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Conserved domains on  [gi|298358756|ref|NP_001177258|]
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ATP synthase F(0) complex subunit C3, mitochondrial isoform B precursor [Homo sapiens]

Protein Classification

ATP synthase subunit c family protein( domain architecture ID 210)

ATP synthase subunit c family protein is essential for facilitating proton translocation across the membrane as part of the Fo proton channel, and this proton movement drives the rotation of the c-ring, which is coupled to the F1 catalytic core, converting the proton gradient into mechanical energy that powers ATP production from ADP and inorganic phosphate

Gene Ontology:  GO:0045263|GO:0046933|GO:0008289
PubMed:  26621635

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13469 super family cl00466
F0F1 ATP synthase subunit C; Provisional
 68-105 1.61e-13

F0F1 ATP synthase subunit C; Provisional


The actual alignment was detected with superfamily member MTH00222:

Pssm-ID: 469780 [Multi-domain]  Cd Length: 77  Bit Score: 60.25  E-value: 1.61e-13
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 298358756  68 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:MTH00222   3 EILTAAKFVGAGAATIGAAGSGAGIGTVFGNLIIGYAR 40
 
Name Accession Description Interval E-value
ATP9 MTH00222
ATP synthase F0 subunit 9; Provisional
 68-105 1.61e-13

ATP synthase F0 subunit 9; Provisional


Pssm-ID: 164765 [Multi-domain]  Cd Length: 77  Bit Score: 60.25  E-value: 1.61e-13
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 298358756  68 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:MTH00222   3 EILTAAKFVGAGAATIGAAGSGAGIGTVFGNLIIGYAR 40
ATP-synt_Fo_c_ATP5G3 cd18182
ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; ATP5G3 (also called ATP ...
 74-105 3.68e-09

ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; ATP5G3 (also called ATP synthase lipid-binding protein, ATP synthase proteolipid P3, ATP synthase proton-transporting mitochondrial F(o) complex subunit C3, ATPase protein 9, or ATPase subunit c) transports protons across the inner mitochondrial membrane to the F1-ATPase protruding on the matrix side, resulting in the generation of ATP.


Pssm-ID: 349422  Cd Length: 65  Bit Score: 48.66  E-value: 3.68e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 298358756  74 KFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:cd18182    1 KYIGAGLATIGLAGAGIGIGNVFGSLINGVAR 32
 
Name Accession Description Interval E-value
ATP9 MTH00222
ATP synthase F0 subunit 9; Provisional
 68-105 1.61e-13

ATP synthase F0 subunit 9; Provisional


Pssm-ID: 164765 [Multi-domain]  Cd Length: 77  Bit Score: 60.25  E-value: 1.61e-13
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 298358756  68 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:MTH00222   3 EILTAAKFVGAGAATIGAAGSGAGIGTVFGNLIIGYAR 40
ATP-synt_Fo_c_ATP5G3 cd18182
ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; ATP5G3 (also called ATP ...
 74-105 3.68e-09

ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; ATP5G3 (also called ATP synthase lipid-binding protein, ATP synthase proteolipid P3, ATP synthase proton-transporting mitochondrial F(o) complex subunit C3, ATPase protein 9, or ATPase subunit c) transports protons across the inner mitochondrial membrane to the F1-ATPase protruding on the matrix side, resulting in the generation of ATP.


Pssm-ID: 349422  Cd Length: 65  Bit Score: 48.66  E-value: 3.68e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 298358756  74 KFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:cd18182    1 KYIGAGLATIGLAGAGIGIGNVFGSLINGVAR 32
PRK07558 PRK07558
F0F1 ATP synthase subunit C; Validated
 72-105 5.42e-05

F0F1 ATP synthase subunit C; Validated


Pssm-ID: 181027  Cd Length: 74  Bit Score: 38.03  E-value: 5.42e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 298358756  72 AAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR 105
Cdd:PRK07558   5 ALKFIGAGLACIGMAGAALGVGNIFGNYLSGALR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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