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Conserved domains on  [gi|295317377|ref|NP_001171272|]
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ran guanine nucleotide release factor isoform B [Homo sapiens]

Protein Classification

Ran-interacting Mog1 family protein( domain architecture ID 10083114)

Ran-interacting Mog1 family protein similar to Danio rerio Mog1, a small protein that can bind to small GTPase RAN and regulate transport of RNA and proteins between the cytoplasm and nucleus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mog1 cd00224
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-146 1.35e-80

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


:

Pssm-ID: 238137  Cd Length: 173  Bit Score: 235.04  E-value: 1.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPP 146
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVAKDVTIHVALIRLPQYQTDLLLTFNQPP 134
 
Name Accession Description Interval E-value
Mog1 cd00224
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-146 1.35e-80

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


Pssm-ID: 238137  Cd Length: 173  Bit Score: 235.04  E-value: 1.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPP 146
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVAKDVTIHVALIRLPQYQTDLLLTFNQPP 134
Mog1 pfam04603
Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates ...
 8-145 3.95e-60

Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.


Pssm-ID: 461364  Cd Length: 137  Bit Score: 181.97  E-value: 3.95e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377    8 PLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARA-VHVESVQ 86
Cdd:pfam04603   2 PLFGGAITADLPSGFIDVSDLRQVPDNQEVFVDPDTDQSIIVELLERVEPVSDEEAARYHFEDLADDNDASEsSTVESVS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 295317377   87 PLSLENLalrGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQP 145
Cdd:pfam04603  82 KLEDLSL---DETTPAYTLIGTQTVAKFNKEAPNTVAIYLALIRLPEVSTDILITVNVP 137
 
Name Accession Description Interval E-value
Mog1 cd00224
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-146 1.35e-80

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


Pssm-ID: 238137  Cd Length: 173  Bit Score: 235.04  E-value: 1.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPP 146
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVAKDVTIHVALIRLPQYQTDLLLTFNQPP 134
Mog1 pfam04603
Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates ...
 8-145 3.95e-60

Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.


Pssm-ID: 461364  Cd Length: 137  Bit Score: 181.97  E-value: 3.95e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317377    8 PLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARA-VHVESVQ 86
Cdd:pfam04603   2 PLFGGAITADLPSGFIDVSDLRQVPDNQEVFVDPDTDQSIIVELLERVEPVSDEEAARYHFEDLADDNDASEsSTVESVS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 295317377   87 PLSLENLalrGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQP 145
Cdd:pfam04603  82 KLEDLSL---DETTPAYTLIGTQTVAKFNKEAPNTVAIYLALIRLPEVSTDILITVNVP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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