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Conserved domains on  [gi|303305003|ref|NP_001181934|]
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cilia- and flagella-associated protein 300 isoform 2 [Homo sapiens]

Protein Classification

cilia- and flagella-associated protein 300( domain architecture ID 143884)

cilia- and flagella-associated protein 300 (CFAP300) is a DUF4498 domain-containing protein that may play a role in outer and inner dynein arm assembly

Gene Ontology:  GO:0031514
PubMed:  29727693

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFAP300 super family cl20812
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
 14-90 4.30e-35

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


The actual alignment was detected with superfamily member pfam14926:

Pssm-ID: 464382  Cd Length: 246  Bit Score: 119.66  E-value: 4.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 303305003   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLsDSSGQWIILG 90
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLL-SSSGQWGPLG 76
 
Name Accession Description Interval E-value
CFAP300 pfam14926
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
 14-90 4.30e-35

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


Pssm-ID: 464382  Cd Length: 246  Bit Score: 119.66  E-value: 4.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 303305003   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLsDSSGQWIILG 90
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLL-SSSGQWGPLG 76
 
Name Accession Description Interval E-value
CFAP300 pfam14926
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
 14-90 4.30e-35

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


Pssm-ID: 464382  Cd Length: 246  Bit Score: 119.66  E-value: 4.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 303305003   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLsDSSGQWIILG 90
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLL-SSSGQWGPLG 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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