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Conserved domains on  [gi|302191708|ref|NP_001180542|]
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tubulin delta chain isoform 6 [Homo sapiens]

Protein Classification

tubulin family protein( domain architecture ID 10115139)

tubulin family protein similar to tubulin delta chain that acts as a positive regulator of hedgehog signaling and regulates ciliary function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-236 2.03e-97

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


:

Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 290.71  E-value: 2.03e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708   1 MNIKQI-SFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGL 79
Cdd:cd02189  208 LGLKNPvSFSDINRVIARQLAGVLLPSSSPTSPSPLRRCPLGDLLEHLCPHPAYKLLTLRSLPQMPEPSRAFSTYTWPSL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708  80 LKHLRQMLISNAKMEEGIDRHvwpplsglpplsKMSLNKDLHFNTSIANLVILRGKD---VQSADVEGFKDPALYTSWLK 156
Cdd:cd02189  288 LKRLRQMLITGAKLEEGIDWQ------------LLDTSGSHNPNKSLAALLVLRGKDamkVHSADLSAFKDPVLYSPWVP 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708 157 pvNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCN 236
Cdd:cd02189  356 --NPFNVSVSPRPFNGYEKSVTLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQYEKYGVEEEDFLDAFATLEQIIAAYKS 433
 
Name Accession Description Interval E-value
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-236 2.03e-97

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 290.71  E-value: 2.03e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708   1 MNIKQI-SFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGL 79
Cdd:cd02189  208 LGLKNPvSFSDINRVIARQLAGVLLPSSSPTSPSPLRRCPLGDLLEHLCPHPAYKLLTLRSLPQMPEPSRAFSTYTWPSL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708  80 LKHLRQMLISNAKMEEGIDRHvwpplsglpplsKMSLNKDLHFNTSIANLVILRGKD---VQSADVEGFKDPALYTSWLK 156
Cdd:cd02189  288 LKRLRQMLITGAKLEEGIDWQ------------LLDTSGSHNPNKSLAALLVLRGKDamkVHSADLSAFKDPVLYSPWVP 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708 157 pvNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCN 236
Cdd:cd02189  356 --NPFNVSVSPRPFNGYEKSVTLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQYEKYGVEEEDFLDAFATLEQIIAAYKS 433
 
Name Accession Description Interval E-value
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-236 2.03e-97

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 290.71  E-value: 2.03e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708   1 MNIKQI-SFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGL 79
Cdd:cd02189  208 LGLKNPvSFSDINRVIARQLAGVLLPSSSPTSPSPLRRCPLGDLLEHLCPHPAYKLLTLRSLPQMPEPSRAFSTYTWPSL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708  80 LKHLRQMLISNAKMEEGIDRHvwpplsglpplsKMSLNKDLHFNTSIANLVILRGKD---VQSADVEGFKDPALYTSWLK 156
Cdd:cd02189  288 LKRLRQMLITGAKLEEGIDWQ------------LLDTSGSHNPNKSLAALLVLRGKDamkVHSADLSAFKDPVLYSPWVP 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708 157 pvNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCN 236
Cdd:cd02189  356 --NPFNVSVSPRPFNGYEKSVTLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQYEKYGVEEEDFLDAFATLEQIIAAYKS 433
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 1-236 8.24e-39

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 138.10  E-value: 8.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708   1 MNIKQISFSDINQVLAHQLGSVFQPTYSAEssfhYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLayttFTWAGLL 80
Cdd:cd06059  179 LDIDFPPFDDMNNLVAQLLSSLTSSLRFEG----SLNVDLNEITTNLVPFPRLHFLLPSLSPLTSANDV----TLEPLTL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708  81 KHLRQMLISNAKMEEGIDrhvwpplsglpplskmslnkdLHFNTSIANLVILRGKDVQSADVEGFKDPALYTSWLKPVNa 160
Cdd:cd06059  251 DQLFSDLFSKDNQLVGCD---------------------PRHGTYLACALLLRGKVFSLSDVRRNIDRIKPKLKFISWN- 308

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302191708 161 FNVWKTQRAFSK---YEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCN 236
Cdd:cd06059  309 PDGFKVGLCSVPpvgQKYSLLFLSNNTSIASTFERLIERFDKLYKRKAFLHHYTGEGMEEGDFSEARESLANLIQEYQE 387
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-229 1.94e-05

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 44.84  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708   1 MNIKQISFSDINQVLAHQLGSVFqptysaeSSFHYRRNPLGDLME---HLVPHPEFKMLSVRNIPHMSENSLAYTTFTwa 77
Cdd:cd02186  216 LDIERPTYTNLNRLIAQVVSSLT-------ASLRFDGALNVDLNEfqtNLVPYPRIHFPLVSYAPIISAEKANHEQLS-- 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708  78 glLKHLRQMLISNAKMeegidrhvwpplsglpplskMsLNKDLHFNTSIANLVILRGkDVQSADVEgfkdpalytswlkp 157
Cdd:cd02186  287 --VQEITNSCFEPANQ--------------------M-VKCDPRHGKYMACCLLYRG-DVVPKDVN-------------- 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302191708 158 vNAFNVWKTQRA---------------------------FSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQY 210
Cdd:cd02186  329 -AAIATIKTKRTiqfvdwcptgfkvginyqpptvvpgsdLAKVDRSVCMLANSTAIAEAFQRLDHKFDLLYSKRAFVHWY 407

                        250       260
                 ....*....|....*....|..
gi 302191708 211 TKFGIEEEDF---LDSFTSLEQ 229
Cdd:cd02186  408 VGEGMEEGEFseaREDLAALEK 429
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 173-236 2.42e-04

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 41.40  E-value: 2.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302191708 173 YEKSAVLVSNS---QFLVKpldmIVGKAWN-MFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCN 236
Cdd:cd02187  360 LKMSATFIGNStaiQELFK----RLSEQFTaMFRRKAFLHWYTGEGMDEMEFTEAESNLNDLISEYQQ 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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