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Conserved domains on  [gi|295317379|ref|NP_001171273|]
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ran guanine nucleotide release factor isoform C [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mog1 super family cl00169
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-119 4.59e-61

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


The actual alignment was detected with superfamily member cd00224:

Pssm-ID: 469638  Cd Length: 173  Bit Score: 186.50  E-value: 4.59e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317379   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 295317379  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVR 119
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVA 107
 
Name Accession Description Interval E-value
Mog1 cd00224
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-119 4.59e-61

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


Pssm-ID: 238137  Cd Length: 173  Bit Score: 186.50  E-value: 4.59e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317379   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 295317379  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVR 119
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVA 107
Mog1 pfam04603
Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates ...
 8-117 1.07e-44

Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.


Pssm-ID: 461364  Cd Length: 137  Bit Score: 143.45  E-value: 1.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317379    8 PLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARA-VHVESVQ 86
Cdd:pfam04603   2 PLFGGAITADLPSGFIDVSDLRQVPDNQEVFVDPDTDQSIIVELLERVEPVSDEEAARYHFEDLADDNDASEsSTVESVS 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 295317379   87 PLSLENLalrGRCQEAWVLSGKQQIAKENQQ 117
Cdd:pfam04603  82 KLEDLSL---DETTPAYTLIGTQTVAKFNKE 109
 
Name Accession Description Interval E-value
Mog1 cd00224
homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important ...
 7-119 4.59e-61

homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)


Pssm-ID: 238137  Cd Length: 173  Bit Score: 186.50  E-value: 4.59e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317379   7 CPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQ 86
Cdd:cd00224    1 CPLFGGAFSAILPPGFIDVSDLRPVPDNQEVFCHPSTDQSLIVELLELQAHVRDEEAARYHFEDLASVNDAEGVEVLSVQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 295317379  87 PLSLENLALRGRCqeAWVLSGKQqiakENQQVR 119
Cdd:cd00224   81 PLSLEGTSLTGCC--AWLLSGKQ----ENQEVA 107
Mog1 pfam04603
Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates ...
 8-117 1.07e-44

Ran-interacting Mog1 protein; Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.


Pssm-ID: 461364  Cd Length: 137  Bit Score: 143.45  E-value: 1.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317379    8 PLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARA-VHVESVQ 86
Cdd:pfam04603   2 PLFGGAITADLPSGFIDVSDLRQVPDNQEVFVDPDTDQSIIVELLERVEPVSDEEAARYHFEDLADDNDASEsSTVESVS 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 295317379   87 PLSLENLalrGRCQEAWVLSGKQQIAKENQQ 117
Cdd:pfam04603  82 KLEDLSL---DETTPAYTLIGTQTVAKFNKE 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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