NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|291575181|ref|NP_001167563|]
View 

transmembrane protein 185A isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM203 super family cl10951
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 12-194 2.10e-36

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


The actual alignment was detected with superfamily member pfam10269:

Pssm-ID: 448049  Cd Length: 245  Bit Score: 130.27  E-value: 2.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   12 PRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRIER------GSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEI 85
Cdd:pfam10269  42 SRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLEStyvglsGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   86 LC-------------SVNILQFI----FIALRLDKIIH----WPWLVVCVPLWILMSFLClvvlyyIVWSVLFLRSMDVI 144
Cdd:pfam10269 118 FSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEalgwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNI 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 291575181  145 AEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNA----FSCIPIFVPLWLS 194
Cdd:pfam10269 192 SSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAavadIPIAVVFAPLFLL 245
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 12-194 2.10e-36

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 130.27  E-value: 2.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   12 PRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRIER------GSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEI 85
Cdd:pfam10269  42 SRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLEStyvglsGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   86 LC-------------SVNILQFI----FIALRLDKIIH----WPWLVVCVPLWILMSFLClvvlyyIVWSVLFLRSMDVI 144
Cdd:pfam10269 118 FSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEalgwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNI 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 291575181  145 AEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNA----FSCIPIFVPLWLS 194
Cdd:pfam10269 192 SSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAavadIPIAVVFAPLFLL 245
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 12-194 2.10e-36

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 130.27  E-value: 2.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   12 PRAEGETCVEFKAMLIAvgihLLLLMFEVLVCDRIER------GSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEI 85
Cdd:pfam10269  42 SRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLEStyvglsGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   86 LC-------------SVNILQFI----FIALRLDKIIH----WPWLVVCVPLWILMSFLClvvlyyIVWSVLFLRSMDVI 144
Cdd:pfam10269 118 FSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVEalgwWDWFINFGVLYCFAFLVC------TKWSNPVIASQSNI 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 291575181  145 AEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNA----FSCIPIFVPLWLS 194
Cdd:pfam10269 192 SSSSSTHIFYADWYSILKIPLIVFQVLLAAKLEGTPAavadIPIAVVFAPLFLL 245
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 99-191 7.07e-05

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 43.21  E-value: 7.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291575181   99 LRLDKIIHWPWLVVCVPLWIlmsFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMAlswMTIVVPLLTFEILLVHKLDG 178
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWI---FHALVARGRFVAAIVWRSLPASRPEDRHWAPFHA---VVATPLLLAFELLLCIYLES 74

                          90
                  ....*....|....*...
gi 291575181  179 HNAFSCIPI-----FVPL 191
Cdd:pfam10269  75 TYVGLSGALdwtivFLPL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH