T-cell surface glycoprotein CD4 isoform 3 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CD4_CD | cd22570 | cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ... |
128-171 | 2.70e-22 | ||
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis. : Pssm-ID: 439337 Cd Length: 44 Bit Score: 84.48 E-value: 2.70e-22
|
||||||
| CD4-extracel super family | cl48047 | CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ... |
1-43 | 7.76e-19 | ||
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens. The actual alignment was detected with superfamily member pfam09191: Pssm-ID: 462712 Cd Length: 106 Bit Score: 77.34 E-value: 7.76e-19
|
||||||
| C2-set | pfam05790 | Immunoglobulin C2-set domain; |
44-116 | 3.58e-17 | ||
Immunoglobulin C2-set domain; : Pssm-ID: 399065 Cd Length: 80 Bit Score: 72.38 E-value: 3.58e-17
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| CD4_CD | cd22570 | cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ... |
128-171 | 2.70e-22 | ||
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis. Pssm-ID: 439337 Cd Length: 44 Bit Score: 84.48 E-value: 2.70e-22
|
||||||
| CD4-extracel | pfam09191 | CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ... |
1-43 | 7.76e-19 | ||
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens. Pssm-ID: 462712 Cd Length: 106 Bit Score: 77.34 E-value: 7.76e-19
|
||||||
| C2-set | pfam05790 | Immunoglobulin C2-set domain; |
44-116 | 3.58e-17 | ||
Immunoglobulin C2-set domain; Pssm-ID: 399065 Cd Length: 80 Bit Score: 72.38 E-value: 3.58e-17
|
||||||
| IgV_3_CD4 | cd07695 | Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of ... |
1-41 | 1.73e-13 | ||
Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the third immunoglobulin variable (IgV) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. Pssm-ID: 409492 Cd Length: 107 Bit Score: 63.45 E-value: 1.73e-13
|
||||||
| Tcell_CD4_C | pfam12104 | T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell ... |
153-180 | 8.38e-03 | ||
T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalization. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure. Pssm-ID: 403359 Cd Length: 28 Bit Score: 32.86 E-value: 8.38e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| CD4_CD | cd22570 | cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ... |
128-171 | 2.70e-22 | ||
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis. Pssm-ID: 439337 Cd Length: 44 Bit Score: 84.48 E-value: 2.70e-22
|
||||||
| CD4-extracel | pfam09191 | CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ... |
1-43 | 7.76e-19 | ||
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens. Pssm-ID: 462712 Cd Length: 106 Bit Score: 77.34 E-value: 7.76e-19
|
||||||
| C2-set | pfam05790 | Immunoglobulin C2-set domain; |
44-116 | 3.58e-17 | ||
Immunoglobulin C2-set domain; Pssm-ID: 399065 Cd Length: 80 Bit Score: 72.38 E-value: 3.58e-17
|
||||||
| IgV_3_CD4 | cd07695 | Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of ... |
1-41 | 1.73e-13 | ||
Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the third immunoglobulin variable (IgV) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. Pssm-ID: 409492 Cd Length: 107 Bit Score: 63.45 E-value: 1.73e-13
|
||||||
| Tcell_CD4_C | pfam12104 | T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell ... |
153-180 | 8.38e-03 | ||
T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalization. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure. Pssm-ID: 403359 Cd Length: 28 Bit Score: 32.86 E-value: 8.38e-03
|
||||||
| Blast search parameters | ||||
|
