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Conserved domains on  [gi|296434255|ref|NP_001171760|]
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V-set and immunoglobulin domain-containing protein 4 isoform 3 precursor [Homo sapiens]

Protein Classification

IgV_CRIg domain-containing protein( domain architecture ID 11610717)

IgV_CRIg domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 21-137 1.44e-78

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


:

Pssm-ID: 409510  Cd Length: 117  Bit Score: 231.26  E-value: 1.44e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  21 PILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQL 100
Cdd:cd16089    1 PILEGPESITGPWKGSVNLPCTYVPEEGYTQVLVKWLVQRDSDPVTIFLRDSSGDHIQQAKYRGRLEVSKDTPGDVSLQL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 296434255 101 STLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQK 137
Cdd:cd16089   81 DTLEMDDRGHYTCQVTWQTPDGNLIVREKTTELRVQK 117
 
Name Accession Description Interval E-value
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 21-137 1.44e-78

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 231.26  E-value: 1.44e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  21 PILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQL 100
Cdd:cd16089    1 PILEGPESITGPWKGSVNLPCTYVPEEGYTQVLVKWLVQRDSDPVTIFLRDSSGDHIQQAKYRGRLEVSKDTPGDVSLQL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 296434255 101 STLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQK 137
Cdd:cd16089   81 DTLEMDDRGHYTCQVTWQTPDGNLIVREKTTELRVQK 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-135 4.02e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255   24 EVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQR-GSDPVTIFLR--DSSGDHIQQAKYQGRLHVShkvPGDVSLQL 100
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPpGKGPTFLIAYysNGSEEGVKKGRFSGRGDPS---NGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 296434255  101 STLEMDDRSHYTCEVTwqtpDGNQVVRDKITELRV 135
Cdd:pfam07686  78 QNLTLSDSGTYTCAVI----PSGEGVFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
36-115 1.76e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255    36 DVNLPCTY--DPLQGYTqvlVKWLVQRGSDPVTIFLRDSSGDH-IQQAKYQGRLHVSHKV-PGDVSLQLSTLEMDDRSHY 111
Cdd:smart00406   1 SVTLSCKFsgSTFSSYY---VSWVRQPPGKGLEWLGYIGSNGSsYYQESYKGRFTISKDTsKNDVSLTISNLRVEDTGTY 77


                   ....
gi 296434255   112 TCEV 115
Cdd:smart00406  78 YCAV 81
 
Name Accession Description Interval E-value
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 21-137 1.44e-78

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 231.26  E-value: 1.44e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  21 PILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQL 100
Cdd:cd16089    1 PILEGPESITGPWKGSVNLPCTYVPEEGYTQVLVKWLVQRDSDPVTIFLRDSSGDHIQQAKYRGRLEVSKDTPGDVSLQL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 296434255 101 STLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQK 137
Cdd:cd16089   81 DTLEMDDRGHYTCQVTWQTPDGNLIVREKTTELRVQK 117
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 25-135 3.82e-10

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 55.53  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  25 VPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRG--SDPVTIFlRDSSGDHIqQAKYQGRLHVSHKVPG--DVSLQL 100
Cdd:cd05718    5 VPTEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAgsSQNVAVF-HPQYGPSV-PNPYAERVEFLAARLGlrNATLRI 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 296434255 101 STLEMDDRSHYTCEVTwQTPDGNqvvRDKITELRV 135
Cdd:cd05718   83 RNLRVEDEGNYICEFA-TFPQGN---RQGTTWLRV 113
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 35-136 8.35e-09

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 51.94  E-value: 8.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  35 GDVNLPCTYD---PLQGYTQVLVKWLVQRGSD--PVTIFLrdSSGDHIQQ-AKYQGRLHVSHKVPGDVSLQLSTLEMDDR 108
Cdd:cd05877   13 GNVTLPCRYHyepELSAPRKIRVKWTKLEVDYakEEDVLV--AIGTRHKSyGSYQGRVFLRRADDLDASLVITDLRLEDY 90

                         90       100
                 ....*....|....*....|....*...
gi 296434255 109 SHYTCEVTWQTPDGNQVVrdkitELRVQ 136
Cdd:cd05877   91 GRYRCEVIDGLEDESVVV-----ALRLR 113
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-135 4.02e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255   24 EVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQR-GSDPVTIFLR--DSSGDHIQQAKYQGRLHVShkvPGDVSLQL 100
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPpGKGPTFLIAYysNGSEEGVKKGRFSGRGDPS---NGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 296434255  101 STLEMDDRSHYTCEVTwqtpDGNQVVRDKITELRV 135
Cdd:pfam07686  78 QNLTLSDSGTYTCAVI----PSGEGVFGKGTRLTV 108
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 29-124 1.02e-04

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 40.45  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  29 VTGPWKGDVNLPCTYDPLQgytQVLVKWLVQRGSDPVTIFLRDSsgDHI--QQAKYQGR--LHVSHKVPGDVSLQLSTLE 104
Cdd:cd16091    7 VVCLLSEDCILPCSFTPGS---EVVIHWYKQDSDIKVHSYYYGK--DQLesQDQRYRNRtsLFKDQISNGNASLLLRRVQ 81

                         90       100
                 ....*....|....*....|
gi 296434255 105 MDDRSHYTCEVTwqTPDGNQ 124
Cdd:cd16091   82 LQDEGRYKCYTS--TIIGNQ 99
IGv smart00406
Immunoglobulin V-Type;
36-115 1.76e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255    36 DVNLPCTY--DPLQGYTqvlVKWLVQRGSDPVTIFLRDSSGDH-IQQAKYQGRLHVSHKV-PGDVSLQLSTLEMDDRSHY 111
Cdd:smart00406   1 SVTLSCKFsgSTFSSYY---VSWVRQPPGKGLEWLGYIGSNGSsYYQESYKGRFTISKDTsKNDVSLTISNLRVEDTGTY 77


                   ....
gi 296434255   112 TCEV 115
Cdd:smart00406  78 YCAV 81
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 24-125 1.94e-04

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 39.89  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  24 EVPES-VTGPWKGDVNLPCTYDPLQGYT--QVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHK--VPGDVSL 98
Cdd:cd20934    1 RVPEDpVVALVGTDATLRCSFSPEPGFSlaQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDllAQGNASL 80

                         90       100
                 ....*....|....*....|....*..
gi 296434255  99 QLSTLEMDDRSHYTCEVTWQTPDGNQV 125
Cdd:cd20934   81 RLQRVRVADEGSYTCFVSVQDFGSAAV 107
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 37-115 5.80e-04

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.20  E-value: 5.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  37 VNLPCTYDPLQGYTQVL-VKWLVQRgSDPVTIFLRDSSGDHIQQAKY---QGRLH-VSHKVPGDVSLQLSTLEMDDRSHY 111
Cdd:cd20960   18 VTLPCHHQLGLEDQGTLdIEWLLLP-SDKVEKVVITYSGDRVYNHYYpalKGRVAfTSNDLSGDASLNISNLKLSDTGTY 96


                 ....
gi 296434255 112 TCEV 115
Cdd:cd20960   97 QCKV 100
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 36-123 1.69e-03

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 36.81  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434255  36 DVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGR--LHVSHKVPGDVSLQLSTLEMDDRSHYTC 113
Cdd:cd20984   14 DGILSCTFTPDIKLSDIVIQWLKEGDSGLVHEFKEGKDELSRQSPMFRGRtsLFADQVHVGNASLRLKNVQLTDAGTYLC 93

                         90
                 ....*....|
gi 296434255 114 EVTWQTPDGN 123
Cdd:cd20984   94 IISNSKGTGN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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