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Conserved domains on  [gi|283436222|ref|NP_001164006|]
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ATPase family AAA domain-containing protein 3A isoform 2 [Homo sapiens]

Protein Classification

DUF3523 domain-containing ATPase family protein( domain architecture ID 15964341)

DUF3523 domain-containing ATPase family protein associated with various cellular activities (AAA), similar to ATPase AAA-domain protein 3 (ATAD3), a ubiquitously expressed mitochondrial protein

Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|28941010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 42-286 5.01e-110

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


:

Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 330.02  E-value: 5.01e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   42 APKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSE 121
Cdd:pfam12037  15 KPRTAYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVEYEERRKTLQE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  122 ETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR-----RATVEREMELRHKNEMLRVEAEARAR 196
Cdd:pfam12037  95 ETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRiqaqrRQTEEHEAELRRETERAKAEAEAEAR 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  197 AKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIE 276
Cdd:pfam12037 175 AKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAGVYTAKEGTGVAWRYIE 254

                         250
                  ....*....|
gi 283436222  277 ARLGKPSLVR 286
Cdd:pfam12037 255 ARLGKPSLVR 264
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 324-473 2.82e-109

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 323.71  E-value: 2.82e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 324 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 403
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 404 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 473
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
 
Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 42-286 5.01e-110

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 330.02  E-value: 5.01e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   42 APKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSE 121
Cdd:pfam12037  15 KPRTAYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVEYEERRKTLQE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  122 ETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR-----RATVEREMELRHKNEMLRVEAEARAR 196
Cdd:pfam12037  95 ETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRiqaqrRQTEEHEAELRRETERAKAEAEAEAR 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  197 AKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIE 276
Cdd:pfam12037 175 AKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAGVYTAKEGTGVAWRYIE 254

                         250
                  ....*....|
gi 283436222  277 ARLGKPSLVR 286
Cdd:pfam12037 255 ARLGKPSLVR 264
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 324-473 2.82e-109

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 323.71  E-value: 2.82e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 324 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 403
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 404 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 473
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 160-536 7.64e-28

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 115.78  E-value: 7.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 160 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRA 239
Cdd:COG0464    2 AELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 240 FVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDaLEGVV 319
Cdd:COG0464   82 LAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI-LDDLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 320 LSPSLEARVRDIAIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR-EGVTA-- 391
Cdd:COG0464  161 GLEEVKEELRELVALPLKRPELREEYglpppRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDL--VSKyVGETEkn 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 392 MHKLFDWANTSRRGLLLFvDEADAFLRKRATEKiSEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMV 471
Cdd:COG0464  239 LREVFDKARGLAPCVLFI-DEADALAGKRGEVG-DGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEII 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 283436222 472 HFDLPGQEERERLVRMYFDKYVLKPAtegkqrlklaqFDYgrkcSEVARLTEGMSGREIAQLAVS 536
Cdd:COG0464  317 FFPLPDAEERLEIFRIHLRKRPLDED-----------VDL----EELAEATEGLSGADIRNVVRR 366
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
315-569 1.30e-26

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 108.43  E-value: 1.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 315 LEGVVLSPSLEARVRDIaIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR--- 386
Cdd:COG1223    1 LDDVVGQEEAKKKLKLI-IKELRRRENLRKFglwppRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSylg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 387 EGVTAMHKLFDWANtsRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDR 466
Cdd:COG1223   78 ETARNLRKLFDFAR--RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSGSVVIAATNHPELLDSALWRR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 467 INEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKqrlklaqfdygrkcsEVARLTEGMSGREIAQLAVSWQATAYASED 546
Cdd:COG1223  156 FDEVIEFPLPDKEERKEILELNLKKFPLPFELDLK---------------KLAKKLEGLSGADIEKVLKTALKKAILEDR 220

                        250       260
                 ....*....|....*....|...
gi 283436222 547 GVLTEAMmdtrVQDAVQQHQQKM 569
Cdd:COG1223  221 EKVTKED----LEEALKQRKERK 239
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 348-475 2.56e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.66  E-value: 2.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEKIS 426
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVgESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 283436222  427 EDLR--ATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDL 475
Cdd:pfam00004  80 ESRRvvNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
346-533 9.79e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 67.75  E-value: 9.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRE-GVTAMHKLFDWANTSrRGLLLFVDEADAFLRKR-ATE 423
Cdd:PRK10733 186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGvGASRVRDMFEQAKKA-APCIIFIDEIDAVGRQRgAGL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 424 KISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPAT 498
Cdd:PRK10733 265 GGGHDEReQTLNQMLVEMdGFEGNEGIIVIaATNRPDVLDPALlrPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDI 344

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436222 499 EGkqrlklaqfdygrkcSEVARLTEGMSGREIAQL 533
Cdd:PRK10733 345 DA---------------AIIARGTPGFSGADLANL 364
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 346-533 2.26e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 60.31  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEK 424
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGARF 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  425 ISEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQeererlvrmyFDKYVLKPATEGKQ 502
Cdd:TIGR01243 567 DTSVTDRIVNQLLTEMdGIQELSNVVVIaATNRPDILDPALLR----------PGR----------FDRLILVPPPDEEA 626

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 283436222  503 RLKLAQFdYGRKCS--------EVARLTEGMSGREIAQL 533
Cdd:TIGR01243 627 RKEIFKI-HTRSMPlaedvdleELAEMTEGYTGADIEAV 664
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 346-476 2.33e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.53  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   346 RNILMYGPPGTGKTLFAKKLALHSG------------------MDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlL 407
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD-V 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   408 LFVDEADAFLRKRATEKISEDLRATLNAFLyrtgQHSNKFMLVLASNQPEQFDWA-INDRINEMVHFDLP 476
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLI 147
PTZ00121 PTZ00121
MAEBL; Provisional
 56-229 3.51e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRaQAEERRKT----LSEETRQ-HQARA 130
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKK-KADELKKAeelkKAEEKKKaEEAKK 1571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  131 QYQDKLARQRYEDQLKQ---------QQLLNEENLRKQEESVQKQEAMRRA-TVEREMELRHKNEMLRVEAEARARAKAE 200
Cdd:PTZ00121 1572 AEEDKNMALRKAEEAKKaeearieevMKLYEEEKKMKAEEAKKAEEAKIKAeELKKAEEEKKKVEQLKKKEAEEKKKAEE 1651

                         170       180
                  ....*....|....*....|....*....
gi 283436222  201 RENADiirEQIRLKAAEHRQTVLESIRTA 229
Cdd:PTZ00121 1652 LKKAE---EENKIKAAEEAKKAEEDKKKA 1677
 
Name Accession Description Interval E-value
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 42-286 5.01e-110

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 330.02  E-value: 5.01e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   42 APKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSE 121
Cdd:pfam12037  15 KPRTAYSGFDPEALERAAKAARELESSPHAKKALELMKKQEQTRQAELQAKIKEYEAAQEQLKIERQRVEYEERRKTLQE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  122 ETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR-----RATVEREMELRHKNEMLRVEAEARAR 196
Cdd:pfam12037  95 ETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMRiqaqrRQTEEHEAELRRETERAKAEAEAEAR 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  197 AKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIE 276
Cdd:pfam12037 175 AKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWDKLVAAVGGLTALAAGVYTAKEGTGVAWRYIE 254

                         250
                  ....*....|
gi 283436222  277 ARLGKPSLVR 286
Cdd:pfam12037 255 ARLGKPSLVR 264
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 324-473 2.82e-109

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 323.71  E-value: 2.82e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 324 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 403
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 404 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 473
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 324-473 2.18e-34

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 127.78  E-value: 2.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 324 LEARVRDIAIATRNTKKNRS----LYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDW 398
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRyglgLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVgESEKNLRKIFER 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283436222 399 ANTSRRGLLLFvDEADAFLRKRATEKISEDLRATLNAFLYRT--GQHSNKFMLVLASNQPEQFDWAIND--RINEMVHF 473
Cdd:cd19481   81 ARRLAPCILFI-DEIDAIGRKRDSSGESGELRRVLNQLLTELdgVNSRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 160-536 7.64e-28

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 115.78  E-value: 7.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 160 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRA 239
Cdd:COG0464    2 AELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 240 FVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDaLEGVV 319
Cdd:COG0464   82 LAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI-LDDLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 320 LSPSLEARVRDIAIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR-EGVTA-- 391
Cdd:COG0464  161 GLEEVKEELRELVALPLKRPELREEYglpppRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDL--VSKyVGETEkn 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 392 MHKLFDWANTSRRGLLLFvDEADAFLRKRATEKiSEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMV 471
Cdd:COG0464  239 LREVFDKARGLAPCVLFI-DEADALAGKRGEVG-DGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEII 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 283436222 472 HFDLPGQEERERLVRMYFDKYVLKPAtegkqrlklaqFDYgrkcSEVARLTEGMSGREIAQLAVS 536
Cdd:COG0464  317 FFPLPDAEERLEIFRIHLRKRPLDED-----------VDL----EELAEATEGLSGADIRNVVRR 366
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
315-569 1.30e-26

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 108.43  E-value: 1.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 315 LEGVVLSPSLEARVRDIaIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR--- 386
Cdd:COG1223    1 LDDVVGQEEAKKKLKLI-IKELRRRENLRKFglwppRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSylg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 387 EGVTAMHKLFDWANtsRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDR 466
Cdd:COG1223   78 ETARNLRKLFDFAR--RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSGSVVIAATNHPELLDSALWRR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 467 INEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKqrlklaqfdygrkcsEVARLTEGMSGREIAQLAVSWQATAYASED 546
Cdd:COG1223  156 FDEVIEFPLPDKEERKEILELNLKKFPLPFELDLK---------------KLAKKLEGLSGADIEKVLKTALKKAILEDR 220

                        250       260
                 ....*....|....*....|...
gi 283436222 547 GVLTEAMmdtrVQDAVQQHQQKM 569
Cdd:COG1223  221 EKVTKED----LEEALKQRKERK 239
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 348-475 2.56e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.66  E-value: 2.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEKIS 426
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVgESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 283436222  427 EDLR--ATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDL 475
Cdd:pfam00004  80 ESRRvvNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 348-568 9.20e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 93.53  E-value: 9.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRATEKI 425
Cdd:COG1222  115 VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKyiG-EGARNVREVFELAREKAPSIIFI-DEIDAIAARRTDDGT 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 426 SEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFdkyvlkpategk 501
Cdd:COG1222  193 SGEVQRTVNQLLAELdGFESRGDVLIIaATNRPDLLDPALlrPGRFDRVIEVPLPDEEAREEILKIHL------------ 260

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283436222 502 QRLKLA-QFDYgrkcSEVARLTEGMSGREIAQLAVswQATAYASEDGVLTEAMMDtrVQDAVQQHQQK 568
Cdd:COG1222  261 RDMPLAdDVDL----DKLAKLTEGFSGADLKAIVT--EAGMFAIREGRDTVTMED--LEKAIEKVKKK 320
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
346-533 9.79e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 67.75  E-value: 9.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRE-GVTAMHKLFDWANTSrRGLLLFVDEADAFLRKR-ATE 423
Cdd:PRK10733 186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGvGASRVRDMFEQAKKA-APCIIFIDEIDAVGRQRgAGL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 424 KISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPAT 498
Cdd:PRK10733 265 GGGHDEReQTLNQMLVEMdGFEGNEGIIVIaATNRPDVLDPALlrPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDI 344

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436222 499 EGkqrlklaqfdygrkcSEVARLTEGMSGREIAQL 533
Cdd:PRK10733 345 DA---------------AIIARGTPGFSGADLANL 364
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 341-466 8.43e-11

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 60.83  E-value: 8.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 341 NRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVA--PMGrEGVTAMHKLFDWANtSRRGLLLFVDEADAFLR 418
Cdd:cd19509   28 LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVskWVG-ESEKIVRALFALAR-ELQPSIIFIDEIDSLLS 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 283436222 419 KRATEKiSEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFDWAINDR 466
Cdd:cd19509  106 ERGSGE-HEASRRVKTEFLVQmdgvLNKPEDRVLVLGATNRPWELDEAFLRR 156
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 346-463 1.30e-10

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 60.32  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMgREGVTA--MHKLFDWANTSRRgLLLFVDEADAFLRKR-AT 422
Cdd:cd19501   38 KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEM-FVGVGAsrVRDLFEQAKKNAP-CIVFIDEIDAVGRKRgAG 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283436222 423 EKISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI 463
Cdd:cd19501  116 LGGGHDEReQTLNQLLVEMdGFESNTGVIVIaATNRPDVLDPAL 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 329-475 2.42e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 59.08  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 329 RDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYA---------IMTGGDVApmGREGVTAMHKLFDwA 399
Cdd:cd00009    3 QEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGApflylnasdLLEGLVVA--ELFGHFLVRLLFE-L 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283436222 400 NTSRRGLLLFVDEADAFlrkraTEKISEDLRATLNAFLYRTGQHSNkFMLVLASNQPE--QFDWAINDRINEMVHFDL 475
Cdd:cd00009   80 AEKAKPGVLFIDEIDSL-----SRGAQNALLRVLETLNDLRIDREN-VRVIGATNRPLlgDLDRALYDRLDIRIVIPL 151
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 341-472 9.04e-10

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 57.95  E-value: 9.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 341 NRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRGlLLFVDEADAFLR 418
Cdd:cd19521   36 NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSkwMG-ESEKLVKQLFAMARENKPS-IIFIDEVDSLCG 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 283436222 419 KRAtEKISEDLRATLNAFLYR---TGQHSNKFMLVLASNQPEQFDWAINDRINEMVH 472
Cdd:cd19521  114 TRG-EGESEASRRIKTELLVQmngVGNDSQGVLVLGATNIPWQLDSAIRRRFEKRIY 169
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 346-533 2.26e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 60.31  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEK 424
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGARF 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  425 ISEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQeererlvrmyFDKYVLKPATEGKQ 502
Cdd:TIGR01243 567 DTSVTDRIVNQLLTEMdGIQELSNVVVIaATNRPDILDPALLR----------PGR----------FDRLILVPPPDEEA 626

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 283436222  503 RLKLAQFdYGRKCS--------EVARLTEGMSGREIAQL 533
Cdd:TIGR01243 627 RKEIFKI-HTRSMPlaedvdleELAEMTEGYTGADIEAV 664
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 342-472 3.41e-09

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 56.15  E-value: 3.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 342 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR 420
Cdd:cd19522   30 RRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRgESEKLVRLLFEMARFYAPT-TIFIDEIDSICSRR 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283436222 421 ATEKISEDLRATLNAFLYR--------TGQHSNKFMLVL-ASNQPEQFDWAINDRINEMVH 472
Cdd:cd19522  109 GTSEEHEASRRVKSELLVQmdgvggasENDDPSKMVMVLaATNFPWDIDEALRRRLEKRIY 169
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 346-463 4.15e-09

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 55.75  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATE 423
Cdd:cd19511   28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKyvG-ESERAVREIFQKARQAAPC-IIFFDEIDSLAPRRGQS 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283436222 424 KISEDLRATLNAFLYR-TGQHSNKFMLVL-ASNQPEQFDWAI 463
Cdd:cd19511  106 DSSGVTDRVVSQLLTElDGIESLKGVVVIaATNRPDMIDPAL 147
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 346-467 8.66e-09

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 55.12  E-value: 8.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMtggDVAPMGREGVTAMHKLFDWANTSRRGL---LLFVDEADAFLRKR-- 420
Cdd:cd19520   36 KGVLLYGPPGCGKTMLAKATAKEAGARFINL---QVSSLTDKWYGESQKLVAAVFSLASKLqpsIIFIDEIDSFLRQRss 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283436222 421 ----ATEKISEDLRATLNAFlyRTGQHSnKFMLVLASNQPEQFDWAINDRI 467
Cdd:cd19520  113 tdheATAMMKAEFMSLWDGL--STDGNC-RVIVMGATNRPQDLDEAILRRM 160
ftsH CHL00176
cell division protein; Validated
 348-534 1.12e-08

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 58.14  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMgREGVTA--MHKLFDWANtSRRGLLLFVDEADAFLRKRATE-K 424
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEM-FVGVGAarVRDLFKKAK-ENSPCIVFIDEIDAVGRQRGAGiG 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 425 ISEDLR-ATLNAFL-YRTGQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATE 499
Cdd:CHL00176 297 GGNDEReQTLNQLLtEMDGFKGNKGVIVIaATNRVDILDAALlrPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVS 376

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436222 500 GKQrlklaqfdygrkcseVARLTEGMSGREIAQLA 534
Cdd:CHL00176 377 LEL---------------IARRTPGFSGADLANLL 396
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 348-463 1.19e-08

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 54.42  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRATEKI 425
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKyvG-ESERAVRQVFQRARASAPCVIFF-DEVDALVPKRGDGGS 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 283436222 426 SEDLRaTLNAFLYRT--GQHSNKFMLVLASNQPEQFDWAI 463
Cdd:cd19530  111 WASER-VVNQLLTEMdgLEERSNVFVIAATNRPDIIDPAM 149
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 346-463 2.03e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 53.65  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRgLLLFVDEADAFLRKRA-- 421
Cdd:cd19529   28 KGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSkwVG-ESEKAIREIFRKARQVAP-CVIFFDEIDSIAPRRGtt 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 283436222 422 -----TEKISEDLRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI 463
Cdd:cd19529  106 gdsgvTERVVNQLLTELDGL-----EEMNGVVVIAATNRPDIIDPAL 147
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 346-476 2.33e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.53  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   346 RNILMYGPPGTGKTLFAKKLALHSG------------------MDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlL 407
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD-V 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   408 LFVDEADAFLRKRATEKISEDLRATLNAFLyrtgQHSNKFMLVLASNQPEQFDWA-INDRINEMVHFDLP 476
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLI 147
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 346-473 8.76e-08

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 52.34  E-value: 8.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTsRRGLLLFVDEADAFLRKRATEK 424
Cdd:cd19502   38 KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSElVQKYIGEGARLVRELFEMARE-KAPSIIFIDEIDAIGAKRFDSG 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 425 ISED---------LRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI--NDRINEMVHF 473
Cdd:cd19502  117 TGGDrevqrtmleLLNQLDGF-----DPRGNIKVIMATNRPDILDPALlrPGRFDRKIEF 171
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 338-463 8.83e-08

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 52.13  E-value: 8.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 338 TKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRgLLLFVDEADA 415
Cdd:cd19528   20 LKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMwfG-ESEANVRDIFDKARAAAP-CVLFFDELDS 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 283436222 416 FLRKR---------ATEKISEDLRATLNaflyrtGQHSNKFMLVL-ASNQPEQFDWAI 463
Cdd:cd19528   98 IAKARggnigdaggAADRVINQILTEMD------GMNTKKNVFIIgATNRPDIIDPAI 149
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 346-467 1.04e-07

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 52.30  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRAtEK 424
Cdd:cd19525   56 KGILLFGPPGTGKTLIGKCIASQSGATfFSISASSLTSKWVGEGEKMVRALFSVARCKQPA-VIFIDEIDSLLSQRG-EG 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 283436222 425 ISEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFDWAINDRI 467
Cdd:cd19525  134 EHESSRRIKTEFLVQldgaTTSSEDRILVVGATNRPQEIDEAARRRL 180
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 346-463 1.66e-07

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 51.14  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRAT 422
Cdd:cd19503   35 RGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSI--VSKylgESEKNLREIFEEARSHAPS-IIFIDEIDALAPKREE 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283436222 423 --EKISEDLRATLNAFLyrTGQHSNKFMLVLAS-NQPEQFDWAI 463
Cdd:cd19503  112 dqREVERRVVAQLLTLM--DGMSSRGKVVVIAAtNRPDAIDPAL 153
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 346-463 1.98e-07

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 50.90  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRatEK 424
Cdd:cd19519   35 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEImSKLAGESESNLRKAFEEAEKNAPA-IIFIDEIDAIAPKR--EK 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283436222 425 ISEDLRATLNAFLYR--TGQHSNKFMLVL-ASNQPEQFDWAI 463
Cdd:cd19519  112 THGEVERRIVSQLLTlmDGLKQRAHVIVMaATNRPNSIDPAL 153
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 346-534 2.76e-07

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 53.76  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR-- 420
Cdd:TIGR01243 213 KGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEI--MSKyygESEERLREIFKEAEENAPS-IIFIDEIDAIAPKRee 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  421 ATEKISEDLRATLNAfLYRTGQHSNKFMLVLASNQPEQFDWAINDrinemvhfdlPGQEERERLVRMyFDKYVLKPATEG 500
Cdd:TIGR01243 290 VTGEVEKRVVAQLLT-LMDGLKGRGRVIVIGATNRPDALDPALRR----------PGRFDREIVIRV-PDKRARKEILKV 357

                         170       180       190
                  ....*....|....*....|....*....|....
gi 283436222  501 KQRLKLAQFDygRKCSEVARLTEGMSGREIAQLA 534
Cdd:TIGR01243 358 HTRNMPLAED--VDLDKLAEVTHGFVGADLAALA 389
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 348-535 3.19e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 52.91  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTG--------GDVAPMGREgvtamhkLFDWANtSRRGLLLFVDEADAFLRK 419
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGselvqkfiGEGARLVRE-------LFELAR-EKAPSIIFIDEIDAIAAK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 420 RATEKISED---------LRATLNAFLYRtgqhsNKFMLVLASNQPEQFDWAI-----NDRInemVHFDLPGQEERERlv 485
Cdd:PRK03992 240 RTDSGTSGDrevqrtlmqLLAEMDGFDPR-----GNVKIIAATNRIDILDPAIlrpgrFDRI---IEVPLPDEEGRLE-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283436222 486 rmyfdkyVLKPATegkQRLKLAQ-FDYgrkcSEVARLTEGMSGREIAQLAV 535
Cdd:PRK03992 310 -------ILKIHT---RKMNLADdVDL----EELAELTEGASGADLKAICT 346
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 342-472 1.87e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 48.31  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 342 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDY-----AIMTGGDVApmgrEGVTAMHKLFDWAnTSRRGLLLFVDEADAF 416
Cdd:cd19524   30 RAPARGLLLFGPPGNGKTMLAKAVAAESNATFfnisaASLTSKYVG----EGEKLVRALFAVA-RELQPSIIFIDEVDSL 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 417 LRKRATEKiSEDLRATLNAFLYR-TGQHSNKFMLVL---ASNQPEQFDWAINDRINEMVH 472
Cdd:cd19524  105 LSERSEGE-HEASRRLKTEFLIEfDGVQSNGDDRVLvmgATNRPQELDDAVLRRFTKRVY 163
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 346-463 3.44e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 47.40  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAnTSRRGLLLFVDEADAFLRKRAT-- 422
Cdd:cd19518   35 RGVLLHGPPGCGKTMLANAIAGELKVPfLKISATEIVSGVSGESEEKIRELFDQA-ISNAPCIVFIDEIDAITPKRESaq 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 283436222 423 ----EKISEDLRATLNAFLYRtgQHSNKFMLVL-ASNQPEQFDWAI 463
Cdd:cd19518  114 remeRRIVSQLLTCMDELNNE--KTAGGPVLVIgATNRPDSLDPAL 157
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 343-466 4.86e-06

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 46.80  E-value: 4.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 343 SLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTG-GDVAPMGREGVTAMHKLFDWANtSRRGLLLFVDEADAFLRKRA 421
Cdd:cd19523   31 RLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGsTLVAKWAGEGEKILQASFLAAR-CRQPSVLFISDLDALLSSQD 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 283436222 422 TE-----KISEDLRATLNAFLyrtGQHSNKFMLVLASNQPEQFDWAINDR 466
Cdd:cd19523  110 DEaspvgRLQVELLAQLDGVL---GSGEDGVLVVCTTSKPEEIDESLRRY 156
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 346-485 1.34e-05

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 47.84  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRK----- 419
Cdd:PTZ00454 180 RGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEfVQKYLGEGPRMVRDVFRLARENAPS-IIFIDEVDSIATKrfdaq 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 283436222 420 ----RATEKISEDLRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEEReRLV 485
Cdd:PTZ00454 259 tgadREVQRILLELLNQMDGF-----DQTTNVKVIMATNRADTLDPALlrPGRLDRKIEFPLPDRRQK-RLI 324
PTZ00121 PTZ00121
MAEBL; Provisional
 56-229 3.51e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRaQAEERRKT----LSEETRQ-HQARA 130
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKK-KADELKKAeelkKAEEKKKaEEAKK 1571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  131 QYQDKLARQRYEDQLKQ---------QQLLNEENLRKQEESVQKQEAMRRA-TVEREMELRHKNEMLRVEAEARARAKAE 200
Cdd:PTZ00121 1572 AEEDKNMALRKAEEAKKaeearieevMKLYEEEKKMKAEEAKKAEEAKIKAeELKKAEEEKKKVEQLKKKEAEEKKKAEE 1651

                         170       180
                  ....*....|....*....|....*....
gi 283436222  201 RENADiirEQIRLKAAEHRQTVLESIRTA 229
Cdd:PTZ00121 1652 LKKAE---EENKIKAAEEAKKAEEDKKKA 1677
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 348-463 4.34e-05

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 44.04  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 348 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRAT---- 422
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYiGESEANVREVFQKARDAKPCVIFF-DELDSLAPSRGNsgds 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 283436222 423 ----EKISEDLRATLNAfLYRTGQhsnKFMLVLASNQPEQFDWAI 463
Cdd:cd19527  108 ggvmDRVVSQLLAELDG-MSSSGQ---DVFVIGATNRPDLLDPAL 148
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 346-482 4.72e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 44.04  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDyaimtGGDVAPMGREGVTAMHK-----------LFDWANTSRRGLLLFvDEAD 414
Cdd:cd19517   35 RGVLFHGPPGTGKTLMARALAAECSKG-----GQKVSFFMRKGADCLSKwvgeaerqlrlLFEEAYRMQPSIIFF-DEID 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283436222 415 --AFLRKRATEKISEDLRATLNAFLyrTGQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQEERE 482
Cdd:cd19517  109 glAPVRSSKQEQIHASIVSTLLALM--DGLDNRGQVVVIgATNRPDALDPALRR----------PGRFDRE 167
PTZ00121 PTZ00121
MAEBL; Provisional
 57-224 6.94e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   57 RAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQ---LKSEQIRAQAEERRKtlSEETRQHQARAQYQ 133
Cdd:PTZ00121 1558 KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEekkMKAEEAKKAEEAKIK--AEELKKAEEEKKKV 1635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  134 DKLARQRYEDQLKQQQLLNEENL---------RKQEESVQKQEAMRRATVE---------REMELRHKNEMLRVEAEARA 195
Cdd:PTZ00121 1636 EQLKKKEAEEKKKAEELKKAEEEnkikaaeeaKKAEEDKKKAEEAKKAEEDekkaaealkKEAEEAKKAEELKKKEAEEK 1715

                         170       180       190
                  ....*....|....*....|....*....|...
gi 283436222  196 RAKAERENADIIR----EQIRLKAAEHRQTVLE 224
Cdd:PTZ00121 1716 KKAEELKKAEEENkikaEEAKKEAEEDKKKAEE 1748
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 101-224 9.63e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 9.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  101 EQLKSEQIRAQAEERRKT---LSEETRQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEESVQKQEAMRRATV 174
Cdd:pfam17380 418 QKVEMEQIRAEQEEARQRevrRLEEERAREMERVRLEEQERQQQVERLRQQeeeRKRKKLELEKEKRDRKRAEEQRRKIL 497

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 283436222  175 EREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLE 224
Cdd:pfam17380 498 EKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQE 547
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 94-183 1.38e-04

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 44.20  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   94 KEYEAAVEQLKSEQIRAQAEErrktLSEETRQHQARAQYQDKlarqRYEDQLKQ--------QQLLNEENLRKQEESVQK 165
Cdd:pfam02841 202 KEKAIEAERAKAEAAEAEQEL----LREKQKEEEQMMEAQER----SYQEHVKQliekmeaeREQLLAEQERMLEHKLQE 273

                          90
                  ....*....|....*...
gi 283436222  166 QEAMRRATVEREMELRHK 183
Cdd:pfam02841 274 QEELLKEGFKTEAESLQK 291
PTZ00121 PTZ00121
MAEBL; Provisional
 56-220 2.29e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLK---------SEQIRAQAEERRKT----LSEE 122
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKkkaeeakkkADEAKKAAEAKKKAdeakKAEE 1520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  123 TRQ-HQARAQYQDKLARQ--RYEDQLKQQQLLNEENLRKQEEsVQKQEAMRRATVEREMELR-----HKNEMLRVEAEAR 194
Cdd:PTZ00121 1521 AKKaDEAKKAEEAKKADEakKAEEKKKADELKKAEELKKAEE-KKKAEEAKKAEEDKNMALRkaeeaKKAEEARIEEVMK 1599

                         170       180
                  ....*....|....*....|....*...
gi 283436222  195 ARAKAERENADIIR--EQIRLKAAEHRQ 220
Cdd:PTZ00121 1600 LYEEEKKMKAEEAKkaEEAKIKAEELKK 1627
PTZ00121 PTZ00121
MAEBL; Provisional
 57-220 3.30e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   57 RAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVE-QLKSEQIRAQAEERRKTLSEETRQHQARAQYQDK 135
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEaKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEK 1430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  136 L----ARQRYEDQLKQQQLLNE-ENLRKQEESVQKQEAMRRATveremELRHKNEMLRVEAEARARAKAERENADIIR-- 208
Cdd:PTZ00121 1431 KkadeAKKKAEEAKKADEAKKKaEEAKKAEEAKKKAEEAKKAD-----EAKKKAEEAKKADEAKKKAEEAKKKADEAKka 1505

                         170
                  ....*....|..
gi 283436222  209 EQIRLKAAEHRQ 220
Cdd:PTZ00121 1506 AEAKKKADEAKK 1517
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-343 3.83e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  55 LERAAKAARELEHSR---------------YAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTL 119
Cdd:COG1196  318 LEELEEELAELEEELeeleeeleeleeeleEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 120 SEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRAtvEREMELRHKNEMLRVEAEARARAKA 199
Cdd:COG1196  398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE--EAELEEEEEALLELLAELLEEAALL 475

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 200 ERENADIIREQIRLKAaehRQTVLESIRTAGTLFGEGFRAF---------------VTDWDKVTATVAGLTLLAVGVYSA 264
Cdd:COG1196  476 EAALAELLEELAEAAA---RLLLLLEAEADYEGFLEGVKAAlllaglrglagavavLIGVEAAYEAALEAALAAALQNIV 552

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 265 KNATLVAGRFIE----ARLGK----PSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATR 336
Cdd:COG1196  553 VEDDEVAAAAIEylkaAKAGRatflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARL 632


                 ....*..
gi 283436222 337 NTKKNRS 343
Cdd:COG1196  633 EAALRRA 639
PTZ00121 PTZ00121
MAEBL; Provisional
 56-188 3.98e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKE--YEAAVEQLKSEQIRAQAEERRKtlSEETRQHQARAQYQ 133
Cdd:PTZ00121 1421 DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEeaKKKAEEAKKADEAKKKAEEAKK--ADEAKKKAEEAKKK 1498

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 283436222  134 DKLARQRYEDQLKQQQLLNEENLRKQEESvQKQEAMRRATVEREMELRHKNEMLR 188
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKKAEEAKKADEA-KKAEEAKKADEAKKAEEKKKADELK 1552
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 347-420 5.10e-04

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 40.87  E-value: 5.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283436222 347 NILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP----MGREGVtamHKLFDWANtSRRGLLLFVDEADAFLRKR 420
Cdd:cd19526   29 GILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNkyigASEQNV---RDLFSRAQ-SAKPCILFFDEFDSIAPKR 102
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 346-494 7.23e-04

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 42.45  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR--AT 422
Cdd:PTZ00361 218 KGVILYGPPGTGKTLLAKAVANETSATFLRVVGSElIQKYLGDGPKLVRELFRVAEENAPS-IVFIDEIDAIGTKRydAT 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 283436222 423 EKISEDLRATLNAFLYRTG--QHSNKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVL 494
Cdd:PTZ00361 297 SGGEKEIQRTMLELLNQLDgfDSRGDVKVIMATNRIESLDPALirPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTL 372
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 347-417 8.44e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 41.97  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 347 NILMYGPPGTGKTLFAKKLALHSGMDY----AIMTggdvapmgreGVTAMHKLFDWANTSR---RGLLLFVDE------- 412
Cdd:COG2256   51 SMILWGPPGTGKTTLARLIANATDAEFvalsAVTS----------GVKDIREVIEEARERRaygRRTILFVDEihrfnka 120


                 ....*.
gi 283436222 413 -ADAFL 417
Cdd:COG2256  121 qQDALL 126
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 347-365 8.99e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.98  E-value: 8.99e-04
                          10
                  ....*....|....*....
gi 283436222  347 NILMYGPPGTGKTLFAKKL 365
Cdd:pfam01078  24 NLLMIGPPGSGKTMLAKRL 42
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
348-366 9.72e-04

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 41.95  E-value: 9.72e-04
                         10
                 ....*....|....*....
gi 283436222 348 ILMYGPPGTGKTLFAKKLA 366
Cdd:COG0465  178 VLLVGPPGTGKTLLAKAVA 196
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 346-422 1.35e-03

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 40.17  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 346 RNILMYGPPGTGKTLFAKKLA-LHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRGL-------LLFVDEADA 415
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQIGkMLNAREPKIVNGPEILNkyVG-ESEANIRKLFADAEEEQRRLgansglhIIIFDEIDA 114


                 ....*..
gi 283436222 416 FLRKRAT 422
Cdd:cd19504  115 ICKQRGS 121
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 56-225 1.42e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKsEQIRAQAEERRKTLSEETRQHQARAQYQDK 135
Cdd:COG1196  253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLE-QDIARLEERRRELEERLEELEEELAELEEE 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 136 LARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKA 215
Cdd:COG1196  332 LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                        170
                 ....*....|
gi 283436222 216 AEHRQTVLES 225
Cdd:COG1196  412 LLERLERLEE 421
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 56-188 1.86e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDK 135
Cdd:pfam17380 445 AREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEE 524

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 283436222  136 LARQRYEDQLKQQQllnEENLRKQ---EESVQKQEAMRRATVEREM--ELRHKNEMLR 188
Cdd:pfam17380 525 RQKAIYEEERRREA---EEERRKQqemEERRRIQEQMRKATEERSRleAMEREREMMR 579
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 347-414 1.87e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.81  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  347 NILMYGPPGTGKTLFAKKLA------------LHSGMDYAIMTGG-DVAPMGREG-----VTAMhklfdwantsRRGLLL 408
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsnrpvfyvqLTRDTTEEDLFGRrNIDPGGASWvdgplVRAA----------REGEIA 70


                  ....*.
gi 283436222  409 FVDEAD 414
Cdd:pfam07728  71 VLDEIN 76
PRK10927 PRK10927
cell division protein FtsN;
101-178 1.87e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.82  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 101 EQLKSEQ----IRAQAEERRK--TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN------EENLRKQEESVQKQEA 168
Cdd:PRK10927 112 EQLTPEQrqllEQMQADMRQQptQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAqqsrttEQSWQQQTRTSQAAPV 191

                         90
                 ....*....|
gi 283436222 169 MRRATVEREM 178
Cdd:PRK10927 192 QAQPRQSKPA 201
PTZ00121 PTZ00121
MAEBL; Provisional
 57-188 1.97e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   57 RAAKAARELEHSRYAKDA--LNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQD 134
Cdd:PTZ00121 1182 RKAEEVRKAEELRKAEDArkAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEAR 1261

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 283436222  135 KLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLR 188
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315
PTZ00121 PTZ00121
MAEBL; Provisional
 101-227 2.48e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  101 EQLKSEQIRAQAEERRKTlSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLR--KQEESVQKQEAMRRATVEREM 178
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKA-AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENkiKAEEAKKEAEEDKKKAEEAKK 1751

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 283436222  179 ELRHKNEMLRVEAEARARAKAERENAD-IIREQIRLKAAEHRQTVLESIR 227
Cdd:PTZ00121 1752 DEEEKKKIAHLKKEEEKKAEEIRKEKEaVIEEELDEEDEKRRMEVDKKIK 1801
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 347-417 2.56e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 40.45  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 347 NILMYGPPGTGKTLFAKKLALHSGMDY----AIMTggdvapmgreGVTAMHKLFDWANTSR---RGLLLFVDE------- 412
Cdd:PRK13342  38 SMILWGPPGTGKTTLARIIAGATDAPFealsAVTS----------GVKDLREVIEEARQRRsagRRTILFIDEihrfnka 107


                 ....*.
gi 283436222 413 -ADAFL 417
Cdd:PRK13342 108 qQDALL 113
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 347-365 2.66e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.41  E-value: 2.66e-03
                         10
                 ....*....|....*....
gi 283436222 347 NILMYGPPGTGKTLFAKKL 365
Cdd:COG0606  213 NLLMIGPPGSGKTMLARRL 231
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 347-366 2.80e-03

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 40.42  E-value: 2.80e-03
                         10        20
                 ....*....|....*....|
gi 283436222 347 NILMYGPPGTGKTLFAKKLA 366
Cdd:COG1219  111 NILLIGPTGSGKTLLAQTLA 130
PTZ00121 PTZ00121
MAEBL; Provisional
 59-212 2.84e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   59 AKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVE--------QLKSEQIRAQAEERRKTLSEETRQHQARA 130
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkaeeenKIKAAEEAKKAEEDKKKAEEAKKAEEDEK 1688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  131 QYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVE----REMELRHKNEMLRVEAEARARAKAERENADI 206
Cdd:PTZ00121 1689 KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEeakkEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768


                  ....*.
gi 283436222  207 IREQIR 212
Cdd:PTZ00121 1769 KAEEIR 1774
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
347-366 2.97e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 40.14  E-value: 2.97e-03
                         10        20
                 ....*....|....*....|
gi 283436222 347 NILMYGPPGTGKTLFAKKLA 366
Cdd:PRK05342 110 NILLIGPTGSGKTLLAQTLA 129
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 348-366 4.39e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 36.81  E-value: 4.39e-03
                          10
                  ....*....|....*....
gi 283436222  348 ILMYGPPGTGKTLFAKKLA 366
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLA 19
PRK12704 PRK12704
phosphodiesterase; Provisional
 91-185 4.95e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.76  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  91 SKLKEYEA-AVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN-EENLRKQEESVQKQEa 168
Cdd:PRK12704  31 AKIKEAEEeAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQkEENLDRKLELLEKRE- 109

                         90
                 ....*....|....*..
gi 283436222 169 mrRATVEREMELRHKNE 185
Cdd:PRK12704 110 --EELEKKEKELEQKQQ 124
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 347-366 6.27e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 38.74  E-value: 6.27e-03
                         10        20
                 ....*....|....*....|
gi 283436222 347 NILMYGPPGTGKTLFAKKLA 366
Cdd:cd19497   52 NILLIGPTGSGKTLLAQTLA 71
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 346-366 6.41e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.37  E-value: 6.41e-03
                         10        20
                 ....*....|....*....|.
gi 283436222 346 RNILMYGPPGTGKTLFAKKLA 366
Cdd:COG1401  222 KNVILAGPPGTGKTYLARRLA 242
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-229 8.45e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 8.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  55 LERAAKAAR-------ELEHSRYAKDALNLAQmqEQTLQLEQQSKLKEYEAAVEQLKSE--QIRAQAEERRKTLSEETRQ 125
Cdd:COG1196  205 LERQAEKAEryrelkeELKELEAELLLLKLRE--LEAELEELEAELEELEAELEELEAElaELEAELEELRLELEELELE 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222 126 -HQARAQYQDKLARQ-------RYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVER-EMELRHKNEMLRVEAEARAR 196
Cdd:COG1196  283 lEEAQAEEYELLAELarleqdiARLEERRRELEERLEELEEELAELEEELEELEEELEElEEELEEAEEELEEAEAELAE 362

                        170       180       190
                 ....*....|....*....|....*....|...
gi 283436222 197 AKAERENADIIREQIRLKAAEHRQTVLESIRTA 229
Cdd:COG1196  363 AEEALLEAEAELAEAEEELEELAEELLEALRAA 395
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 55-229 8.92e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.78  E-value: 8.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222   55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQyQD 134
Cdd:pfam15709 348 LEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQ-QE 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436222  135 KLARQRYEDQLKQQQllneENLRKQEESVQKQeamrratveREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLK 214
Cdd:pfam15709 427 EFRRKLQELQRKKQQ----EEAERAEAEKQRQ---------KELEMQLAEEQKRLMEMAEEERLEYQRQKQEAEEKARLE 493

                         170
                  ....*....|....*
gi 283436222  215 AAEHRQTVLESIRTA 229
Cdd:pfam15709 494 AEERRQKEEEAARLA 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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