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Conserved domains on  [gi|284172473|ref|NP_001165101|]
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vascular endothelial growth factor A, long form isoform p precursor [Homo sapiens]

Protein Classification

PDGF/VEGF family growth factor( domain architecture ID 11255535)

PDGF/VEGF family growth factor binds to its receptor tyrosine kinase and regulates a variety of biological processes such as blood and lymphatic vessel development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-131 8.64e-42

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 133.32  E-value: 8.64e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 284172473   130 CR 131
Cdd:smart00141  81 CR 82
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-131 8.64e-42

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 133.32  E-value: 8.64e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 284172473   130 CR 131
Cdd:smart00141  81 CR 82
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-132 9.93e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 123.25  E-value: 9.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473  50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 127
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*
gi 284172473 128 CECRC 132
Cdd:cd00135   81 CECRP 85
PDGF pfam00341
PDGF/VEGF domain;
52-130 1.46e-36

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 120.08  E-value: 1.46e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473   52 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 284172473  129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-131 1.69e-30

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 107.01  E-value: 1.69e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473  22 KWSQAAPMAEGGGqnhHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESN 101
Cdd:PHA02661  21 PWCFSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSN 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 284172473 102 ITMQIM----RIKPHQGQHIGEMSFLQHNKCECR 131
Cdd:PHA02661  98 VTVTVMltsvSGSTGATSNFQTISVEEHTKCKCE 131
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-131 8.64e-42

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 133.32  E-value: 8.64e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 284172473   130 CR 131
Cdd:smart00141  81 CR 82
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-132 9.93e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 123.25  E-value: 9.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473  50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 127
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*
gi 284172473 128 CECRC 132
Cdd:cd00135   81 CECRP 85
PDGF pfam00341
PDGF/VEGF domain;
52-130 1.46e-36

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 120.08  E-value: 1.46e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473   52 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 284172473  129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-131 1.69e-30

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 107.01  E-value: 1.69e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172473  22 KWSQAAPMAEGGGqnhHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESN 101
Cdd:PHA02661  21 PWCFSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSN 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 284172473 102 ITMQIM----RIKPHQGQHIGEMSFLQHNKCECR 131
Cdd:PHA02661  98 VTVTVMltsvSGSTGATSNFQTISVEEHTKCKCE 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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