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Conserved domains on  [gi|300796069|ref|NP_001178698|]
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tRNA (32-2'-O)-methyltransferase regulator THADA [Rattus norvegicus]

Protein Classification

THADA/TRM732 family protein( domain architecture ID 10563587)

thyroid adenoma-associated protein (THADA)/TRM732 family protein is a DUF2428 domain-containing protein; similar to Homo sapiens thyroid adenoma-associated protein (THADA) and the tRNA -methyltransferase non-catalytic subunit TRM732

Gene Ontology:  GO:0030488
PubMed:  17889454

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239 1.90e-83

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


:

Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 274.62  E-value: 1.90e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069   938 PVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqvilneiqprdtndyfsqakilkecdsfdledlstsvs 1017
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1018 nidssaEIKGKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPVPESAAGLLTVQQVKEIGEYFKQHLLQSRHR 1097
Cdd:pfam10350   41 ------STIDESEETEGLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1098 GAFELAYTGFVKLTEILNRCSNVSLQKLPEQWLWSVLEEIKssdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLRV 1177
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1178 TMRELISLA--------LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWA 1239
Cdd:pfam10350  191 AMKELLEIAtspvssdeESESDETVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 super family cl47095
Uncharacterized conserved protein [Function unknown];
394-1408 8.45e-41

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG5543:

Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  394 EYVYTHWEHPLDALRHQTKIIFRNLLQMHRLTIEGADLvtDPFFLELTKSLLQLEWHIKGKYACLGYLVESLGIEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  474 DKTIPSQILEVMGDQSLVPYASDLLETMFKN-HKSHLKSQT-VTNTWMDKWHETwvfpvlsVLCGGNLDQRSYVIDYYL- 550
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEgEEVMWMNLWCPK-------DLKYIHDKQPADPDSIRAv 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  551 PRLLNYSPE-SLHYMVQILQtpidtetgscNHRGALGALMACLRTARAHGHLqsathawENLVCS---ARVKQGLIHQHC 626
Cdd:COG5543   259 KRLFSSMPKaSFRYSLRILK----------NKDERFFVYLPDLKISTGYSIL-------RELLGKlspDRVRSIIKIVGD 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  627 QVRIDTLGLLCESSRSTEVVSREEMQWVQFFLTYNLNSQSPGVRQQICSLLTKLFCRIQESsqvLYKLEQRNSTPDSEKR 706
Cdd:COG5543   322 EYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSM---LKSLARYFRKFPDEQL 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  707 STREQpsvsLQQYKNFMSSVCNILFEALFPGSSYSTRFSALTILGSIAEVFPASKGNIQTVYQLSHD--------IDAGR 778
Cdd:COG5543   399 WLKEK----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSLIAEGIDKSTPQKFLIQNKREfpfsaqllFDSDH 474
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  779 FQILMECFTSTFEEVKTLAFDLLMNLSSvtAGQLQGSEKLQDLFQAALELSTSTKPYDC---VTASYLLNLLIwqdalpa 855
Cdd:COG5543   475 ERLMIDLLVSNYADIRKLSTKILLGLES--MSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCVEFI------- 545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  856 slsASSAQQPTCGageksavverNTLVVIKCLMENLE-DEISQAENSLlqaassFPMYGRVHCITRAFQKLPLHDlrlvS 934
Cdd:COG5543   546 ---KSCQSRSFVG----------HTKSILDSHMKNFVsGKKSMEEISI------GPHFAALSLILGLFNSEENHQ----D 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  935 EWKpVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqvilneiqprdtndyfsqakilkecdsfdledlst 1014
Cdd:COG5543   603 TSK-ILSELIEHDIITWVDIVYVCCFDSLSGVLP---------------------------------------------- 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1015 svsnidssaeikgKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPvpesaaglltvQQVKEIGEYFKQHLLQS 1094
Cdd:COG5543   636 -------------GQEDDCGVPDQVILSVYWRNMKECSSLLCGMLLKYPLTR-----------GNLALSGRLVQVLLSHI 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1095 RHRGAFELAYTGFVkltEILNRCsNVSLQKLPEQWLWSVLEEIKSSDPSsklcATRRSAGIPFYIQALLASEPKKGRmDL 1174
Cdd:COG5543   692 RHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRIEKCKA----ITRRSGGIPLLFTSILRAEVTKYP-SL 762
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1175 LRVTMRELISLA---LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWAVRNSSTLLFSSL 1251
Cdd:COG5543   763 LERTLKRLLELAetpESSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIRNCSIMLFTNL 842
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1252 ITRVFGVKRGKDeLSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDLGDPDGHPGMFLLLLVLERLYPspmdgTAS 1331
Cdd:COG5543   843 VNRAFGRGPEGI-VGMAHAGSRKLFFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIFLVTEALWRLSP-----RGG 916
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300796069 1332 TLSLAPFVPFIIRCGRSPFYRSREMAARALVPFITIDQIPSTLHALLDSLpsstdqCFRQNHIHGTLLQVFHLLQAY 1408
Cdd:COG5543   917 VTGLKSFNICTKKCWKMPNWKARPRASMVLNPLLSEGEVLLRVLILLDSE------AVEQNGMHGSLLENVYGLSSY 987
 
Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239 1.90e-83

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 274.62  E-value: 1.90e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069   938 PVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqvilneiqprdtndyfsqakilkecdsfdledlstsvs 1017
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1018 nidssaEIKGKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPVPESAAGLLTVQQVKEIGEYFKQHLLQSRHR 1097
Cdd:pfam10350   41 ------STIDESEETEGLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1098 GAFELAYTGFVKLTEILNRCSNVSLQKLPEQWLWSVLEEIKssdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLRV 1177
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1178 TMRELISLA--------LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWA 1239
Cdd:pfam10350  191 AMKELLEIAtspvssdeESESDETVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 COG5543
Uncharacterized conserved protein [Function unknown];
394-1408 8.45e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  394 EYVYTHWEHPLDALRHQTKIIFRNLLQMHRLTIEGADLvtDPFFLELTKSLLQLEWHIKGKYACLGYLVESLGIEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  474 DKTIPSQILEVMGDQSLVPYASDLLETMFKN-HKSHLKSQT-VTNTWMDKWHETwvfpvlsVLCGGNLDQRSYVIDYYL- 550
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEgEEVMWMNLWCPK-------DLKYIHDKQPADPDSIRAv 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  551 PRLLNYSPE-SLHYMVQILQtpidtetgscNHRGALGALMACLRTARAHGHLqsathawENLVCS---ARVKQGLIHQHC 626
Cdd:COG5543   259 KRLFSSMPKaSFRYSLRILK----------NKDERFFVYLPDLKISTGYSIL-------RELLGKlspDRVRSIIKIVGD 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  627 QVRIDTLGLLCESSRSTEVVSREEMQWVQFFLTYNLNSQSPGVRQQICSLLTKLFCRIQESsqvLYKLEQRNSTPDSEKR 706
Cdd:COG5543   322 EYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSM---LKSLARYFRKFPDEQL 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  707 STREQpsvsLQQYKNFMSSVCNILFEALFPGSSYSTRFSALTILGSIAEVFPASKGNIQTVYQLSHD--------IDAGR 778
Cdd:COG5543   399 WLKEK----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSLIAEGIDKSTPQKFLIQNKREfpfsaqllFDSDH 474
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  779 FQILMECFTSTFEEVKTLAFDLLMNLSSvtAGQLQGSEKLQDLFQAALELSTSTKPYDC---VTASYLLNLLIwqdalpa 855
Cdd:COG5543   475 ERLMIDLLVSNYADIRKLSTKILLGLES--MSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCVEFI------- 545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  856 slsASSAQQPTCGageksavverNTLVVIKCLMENLE-DEISQAENSLlqaassFPMYGRVHCITRAFQKLPLHDlrlvS 934
Cdd:COG5543   546 ---KSCQSRSFVG----------HTKSILDSHMKNFVsGKKSMEEISI------GPHFAALSLILGLFNSEENHQ----D 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  935 EWKpVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqvilneiqprdtndyfsqakilkecdsfdledlst 1014
Cdd:COG5543   603 TSK-ILSELIEHDIITWVDIVYVCCFDSLSGVLP---------------------------------------------- 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1015 svsnidssaeikgKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPvpesaaglltvQQVKEIGEYFKQHLLQS 1094
Cdd:COG5543   636 -------------GQEDDCGVPDQVILSVYWRNMKECSSLLCGMLLKYPLTR-----------GNLALSGRLVQVLLSHI 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1095 RHRGAFELAYTGFVkltEILNRCsNVSLQKLPEQWLWSVLEEIKSSDPSsklcATRRSAGIPFYIQALLASEPKKGRmDL 1174
Cdd:COG5543   692 RHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRIEKCKA----ITRRSGGIPLLFTSILRAEVTKYP-SL 762
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1175 LRVTMRELISLA---LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWAVRNSSTLLFSSL 1251
Cdd:COG5543   763 LERTLKRLLELAetpESSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIRNCSIMLFTNL 842
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1252 ITRVFGVKRGKDeLSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDLGDPDGHPGMFLLLLVLERLYPspmdgTAS 1331
Cdd:COG5543   843 VNRAFGRGPEGI-VGMAHAGSRKLFFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIFLVTEALWRLSP-----RGG 916
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300796069 1332 TLSLAPFVPFIIRCGRSPFYRSREMAARALVPFITIDQIPSTLHALLDSLpsstdqCFRQNHIHGTLLQVFHLLQAY 1408
Cdd:COG5543   917 VTGLKSFNICTKKCWKMPNWKARPRASMVLNPLLSEGEVLLRVLILLDSE------AVEQNGMHGSLLENVYGLSSY 987
 
Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239 1.90e-83

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 274.62  E-value: 1.90e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069   938 PVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqvilneiqprdtndyfsqakilkecdsfdledlstsvs 1017
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1018 nidssaEIKGKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPVPESAAGLLTVQQVKEIGEYFKQHLLQSRHR 1097
Cdd:pfam10350   41 ------STIDESEETEGLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1098 GAFELAYTGFVKLTEILNRCSNVSLQKLPEQWLWSVLEEIKssdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLRV 1177
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  1178 TMRELISLA--------LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWA 1239
Cdd:pfam10350  191 AMKELLEIAtspvssdeESESDETVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 COG5543
Uncharacterized conserved protein [Function unknown];
394-1408 8.45e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  394 EYVYTHWEHPLDALRHQTKIIFRNLLQMHRLTIEGADLvtDPFFLELTKSLLQLEWHIKGKYACLGYLVESLGIEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  474 DKTIPSQILEVMGDQSLVPYASDLLETMFKN-HKSHLKSQT-VTNTWMDKWHETwvfpvlsVLCGGNLDQRSYVIDYYL- 550
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEgEEVMWMNLWCPK-------DLKYIHDKQPADPDSIRAv 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  551 PRLLNYSPE-SLHYMVQILQtpidtetgscNHRGALGALMACLRTARAHGHLqsathawENLVCS---ARVKQGLIHQHC 626
Cdd:COG5543   259 KRLFSSMPKaSFRYSLRILK----------NKDERFFVYLPDLKISTGYSIL-------RELLGKlspDRVRSIIKIVGD 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  627 QVRIDTLGLLCESSRSTEVVSREEMQWVQFFLTYNLNSQSPGVRQQICSLLTKLFCRIQESsqvLYKLEQRNSTPDSEKR 706
Cdd:COG5543   322 EYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSM---LKSLARYFRKFPDEQL 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  707 STREQpsvsLQQYKNFMSSVCNILFEALFPGSSYSTRFSALTILGSIAEVFPASKGNIQTVYQLSHD--------IDAGR 778
Cdd:COG5543   399 WLKEK----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSLIAEGIDKSTPQKFLIQNKREfpfsaqllFDSDH 474
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  779 FQILMECFTSTFEEVKTLAFDLLMNLSSvtAGQLQGSEKLQDLFQAALELSTSTKPYDC---VTASYLLNLLIwqdalpa 855
Cdd:COG5543   475 ERLMIDLLVSNYADIRKLSTKILLGLES--MSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCVEFI------- 545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  856 slsASSAQQPTCGageksavverNTLVVIKCLMENLE-DEISQAENSLlqaassFPMYGRVHCITRAFQKLPLHDlrlvS 934
Cdd:COG5543   546 ---KSCQSRSFVG----------HTKSILDSHMKNFVsGKKSMEEISI------GPHFAALSLILGLFNSEENHQ----D 602
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069  935 EWKpVLGKLLLLSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqvilneiqprdtndyfsqakilkecdsfdledlst 1014
Cdd:COG5543   603 TSK-ILSELIEHDIITWVDIVYVCCFDSLSGVLP---------------------------------------------- 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1015 svsnidssaeikgKEEKACDVTAQMVLTCCWRSMKEVALLLGTLCQLLPLQPvpesaaglltvQQVKEIGEYFKQHLLQS 1094
Cdd:COG5543   636 -------------GQEDDCGVPDQVILSVYWRNMKECSSLLCGMLLKYPLTR-----------GNLALSGRLVQVLLSHI 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1095 RHRGAFELAYTGFVkltEILNRCsNVSLQKLPEQWLWSVLEEIKSSDPSsklcATRRSAGIPFYIQALLASEPKKGRmDL 1174
Cdd:COG5543   692 RHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRIEKCKA----ITRRSGGIPLLFTSILRAEVTKYP-SL 762
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1175 LRVTMRELISLA---LSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGGAKAAILGFTSPVWAVRNSSTLLFSSL 1251
Cdd:COG5543   763 LERTLKRLLELAetpESSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIRNCSIMLFTNL 842
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796069 1252 ITRVFGVKRGKDeLSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDLGDPDGHPGMFLLLLVLERLYPspmdgTAS 1331
Cdd:COG5543   843 VNRAFGRGPEGI-VGMAHAGSRKLFFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIFLVTEALWRLSP-----RGG 916
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300796069 1332 TLSLAPFVPFIIRCGRSPFYRSREMAARALVPFITIDQIPSTLHALLDSLpsstdqCFRQNHIHGTLLQVFHLLQAY 1408
Cdd:COG5543   917 VTGLKSFNICTKKCWKMPNWKARPRASMVLNPLLSEGEVLLRVLILLDSE------AVEQNGMHGSLLENVYGLSSY 987
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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