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Conserved domains on  [gi|299782608|ref|NP_001177720|]
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zinc finger protein 317 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 4.99e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.99e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 299782608   56 SVTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLD 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-548 1.14e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 190 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 243
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 244 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 295
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 296 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 374
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 375 KH-----MRIHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 442
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 443 ECaacgkvfgDYLSRRRHMSVHLVKKRVECRQcgkafrnqstlktHMRSHTGEKPYECDH--CGKAFSIGSNLNVHRRIH 520
Cdd:COG5048  353 KE--------KLLNSSSKFSPLLNNEPPQSLQ-------------QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|
gi 299782608 521 TGEKPYEC--LVCGKAFSDHSSLRSHVKTH 548
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 4.99e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.99e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 299782608   56 SVTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLD 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
57-103 7.47e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 7.47e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 299782608    57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLDWETPSK 103
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKP 47
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-96 1.26e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.26e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 299782608  57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSL 96
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-548 1.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 190 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 243
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 244 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 295
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 296 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 374
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 375 KH-----MRIHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 442
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 443 ECaacgkvfgDYLSRRRHMSVHLVKKRVECRQcgkafrnqstlktHMRSHTGEKPYECDH--CGKAFSIGSNLNVHRRIH 520
Cdd:COG5048  353 KE--------KLLNSSSKFSPLLNNEPPQSLQ-------------QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|
gi 299782608 521 TGEKPYEC--LVCGKAFSDHSSLRSHVKTH 548
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-508 6.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.77e-05
                          10        20
                  ....*....|....*....|....
gi 299782608  485 LKTHMRSHTGEKPYECDHCGKAFS 508
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-268 6.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 299782608 216 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 268
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 4.99e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.99e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 299782608   56 SVTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLD 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
57-103 7.47e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 7.47e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 299782608    57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLDWETPSK 103
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKP 47
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-96 1.26e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.26e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 299782608  57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSL 96
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-548 1.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 190 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 243
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 244 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 295
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 296 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 374
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 375 KH-----MRIHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 442
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 443 ECaacgkvfgDYLSRRRHMSVHLVKKRVECRQcgkafrnqstlktHMRSHTGEKPYECDH--CGKAFSIGSNLNVHRRIH 520
Cdd:COG5048  353 KE--------KLLNSSSKFSPLLNNEPPQSLQ-------------QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|
gi 299782608 521 TGEKPYEC--LVCGKAFSDHSSLRSHVKTH 548
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
301-460 2.62e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 301 PYECHDCGKAFQHPSHLKEHVR--NHTGE--KPYACT--QCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSFGDLVS 372
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 373 RRKHMRIHIVKKPVECRQ-------CGKTFRNQSILKTHMNSHTGEKPYGCD--LCGKAFSASSNLTAHRKIHTQERRYE 443
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 299782608 444 CAACGKVFGDYLSRRRH 460
Cdd:COG5048  449 CSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-528 5.54e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 216 KPYECSDCGKAFNDPSALRSHARTHLKEKPFDCSQ--CGNAFRTLSALKIHMRVHTGERPYKC-DQCGKAYGRSCHLIAH 292
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 293 KRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLHKKNHMVEKTyeckecGKSFGDLVS 372
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 373 RRKHMRIHIVKKPVECRQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACGKVFG 452
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 453 DYLSRRRHMSVHL--VKKRVE-----CRQCGKAFRNQSTLKTHMRS--HTGE--KPYECDH--CGKAFSIGSNLNVHRRI 519
Cdd:COG5048  266 PTASSQSSSPNESdsSSEKGFslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ....*....
gi 299782608 520 HTGEKPYEC 528
Cdd:COG5048  346 HTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-508 6.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.77e-05
                          10        20
                  ....*....|....*....|....
gi 299782608  485 LKTHMRSHTGEKPYECDHCGKAFS 508
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-550 8.40e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 300 RPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKA---FRWKSNFNLHKKNHMVEKTYECKECGKSFGDLVSRRKH 376
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 377 MRIHIVKK--PVECRQCGKTFRNQSILKTHMNSHTGEKPY---------------------GCDLCGKAFSASSNLTAHR 433
Cdd:COG5048  112 SSSSNSNDnnLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 434 KIHTQERRYECAACGKVFGDYLSRRRHMSVHLVkKRVECRQCGKAF-------RNQSTLKTHMRSHTGE----------- 495
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS-SSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASEsprsslptass 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 299782608 496 -----------------KPYECDHCGKAFSIGSNLNVHRR--IHTGE--KPYEC--LVCGKAFSDHSSLRSHVKTHRG 550
Cdd:COG5048  271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-259 2.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 133 STEYAHLFEVFGMDPHLTQPMGRHAGKRPYHR------RDYGVAFKGRPHLTQHM---SMYDGRKMHECHQCQKAFTTSA 203
Cdd:COG5048  323 SCPYSLCGKLFSRNDALKRHILLHTSISPAKEkllnssSKFSPLLNNEPPQSLQQykdLKNDKKSETLSNSCIRNFKRDS 402

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 299782608 204 SLTRHRRIHTGEKPYEC--SDCGKAFNDPSALRSHARTHLKEKPFDCSQCGNAFRTLS 259
Cdd:COG5048  403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-339 2.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|....
gi 299782608  316 HLKEHVRNHTGEKPYACTQCGKAF 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-228 4.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|....*
gi 299782608  204 SLTRHRRIHTGEKPYECSDCGKAFN 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-268 6.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 299782608 216 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 268
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-283 7.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.63e-04
                          10        20
                  ....*....|....*....|....
gi 299782608  260 ALKIHMRVHTGERPYKCDQCGKAY 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-400 8.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 216 KPYECSDCGKAFNDPSALRSHARTHLKE----KPFDC--SQCGNAFRTLSALKIHMRVHTGERPYKcdqcgkaygrsCHL 289
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK-----------EKL 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 290 IAHKRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGekpyactqCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSF 367
Cdd:COG5048  357 LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        170       180       190
                 ....*....|....*....|....*....|...
gi 299782608 368 GDLVSRRKHMRIHIVKKPVECRQCGKTFRNQSI 400
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
481-557 9.11e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782608 481 NQSTLKTHMRSHTGE----KPYECDHCGKAFSIGSNLNVHRRIHTGEKPYECLV--CGKAFSDHSSLRSHVKTHRGEKLF 554
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92


                 ...
gi 299782608 555 VSS 557
Cdd:COG5048   93 LNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-449 9.35e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.35e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299782608 383 KKPVECRQCGKTFRNQSILKTHMNSHTGEKPYGC--DLCGKAFSASSNLTAHRKIHTQERRYECAACGK 449
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-536 9.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.66e-04
                          10        20
                  ....*....|....*....|....*
gi 299782608  512 NLNVHRRIHTGEKPYECLVCGKAFS 536
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 475-546 2.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.07e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 299782608 475 CGKAFRNQSTLKTHMRShtgekpyecDHCGKAFSIGSNLNVHRRIHTGEKPYECLVCGKAFSDHSSLRSHVK 546
Cdd:COG5189  357 CNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-311 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....
gi 299782608  288 HLIAHKRTHTGERPYECHDCGKAF 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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