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Conserved domains on  [gi|301897479|ref|NP_001180432|]
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beta-enolase isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00191 super family cl33421
enolase
 2-388 0e+00

enolase


The actual alignment was detected with superfamily member PLN00191:

Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 748.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   2 AMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKgRYLG---------------------- 59
Cdd:PLN00191  27 TITKVKARQIIDSRGNPTVEVDLHTSKGMFRAAVPSGASTGIYEALELRDGDK-DYLGkgvlkavknvneiiapaligmd 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 -------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKL 120
Cdd:PLN00191 106 ptdqtqidnfmleldgtpnKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNKKLVLPVPAFNVINGGSHAGNKL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 121 AMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIG 200
Cdd:PLN00191 186 AMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKYGQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYTGKIKIG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 201 MDVAASEFY-RNGKYDLDFKSPD-DPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLT 278
Cdd:PLN00191 266 MDVAASEFYtKDKKYDLDFKEENnDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSLEDVQIVGDDLL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 279 VTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRS 358
Cdd:PLN00191 346 VTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIKTGAPCRS 425

                        410       420       430
                 ....*....|....*....|....*....|
gi 301897479 359 ERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:PLN00191 426 ERLAKYNQLLRIEEELGDEAVYAGENFRKP 455
 
Name Accession Description Interval E-value
PLN00191 PLN00191
enolase
 2-388 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 748.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   2 AMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKgRYLG---------------------- 59
Cdd:PLN00191  27 TITKVKARQIIDSRGNPTVEVDLHTSKGMFRAAVPSGASTGIYEALELRDGDK-DYLGkgvlkavknvneiiapaligmd 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 -------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKL 120
Cdd:PLN00191 106 ptdqtqidnfmleldgtpnKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNKKLVLPVPAFNVINGGSHAGNKL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 121 AMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIG 200
Cdd:PLN00191 186 AMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKYGQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYTGKIKIG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 201 MDVAASEFY-RNGKYDLDFKSPD-DPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLT 278
Cdd:PLN00191 266 MDVAASEFYtKDKKYDLDFKEENnDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSLEDVQIVGDDLL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 279 VTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRS 358
Cdd:PLN00191 346 VTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIKTGAPCRS 425

                        410       420       430
                 ....*....|....*....|....*....|
gi 301897479 359 ERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:PLN00191 426 ERLAKYNQLLRIEEELGDEAVYAGENFRKP 455
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 5-372 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 682.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   5 KIFAREILDSRGNPTVEVDLHTA-KGRFRAAVPSGASTGIYEALELRDGDKGRYLG------------------------ 59
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEdGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGkgvlkavknvneiiapaligmdvt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 -----------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAgnpDLILPVPAFNVINGGSHAGNKLAM 122
Cdd:cd03313   81 dqraidkllieldgtpnKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA---AYVLPVPMFNVINGGAHAGNKLDF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 123 QEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPD--KVVIG 200
Cdd:cd03313  158 QEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGGLLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPgkKIAIA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 201 MDVAASEFYRNGKYDLDfkspDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDDLT 278
Cdd:cd03313  238 LDVAASEFYDEGKYVYD----SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAklGDKIQIVGDDLF 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 279 VTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRS 358
Cdd:cd03313  314 VTNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRS 393

                        410
                 ....*....|....
gi 301897479 359 ERLAKYNQLMRIEE 372
Cdd:cd03313  394 ERTAKYNQLLRIEE 407
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 4-387 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 633.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   4 QKIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLG----------------------- 59
Cdd:COG0148    5 EDVHAREILDSRGNPTVEVEVTLEDGAVgRAAVPSGASTGSHEAVELRDGDKSRYLGkgvlkavenvneeiapaligmda 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 ------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNpdlILPVPAFNVINGGSHAGNKLA 121
Cdd:COG0148   85 tdqraidramieldgtpnKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAK---TLPVPMMNIINGGAHADNNVD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 122 MQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKygKDATNVGDEGGFAPNILENNEALELLKTAIQAAGY-P-DKVVI 199
Cdd:COG0148  162 IQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEK--GLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYkPgEDIAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 200 GMDVAASEFYRNGKYDLDFKSpddpaRHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDDL 277
Cdd:COG0148  240 ALDVAASEFYKDGKYHLKGEG-----KELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEklGDKVQLVGDDL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 278 TVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCR 357
Cdd:COG0148  315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                        410       420       430
                 ....*....|....*....|....*....|.
gi 301897479 358 SERLAKYNQLMRIEEALGDKAIFAGRK-FRN 387
Cdd:COG0148  395 SERVAKYNQLLRIEEELGDAARYAGRSaFKR 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 5-388 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 530.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479    5 KIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLGK----------------------- 60
Cdd:TIGR01060   3 DIRAREILDSRGNPTVEVEVILEDGTFgRAAVPSGASTGEREALELRDGDKKRYLGKgvlkavenvneiiapeligmdat 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   61 ------------------AKFGANAILGVSLAVCKAGAAEKGVPLYRHiadLAGNPDLILPVPAFNVINGGSHAGNKLAM 122
Cdd:TIGR01060  83 dqreidqilieldgtpnkSKLGANAILGVSMAVAKAAADSLGLPLYRY---LGGFNAYVLPVPMMNIINGGAHADNNLDF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  123 QEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYgkDATNVGDEGGFAPNILENNEALELLKTAIQAAGYP--DKVVIG 200
Cdd:TIGR01060 160 QEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKG--LATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKpgEDVALA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  201 MDVAASEFY--RNGKYDLDFKSpddpaRHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDD 276
Cdd:TIGR01060 238 LDCAASEFYdeEDGKYVYKGEN-----KQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKrlGDKVQIVGDD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  277 LTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPC 356
Cdd:TIGR01060 313 LFVTNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLS 392

                         410       420       430
                  ....*....|....*....|....*....|..
gi 301897479  357 RSERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:TIGR01060 393 RSERIAKYNQLLRIEEELGDSARYAGKNSFYR 424
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
100-388 0e+00

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 507.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  100 LILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNE 179
Cdd:pfam00113   2 YVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQSATNVGDEGGFAPNLQSNKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  180 ALELLKTAIQAAGYPDKVVIGMDVAASEFY--RNGKYDLDFKSPD-DPARHITGEKLGELYKSFIKNYPVVSIEDPFDQD 256
Cdd:pfam00113  82 ALDLIVEAIEKAGYKGKIKIAMDVASSEFYnkKDGKYDLDFKGEKsDKSKKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  257 DWATWTSFL--SGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETE 334
Cdd:pfam00113 162 DWEAWKYLTerLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 301897479  335 DTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKP 295
 
Name Accession Description Interval E-value
PLN00191 PLN00191
enolase
 2-388 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 748.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   2 AMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKgRYLG---------------------- 59
Cdd:PLN00191  27 TITKVKARQIIDSRGNPTVEVDLHTSKGMFRAAVPSGASTGIYEALELRDGDK-DYLGkgvlkavknvneiiapaligmd 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 -------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKL 120
Cdd:PLN00191 106 ptdqtqidnfmleldgtpnKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNKKLVLPVPAFNVINGGSHAGNKL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 121 AMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIG 200
Cdd:PLN00191 186 AMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKYGQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYTGKIKIG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 201 MDVAASEFY-RNGKYDLDFKSPD-DPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLT 278
Cdd:PLN00191 266 MDVAASEFYtKDKKYDLDFKEENnDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSLEDVQIVGDDLL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 279 VTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRS 358
Cdd:PLN00191 346 VTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIKTGAPCRS 425

                        410       420       430
                 ....*....|....*....|....*....|
gi 301897479 359 ERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:PLN00191 426 ERLAKYNQLLRIEEELGDEAVYAGENFRKP 455
PTZ00081 PTZ00081
enolase; Provisional
 1-382 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 721.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   1 MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLG--------------------- 59
Cdd:PTZ00081   2 STIKSIKAREILDSRGNPTVEVDLTTEKGVFRAAVPSGASTGIYEALELRDGDKSRYLGkgvlkavenvneiiapaligk 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 --------------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNP--DLILPVPAFNVIN 111
Cdd:PTZ00081  82 dvtdqkkldklmveqldgtknewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKPtdKFVLPVPCFNVIN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 112 GGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAA 191
Cdd:PTZ00081 162 GGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKYGLDATNVGDEGGFAPNIKDPEEALDLLVEAIKKA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 192 GYPDKVVIGMDVAASEFYRNGK--YDLDFKSPDDP-ARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS-- 266
Cdd:PTZ00081 242 GYEGKVKICMDVAASEFYDKEKkvYDLDFKNPNNDkSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKLTAai 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 267 GVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLC 346
Cdd:PTZ00081 322 GQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLVVGLG 401

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 301897479 347 TGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAG 382
Cdd:PTZ00081 402 TGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAG 437
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 5-372 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 682.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   5 KIFAREILDSRGNPTVEVDLHTA-KGRFRAAVPSGASTGIYEALELRDGDKGRYLG------------------------ 59
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEdGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGkgvlkavknvneiiapaligmdvt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 -----------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAgnpDLILPVPAFNVINGGSHAGNKLAM 122
Cdd:cd03313   81 dqraidkllieldgtpnKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA---AYVLPVPMFNVINGGAHAGNKLDF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 123 QEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPD--KVVIG 200
Cdd:cd03313  158 QEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGGLLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPgkKIAIA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 201 MDVAASEFYRNGKYDLDfkspDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDDLT 278
Cdd:cd03313  238 LDVAASEFYDEGKYVYD----SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAklGDKIQIVGDDLF 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 279 VTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRS 358
Cdd:cd03313  314 VTNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRS 393

                        410
                 ....*....|....
gi 301897479 359 ERLAKYNQLMRIEE 372
Cdd:cd03313  394 ERTAKYNQLLRIEE 407
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 4-387 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 633.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   4 QKIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLG----------------------- 59
Cdd:COG0148    5 EDVHAREILDSRGNPTVEVEVTLEDGAVgRAAVPSGASTGSHEAVELRDGDKSRYLGkgvlkavenvneeiapaligmda 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 ------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNpdlILPVPAFNVINGGSHAGNKLA 121
Cdd:COG0148   85 tdqraidramieldgtpnKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAK---TLPVPMMNIINGGAHADNNVD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 122 MQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKygKDATNVGDEGGFAPNILENNEALELLKTAIQAAGY-P-DKVVI 199
Cdd:COG0148  162 IQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEK--GLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYkPgEDIAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 200 GMDVAASEFYRNGKYDLDFKSpddpaRHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDDL 277
Cdd:COG0148  240 ALDVAASEFYKDGKYHLKGEG-----KELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEklGDKVQLVGDDL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 278 TVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCR 357
Cdd:COG0148  315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                        410       420       430
                 ....*....|....*....|....*....|.
gi 301897479 358 SERLAKYNQLMRIEEALGDKAIFAGRK-FRN 387
Cdd:COG0148  395 SERVAKYNQLLRIEEELGDAARYAGRSaFKR 425
eno PRK00077
enolase; Provisional
 1-390 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 605.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   1 MAMQKIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLG-------------------- 59
Cdd:PRK00077   2 SKIEDIIAREILDSRGNPTVEVEVTLEDGAFgRAAVPSGASTGEREAVELRDGDKSRYLGkgvlkavenvneeiapalig 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  60 ---------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHiadLAGNPDLILPVPAFNVINGGSHAGN 118
Cdd:PRK00077  82 ldaldqraidkamieldgtpnKSKLGANAILGVSLAVAKAAADSLGLPLYRY---LGGPNAKVLPVPMMNIINGGAHADN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 119 KLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKyGKdATNVGDEGGFAPNILENNEALELLKTAIQAAGY-PDK- 196
Cdd:PRK00077 159 NVDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEK-GL-STAVGDEGGFAPNLKSNEEALDLILEAIEKAGYkPGEd 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 197 VVIGMDVAASEFYRNGKYDLDFKSpddparhITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVG 274
Cdd:PRK00077 237 IALALDCAASEFYKDGKYVLEGEG-------LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEklGDKVQLVG 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 275 DDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGA 354
Cdd:PRK00077 310 DDLFVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGS 389

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 301897479 355 PCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNPKA 390
Cdd:PRK00077 390 LSRSERIAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 5-388 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 530.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479    5 KIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLGK----------------------- 60
Cdd:TIGR01060   3 DIRAREILDSRGNPTVEVEVILEDGTFgRAAVPSGASTGEREALELRDGDKKRYLGKgvlkavenvneiiapeligmdat 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   61 ------------------AKFGANAILGVSLAVCKAGAAEKGVPLYRHiadLAGNPDLILPVPAFNVINGGSHAGNKLAM 122
Cdd:TIGR01060  83 dqreidqilieldgtpnkSKLGANAILGVSMAVAKAAADSLGLPLYRY---LGGFNAYVLPVPMMNIINGGAHADNNLDF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  123 QEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYgkDATNVGDEGGFAPNILENNEALELLKTAIQAAGYP--DKVVIG 200
Cdd:TIGR01060 160 QEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKG--LATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKpgEDVALA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  201 MDVAASEFY--RNGKYDLDFKSpddpaRHITGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLS--GVNIQIVGDD 276
Cdd:TIGR01060 238 LDCAASEFYdeEDGKYVYKGEN-----KQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKrlGDKVQIVGDD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  277 LTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPC 356
Cdd:TIGR01060 313 LFVTNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLS 392

                         410       420       430
                  ....*....|....*....|....*....|..
gi 301897479  357 RSERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:TIGR01060 393 RSERIAKYNQLLRIEEELGDSARYAGKNSFYR 424
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
100-388 0e+00

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 507.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  100 LILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNE 179
Cdd:pfam00113   2 YVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQSATNVGDEGGFAPNLQSNKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  180 ALELLKTAIQAAGYPDKVVIGMDVAASEFY--RNGKYDLDFKSPD-DPARHITGEKLGELYKSFIKNYPVVSIEDPFDQD 256
Cdd:pfam00113  82 ALDLIVEAIEKAGYKGKIKIAMDVASSEFYnkKDGKYDLDFKGEKsDKSKKLTSAQLADLYEELVKKYPIVSIEDPFDED 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479  257 DWATWTSFL--SGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETE 334
Cdd:pfam00113 162 DWEAWKYLTerLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGETE 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 301897479  335 DTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAIFAGRKFRNP 388
Cdd:pfam00113 242 DTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKP 295
Enolase_N pfam03952
Enolase, N-terminal domain;
4-91 8.21e-51

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 166.78  E-value: 8.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479    4 QKIFAREILDSRGNPTVEVDLHTAKGRF-RAAVPSGASTGIYEALELRDGDKGRYLG----------------------- 59
Cdd:pfam03952   2 TKVKAREILDSRGNPTVEVEVTLEDGTFgRAAVPSGASTGEHEAVELRDGDKSRYGGkgvlkavenvneiiapaligmda 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 301897479   60 ------------------KAKFGANAILGVSLAVCKAGAAEKGVPLYRHI 91
Cdd:pfam03952  82 tdqraidralieldgtenKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 223-345 7.60e-16

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 76.21  E-value: 7.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 223 DPARHITGEKLGELYKSFIKnYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRiAQAVEKKACNCLLLKVN 302
Cdd:cd00308  100 DANGAWTPKEAIRLIRALEK-YGLAWIEEPCAPDDLEGYAALRRRTGIPIAADESVTTVDDA-LEALELGAVDILQIKPT 177

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 301897479 303 QIGSVTESIQACKLAQSNGWGVMVSHRSG-ETEDTFIADLVVGL 345
Cdd:cd00308  178 RVGGLTESRRAADLAEAFGIRVMVHGTLEsSIGTAAALHLAAAL 221
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 244-326 3.68e-04

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 42.12  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479 244 YPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDlTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWG 323
Cdd:COG4948  208 LGLEWIEQPLPAEDLEGLAELRRATPVPIAADE-SLTSRADFRRLIEAGAVDIVNIKLSKVGGLTEALRIAALAEAHGVP 286


                 ...
gi 301897479 324 VMV 326
Cdd:COG4948  287 VMP 289
PRK08350 PRK08350
hypothetical protein; Provisional
 3-105 1.87e-03

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 39.79  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301897479   3 MQKIFAREILDSRGNPTVEVDLHTAK--GRFRAAVPSGASTGIYEA----------------------LELRDGDKGRYL 58
Cdd:PRK08350   4 IENIIGRVAVLRGGKYSVEVDVITDSgfGRFAAPIDENPSLYIAEAhravsevdeiigpeligfdaseQELIDSYLWEID 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 301897479  59 GKAKF---GANAILGVSLAVCKAGAAEKGVPLYRHIadlAGNPDLILPVP 105
Cdd:PRK08350  84 GTEDFshiGANTALAVSVAVAKAAANSKNMPLYSYI---GGTFTTELPVP 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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