265857 555 KVTDSSRQQSTAvVTVIVQPenNRPP 580
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
|
|
| PARM |
pfam17061 |
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ... |
157-292 |
8.57e-04 |
|
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.
Pssm-ID: 465341 [Multi-domain] Cd Length: 296 Bit Score: 42.54 E-value: 8.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 157 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 226
Cdd:pfam17061 78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270265857 227 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 292
Cdd:pfam17061 158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
125-286 |
3.28e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.45 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 125 PSGKQEPRGSAEYTDWGLLP---GSEGAFNSSVGDSPAVPAETQQDPelhyLNESASTPAPKLPERsvllPLPTTPSSGe 201
Cdd:PLN03209 324 PSQRVPPKESDAADGPKPVPtkpVTPEAPSPPIEEEPPQPKAVVPRP----LSPYTAYEDLKPPTS----PIPTPPSSS- 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 202 vleKEKASQLQEQSSNSSGKevLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSI-------PTPPTSAAPSESTPS 274
Cdd:PLN03209 395 ---PASSKSVDAVAKPAEPD--VVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLkpptspsPTAPTGVSPSVSSTS 469
|
170
....*....|..
gi 270265857 275 ELPISPTTAPRT 286
Cdd:PLN03209 470 SVPAVPDTAPAT 481
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
386-768 |
4.34e-38 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 155.20 E-value: 4.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 386 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDSP--------VLRLSNLdpgnySF 456
Cdd:NF038112 1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTAtpsftapeVTADTVL-----TF 1256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 457 RLTVTDSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQ 536
Cdd:NF038112 1257 QLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGAT 1331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 537 TPYLHLSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFY 613
Cdd:NF038112 1332 TATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTY 1408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 614 HWEHVRGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNS 690
Cdd:NF038112 1409 AWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGST 1485
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 691 ITLDGSRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 768
Cdd:NF038112 1486 VTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
359-675 |
7.16e-31 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 132.09 E-value: 7.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 359 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 436
Cdd:NF038112 1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 437 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 511
Cdd:NF038112 1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 512 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 587
Cdd:NF038112 1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 588 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 664
Cdd:NF038112 1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555
|
330
....*....|.
gi 270265857 665 AVKKENNSPPR 675
Cdd:NF038112 1556 TVKNVNRAPDG 1566
|
|
| MANEC |
smart00765 |
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ... |
4-57 |
2.33e-15 |
|
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.
Pssm-ID: 129004 Cd Length: 93 Bit Score: 72.48 E-value: 2.33e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270265857 4 SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKENCepkKMGPIRSYLTF 57
Cdd:smart00765 35 IAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKEVC---KFKPHEGYTSY 93
|
|
| REJ |
pfam02010 |
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ... |
501-781 |
3.60e-10 |
|
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Pssm-ID: 366875 [Multi-domain] Cd Length: 448 Bit Score: 63.29 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 501 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 572
Cdd:pfam02010 1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 573 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 630
Cdd:pfam02010 80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 631 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 702
Cdd:pfam02010 157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 703 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 769
Cdd:pfam02010 235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313
|
330
....*....|..
gi 270265857 770 SGLVELTLQVGV 781
Cdd:pfam02010 314 GGTCSVTPTEGT 325
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
390-476 |
6.93e-10 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 56.31 E-value: 6.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 390 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 469
Cdd:smart00089 1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71
|
....*..
gi 270265857 470 TTAALIV 476
Cdd:smart00089 72 ATVTVVV 78
|
|
| REJ |
pfam02010 |
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ... |
347-672 |
3.04e-09 |
|
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Pssm-ID: 366875 [Multi-domain] Cd Length: 448 Bit Score: 60.59 E-value: 3.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 347 TLNLSQLSVGLYVFKVTVSSE---NAFGEGFVNVTVKPArrvnlPPVAV-------VSPQLQELTLpltsaliDGSQSTD 416
Cdd:pfam02010 44 TIPSGTLPYGTYVFTLTVSLSstpSLAGTDIITVTVQPS-----PLVAVidggssrVVGYNQDLTL-------DGSESYD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 417 ------DTEIVSYHWEEINGPFIEEKTSVDSPV-----LRLSNLDPGN---------------YSFRLTVTDSDGATNST 470
Cdd:pfam02010 112 pdvdpgSSSGLTYLWSCRRSSSGDNPLLNNDPVcfsdqNEGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSAST 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 471 TAALIVNNavDYPP------VANAGpnhTITLPQNS---ITLNGNQSSDDHQIVLYEWsLGPGSEGKHVV--------MQ 533
Cdd:pfam02010 192 TQTILVVD--GNPPiiilscISNCN---RKNNPVDRlvlLASTCLNCSSDLSDVTYRW-LSLGSENTSLVldqlnsqtST 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 534 GVQTPYLHLSA--MQEG-DYTFQLKVTDSSRQQS-TAVVTVIvqpeNNRPPVAVA-------GPDKELIFPVESatldgS 602
Cdd:pfam02010 266 GRSGPYLVIKAgvLQSGvSYRFTLIVTVYPGLVSgLASISFI----TNAPPTGGTcsvtpteGTALETKFTVTC-----Q 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 603 SSSDDHGIVFYHWEHVRGPSAVEMENI------DKAIATVTGLQVGTYHFRLT----VKDQQGLSSTSTLTVAVKKENNS 672
Cdd:pfam02010 337 GWTDDDLPLTYQFGDISFREASEEWFLlyegssQISISTFLPPGLPANDYQVTvvvvVYDSLGAATSVSLTITVTPPSSS 416
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
485-573 |
7.37e-09 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 53.61 E-value: 7.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 485 VANAGPNHTITLPQNSITLNGnQSSDDHQIVLYEWSLGPG--SEGKHVVMQgvqtpYLHlsamqEGDYTFQLKVTDSSRq 562
Cdd:smart00089 1 VADVSASPTVGVAGESVTFTA-TSSDDGSIVSYTWDFGDGtsSTGPTVTHT-----YTK-----PGTYTVTLTVTNAVG- 68
|
90
....*....|.
gi 270265857 563 QSTAVVTVIVQ 573
Cdd:smart00089 69 SASATVTVVVQ 79
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
581-667 |
8.37e-09 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 53.22 E-value: 8.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 581 VAVAGPDKELIFPVESATLDGSSSsDDHGIVFYHWEHVRGPSAVEmenidkAIATVTGLQVGTYHFRLTVKDQQGlSSTS 660
Cdd:smart00089 1 VADVSASPTVGVAGESVTFTATSS-DDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SASA 72
|
....*..
gi 270265857 661 TLTVAVK 667
Cdd:smart00089 73 TVTVVVQ 79
|
|
| REJ |
pfam02010 |
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ... |
444-765 |
1.05e-08 |
|
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Pssm-ID: 366875 [Multi-domain] Cd Length: 448 Bit Score: 58.67 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 444 LRLSNLDPGNYSFRLTVTDSDgaTNSTTAALIVNNAVDYPP-VANAGPNHTITLPQNS-ITLNGNQSSD------DHQIV 515
Cdd:pfam02010 45 IPSGTLPYGTYVFTLTVSLSS--TPSLAGTDIITVTVQPSPlVAVIDGGSSRVVGYNQdLTLDGSESYDpdvdpgSSSGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 516 LYEWSLGPGSEGKHVVM--QGVQTPYLH-LSAMQEGD---------------YTFQLKVTDSSRQQSTAVVTVIVQPENn 577
Cdd:pfam02010 123 TYLWSCRRSSSGDNPLLnnDPVCFSDQNeGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSASTTQTILVVDGN- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 578 rPP---VAVAGPDKELIFPVES---ATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENI--DKAIATVTG---------LQ 640
Cdd:pfam02010 202 -PPiiiLSCISNCNRKNNPVDRlvlLASTCLNCSSDLSDVTYRWLSLGSENTSLVLDQlnSQTSTGRSGpylvikagvLQ 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 641 VGT-YHFRLTVKDQQGLSSTSTlTVAVKkeNNSPPRaraGGRhVLVLPNN------SITLDGSRSTDD------------ 701
Cdd:pfam02010 281 SGVsYRFTLIVTVYPGLVSGLA-SISFI--TNAPPT---GGT-CSVTPTEgtaletKFTVTCQGWTDDdlpltyqfgdis 353
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270265857 702 --QRIVSYLWIRDGQSPaagdvidgSDHSVALQLTNLVEG-VYTFHLRVTDSQGASDTDTATVEVQP 765
Cdd:pfam02010 354 frEASEEWFLLYEGSSQ--------ISISTFLPPGLPANDyQVTVVVVVYDSLGAATSVSLTITVTP 412
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
581-666 |
2.10e-08 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 52.11 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 581 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 660
Cdd:cd00146 1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75
|
....*.
gi 270265857 661 TLTVAV 666
Cdd:cd00146 76 TTTVVV 81
|
|
| PKD |
smart00089 |
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
675-764 |
8.33e-08 |
|
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 50.53 E-value: 8.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 675 RARAGGRHVLVLPNNSITLDGSrSTDDQRIVSYLWirdgqspaagDVIDGSD-HSVALQLTNLVEGVYTFHLRVTDSQGa 753
Cdd:smart00089 1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW----------DFGDGTSsTGPTVTHTYTKPGTYTVTLTVTNAVG- 68
|
90
....*....|.
gi 270265857 754 SDTDTATVEVQ 764
Cdd:smart00089 69 SASATVTVVVQ 79
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
577-666 |
1.93e-07 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 49.58 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 577 NRPPVAVAGPDKElIFPVESATLDGSSSSD-DHGIVFYHWEHVRGpSAVEMENIDKAIATvtglqVGTYHFRLTVKDQQG 655
Cdd:pfam18911 1 NAAPVADAGGDRI-VAEGETVTFDASASDDpDGDILSYRWDFGDG-TTATGANVSHTYAA-----PGTYTVTLTVTDDSG 73
|
90
....*....|..
gi 270265857 656 LS-STSTLTVAV 666
Cdd:pfam18911 74 ASnSTATDTVTV 85
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
674-763 |
2.97e-07 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 49.03 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 674 PRARAGGRHVlVLPNNSITLDGSrSTDDQRIVSYLWIRDGqspaaGDVIDGSDHSValQLTNLVEGVYTFHLRVTDSQGA 753
Cdd:cd00146 1 PTASVSAPPV-AELGASVTFSAS-DSSGGSIVSYKWDFGD-----GEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGS 71
|
90
....*....|
gi 270265857 754 SDTDTATVEV 763
Cdd:cd00146 72 SSTKTTTVVV 81
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
484-572 |
6.07e-07 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 48.26 E-value: 6.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 484 PVANAGPNHTITLPQnSITLNGNqSSDDHQIVLYEWSLGPGSegkhVVMQGVQTPylHLSAMQEGDYTFQLKVTDSSRQQ 563
Cdd:cd00146 1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFGDGE----VSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72
|
....*....
gi 270265857 564 STAVVTVIV 572
Cdd:cd00146 73 STKTTTVVV 81
|
|
| PKD |
cd00146 |
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
388-476 |
1.27e-06 |
|
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 47.11 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 388 PPVAVVSPQLQELTLPLT-SAlidgsQSTDDTEIVSYHWEEINGPFIeektSVDSPVLRLSNLDPGNYSFRLTVTDSDGA 466
Cdd:cd00146 1 PTASVSAPPVAELGASVTfSA-----SDSSGGSIVSYKWDFGDGEVS----SSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71
|
90
....*....|
gi 270265857 467 TNSTTAALIV 476
Cdd:cd00146 72 SSTKTTTVVV 81
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
483-572 |
1.94e-06 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 46.88 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 483 PPVANAGPNHTITLPQnSITLNGNQSSD-DHQIVLYEWSLGPGSEG-----KHVvmqgvqtpYlhlsaMQEGDYTFQLKV 556
Cdd:pfam18911 3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGDGTTAtganvSHT--------Y-----AAPGTYTVTLTV 68
|
90
....*....|....*..
gi 270265857 557 TDSS-RQQSTAVVTVIV 572
Cdd:pfam18911 69 TDDSgASNSTATDTVTV 85
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
671-763 |
2.27e-06 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 46.49 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 671 NSPPRARAGGRhVLVLPNNSITLDGSRSTD-DQRIVSYLWirdgqspaagDVIDGSdhsvALQLTNLV-----EGVYTFH 744
Cdd:pfam18911 1 NAAPVADAGGD-RIVAEGETVTFDASASDDpDGDILSYRW----------DFGDGT----TATGANVShtyaaPGTYTVT 65
|
90 100
....*....|....*....|
gi 270265857 745 LRVTDSQGASD-TDTATVEV 763
Cdd:pfam18911 66 LTVTDDSGASNsTATDTVTV 85
|
|
| PKD_4 |
pfam18911 |
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
386-476 |
2.84e-06 |
|
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 46.11 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 386 NLPPVAVVSPQlQELTLPLTSALiDGSQSTD-DTEIVSYHWEEINGpfieekTSVDSPVLRLSNLDPGNYSFRLTVTDSD 464
Cdd:pfam18911 1 NAAPVADAGGD-RIVAEGETVTF-DASASDDpDGDILSYRWDFGDG------TTATGANVSHTYAAPGTYTVTLTVTDDS 72
|
90
....*....|...
gi 270265857 465 GATNST-TAALIV 476
Cdd:pfam18911 73 GASNSTaTDTVTV 85
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
436-773 |
6.70e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.92 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 436 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 514
Cdd:COG3401 186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 515 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 593
Cdd:COG3401 262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 594 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 662
Cdd:COG3401 334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 663 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 742
Cdd:COG3401 412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490
|
330 340 350
....*....|....*....|....*....|.
gi 270265857 743 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 773
Cdd:COG3401 491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
|
|
| MANEC |
pfam07502 |
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ... |
11-42 |
6.37e-04 |
|
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.
Pssm-ID: 462186 Cd Length: 90 Bit Score: 39.60 E-value: 6.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 270265857 11 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 42
Cdd:pfam07502 38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
353-580 |
6.51e-04 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 43.92 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 353 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 424
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 425 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 491
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 492 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 554
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445
|
250 260
....*....|....*....|....*.
gi 270265857 555 KVTDSSRQQSTAvVTVIVQPenNRPP 580
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
|
|
| PARM |
pfam17061 |
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ... |
157-292 |
8.57e-04 |
|
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.
Pssm-ID: 465341 [Multi-domain] Cd Length: 296 Bit Score: 42.54 E-value: 8.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 157 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 226
Cdd:pfam17061 78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270265857 227 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 292
Cdd:pfam17061 158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
125-286 |
3.28e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.45 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 125 PSGKQEPRGSAEYTDWGLLP---GSEGAFNSSVGDSPAVPAETQQDPelhyLNESASTPAPKLPERsvllPLPTTPSSGe 201
Cdd:PLN03209 324 PSQRVPPKESDAADGPKPVPtkpVTPEAPSPPIEEEPPQPKAVVPRP----LSPYTAYEDLKPPTS----PIPTPPSSS- 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265857 202 vleKEKASQLQEQSSNSSGKevLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSI-------PTPPTSAAPSESTPS 274
Cdd:PLN03209 395 ---PASSKSVDAVAKPAEPD--VVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLkpptspsPTAPTGVSPSVSSTS 469
|
170
....*....|..
gi 270265857 275 ELPISPTTAPRT 286
Cdd:PLN03209 470 SVPAVPDTAPAT 481
|
|
|