NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|296434229|ref|NP_001171785|]
View 

kelch domain-containing protein 4 isoform 2 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-311 5.33e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 5.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055    8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQV---------------KDYIYY----------NDVYAFNLDTFTWSKLSPS 193
Cdd:COG3055   78 GFTGANPSSTP--LNDVYVYDPATNTWTKLapmptprggatalllDGKIYVvggwddggnvAWVEVYDPATGTWTQLAPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 194 gtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmA 273
Cdd:COG3055  156 ---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-V 204

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 296434229 274 PNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 311
Cdd:COG3055  205 LGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-311 5.33e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 5.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055    8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQV---------------KDYIYY----------NDVYAFNLDTFTWSKLSPS 193
Cdd:COG3055   78 GFTGANPSSTP--LNDVYVYDPATNTWTKLapmptprggatalllDGKIYVvggwddggnvAWVEVYDPATGTWTQLAPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 194 gtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmA 273
Cdd:COG3055  156 ---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-V 204

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 296434229 274 PNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 311
Cdd:COG3055  205 LGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
PLN02193 PLN02193
nitrile-specifier protein
 77-283 3.42e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 3.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  77 ELILFGGEY--FNGQKTFLYNELYVYNTRKDT------WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGE 147
Cdd:PLN02193 115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPSTpkllgkWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 148 QFYHykdLWVLHLATKTWE-------------------QVKDYIY----------YNDVYAFNLDTFTWSKLSPSGTGPT 198
Cdd:PLN02193 191 IDKH---LYVFDLETRTWSispatgdvphlsclgvrmvSIGSTLYvfggrdasrqYNGFYSFDTTTNEWKLLTPVEEGPT 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 199 PRSGCQMSVTPQGgIVVYGGYS-KQRVK-----KDVDKGTRH----SDMFLLKPEDGRE----DKWV------------- 251
Cdd:PLN02193 268 PRSFHSMAADEEN-VYVFGGVSaTARLKtldsyNIVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcevddvh 346

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 296434229 252 --------WTRMNPSGVKPTPRSGFSVAMAPNHqTLFFGG 283
Cdd:PLN02193 347 yydpvqdkWTQVETFGVRPSERSVFASAAVGKH-IVIFGG 385
Kelch_4 pfam13418
Galactose oxidase, central domain;
63-117 4.32e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 49.53  E-value: 4.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 296434229   63 PRLNASLSVHPeKDELILFGGEYFNGQktfLYNELYVYNTRKDTWTKvdIPSPPP 117
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTR--LGSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-311 5.33e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 5.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055    8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQV---------------KDYIYY----------NDVYAFNLDTFTWSKLSPS 193
Cdd:COG3055   78 GFTGANPSSTP--LNDVYVYDPATNTWTKLapmptprggatalllDGKIYVvggwddggnvAWVEVYDPATGTWTQLAPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 194 gtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmA 273
Cdd:COG3055  156 ---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-V 204

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 296434229 274 PNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 311
Cdd:COG3055  205 LGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-222 7.38e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 68.64  E-value: 7.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  59 PPPSPRLNASLSVHpeKDELILFGGEyfngQKTFLYNELYVYNTRKDTWTKvdIPSPPPRRCAHQAVVVPqgGGQLWVFG 138
Cdd:COG3055  107 PMPTPRGGATALLL--DGKIYVVGGW----DDGGNVAWVEVYDPATGTWTQ--LAPLPTPRDHLAAAVLP--DGKILVIG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 139 GEFASPNGEQFYHYKDLWVL---HLATKTWEQVK----DYIYYNDVYAFNLDTFTWSKLspsGTGPTPRSGcQMSVTPQG 211
Cdd:COG3055  177 GRNGSGFSNTWTTLAPLPTAragHAAAVLGGKILvfggESGFSDEVEAYDPATNTWTAL---GELPTPRHG-HAAVLTDG 252

                        170
                 ....*....|.
gi 296434229 212 GIVVYGGYSKQ 222
Cdd:COG3055  253 KVYVIGGETKP 263
PLN02193 PLN02193
nitrile-specifier protein
 77-283 3.42e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 3.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  77 ELILFGGEY--FNGQKTFLYNELYVYNTRKDT------WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGE 147
Cdd:PLN02193 115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPSTpkllgkWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 148 QFYHykdLWVLHLATKTWE-------------------QVKDYIY----------YNDVYAFNLDTFTWSKLSPSGTGPT 198
Cdd:PLN02193 191 IDKH---LYVFDLETRTWSispatgdvphlsclgvrmvSIGSTLYvfggrdasrqYNGFYSFDTTTNEWKLLTPVEEGPT 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 199 PRSGCQMSVTPQGgIVVYGGYS-KQRVK-----KDVDKGTRH----SDMFLLKPEDGRE----DKWV------------- 251
Cdd:PLN02193 268 PRSFHSMAADEEN-VYVFGGVSaTARLKtldsyNIVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcevddvh 346

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 296434229 252 --------WTRMNPSGVKPTPRSGFSVAMAPNHqTLFFGG 283
Cdd:PLN02193 347 yydpvqdkWTQVETFGVRPSERSVFASAAVGKH-IVIFGG 385
Kelch_4 pfam13418
Galactose oxidase, central domain;
63-117 4.32e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 49.53  E-value: 4.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 296434229   63 PRLNASLSVHPeKDELILFGGEYFNGQktfLYNELYVYNTRKDTWTKvdIPSPPP 117
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTR--LGSLPS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
75-127 4.78e-08

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 49.21  E-value: 4.78e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 296434229   75 KDELILFGGEYFNGQKtfLYNELYVYNTRKDTWTKVDiPSPPPRRCaHQAVVV 127
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT--RLNDLYVYDLDTNTWTQIG-DLPPPRSG-HSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 61-311 1.77e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  61 PSPRLNASLSVhpEKDELILFGGEYFNGQKtfLYNELYVYNTRKDTWTKVDIPSPPPRrCAHQAVVVPQGGGQLWVFGGE 140
Cdd:PLN02153  20 PGPRCSHGIAV--VGDKLYSFGGELKPNEH--IDKDLYVFDFNTHTWSIAPANGDVPR-ISCLGVRMVAVGTKLYIFGGR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 141 FASPNGEQFYHY---KDLWVLHLA--------TKTWEQV---KDYIY----------------YNDVYAFNLDTFTWSKL 190
Cdd:PLN02153  95 DEKREFSDFYSYdtvKNEWTFLTKldeeggpeARTFHSMasdENHVYvfggvskgglmktperFRTIEAYNIADGKWVQL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 191 SPSGTGPTPRSGCQMSVTpQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLlKPEDGRedkwvWTRMNPSGVKPTPRSGFSV 270
Cdd:PLN02153 175 PDPGENFEKRGGAGFAVV-QGKIWVVYGFATSILPGGKSDYESNAVQFF-DPASGK-----WTEVETTGAKPSARSVFAH 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 296434229 271 AMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 311
Cdd:PLN02153 248 AVVGKYIIIFGGEVWPDLKGHLGPGTLSNEGYALDTETLVW 288
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
51-140 1.68e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.69  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  51 TQTVELPCPPPSPRLNASLSVHpeKDELILFGGEYFNgqktflYNELYVYNTRKDTWTKVdiPSPPPRRCAHQAVVVpqg 130
Cdd:COG3055  184 SNTWTTLAPLPTARAGHAAAVL--GGKILVFGGESGF------SDEVEAYDPATNTWTAL--GELPTPRHGHAAVLT--- 250

                         90
                 ....*....|
gi 296434229 131 GGQLWVFGGE 140
Cdd:COG3055  251 DGKVYVIGGE 260
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
186-314 1.96e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.30  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 186 TWSKLSPSgtgPTPRSGCQMsVTPQGGIVVYGGYSKqrvkkdvdkGTRHSDMFLLKPEDGRedkwvWTRMNPsgvKPTPR 265
Cdd:COG3055    2 TWSSLPDL---PTPRSEAAA-ALLDGKVYVAGGLSG---------GSASNSFEVYDPATNT-----WSELAP---LPGPP 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 296434229 266 SGFSVAMAPNHQTLFFGGvcdeEEEESLSGEFFNDLYFYDATRNRWFEG 314
Cdd:COG3055   61 RHHAAAVAQDGKLYVFGG----FTGANPSSTPLNDVYVYDPATNTWTKL 105
Kelch_3 pfam13415
Galactose oxidase, central domain;
131-207 1.13e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 1.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296434229  131 GGQLWVFGGEFASPNgeqfyhykdlwvlhlatktweqvkdyIYYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMSV 207
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ--------------------------TRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
117-170 1.20e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.52  E-value: 1.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 296434229  117 PRRCaHQAVVVPqgGGQLWVFGGEfaSPNGEQfyhYKDLWVLHLATKTWEQVKD 170
Cdd:pfam13418   1 PRAY-HTSTSIP--DDTIYLFGGE--GEDGTL---LSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
119-168 2.14e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.86  E-value: 2.14e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 296434229  119 RCAHQAVVVpqgGGQLWVFGGefaspNGEQFYHYKDLWVLHLATKTWEQV 168
Cdd:pfam13964   2 RTFHSVVSV---GGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEEL 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
76-221 3.95e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.69  E-value: 3.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229  76 DELILFGG--EYFNGQKTFLYNELYVYNTRKDTWTKVDipSPPPRRCAHQAVVVPQgGGQLWVFGG-------------- 139
Cdd:PRK14131  85 GKLYVFGGigKTNSEGSPQVFDDVYKYDPKTNSWQKLD--TRSPVGLAGHVAVSLH-NGKAYITGGvnknifdgyfedla 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434229 140 ---EFASPNGEQFYHYKDLwvlhlatktweQVKDYIYYNDVYAFNLDTFTWSKLspsgtGPTPRSG-CQMSVTPQGG-IV 214
Cdd:PRK14131 162 aagKDKTPKDKINDAYFDK-----------KPEDYFFNKEVLSYDPSTNQWKNA-----GESPFLGtAGSAVVIKGNkLW 225


                 ....*..
gi 296434229 215 VYGGYSK 221
Cdd:PRK14131 226 LINGEIK 232
Kelch_4 pfam13418
Galactose oxidase, central domain;
199-255 1.13e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 296434229  199 PRSGCQMSVTPQGGIVVYGGYSkqrvkkdvDKGTRHSDMFLLKPEDGRedkwvWTRM 255
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEG--------EDGTLLSDLWVFDLSTNE-----WTRL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH