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Conserved domains on  [gi|307219194|ref|NP_001177789|]
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pleckstrin homology domain-containing family A member 5 isoform 3 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
12-41 3.32e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 34.40  E-value: 3.32e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 307219194  12 LPRSWTYGITRGGRVFFINEEAKSTTWLHP 41
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
58-76 5.50e-03

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 31.32  E-value: 5.50e-03
                         10
                 ....*....|....*....
gi 307219194  58 LPTGWEEAYTFEGARYYIN 76
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYN 19
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
12-41 3.32e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 34.40  E-value: 3.32e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 307219194  12 LPRSWTYGITRGGRVFFINEEAKSTTWLHP 41
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
58-76 5.50e-03

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 31.32  E-value: 5.50e-03
                         10
                 ....*....|....*....
gi 307219194  58 LPTGWEEAYTFEGARYYIN 76
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYN 19
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
11-42 8.30e-03

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 30.65  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307219194   11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPV 42
Cdd:smart00456  1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
12-41 3.32e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 34.40  E-value: 3.32e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 307219194  12 LPRSWTYGITRGGRVFFINEEAKSTTWLHP 41
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
58-76 5.50e-03

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 31.32  E-value: 5.50e-03
                         10
                 ....*....|....*....
gi 307219194  58 LPTGWEEAYTFEGARYYIN 76
Cdd:pfam00397  1 LPPGWEERWDPDGRVYYYN 19
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
11-42 8.30e-03

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 30.65  E-value: 8.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307219194   11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPV 42
Cdd:smart00456  1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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