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Conserved domains on  [gi|300244535|ref|NP_001177910|]
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interleukin-6 receptor subunit beta isoform 3 precursor [Homo sapiens]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 11162515)

protein containing domains Lep_receptor_Ig, and FN3

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
26-112 2.05e-37

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 134.68  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80

                  ....*..
gi 300244535  106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
222-321 8.92e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76
                         90       100
                 ....*....|....*....|
gi 300244535 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
458-538 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   458 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 537
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   .
gi 300244535   538 G 538
Cdd:smart00060  81 G 81
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
121-215 2.30e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 43.95  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81
                          90       100
                  ....*....|....*....|...
gi 300244535  193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
308-538 1.46e-03

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.30  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 308 GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATkl 387
Cdd:COG3401   85 AAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASS-- 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 388 TVNLTNDRYLATLTVRNLVGKSDAAVLTIPAcDFQGNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRT 466
Cdd:COG3401  163 VAGAGVVVSPDTSATAAVATTSLTVTSTTLV-DGGGDIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTA 241
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300244535 467 KKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTIIGNETAVNV-DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:COG3401  242 TADTPGSVTLSWD----PVTESDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
26-112 2.05e-37

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 134.68  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80

                  ....*..
gi 300244535  106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
222-321 8.92e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76
                         90       100
                 ....*....|....*....|
gi 300244535 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
224-311 3.14e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 3.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  224 PPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQipPEDTASTRSSFTVQDLKPFTEYVFRIRCMK 303
Cdd:pfam00041   2 APSNLTVTDVTS-TSLT-VSWTPPPDGNGPITGYEVEYRPKNSGEPWN--EITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77

                  ....*...
gi 300244535  304 EDGKGYWS 311
Cdd:pfam00041  78 GGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
458-538 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   458 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 537
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   .
gi 300244535   538 G 538
Cdd:smart00060  81 G 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
222-308 2.28e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 2.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   222 PNPPHNLSVINSEelSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76

                   ....*..
gi 300244535   302 MKEDGKG 308
Cdd:smart00060  77 VNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
458-549 8.49e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 8.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 458 PSKGPTVRTKKVGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNE--TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYT 535
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
                         90
                 ....*....|....*
gi 300244535 536 DEG-GKDGPEFTFTT 549
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
221-412 1.17e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.86  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 221 KPNPPHNLSVINSeeLSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIppeDTASTRSSFTVQDLKPFTEYVFRIR 300
Cdd:COG3401  326 PPAAPSGLTATAV--GSSSITLSWTASSDADVT--GYNVYRSTSGGGTYTKI---AETVTTTSYTDTGLTPGTTYYYKVT 398
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 301 CMkeDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWkTLPPFEANGKILDYEVTLTRWKSHLQNY 380
Cdd:COG3401  399 AV--DAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA-ASNPGVSAAVLADGGDTGNAVPFTTTSS 475
                        170       180       190
                 ....*....|....*....|....*....|..
gi 300244535 381 TVNATKLTVNLTNDRYLATLTVRNLVGKSDAA 412
Cdd:COG3401  476 TVTATTTDTTTANLSVTTGSLVGGSGASSVTN 507
fn3 pfam00041
Fibronectin type III domain;
469-538 3.45e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 3.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300244535  469 VGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNETA--VNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
121-215 2.30e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 43.95  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81
                          90       100
                  ....*....|....*....|...
gi 300244535  193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
308-538 1.46e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.30  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 308 GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATkl 387
Cdd:COG3401   85 AAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASS-- 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 388 TVNLTNDRYLATLTVRNLVGKSDAAVLTIPAcDFQGNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRT 466
Cdd:COG3401  163 VAGAGVVVSPDTSATAAVATTSLTVTSTTLV-DGGGDIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTA 241
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300244535 467 KKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTIIGNETAVNV-DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:COG3401  242 TADTPGSVTLSWD----PVTESDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
26-112 2.05e-37

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 134.68  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80

                  ....*..
gi 300244535  106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
222-321 8.92e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76
                         90       100
                 ....*....|....*....|
gi 300244535 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
224-311 3.14e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 3.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  224 PPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQipPEDTASTRSSFTVQDLKPFTEYVFRIRCMK 303
Cdd:pfam00041   2 APSNLTVTDVTS-TSLT-VSWTPPPDGNGPITGYEVEYRPKNSGEPWN--EITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77

                  ....*...
gi 300244535  304 EDGKGYWS 311
Cdd:pfam00041  78 GGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
458-538 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   458 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 537
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   .
gi 300244535   538 G 538
Cdd:smart00060  81 G 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
222-308 2.28e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 2.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535   222 PNPPHNLSVINSEelSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76

                   ....*..
gi 300244535   302 MKEDGKG 308
Cdd:smart00060  77 VNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
458-549 8.49e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 8.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 458 PSKGPTVRTKKVGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNE--TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYT 535
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
                         90
                 ....*....|....*
gi 300244535 536 DEG-GKDGPEFTFTT 549
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
221-412 1.17e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.86  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 221 KPNPPHNLSVINSeeLSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIppeDTASTRSSFTVQDLKPFTEYVFRIR 300
Cdd:COG3401  326 PPAAPSGLTATAV--GSSSITLSWTASSDADVT--GYNVYRSTSGGGTYTKI---AETVTTTSYTDTGLTPGTTYYYKVT 398
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 301 CMkeDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWkTLPPFEANGKILDYEVTLTRWKSHLQNY 380
Cdd:COG3401  399 AV--DAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA-ASNPGVSAAVLADGGDTGNAVPFTTTSS 475
                        170       180       190
                 ....*....|....*....|....*....|..
gi 300244535 381 TVNATKLTVNLTNDRYLATLTVRNLVGKSDAA 412
Cdd:COG3401  476 TVTATTTDTTTANLSVTTGSLVGGSGASSVTN 507
fn3 pfam00041
Fibronectin type III domain;
469-538 3.45e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 3.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300244535  469 VGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNETA--VNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
121-215 2.30e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 43.95  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81
                          90       100
                  ....*....|....*....|...
gi 300244535  193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
131-216 1.12e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 42.01  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  131 NLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKA-KRDTPTSC-------TVDYSTVYFVNIEVWVeaE 201
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPlGPVLQCQYyIRDDGTRIgcqfddlEGLSSSFHQVYICVNG--S 78
                          90
                  ....*....|....*
gi 300244535  202 NALGKVTSDHINFDP 216
Cdd:pfam09240  79 SSAGPIRSSDQTFQL 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
308-538 1.46e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.30  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 308 GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATkl 387
Cdd:COG3401   85 AAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASS-- 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 388 TVNLTNDRYLATLTVRNLVGKSDAAVLTIPAcDFQGNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRT 466
Cdd:COG3401  163 VAGAGVVVSPDTSATAAVATTSLTVTSTTLV-DGGGDIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTA 241
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300244535 467 KKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTIIGNETAVNV-DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:COG3401  242 TADTPGSVTLSWD----PVTESDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
242-313 5.67e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 37.00  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535  242 LTW-TNPSIKSVIIlkyniQYRTKDASTWSQIPPEDTASTRS--------SFTVQDLKPFTEYVFRIRcmkeDGKGYWSD 312
Cdd:pfam16656  17 VSWvTPSAVTSPVV-----QYGTSSSALTSTATATSSTYTTGdggtgyihRATLTGLEPGTTYYYRVG----DDNGGWSE 87

                  .
gi 300244535  313 W 313
Cdd:pfam16656  88 V 88
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
104-538 7.95e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 104 NILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAThkfadcKAKRDTPTSCT 183
Cdd:COG3401   27 SKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPP------TATGLTTLTGS 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 184 VDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSeelSSILKLTWTNPSIKSVIILKYNIQYRT 263
Cdd:COG3401  101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGV---DGANASGTTASSVAGAGVVVSPDTSAT 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 264 KDASTWSQIPPEDTASTrssfTVQDLKPFTEYVFRIRCMkedGKGYWSDWSEEASGITYEDRPSkAPSFWYkidpSHTQG 343
Cdd:COG3401  178 AAVATTSLTVTSTTLVD----GGGDIEPGTTYYYRVAAT---DTGGESAPSNEVSVTTPTTPPS-APTGLT----ATADT 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 344 YRTVQLVWKTLPPFEANGkildYEVTltRWKSHLQNYTVNATkltvnLTNDRYLATltvrnlvgksdaavltipacdfqg 423
Cdd:COG3401  246 PGSVTLSWDPVTESDATG----YRVY--RSNSGDGPFTKVAT-----VTTTSYTDT------------------------ 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244535 424 NLAESKCYLITVTPVYADGPGSPES--IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTII 501
Cdd:COG3401  291 GLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAAPSGLTATAVGSSSITLSWT----ASSDADVTGYNV-YRSTS 365
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 300244535 502 GNETAVNVDSSH--TEYTLSSLTSDTLYMVRMAAYTDEG 538
Cdd:COG3401  366 GGGTYTKIAETVttTSYTDTGLTPGTTYYYKVTAVDAAG 404
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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