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Conserved domains on  [gi|292658846|ref|NP_001167624|]
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rab9 effector protein with kelch motifs isoform b [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
48-218 1.20e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.62  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  48 GKVFIVGGANPNRSFSDVHTMDLETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANT 126
Cdd:COG3055   23 GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGfTGANPSSTPLNDVYVYDPAT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 127 LTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYI 206
Cdd:COG3055  100 NTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA--AVLPDGKILV 174

                        170
                 ....*....|..
gi 292658846 207 FGGMTPAGALDT 218
Cdd:COG3055  175 IGGRNGSGFSNT 186
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
48-218 1.20e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.62  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  48 GKVFIVGGANPNRSFSDVHTMDLETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANT 126
Cdd:COG3055   23 GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGfTGANPSSTPLNDVYVYDPAT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 127 LTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYI 206
Cdd:COG3055  100 NTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA--AVLPDGKILV 174

                        170
                 ....*....|..
gi 292658846 207 FGGMTPAGALDT 218
Cdd:COG3055  175 IGGRNGSGFSNT 186
PLN02193 PLN02193
nitrile-specifier protein
 75-229 1.88e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.56  E-value: 1.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  75 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 153
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 292658846 154 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 229
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
Kelch_3 pfam13415
Galactose oxidase, central domain;
98-150 1.09e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 292658846   98 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 150
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
48-218 1.20e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.62  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  48 GKVFIVGGANPNRSFSDVHTMDLETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANT 126
Cdd:COG3055   23 GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGfTGANPSSTPLNDVYVYDPAT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 127 LTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYI 206
Cdd:COG3055  100 NTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA--AVLPDGKILV 174

                        170
                 ....*....|..
gi 292658846 207 FGGMTPAGALDT 218
Cdd:COG3055  175 IGGRNGSGFSNT 186
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-219 1.24e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 95.22  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  13 PRKATWYTLtvpGDSPCARVGHSCSYLppvgnakRGKVFIVGGANPNRSFSDVHTMDLETRTWTTpevTSPPPSPRTFHT 92
Cdd:COG3055   97 PATNTWTKL---APMPTPRGGATALLL-------DGKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  93 SSAAIGNQLYVFGGGErgaqpvqdtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCI 172
Cdd:COG3055  164 AAVLPDGKILVIGGRN-------------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAY 225

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 292658846 173 DISDMKWQKLNPTgaaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTM 219
Cdd:COG3055  226 DPATNTWTALGEL---PTPRHGHAAVLTDGKVYVIGGETKPGVRTPL 269
PLN02193 PLN02193
nitrile-specifier protein
 75-229 1.88e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.56  E-value: 1.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  75 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 153
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 292658846 154 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 229
Cdd:PLN02193 231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
PLN02153 PLN02153
epithiospecifier protein
 85-228 1.01e-19

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 88.12  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  85 PSPRTFHtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDANTLTWSQPETLGNPPS-PRHGHVMVAAGTKLFIHGGLAGD 163
Cdd:PLN02153  20 PGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDEK 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292658846 164 RFYDDLHCIDISDMKWQ---KLNPTGAaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 228
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAY 164
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
74-232 3.04e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.59  E-value: 3.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  74 TWTTpevTSPPPSPRTfHTSSAAIGNQLYVFGGGERGAQPvqdTKLHVFDANTLTWSQpetLGNPP-SPRHGHVMVAAGT 152
Cdd:COG3055    2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGLSGGSAS---NSFEVYDPATNTWSE---LAPLPgPPRHHAAAVAQDG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 153 KLFIHGGLAGD----RFYDDLHCIDISDMKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 228
Cdd:COG3055   72 KLYVFGGFTGAnpssTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGT 148


                 ....
gi 292658846 229 WTLL 232
Cdd:COG3055  149 WTQL 152
PLN02193 PLN02193
nitrile-specifier protein
 9-232 2.05e-17

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 82.31  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846   9 PGDKPRKATWYTLTVPGDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSFSD-VHTMDLETRTWTTPEVTSPPPS 86
Cdd:PLN02193 144 PSTPKLLGKWIKVEQKGEGPGLRCSHG---IAQVGN----KIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVPH 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  87 PRTFHTSSAAIGNQLYVFGGgeRGAQPvQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA----- 161
Cdd:PLN02193 217 LSCLGVRMVSIGSTLYVFGG--RDASR-QYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSatarl 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 162 -------------------GDRF-------------------------YDDLHCIDISDMKWQKLNPTGAAPAGCAAHSA 197
Cdd:PLN02193 294 ktldsynivdkkwfhcstpGDSFsirggaglevvqgkvwvvygfngceVDDVHYYDPVQDKWTQVETFGVRPSERSVFAS 373

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 292658846 198 VAMGKHVYIFGG---------MTPAGALDTMYQYHTEEQHWTLL 232
Cdd:PLN02193 374 AAVGKHIVIFGGeiamdplahVGPGQLTDGTFALDTETLQWERL 417
PLN02153 PLN02153
epithiospecifier protein
 17-209 2.57e-15

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 75.41  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  17 TWYTLTVPGDSPcaRVGHSCSYLPPVGNakrgKVFIVGGANPNRSFSDVHTMDLETRTWT--TPEVTSPPPSPRTFHtSS 94
Cdd:PLN02153  61 TWSIAPANGDVP--RISCLGVRMVAVGT----KLYIFGGRDEKREFSDFYSYDTVKNEWTflTKLDEEGGPEARTFH-SM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  95 AAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLT---WSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA------GDRF 165
Cdd:PLN02153 134 ASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIAdgkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpgGKSD 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 292658846 166 YDD--LHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG 209
Cdd:PLN02153 214 YESnaVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
PLN02153 PLN02153
epithiospecifier protein
 136-247 5.59e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.70  E-value: 5.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 136 GNPPSPRHGHVMVAAGTKLFIHGG-LAGDRFYD-DLHCIDISDMKWQKLNPTGAAPA-GCAAHSAVAMGKHVYIFGGMTP 212
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDE 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 292658846 213 AGALDTMYQYHTEEQHWTLL-KFDTL-LPPGRLDHSM 247
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLtKLDEEgGPEARTFHSM 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-247 1.33e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.94  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 128 TWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYIF 207
Cdd:COG3055    2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAA--AVAQDGKLYVF 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 292658846 208 GGMTPA----GALDTMYQYHTEEQHWTLLkfdTLLPPGRLDHSM 247
Cdd:COG3055   77 GGFTGAnpssTPLNDVYVYDPATNTWTKL---APMPTPRGGATA 117
PRK14131 PRK14131
N-acetylneuraminate epimerase;
94-209 4.76e-09

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 56.95  E-value: 4.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  94 SAAIGNQLYVfGGGERGaqpvqdTKLHVFDANTLT--WSQPETLgnPPSPRHGHVMVAAGTKLFIHGGL------AGDRF 165
Cdd:PRK14131  34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSkgWTKIAAF--PGGPREQAVAAFIDGKLYVFGGIgktnseGSPQV 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 292658846 166 YDDLHCIDISDMKWQKLNPTgaAPAGCAAHSAVAM-GKHVYIFGG 209
Cdd:PRK14131 105 FDDVYKYDPKTNSWQKLDTR--SPVGLAGHVAVSLhNGKAYITGG 147
PHA03098 PHA03098
kelch-like protein; Provisional
 50-250 1.01e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 53.23  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  50 VFIVGGANPNR-SFSDVHTMDLETRTWTT-PEVTSPPPSPrtfhtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDANTl 127
Cdd:PHA03098 297 IYFIGGMNKNNlSVNSVVSYDTKTKSWNKvPELIYPRKNP-----GVTVFNNRIYVIGG-IYNSISLNTVESWKPGESK- 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 128 tWSQPETLgnpPSPRHGHVMVAAGTKLFIHGGLA-GDRFYDDLHCIDISDMKWQKLNPTgaaPAGCAAHSAVAMGKHVYI 206
Cdd:PHA03098 370 -WREEPPL---IFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYV 442

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 292658846 207 FGGMTPA---GALDTMYQYHTEEQHWTLLKfdTLLPPgRLDHSMCII 250
Cdd:PHA03098 443 IGGISYIdniKVYNIVESYNPVTNKWTELS--SLNFP-RINASLCIF 486
PLN02153 PLN02153
epithiospecifier protein
 25-242 1.96e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.91  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  25 GDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSF-SDVHTMDLETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLY 102
Cdd:PLN02153  17 GKGPGPRCSHG---IAVVGD----KLYSFGGElKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 103 VFGGGErgaQPVQDTKLHVFDANTLTW---SQPETLGNPPSpRHGHVMVAAGTKLFIHGGLAG-------DRFyDDLHCI 172
Cdd:PLN02153  90 IFGGRD---EKREFSDFYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMASDENHVYVFGGVSKgglmktpERF-RTIEAY 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292658846 173 DISDMKWQKL-NPTGAAPAGCAAHSAVAMGKHVYIFGGMT---PAGALD----TMYQYHTEEQHWTLLKFDTLLPPGR 242
Cdd:PLN02153 165 NIADGKWVQLpDPGENFEKRGGAGFAVVQGKIWVVYGFATsilPGGKSDyesnAVQFFDPASGKWTEVETTGAKPSAR 242
Kelch_3 pfam13415
Galactose oxidase, central domain;
98-150 1.09e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 292658846   98 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 150
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
30-85 1.98e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 1.98e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 292658846   30 ARVGHSCSYLPpvgnakRGKVFIVGGAN-PNRSFSDVHTMDLETRTWTTpeVTSPPP 85
Cdd:pfam13418   1 PRAYHTSTSIP------DDTIYLFGGEGeDGTLLSDLWVFDLSTNEWTR--LGSLPS 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
13-221 4.33e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 47.70  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  13 PRKATWYTLtvPGDSPCARVGHScSYLPpvgnaKRGKVFIVGGANP---NRSFSDVHT---------------MDLETRT 74
Cdd:PRK14131 113 PKTNSWQKL--DTRSPVGLAGHV-AVSL-----HNGKAYITGGVNKnifDGYFEDLAAagkdktpkdkindayFDKKPED 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  75 WT-TPEVTSPPPSPRTFH---------TSSAAI---GNQLYVFGG----GERGAQpvqdTKLHVFDANTLTWSQPETLgn 137
Cdd:PRK14131 185 YFfNKEVLSYDPSTNQWKnagespflgTAGSAVvikGNKLWLINGeikpGLRTDA----VKQGKFTGNNLKWQKLPDL-- 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846 138 PPSPR---------------HGHVMVAAGT------------KLFIHGGLAgDRFYDDLHCIDisDMKWQKLnptGAAPA 190
Cdd:PRK14131 259 PPAPGgssqegvagafagysNGVLLVAGGAnfpgarenyqngKLYAHEGLK-KSWSDEIYALV--NGKWQKV---GELPQ 332

                        250       260       270
                 ....*....|....*....|....*....|..
gi 292658846 191 GCAAHSAVAMGKHVYIFGGMTPAG-ALDTMYQ 221
Cdd:PRK14131 333 GLAYGVSVSWNNGVLLIGGETAGGkAVSDVTL 364
Kelch_6 pfam13964
Kelch motif;
87-142 5.27e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 5.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 292658846   87 PRTFHtSSAAIGNQLYVFGGGERGAQPVQdtKLHVFDANTLTWsqpETLGNPPSPR 142
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
47-96 1.73e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 41.51  E-value: 1.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 292658846   47 RGKVFIVGGANPNRS--FSDVHTMDLETRTWTTpevTSPPPSPRTFHTSSAA 96
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 192-232 1.86e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 292658846  192 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 232
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
20-123 1.02e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 43.22  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  20 TLTVPGDSPCARVGHSCSYLppvgnakRGKVFIVGGANpnRSFSDVHTMDLETRTWTTpevTSPPPSPRTFHTSsAAIGN 99
Cdd:COG3055  186 TWTTLAPLPTARAGHAAAVL-------GGKILVFGGES--GFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLTDG 252

                         90       100
                 ....*....|....*....|....*
gi 292658846 100 QLYVFGGG-ERGAQPVQDTKLHVFD 123
Cdd:COG3055  253 KVYVIGGEtKPGVRTPLVTSAEVYD 277
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 141-184 1.16e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 292658846  141 PRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNP 184
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
87-140 1.19e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 292658846   87 PRTFHTSSAAIGNQLYVFGGgeRGAQPVQDTKLHVFDANTLTWSQpetLGNPPS 140
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--EGEDGTLLSDLWVFDLSTNEWTR---LGSLPS 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
141-182 3.85e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 292658846  141 PRHGHVMVA-AGTKLFIHGGLAGD-RFYDDLHCIDISDMKWQKL 182
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRL 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 139-170 4.79e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 4.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 292658846  139 PSPRHGHVMVAAGTKLFIHGGLAGDR--FYDDLH 170
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVY 34
PLN02772 PLN02772
guanylate kinase
 93-163 6.84e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 6.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292658846  93 SSAAIGNQLYVFGGGERGAQPVQDTKLhvFDANTLTWSQPETLGNPPSPRHGH--VMVAAGTKLFIHGGLAGD 163
Cdd:PLN02772  29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPD 99
PLN02153 PLN02153
epithiospecifier protein
 18-170 1.04e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 40.35  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  18 WYTLTVPGDSPCARVGHSCSYLppvgnakRGKVFIV---------GGANPNRSfSDVHTMDLETRTWTTPEVTSPPPSPR 88
Cdd:PLN02153 171 WVQLPDPGENFEKRGGAGFAVV-------QGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKPSAR 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292658846  89 TFHtSSAAIGNQLYVFGG-------GERGAQPVQDTKlHVFDANTLTWSQPETLGNPPSPRHGHVMVAA---GTK-LFIH 157
Cdd:PLN02153 243 SVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSNEG-YALDTETLVWEKLGECGEPAMPRGWTAYTTAtvyGKNgLLMH 320

                        170
                 ....*....|....
gi 292658846 158 GG-LAGDRFYDDLH 170
Cdd:PLN02153 321 GGkLPTNERTDDLY 334
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 30-76 2.45e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 2.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 292658846   30 ARVGHSCSYLppvgnakRGKVFIVGGANPNRSFSDVHTMDLETRTWT 76
Cdd:pfam01344   1 RRSGAGVVVV-------GGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 31-76 4.33e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.62  E-value: 4.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 292658846   31 RVGHSCSYLppvgnakRGKVFIVGGA--NPNRSFSDVHTMDLETRTWT 76
Cdd:pfam07646   2 RYPHASSVP-------GGKLYVVGGSdgLGDLSSSDVLVYDPETNVWT 42
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 189-225 8.10e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 8.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 292658846  189 PAGCAAHSAVAMGKHVYIFGGMTPAG--ALDTMYQYHTE 225
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVYVLSLP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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