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Conserved domains on  [gi|302699215|ref|NP_001181867|]
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pogo transposable element with ZNF domain isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
959-1020 1.26e-13

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


:

Pssm-ID: 197828  Cd Length: 66  Bit Score: 66.93  E-value: 1.26e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302699215    959 KYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSL-EGGFKISYEWAVRFMLRHHLT 1020
Cdd:smart00674    1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLgLENFKASKGWLTRFKKRHNIV 63
DDE_3 super family cl46863
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 1100-1211 8.84e-10

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


The actual alignment was detected with superfamily member pfam03184:

Pssm-ID: 481203  Cd Length: 177  Bit Score: 59.33  E-value: 8.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302699215  1100 AILADGTVLPTLVFYRGQ-------MDQPANMPdsILLEAKESGYSDDEIMELWSTRVWQKHTACQRS-KGMLVMDCHRT 1171
Cdd:pfam03184   10 CNAAGSEKLPPLVIGKGKnprafknEKTPKPLP--VEYKSNGKAWMTTSIFEEWLQKWFDPRMRESPGrKVLLLLDGSGS 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 302699215  1172 HLSEEVLAMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVK 1211
Cdd:pfam03184   88 HPTVELIRSCGLQNIFLVFLPANSTSILQPLDQGVVSTFK 127
PLN02983 super family cl33616
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 351-400 2.68e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


The actual alignment was detected with superfamily member PLN02983:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.36  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302699215  351 SEPSVPSAAKPPSPEKTAPVASTPSSTPI--PALSPPTKV-------------------PEPNE----NVGDAVQ 400
Cdd:PLN02983  153 MQPPPPHAMPPASPPAAQPAPSAPASSPPptPASPPPAKApksshpplkspmagtfyrsPAPGEppfvKVGDKVQ 227
 
Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
959-1020 1.26e-13

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 66.93  E-value: 1.26e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302699215    959 KYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSL-EGGFKISYEWAVRFMLRHHLT 1020
Cdd:smart00674    1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLgLENFKASKGWLTRFKKRHNIV 63
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 1100-1211 8.84e-10

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 59.33  E-value: 8.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302699215  1100 AILADGTVLPTLVFYRGQ-------MDQPANMPdsILLEAKESGYSDDEIMELWSTRVWQKHTACQRS-KGMLVMDCHRT 1171
Cdd:pfam03184   10 CNAAGSEKLPPLVIGKGKnprafknEKTPKPLP--VEYKSNGKAWMTTSIFEEWLQKWFDPRMRESPGrKVLLLLDGSGS 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 302699215  1172 HLSEEVLAMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVK 1211
Cdd:pfam03184   88 HPTVELIRSCGLQNIFLVFLPANSTSILQPLDQGVVSTFK 127
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
964-1020 2.79e-07

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 48.78  E-value: 2.79e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302699215   964 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSL----EGGFKISYEWAVRFMLRHHLT 1020
Cdd:pfam03221    3 DLEKALYEWILQLRARGIPITGPMIREKALELAQLAadlgEPDFKASKGWLDRFKKRHGIK 63
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 351-400 2.68e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.36  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302699215  351 SEPSVPSAAKPPSPEKTAPVASTPSSTPI--PALSPPTKV-------------------PEPNE----NVGDAVQ 400
Cdd:PLN02983  153 MQPPPPHAMPPASPPAAQPAPSAPASSPPptPASPPPAKApksshpplkspmagtfyrsPAPGEppfvKVGDKVQ 227
zntR PRK09514
Zn(2+)-responsive transcriptional regulator;
1099-1163 3.83e-03

Zn(2+)-responsive transcriptional regulator;


Pssm-ID: 181924 [Multi-domain]  Cd Length: 140  Bit Score: 39.18  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302699215 1099 LAILADGTVlPTLVFY-RGQMDQPANMPDS--------------ILLEAKESGYSDDEIMELWSTRVWQKHTACQRSKGM 1163
Cdd:PRK09514    7 LAKLAEVTP-DTLRFYeKQGLMDPEVRTEGgyrlyteqdlqrlrFIRRAKQLGFTLEEIRELLSIRLDPEHHTCQEVKGI 85
 
Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
959-1020 1.26e-13

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 66.93  E-value: 1.26e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302699215    959 KYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSL-EGGFKISYEWAVRFMLRHHLT 1020
Cdd:smart00674    1 RRLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLgLENFKASKGWLTRFKKRHNIV 63
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 1100-1211 8.84e-10

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 59.33  E-value: 8.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302699215  1100 AILADGTVLPTLVFYRGQ-------MDQPANMPdsILLEAKESGYSDDEIMELWSTRVWQKHTACQRS-KGMLVMDCHRT 1171
Cdd:pfam03184   10 CNAAGSEKLPPLVIGKGKnprafknEKTPKPLP--VEYKSNGKAWMTTSIFEEWLQKWFDPRMRESPGrKVLLLLDGSGS 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 302699215  1172 HLSEEVLAMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVK 1211
Cdd:pfam03184   88 HPTVELIRSCGLQNIFLVFLPANSTSILQPLDQGVVSTFK 127
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
964-1020 2.79e-07

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 48.78  E-value: 2.79e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302699215   964 EAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSL----EGGFKISYEWAVRFMLRHHLT 1020
Cdd:pfam03221    3 DLEKALYEWILQLRARGIPITGPMIREKALELAQLAadlgEPDFKASKGWLDRFKKRHGIK 63
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 351-400 2.68e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.36  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302699215  351 SEPSVPSAAKPPSPEKTAPVASTPSSTPI--PALSPPTKV-------------------PEPNE----NVGDAVQ 400
Cdd:PLN02983  153 MQPPPPHAMPPASPPAAQPAPSAPASSPPptPASPPPAKApksshpplkspmagtfyrsPAPGEppfvKVGDKVQ 227
zntR PRK09514
Zn(2+)-responsive transcriptional regulator;
1099-1163 3.83e-03

Zn(2+)-responsive transcriptional regulator;


Pssm-ID: 181924 [Multi-domain]  Cd Length: 140  Bit Score: 39.18  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302699215 1099 LAILADGTVlPTLVFY-RGQMDQPANMPDS--------------ILLEAKESGYSDDEIMELWSTRVWQKHTACQRSKGM 1163
Cdd:PRK09514    7 LAKLAEVTP-DTLRFYeKQGLMDPEVRTEGgyrlyteqdlqrlrFIRRAKQLGFTLEEIRELLSIRLDPEHHTCQEVKGI 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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