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Conserved domains on  [gi|281371406|ref|NP_001163800|]
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uncharacterized protein LOC292711 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 23-124 1.26e-43

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467144  Cd Length: 102  Bit Score: 142.83  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371406  23 SLTCLDGSMVKFGSNLTKEAVDWVEKLTASSDALmVMCQETLVLIDVGEQSVLLWSKGLSKL-SGEIKKAQVFSSGPGIV 101
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAG-EVCQETLLLIDVGPKSLLLGSKGCSKPgAQDSQKVSIHSGPPGIL 79

                         90       100
                 ....*....|....*....|...
gi 281371406 102 AASYIHFCSTENCNKATSTKVLL 124
Cdd:cd23624   80 VASYVHFCSSDLCNRANSSSVLL 102
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 136-211 2.89e-34

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


:

Pssm-ID: 467797  Cd Length: 76  Bit Score: 118.18  E-value: 2.89e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371406 136 GTLQCPVCLHFKGSCDPKSNLVLCPVNTKCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVREILE 211
Cdd:cd23633    1 GTLQCPVCLHFKGSCSSNSNLVLCPKNTRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 23-124 1.26e-43

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 142.83  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371406  23 SLTCLDGSMVKFGSNLTKEAVDWVEKLTASSDALmVMCQETLVLIDVGEQSVLLWSKGLSKL-SGEIKKAQVFSSGPGIV 101
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAG-EVCQETLLLIDVGPKSLLLGSKGCSKPgAQDSQKVSIHSGPPGIL 79

                         90       100
                 ....*....|....*....|...
gi 281371406 102 AASYIHFCSTENCNKATSTKVLL 124
Cdd:cd23624   80 VASYVHFCSSDLCNRANSSSVLL 102
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 136-211 2.89e-34

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 118.18  E-value: 2.89e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371406 136 GTLQCPVCLHFKGSCDPKSNLVLCPVNTKCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVREILE 211
Cdd:cd23633    1 GTLQCPVCLHFKGSCSSNSNLVLCPKNTRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 140-208 5.53e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 34.82  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371406  140 CPVCL-HFKGSCDPKSNlvlCPVNTK-CYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVRE 208
Cdd:pfam00021   1 CYSCLgVSNEDCLSEVT---CPLSDGqCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSE 68
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 23-124 1.26e-43

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 142.83  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371406  23 SLTCLDGSMVKFGSNLTKEAVDWVEKLTASSDALmVMCQETLVLIDVGEQSVLLWSKGLSKL-SGEIKKAQVFSSGPGIV 101
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAG-EVCQETLLLIDVGPKSLLLGSKGCSKPgAQDSQKVSIHSGPPGIL 79

                         90       100
                 ....*....|....*....|...
gi 281371406 102 AASYIHFCSTENCNKATSTKVLL 124
Cdd:cd23624   80 VASYVHFCSSDLCNRANSSSVLL 102
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 136-211 2.89e-34

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 118.18  E-value: 2.89e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371406 136 GTLQCPVCLHFKGSCDPKSNLVLCPVNTKCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVREILE 211
Cdd:cd23633    1 GTLQCPVCLHFKGSCSSNSNLVLCPKNTRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76
TFP_LU_ECD_LYPD4_rpt1_like cd23564
first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 24-124 7.48e-16

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.


Pssm-ID: 467094  Cd Length: 99  Bit Score: 70.92  E-value: 7.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371406  24 LTCLDGSMVKFGSNLTKEAVDWVEKlTASSDALMVmCQETLVLIDVGEQSVLLWSKGLSKLSGEIKKAQVFSSGPGIVAA 103
Cdd:cd23564    1 LTCYRGTSLYVGANLANEPNWTTSR-NETCEAGEV-CQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIIT 78

                         90       100
                 ....*....|....*....|.
gi 281371406 104 SYIHFCSTENCNKATSTKVLL 124
Cdd:cd23564   79 SYTRVCNSDFCNNLSSTSPFL 99
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 136-211 1.06e-14

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 66.95  E-value: 1.06e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371406 136 GTLQCPVCLHFKGSCDPKSNlVLCPVN-TKCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVREILE 211
Cdd:cd23637    2 GDLQCPVCVNFFGSCSDPST-VTCPKGtTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTENSE 77
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 135-208 3.01e-09

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 52.36  E-value: 3.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371406 135 LGTLQCPVCLHfKGSCDPKSNLVLCPV-NTKCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVRE 208
Cdd:cd23636    1 PGSLRCPVCLS-TGSCPEAATLVPCPAgTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSE 74
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 136-208 1.72e-06

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 45.06  E-value: 1.72e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281371406 136 GTLQCPVCLHFkGSCDPKSNLVlCPVNT-KCYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVRE 208
Cdd:cd23634    1 TTLHCPTCVAL-GSCFSAPSLP-CPRGTtRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSE 72
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 60-119 3.30e-05

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 41.57  E-value: 3.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281371406  60 CQETLVLIDVGEQSVLLWSKGLSklSGEIkKAQVF---SSGPGIVAASYIHFCSTENCNKATS 119
Cdd:cd23622   35 CQETILMIKAGTKTAILATKGCI--SEGM-EAVTFiqhTPPPGLVAVSYSNYCEDSLCNNKKS 94
TFP_LU_ECD_LYPD4_rpt1 cd23621
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
 60-119 1.74e-04

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467141  Cd Length: 103  Bit Score: 39.84  E-value: 1.74e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371406  60 CQETLVLIDVGEQSVLLWSKGLSKLSGEIKKAQVFSSGPGIVAASYIHFCSTENCNKATS 119
Cdd:cd23621   36 CEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIASYSRVCRSYLCNNLTN 95
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 60-123 4.35e-03

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 35.76  E-value: 4.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371406  60 CQETLVLIDVGEQSVLLWSKGLSKlsGEIKKAQV--FSSGPGIVAASYIHFCSTEN-CNKATSTKVL 123
Cdd:cd23623   35 CQDTLMLIENGPQVNLVLIKGCTQ--AEDQEPRVtqHRAGPGLSIVSYTRVCRHQDlCNDLSSTLPL 99
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 140-208 5.53e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 34.82  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371406  140 CPVCL-HFKGSCDPKSNlvlCPVNTK-CYASSMGIQGGSLSIFLNIFGCLESSRNVLLNNQTSIGVMSVRE 208
Cdd:pfam00021   1 CYSCLgVSNEDCLSEVT---CPLSDGqCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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