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Conserved domains on  [gi|300192909|ref|NP_001177885|]
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disintegrin and metalloproteinase domain-containing protein 18 isoform 2 precursor [Homo sapiens]

Protein Classification

Pep_M12B_propep domain-containing protein( domain architecture ID 10480566)

Pep_M12B_propep domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 27-141 2.67e-26

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 97.00  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300192909   27 VTVPRKIKSN------DSEVSERKMI-YIITIDGQPYTLHLGKQS-FLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYA 98
Cdd:pfam01562   2 VVIPVRLDPSrrrrslASESTYLDTLsYRLAAFGKKFHLHLTPNRlLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQGHV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 300192909   99 AEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSAR----FEHIIY 141
Cdd:pfam01562  82 EGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSReeggHPHVVY 128
 
Name Accession Description Interval E-value
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 27-141 2.67e-26

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 97.00  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300192909   27 VTVPRKIKSN------DSEVSERKMI-YIITIDGQPYTLHLGKQS-FLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYA 98
Cdd:pfam01562   2 VVIPVRLDPSrrrrslASESTYLDTLsYRLAAFGKKFHLHLTPNRlLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQGHV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 300192909   99 AEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSAR----FEHIIY 141
Cdd:pfam01562  82 EGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSReeggHPHVVY 128
 
Name Accession Description Interval E-value
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 27-141 2.67e-26

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 97.00  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300192909   27 VTVPRKIKSN------DSEVSERKMI-YIITIDGQPYTLHLGKQS-FLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYA 98
Cdd:pfam01562   2 VVIPVRLDPSrrrrslASESTYLDTLsYRLAAFGKKFHLHLTPNRlLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQGHV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 300192909   99 AEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSAR----FEHIIY 141
Cdd:pfam01562  82 EGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSReeggHPHVVY 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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